Immunology
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Transcript of Immunology
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IMMUNOLOGYDR. MA. TERESA S. FAJARDO
PEDIATRICSHEMATOLOGY/ ONCOLOGY
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LYMPHOID ORGANSBONE MARROWTHYMUSLYMPH NODESSPLEENPERIPHERAL LYMPHOID TISSUES
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BONE MARROW
SITE OF HEMATOPOEISISMOSTLY ON THE FLAT BONES AFTER PUBERTY
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THYMUS
CENTRAL LYMPHOID ORGAN ACTIVE IN THE EARLY STAGES OF LIFE DEVELOPMENT AND MAINTENANCE OF PERIPHERAL LYMPHOID TISSUES ( SPLEEN , LN , MALT)
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FUNCTIONS OF THE THYMUS
MATURATION OF THE PRECURSOR T- LYMPHOCYTES FROM THE BM INDUCTION OF IMMUNOCOMPETENCE
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LYMPH NODES
ANATOMICAL GROUPINGS: NECK, AXILLA FEMORAL AND POPLITEAL AREAANTIGENS ARE DELIVERED VIA LYMPHATICS TO LN WHERE SPECIFIC IMMUNE RESPONSE ARE GENERATED
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SPLEEN
VITAL FOR IMMUNE RESPONSE TO BLOOD BORNE ANTIGENSWASTE DISPOSAL SYSTEM ( MACROPHAGES)ASPLENIC PATIENTS ARE ALREADY RENDERED SUSCEPTIBLE TO INFECTION BY ENCAPSULATED BACTERIA
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PERIPHERAL LYMPHOID ORGANS
MUCOSAL IMMUNITY IS A FUNCTION OF AGGREGATES OF LYMPHOCYTES MACROPHAGES AND ACCESSORY CELLS BENEATH THE MUCOSAL EPITHELIUMPAYER’S PATCHES IN THE SMALL INTESTINESMALT( MUCOSA ASS. LYMPHOID TISSUES)
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CUTANEOUS IMMUNE SYSTEMINTRAEPIDERMAL LYMPHOCYTES LYMPHOCYTE AND ACCESSORY CELLS IN THE DERMISLANGERHAN’S CELL, AN ANTIGEN PRESENTING CELL IN THE SKIN
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CELLULAR ELEMENTS OF THEIMMUNE SYSTEMLYMPHOCYTES MULTIPOTENTIAL CELLS WHICH CAN SERVE AS MEMORY AND EFFECTOR CELLS KILLER CELLS, IMMUNOREGULATORY CELLS AND IG- PRODUCING CELLS SYNTHESIZE AND SECRETE CYTOKINES
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CLASSES OF LYMPHOCYTESB CELL ( BURSA/ BONE MARROW DERIVED)T CELL( THYMUS DERIVED)
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NATURAL KILLER CELLS“ NULL CELLS” ( NO SURFACE MARKERS) LARGE GRANULAR LYMPHOCYTES 5 % of THE PERIPHERAL BLD LYMPHOCYTES PERFORM ANTIBODY DEPENDENT CELL CYTOTOXICITY ( ADCC) LYSIS OF TUMOR ( IMMUNOSURVEILLANCE) ANTI –CANCER RESPONSE 1ST LINE OF DEFENS IN NEONATAL HERPES VIRUS INFECTION
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PHAGOCYTOSIS
PERIPHERAL DEFENSE MECHANISM AGAINST MICROORGANISMS
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PHAGOCYTES
POLYMORPHONUCLEAR
MONONUCLEAR
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FUNCTION OF THE PMNADHERENCE TO VASCULAR EPITHELIUM IN RESPONSE TO INFLAMMATORY MEDIATORSCHEMOTAXIS AS MIGRATION TOWARD SITE OF ANTIGEN OR MICROBIAL INVASIONKILLING OF INGESTED MICROORGANISM
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FUNCTION OF THE MONONUCLEARLYMPHOCYTES INGESTION OF MICROORGANISMS AND
OTHER FOREIGN MATERIALS
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EFFECTOR CELLS OF THEIMMUNE RESPONSE
EOSINOPHILS
MAST CELLS
BASOPHILS
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EOSINOPHILSBONE MARROW DERIVED GRANULOCYTES WITH GRANULES CONTAINING PROTEINS THAT BINDS DYES AS EOSINPRINCIPAL EFFECTOR CELLS AGAINST HELMINTHIC PARASITES
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MAST CELLS AND BASOPHILSEFFECTORS OF HYPERSENSITIVITYCARRY FC RECEPTORS FOR I g EINCREASED NUMBER OF IgE MOLECULES IN ALLERGIC PATIENTS
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HUMORAL ELEMENTS OFTHE IMMUNE SYSTEMIMMUNOGLOBULIN
COMPLEMENT
CYTOKINES
CLUSTER DIFFERENTIATION ANTIGEN
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IMMUNOGLOBULINS( ANTIBODIES)SERUM PROTEINS PRODUCED BY B CELLS ( SURFACE Ig) , PLASMA CELLS ( SECRETORY Ig) , COLOSTRUM , SALIVA , GIT AND UT20 % OF THE TOTAL PLASMA PROTEINS
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IgM IO % OF THE NORMAL SERUM Ig
PENTAMER
LARGEST Ig
EARLIEST ANTIBODY IN RESPONSE TO Ag
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IgGMOST ABUNDANT
CAN TRAVERSE THE PLACENTAL BARRIER
VITAL ROLE IN THE DEFENSE OF NEWBORN
AGAINST INFECTION
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IgA SYNTHESIZED IN THE PLASMA CELLS
LOCATED IN THE SUBMUCOSA OF THE RESPIRATORY TRACT, INTESTINES, AND EXCRETORY GLANDS ANTIBODY IN PREVENTING INFECTION OF THE ABOVE ORGANS
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IgD MONOMER
PRESENT IN THE SERUM IN SMALL AMOUNTS
PLAY A ROLE IN THE DIFFERENTIATION OF B CELLS
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IgE PLAYS A ROLE IN PARASITIC INFECTION AND ALLERGIC REACTION
MEDIATES ACTIVATION OF THE EOSINOPHILS FOR THE IMMUNITY OF PARASITES AND IN THE LATE PHASE OF ALLERGIC REACTION
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CLUSTER DIFFERENTIATIONANTIGENCELL SURFACE PROTEINS THAT IDENTIFY A CELL LINEAGE / DIFFERENTIATION STAGE ( PHENOTYPIC MARKERS )PROMOTE LYMPHOCYTIC ACTIVATION
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IMMUNITY
MECHANISM INVOLVED IN THE RESISTANCE TO INFECTIOUS AND NON- INFECTIOUS FOREIGN SUBSTANCES
COLLECTIVE AND COORDINATED CELLULAR AND HUMORAL RESPONSE TO FOREIGN SUBSTANCES
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TYPE 1IMMEDIATE HYPERSENSITIVITYPROTOTYPE : BRONCHIAL ASTHMAURTICARIAALLERGIC RHINITISALLERGIC CONJUNCTIVITISALLERGIC ASTHMASYSTEMIC ANAPHYLAXIS
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TYPE 2ANTIBODY DEPENDENT CELLULARCYTOTOXICITYPROTOTYPE: HEMOLYTIC DISEASEERYTHROBLASTOSIS FETALISACQUIRED HEMOLYTIC ANEMIATHROMBOCYTOPENIAGOODPASTURE ‘ S SYNDROMEGRAFT REJECTIONNEUTROPENIA AND CHRONIC KERATITIS PEMPHIGUS
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IMMUNE COMPLEXMEDIATED INJURYSERUM SICKNESSPOLYARTERITIS NODOSAPOST- STREPTOCCOCAL GLOMERULONEPHRITISARTHUS REACTIONRHEUMATOID ARTHRITISSLESTEVEN- JONSON SYNDROME
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TYPE 4T – CELL MEDIATED/ DELAYED TYPEHYPERSENSITIVITY
PROTOTYPE : TUBERCULIN SKIN TESTAUTOIMMUNE DISEASESCONTACT ALLERGIC DERMATITISSYPHILISLEPROSYPARASITIC INFECTION
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