Immunology Plan of the Course 2014
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Transcript of Immunology Plan of the Course 2014
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University of Zagreb School of Medicine
Plan of the course
Immunology
Academic year 2013/14
Course coordinators:
Professor Dora Vinji, MD, PhD Assistant Professor Vesna Lukinovi-kudar, MD, PhD
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I.I.I.I.
COURSE AIMSCOURSE AIMSCOURSE AIMSCOURSE AIMS: : : :
The course is intended to provide important and recent knowledge of cellular and molecular immunology. Students will be presented large amount of complex information within three weeks; therefore, the main aim is to teach basic concepts of experimental immunology, which are also applicable in a clinical setting. The extensive additional reading will be provided for students who would like to learn more about immune system function in health and disease. Lectures will be focused on important concepts of immune system function in physiological and pathological conditions. Seminars will include interactive discussion, as well as the presentation of clinical cases, in order to present complex mechanisms of immune response in a clear and understandable way. Practical part of the course will be performed in small groups to allow students to acquire lab-work skills related to some commonly used immunological techniques. II. COURSE STRUCTUREII. COURSE STRUCTUREII. COURSE STRUCTUREII. COURSE STRUCTURE
Lectures 7 (total 9 hours) Seminars 12 (total 26 hours) Practicals 3 (total 15 hours) Total 50 hours
WEEK 1 TYPE TOPIC (duration) Chapter Lectures Introduction to immunology (45 min)
Organization of the immune system (245 min) Innate immunity (2x45 min) Antigen processing and presentation (45 min)
Seminars Antibody structure and the generation of B cell diversity (2x45) Development of B lymphocytes (45) Humoral immunity (345 min)
Ch 4 Ch 6 Ch 9
Practicals Preparation of cell suspension, Immunoflurescence staining, Flow-cytometric analysis (6x45 min)
WEEK 2 TYPE TOPIC (duration) Chapter Lectures Regulation of the immune response (45 min)
Cytokines (45 min) Immunological tolerance (45 min)
Seminars Antigen recognition by T lymphocytes (45 min) Development of T lymphocytes (45 min) Cellular immunity (345 min) Autoimmunity (345 min)
Ch 5 (125-132) Ch 7 Ch 8 Ch 13
Practicals Application of immunological techniques in clinical medicine (345)
WEEK 3 TYPE TOPIC (duration) Chapter Lectures Seminars Immunodeficiency (245 min)
Hypersensitivity (345 min) Histocompatibility.Transplantation (345 min) Tumor immunology (245 min) Immunity to infections. Vaccination (2x45 min)
Ch 11 Ch 12 Ch 5 (145-154), Ch 15 Ch 16 Ch 10,14
Practical Blood groups. Differential. (645 min)
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III. III. III. III. PLAN OF THEPLAN OF THEPLAN OF THEPLAN OF THE COURSE AND COURSE SCHEDULECOURSE AND COURSE SCHEDULECOURSE AND COURSE SCHEDULECOURSE AND COURSE SCHEDULE
WEEK 1
Day Time Type Group Topic Faculty
Monday
7.4.14.
Tuesday
8.4.14.
9.00-9.45
10.00-11.30
12.00-13.30
L (M)
L (M)
L (M)
A+B
A+B
A+B
Introduction to immunology
Organization of the immune system
Innate immunity
Wednesday
9.4.14.
8.00-12.30
13.00-17.30
P
P
A
B
Preparation of cell suspension, immunofluor. staining, FACS
Preparation of cell suspension, immunofluor. staining, FACS
Thursday
10.4.14.
8.00-9.30
10.00-10.45
11.00-12.30
S (M)
L (M)
S (M)
B
A+B
A
Antibody structure and the generation of B cell diversity
Antigen processing and presentation
Antibody structure and the generation of B cell diversity
Friday
11.4.14.
8.00-8.45
9.00-11.15
11.30-12.15
12.30-14.45
S (M)
S (M)
S (M)
S (M)
A
A
B
B
Development of B lymphocytes
Humoral immunity
Development of B lymphocytes
Humoral immunity
WEEK 2
Day Time Type Group Topic Faculty
Monday
14.4.14.
8.00-8.45
9.00-9.45
14.00-16.15
S (M)
S (M)
P*
A
A
B
Antigen recognition by T lymphocytes
Development of T lymphocytes
Application of immunological techniques in clinical medicine
Tuesday
15.4.14.
8.00-8.45
9.00-9.45
14.00-16.15
S (M)
S (M)
P*
B
B
A
Antigen recognition by T lymphocytes
Development of T lymphocytes
Application of immunological techniques in clinical medicine
Wednesday
16.4.14.
8.00-10.15
10.30-12.45
S (M)
S (M)
A
B
Cellular immunity
Cellular immunity
Thursday
17.4.14.
8.00-8.45
9.00-9.45
10.00-10.45
L (W)
L (W)
L (W)
A+B
A+B
A+B
Regulation of the immune response
Cytokines
Immunological tolerance
Friday
18.4.14.
8.00-10.15
10.30-12.45
S (M)
S (M)
B
A
Autoimmunity
Autoimmunity
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WEEK 3
Day Time Type Group Topic Faculty
Monday
21.4.14.
EASTER
Tuesday
22.4.14.
8.00-9.30
10.00-12.15
10.45-12.15
12.45-15.00
S (NV)
S (NV)
S ()
S (NV)
A
A
B
B
Immunodeficiency
Hypersensitivity
Immunodeficiency
Hypersensitivity
Wednesday
23.4.14.
8.00-10.15
13.00-17.30
S (M)
P
B
A
Histocompatibility. Transplantation.
Blood groups. Differential.
Thursday
24.4.14.
8.00-10.15
13.00-17.30
S (M)
P
A
B
Histocompatibility. Transplantation
Blood groups. Differential.
Friday
25.4.14.
8.00-9.30
10.00-11.30
12.00-13.30
14.00-15.30
S (M)
S (M)
S (M)
S (M)
B
B
A
A
Tumor immunology
Immunity to infections. Vaccination.
Tumor immunology.
Immunity to infections. Vaccination.
L-lecture, S-seminar, P-practical, M-Masek Room, W Wickerhauser Room, NV- Nova vijecnica, - akovi
Room
The practical (P*) Application of immunological techniques in clinical medicine will be held at the Immunology
Laboratory, Rebro University Hospital, Kipatieva 12 (Prof. Drago Batini)
All other practicals will be held at the Lab, Department of Physiology.
IV. IV. IV. IV. EXAMINAEXAMINAEXAMINAEXAMINATIONTIONTIONTION Final examination (written+oral) will be organized at the end of the course (Friday, 3.5.2013., 8.00 Cackovic Room) and several times thereafter, within the academic year. Written exam (test) will include 40 multiple-choice questions. Students need to answer at least 55% of the questions correctly to pass the written exam and to qualify for taking the oral examination. Students seminar work and presentation will be evaluated and included in the final score (maximum 10% of total points). The final oral examination determines the final mark of the course.
Regular terms Date
Winter 2.5.2014.
Summer
8.7.2014.
22.7.2014.
Autumn
9.9.2014.
23.9.2014.
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V./I. LIST OF LECTURERS AND TEACHING STAFFV./I. LIST OF LECTURERS AND TEACHING STAFFV./I. LIST OF LECTURERS AND TEACHING STAFFV./I. LIST OF LECTURERS AND TEACHING STAFF
Professor Drago Batini, MD, PhD Vilma Dembitz, MD Assistant Professor Tomislav Kelava, MD, PhD Hrvoje Lali, MD Assistant Professor Vesna Lukinovi-kudar, MD, PhD Alan uur, MD Professor Dora Vinji, MD, PhD Professor Mirza iak, MD, PhD VVVVI. LITERATUREI. LITERATUREI. LITERATUREI. LITERATURE A.A.A.A. ObligatoryObligatoryObligatoryObligatory
Parham Peter. The Immune System, Third Edition, New York-London,
Garland Science, Taylor & Francis Group, 2009. B. AdditionalB. AdditionalB. AdditionalB. Additional
1. Delves PJ. Martin SJ, Burton DR, Roitt IM, Roitt's Essential Immunology, 12th edition. Wiley-Blackwell, 2011.
2. Abbas AK, Lichtman H, Pallai S. Cellular and molecular immunology, 7th edition, Philadelphia Saunders, 2011.
3. Murphy K. Janeway's Immunobiology, 8th edition. New York: Garland Publishing; 2011. 4. Geha RS, Rosen FS. Case studies in immunology: A clinical companion, 5th edition. New York: Garland
Publishing; 2007. 5. Johnson AG, Ziegler RJ, Hawley LB. Microbiology & Immunology: Board Review Series, 5th edition.
Philadelphia: Lippincott Williams & Wilkins; 2009.