IMMUNITY & INFECTIONRandanan BandasoBagian Patologi FK Unhas

INFECTION IMMUNITYINSEPERABLE INFLAMMATION

H0W ANIMALBECOMES IMMUNENATURAL AND ARTIFICIALIMMUNOLOGY

BAKTERI,VIRUS, PARASITESINFECTION UNCOMMONNATURAL RESISTENCEANATOMIC BARRIERPHAGOCYTOSISCOMPLEMENT

NUTRTIONALHORMONAL GENETIC

HOST DEFENCELOCALSYSTEMICNONSPECIFCHUMORALCELLULAR

MANOBSERVEDRECOVERY FROM INFECTIONIMMUNJENNER : VACCINATION OF SMALL FOXSUCCESFULL APLICATION OF OBSERVATION

NONSPESIFIC IMMUNITYBODY SURFACEDISCHARGE MICROORGANISM FROM THE BODYLOCAL PRODUCTION OF CHEMICAL ANTIMICROBESBACTERIAL INTERFERENCE LACTOBACILLUS

BODY SURFACEMICROORGANISME TO PRODUCE INFECTION SLIP TO BARRIER SURFACE DEFENCESTHIKNESS OF EPITHELIAL IS DIFFERNONSFECIFIC

DISCHARGE OF MICROORGANISME FROM THE BODYMUCOCILIARY ESCALATOR OF THE RESPIRATORY TRACT OROPHARYNX COUGHED OR SWALLOWEDDESQUAMATION OF EPITHELIAL CELL REMOVED LARGE AMOUNT OF BACTERIALDEFECATION ELIMINATE 10.000 000 000 000 /DAYURINATION ELIMINATE BACTERIAL COLONIZING IN URETHRAL EPITHELIUM RETENTION OF URINE ENHANCE THE RISK OF INFECTIONSALIVATION, LACRIMATION, SNEEZING DISPLACE POTENTIALLY INFECTIVE MICROORGANISME

RESPONS IMUN NON SPESIFIK PALING LUARKULITSUHU TINGGIPERGANTIAN KULIT.LEMAK KULITFLORA NORMAL KULITMUKOSAPERGANTIAN MUKOSAASAM LAMBUNGSALIVAPERISTALTIK USUSBATUKFLORA NORMALORAL,GIGI,VAGINA,KOLON

RESPON IMUN NON SPESIFIK LAPIS KEDUAMONOSITMAKROFAGGRANULOSIT NEUTROFILEOSINOFIBASOFILDIBAWAH KULITDIBAWAH MUKOSA

epithelmikrobamakrophagstimulasiSitokin ,TNF

NORMAL MICROBIAL FLORALOCAL FACTOR :FIBRONECTIN,GLYCOPROTEINS AND PhANTIBODY ON MUCOSAL SURFACEIgALACTOFERINHOST DEFENSES AGAINTS ATTACHEMENT TO EPITHELIAL CELL

CELLULAR SYSTEM OF SYSTEMIC IMMUNITYPROFESIONAL PHAGOCYTICPMNMACROPHAGENONPROFESIONAL PHAGOCYTICENDOTHELIAL, EPITHELIAL, FIBROBLAST

SIGNIFICANCE OF EPITHELIAL CELL PROLIFERATIONMICROBIAL ATTACHEMENT IS NOT NECESSARY FOLLOWED BY CELL PENETRATIONM.PNEUMONIAE, C.DIPHTERIAE, B.PERTUSSIS,V.CHOLERA SURFACESHIGELLA PENETRATE EPITHELIAL CELLSALLMONELA PROCEED TO SYSTEMIC INFECTIONINTRAEPITHELIAL PATHOGENS PROTECTECTED FROM ANTIBODY, ANTIBIOTIC, AND INGESTION AND KILLING BY PMN

SYSTEMIC IMMUNITY TO INFECTIONHUMORAL SYSTEMCELL MEDIATED IMMUNITY

IMFLAMATIONRESPONSE OF TISSUE TO DAMAGING AGENTACUTE IMFLAMMATIONINITIAL RESPONSE OF TISSUECHRONIC IMFLAMTION DAMAGING AGENT PERSISTS

INFLAMATIONBLOOD SUPPLY INCREASEDGLUCOSA OKSIGENINCREASED IN CAPILLARY PERMIABILITYMIGRATION OF NEUTROPHYL, MACROPHAGES, LYMPHOCYTE

CLINICAL EFFECTS OF ACUTE INFLAMMATIONRUBOR (REDNESS)CALOR (HEAT)DOLOR (PAIN)TUMOR (SWELLING)

STEPS OF CHANGESSMALL VESSEL DILATED AND INCREASED BLOOD FLOWENDOTHELIAL CELL SWELL AND RETRACTLEAKINGEXUDATIONPMN MARGINATION EMIGRATIONLATER MONOCYTE, LYMPHOCYTE ALSO MIGRATE

CONTROL OF INFLAMATIONCYTOKINESPRODUCTS OF PLASMA ENZYMESVASOACTIVE MEDIATOR MAST CELLSBASOPHILSPLATELETS

MEDIATOR OF INFLAMATIONHISTAMINE MAST CELLS + BASOPPHYL VASCULAR PERMIABILITY, SMOOTH MUSCLE CONTRACTIONSEROTONIN PLATLETS VASC PERMIABILITY, SMOOTH MUSCLE CONTRACTIONIL8 LYMPHOCYTES MONOCYTE LOCALIZATIONC3A COMPLEMENT C3 MAST CELL DEGRANULATION + SMOOTH MUSCLE CONTRACTION.BRADYKININ KININ SYSTEM VASODILATATION

Mediator in inflammationVasodilatation : Histamine,Prostaglandins, nitric oxide.Increased Permiability : Histamine,C3a,C5a,bradykinin,Leukotrienes,PAF, Nitric OxydeNeutrophil Adhesion : IL-1,TNF,PAF,C5aNeutrophil chemotaxis : C5a, bacterial componentsFever: IL1,TNF,ProstaglandinsPain : Prostaglandins, bradykininTissue Necrosis: Neutrophil, lysosomal granules,free radical generated by PMN

CELLULAR MEDIATORSTORED : HISTAMINACTIVE SYNTHESIS: PROSTAGLANDINS, LEUKOTRIENES,PLATELET ACTIVATING FACTOR, CYTOKINES, NITRIC OXIDEPLASMA DERIVE:BRADYKININ, HAGEMAN FACTOR, PLASMAIN, C3a, C3b and C5a

The End