BIOREGION OF CATALONIA

www.biocat.cat

IMPACTMETRICS

THE BIOREGION OF CATALONIAA RESEARCH AND INNOVATION HUB IN SOUTHERN EUROPECatalonia is the most dynamic bioregion in Spain. The BioRegion of Catalonia brings together 560 companies as well as 56 research centers, 17 university hospitals and 11 universities offering studies in the life sciences. 16 science and technology parks with activity in the life sciences, more than 100 scientific platforms and large research facilities like the Alba-Cells Synchrotron, the Barcelona Supercomputing Center (BSC) and the National Center for Genomic Analysis (CNAG) make Catalonia and its capital, Barcelona, an outstanding research and innovation hub in southern Europe.

BIOCAT, DRIVING THE BIOCLUSTERBiocat is the organization that coordinates and promotes the life sciences sector in Catalonia. Biocat’s mission is to support and dynamize all the stakeholders in this area to boost research, innovation and companies’ growth in order to make the life sciences a driving force for the country’s economy and contribute to the wellbeing of society as a whole. Created in 2006 at the behest of the Government of Catalonia and the Barcelona City Council, Biocat is a foundation that brings together representatives from all areas of the biotechnology, biomedicine and medical technology sector: administrations, universities, research centers, companies and support bodies.

UNIVERSITIES (OUT OF 12)OFFERING STUDIES INLIFE SCIENCES

11

LARGE RESEARCHFACILITIES

2

UNIVERSITY HOSPITALS17

RESEARCH INSTITUTES(OUT OF 66)

56

TECHNOLOGICALCENTERS

12

SCIENCE &TECHNOLOGY PARKS

16

64 MEDTECH

39 PHARMA

124 SUPPLIER& ENGINEERING

25 INVESTORS

PROFESSIONALSERVICES ANDCONSULTING

111

BIOTECH197

11 2

1756

1216

64

39

124

25

111

197

114RESEARCH

ORGANIZATIONS

560COMPANIES

Source: Biocat Directory (December 2014)

A WIDE ECOSYSTEM WHERE SCIENCE AND BUSINESS MEET

Sources: Biocat Directory (Dec. 2014), Catalan Union of Hospitals, Government of Catalonia and SABI

EMPLOYMENT AND RESOURCESCOMPANIES RESEARCH CENTERS HOSPITALS

3.500

7.200WORKERS

+90.000 WORKERS (PUBLIC PROVIDERS)

4.500RESEARCHERS RESEARCHERS

IN BIOMEDICINE

35.000

PHARMA13.800

BIOTECH8.500 OTHERS

6.300

MEDTECH6.400

WORKERS

COMPANIES HAD REVENUESOVER 11.000 M€ AND CONTRIBUTED WITH 6%

TO THE GDP IN CATALONIA IN 10 YEARS, HUMAN RESOURCES IN R&D HAVE

INCREASED 50% AND THE RESEARCH COMMUNITY 60%

Source: FECYT, Farmaindustria, INE (2013)

INVESTMENT IN CATALONIA IN R&D

€ 345MPHARMA

INDUSTRY

€ 147MBIOTECH

COMPANIES

€ 681MUNIVERSITIES

FINANCEPRIVATE INVESTMENTS IN CATALAN LIFE SCIENCE COMPANIES

MAB* VENTURE CAPITAL

Source: BiotechGate. Biocat Directory

IN MILLION EUROS / *MAB: Spanish sub-market for smaller, growing companies

35

30

25

20

15

10

5

0

2013

25.6

3.6

2012

18

5

2008

12,4

12.4

2010

6.6

2009

5.6

2011

12.9

4.3

AN INTERNATIONAL COMPETITIVE R&D SYSTEM

Source: Government of Catalonia

1 2 32 UNIVERSITIES AMONG THE 200

BEST INTHE WORLD

3 UNIVERSITIESAMONG

THE 50 BESTUNDER

50 YEARS

19TH BEST STUDENTCITY OF THE WORLD

BARCELONA 1 UNIVERSITY AMONG THE 60 TOP

UNIVERSITIESIN THE WORLD IN

SCIENTIFIC PRODUCTION

CRG9TH IN THE TOP 100 BEST BIOMEDICAL CENTERS

IN THE WORLDScimago Report (SIR 2013)

ICIQ1ST WORLD INSTITUTION

IN CHEMISTRYMax Plank Institute (2014)

ICFO 1ST WORLD INSTITUTION

IN PHYSICS Max Plank Institute (2013)

URAP (2014) ARWU AND QS (2014)QS TOP-50 UNIVERSITIESUNDER 50 YEARS (2014) QS BEST STUDENTS CITIES 2015

EUROPEAN RESEARCH COUNCIL GRANTS (ERC)PER MILLION INHABITANTS (2007-2014)

Source: Government of Catalonia

SWITZERLAND*ISRAEL*

NETHERLANDSCATALONIA

SWEDEN DENMARK

UNITED KINGDOMFINLANDBELGIUMCYPRUSAUSTRIAIRELANDFRANCENORWAY

GERMANY

EUROPEAN UNIONEUROPEAN RESEARCH AREA

SPAINITALY

HUNGARYPORTUGAL

SPAIN EXCLUDING CATALONIAGREECE

COUNTRY ERC GRANTS39.3

34.125.1

20.4

5.97.4

7.9

3.2

CATALONIA STANDS IN 2ND POSITION IN THE EUROPEAN UNION IN TERMS OF ERC GRANTS

17.316.8

15.714.0

13.512.812.7

10.79.1

8.57.9

4.54.0

3.7

3.1

*NON-EU COUNTRIES

SUCESS STORIESSUCESS STORIES

SUBSECTOR OF ACTIVITY OF MEDTECH COMPANIES

Source: Biocat Directory (December 2014)

EACH COMPANY MAY BE INCLUDED INTO MORE THAN ONE CATEGORY

REUSABLE INSTRUMENTS

NON-ACTIVE IMPLANTABLE DEVICES

ELECTRO MECHANICAL MEDICAL DEVICES

DENTAL DEVICES

SINGLE USE DEVICES

OPHTHALMIC AND OPTICAL DEVICES

IMAGING

ANESTHETIC AND RESPIRATORY DEVICES

HOSPITAL HARDWARE

BIOMATERIALS

IN VITRO DIAGNOSTICS DEVICES

DIAGNOSTIC AND THERAPEUTIC RADIATION DEVICES

TECHNICAL AIDS FOR DISABLED PERSONS

REGENERATIVE MEDICINE

WOUND CARE

DELIVERY DEVICES

OTHER

THERAPEUTIC AREAS NUMBER OF COMPANIES23

1616

1311

11

11

9

6

6

5

53

3

2

2

COMPANIES WORKING IN MEDTECH:

16

64

45

DEVELOP R&DFOR NEW MEDICALAND DIAGNOSTICDEVICES

WORK IN RELATEDAREAS LIKESOFTWARE,ELECTRONICS,INSTRUMENTATIONOR DISTRIBUTION

109

MAIN THERAPEUTIC AREAS (BIOTECH & PHARMA)

Source: Biocat Directory (December 2014)

CENTRAL NERVOUS SYSTEMONCOLOGY

CARDIOVASCULAR DISEASESINFECTIOUS DISEASES

DERMATOLOGYIMMUNOLOGY AND HEMATOLOGY

RESPIRATORYINFLAMMATORY DISEASES

ENDOCRINOLOGYMENTAL DISORDERS

GENITOURINARY SYSTEMOPHTHALMOLOGYDIGESTIVE SYSTEM

OBSTETRICS & GYNECOLOGYOTOLOGY

THERAPEUTIC AREAS NUMBER OF COMPANIES 27

2219

18

17

14

14

14

13

11

9

7

7

2

1

EACH COMPANY MAY BE INCLUDED INTO MORE THAN ONE CATEGORY

BIOTECH COMPANIES ACTIVITIES

Source: Biocat Directory (December 2014)

THERAPIES & DIAGNOSTICSR&D SERVICES

BIOTECH-OTHER*

ACTIVITIES NUMBER OF COMPANIES

49

7276

*EACH COMPANY MAY BE INCLUDED INTO MORE THAN ONE CATEGORY

BIOTECH-OTHER*45%

35%

11%11%

14%8%

VETERINARY

FOOD & NUTRACEUTICALS

AGROBIO

COSMETICS

INDUSTRIAL BIOTECHNOLOGY

ENVIRONMENTAL

65% OF CATALAN BIOTECH, PHARMA AND MEDTECHCOMPANIES ARE TRADING THEIR PRODUCTS ININTERNATIONAL MARKETS

Source: Biocat's Internationalization Survey, 2013

30%

25%

20%

15%

10%

5%

0%

FranceGermany

United StatesItaly

Portugal

United KingdomJapan

Mexico

Russian Federation

Brasil

Switzerland

SwedenBelgium

ChinaIndia

Perce

ntatge

of co

mpan

ies

Sales Collaborations Future entrance

INTERNATIONAL MARKETS

Source: Biocat Directory (December 2014)

ENTREPRENEURSHIP INITIATIVES SUCH AS BIOEMPRENEDORXXI PROGRAMSUPPORTED THE CREATION OF 61 COMPANIES (2007-2014)

68 SPIN-OFF FROM UNIVERSITIES, RESEARCH INSTITUTES AND HOSPITALS

25

15

22

27 27

32

28

35

20

26

36 3638

28

18

0

40

30

20

10

20002001

20022003

20042005

20062007

20082009

20102011

20122013

2014

A CLUSTER IN EXPANSIONNEW COMPANIES CREATED (2000-2014)

87% OF BIOREGION COMPANIES ARE SMEsBIG COMPANIES ARE MAINLY MULTINATIONAL PHARMAS

BIG COMPANIES

MEDIUM-SIZEDCOMPANIES

SMALLCOMPANIES

MICROCOMPANIES

13%

19%

20%

48% COMPANIESSIZE

Source: Biocat Directory (December 2014)

Company category

Balance sheet totalEmployees

Medium-sized

Small

Micro

< 250

< 50

< 10

≤ € 50 m

≤ € 10 m

≤ € 2 m

≤ € 43 m

≤ € 10 m

≤ € 2 m

Turnover

A BUSINESS HUB WITH BALANCED REPRESENTATIONOF ALL FIELDS OF LIFE SCIENCES

Source: Biocat Directory (December 2014) and SABI

197 BIOTECH

THERAPEUTICS AND DIAGNOSTICS 9%

R&D SERVICES 14%

OTHERS 13%

PHARMA7%

MEDICALTECHNOLOGY 11%

SUPPLIER & ENGINEERING

22%

PROFESSIONAL SERVICES AND CONSULTING

20%

INVESTORS4%

4976

72

6439

124

11125

THERAPEUTICS AND DIAGNOSTICS 9%

> €5.000M2.5 % GDP CATALONIA€154.8M IN R&D3.564 EMPLOYEES (2.493 IN R&D)

€11.500 M6% GDP CATALONIA*35.000 EMPLOYEES

560COMPANIES

BARCELONABARCELONA

CATALONIA

WITH A LONG INDUSTRIAL TRADITION, CATALONIA HASA DENSE AND INNOVATIVE INDUSTRIAL COMMUNITY

• 23% OF SPANISH INVESTMENT IN R&D

• 20% OF GDP• 45% OF PHARMACEUTICAL INDUSTRY

• 6% OF SPANISH TERRITORY• 15% OF POPULATION (7M INHABITANTS)

BIOREGION OF CATALONIA

www.biocat.cat

IMPACTMETRICS