Implementing 3-D ultrasound elastography in an automated ...
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Introduction Automated breast volume scanner (ABVS) [1] • Designed for screening with ultrasound (US) • Creates stacks of continious US images covering the entire breast • Operator-independent • Suitable for dense breasts Ultrasound elastography • Imaging method based on lesion stiffness (malignant lesions are stiffer than healthy breast tissue) • Can be used as add-on to gray-scale ultrasound to improve specificity for cancer detection [2] • So far not available for ABVS Objective Development of 3-D ultrasound elastography for ABVS to improve breast lesion classification Material and Methods • Two ABVS scans of the breast at different rates of deformation • Analysis of raw ultrasound data to estimate the tissue stiffness • Validation in breast elastography phantom • Feasibility evaluation with initial patient studies Results Elastographic breast phantom In-patient: invasive ductal carcinoma Discussion 3-D ultrasound elastography is feasible for ABVS • Verified by phantom and initial in-patient results • Expected to improve specificity of ABVS [2] • Operator-independent elastography • Relatively easy to implement in clinical routine • Allows simultaneous reading of elastographs and B-mode Future steps: • Automated acquisition of pre- and post-deformation scans • Patient study to determine clinical value • Reduce breathing artifacts by ultrafast ultrasound imaging • In house-developed ABVS prototype demonstrates that this might be possible [3] Conclusion An operator-independent 3-D breast ultrasound elastography method was brought from bench to bedside, in order to improve specificity of the ABVS system. Implementing 3-D ultrasound elastography in an automated breast volume scanner to improve specificity for breast cancer detection Gijs A.G.M. Hendriks 1 , Chuan Chen 1 , Aisha S.S. Meel - Van Den Abeelen 1 , Hendrik H.G. Hansen 1 , Chris L. De Korte 1 ¹Medical UltraSound Imaging Center, Department of Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, the Netherlands Gijs.Hendriks @radboudumc.nl www.radboudmusic.nl [1] Acuson S2000 ABVS, Siemens Healthcare, Issaquah, WA [2] Barr RG, J Ultrasound Med, 2012: 31(5): 773-83. [3] Hendriks GAGM et al., Phys Med Biol. 2016: 61(7):2665-79 This research is supported by Siemens Medical Solutions and by the Dutch Technology Foundation STW (Project 13290) which is part of the Netherlands Organization for Scientific Research (NWO) and is partly funded by the Ministry of Economic Affairs. 3-D elastographic volume Pre- and post deformation 3-D scan In house-developed 3-D elastography algorithm [3] Stiff Soft Pre-deformation ultrasound volume Post-deformation ultrasound volume Pre-deformation Post-deformation (↓2 mm) Transverse Sagittal Coronal Transverse Sagittal Coronal
Transcript of Implementing 3-D ultrasound elastography in an automated ...
IntroductionAutomated breast volume scanner (ABVS) [1]
• Designed for screening with ultrasound (US)• Creates stacks of continious US
images covering the entire breast• Operator-independent• Suitable for dense breasts
Ultrasound elastography• Imaging method based on lesion
stiffness (malignant lesions arestiffer than healthy breast tissue)
• Can be used as add-on to gray-scale ultrasound to improve specificity for cancer detection [2]
• So far not available for ABVS
ObjectiveDevelopment of 3-D ultrasound elastography for ABVS to improve breast lesion classification
Material and Methods• Two ABVS scans of the breast at different rates of deformation• Analysis of raw ultrasound data to estimate the tissue stiffness• Validation in breast elastography phantom• Feasibility evaluation with initial patient studies
ResultsElastographic breast phantom
In-patient: invasive ductal carcinoma
Discussion3-D ultrasound elastography is feasible for ABVS• Verified by phantom and initial in-patient results• Expected to improve specificity of ABVS [2]• Operator-independent elastography• Relatively easy to implement in clinical routine• Allows simultaneous reading of elastographs and B-mode
Future steps:• Automated acquisition of pre- and post-deformation scans• Patient study to determine clinical value• Reduce breathing artifacts by ultrafast ultrasound imaging
• In house-developed ABVS prototype demonstrates that this might be possible [3]
ConclusionAn operator-independent 3-D breast ultrasound elastography method was brought from bench to bedside, in order to improve specificity of the ABVS system.
Implementing 3-D ultrasound elastography in an automated breast volume scanner to improve specificity for breast cancer detection
Gijs A.G.M. Hendriks1, Chuan Chen1, Aisha S.S. Meel - Van Den Abeelen1, Hendrik H.G. Hansen1, Chris L. De Korte1
¹Medical UltraSound Imaging Center, Department of Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, the Netherlands
[1] Acuson S2000 ABVS, Siemens Healthcare, Issaquah, WA [2] Barr RG, J Ultrasound Med, 2012: 31(5): 773-83. [3] Hendriks GAGM et al., Phys Med Biol. 2016: 61(7):2665-79
This research is supported by Siemens Medical Solutions and by the Dutch Technology Foundation STW (Project 13290) which is part of the Netherlands Organization for Scientific Research (NWO) and is partly funded by the Ministry of Economic Affairs.
3-D elastographic volume
Pre- and post deformation
3-D scan
In house-developed
3-D elastography algorithm [3]
Stiff
Soft
Pre-deformation ultrasound volume
Post-deformation ultrasound volume
Pre-deformation Post-deformation (↓2 mm)
Transverse
SagittalCoronal
Transverse
SagittalCoronal
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