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Immune Panel
Health Action Plan
October 1, 2019
Demo ClientKit #1234ABCD5678
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Table of Contents
Understand Your Genetics
How These Traits Affect You
Recommendations
Supplements
Diet
Lifestyle
Exercise
Further Testing
Traits
Inflammation
Rheumatoid Arthritis
Recommendation Detailed Appendix
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Understand Your GeneticsThis report is broken down into three main sections: TraitImpact, Recommendations and Trait Detail. Depending onthe number of traits being reviewed, your report willcontain multiple trait and recommendation detailsections. Terms and sections of the report are definedbelow.
DNA
DNA is a long, ladder-shaped molecule. The rungs of the ladder are madeof two amino acids pairing together, these are called bases. They alwayspair the same way, A (Adenine) with T (Thymine), and C (Cytosine) with G(Guanine). The body is constantly replicating DNA strands.
GENE
Genes are the basic units of heredity (passeddown from generation to generation). Theyare made of DNA and provide theinstructions for how our body works, whatwe look like, etc. Humans have between20,000 - 25,000 genes. We inherit half ofthem from our mother and half from ourfather.
SNP
A SNP is a Single Nucleotide Polymorphism. SNPsoccur when the amino acids making up the basepair do not come together in the same way as theoriginal DNA strand. For example, the originalstrand may have had an A but the replicatedstrand has a G. SNPs are common and many ofthem have no impact to the individual, however,some can change how our body works.
VARIANT
Variants are how SNPs are referred to in thisreport. When the amino acid in the copiedstrand is different from the original, it iscalled a variant - it varies from the original.Variants are not necessarily 'good' or 'bad'they are simply different from the original.The depiction of variants is shown as: +/+(both copies have different amino acids), +/-(one copy has a different amino acid), -/-(both copies have the same amino acid as theoriginal) or U (one copy is indeterminate).
Reading This Report
Trait Impact Traits Recommendations
This report focuses on traits. These aretypically groups of SNPs that have asimilar impact on the body’s function.We use a proprietary algorithm todetermine the impact a group of SNPsmay have on a specific function in thebody based on your individual testresults.
The traits in our reports aretypically grouped by body function,a symptom type, a disease, anutrient need, or a response toenvironment. Within the traitpages, you will see the SNPs thatare looked at for that trait, yourvariant type and recommendationsto optimize health and minimize riskbased on your individual results.
Your genes, and therefore yourSNPs, will not change during yourlife. However, this report focuseson SNPs whose impact can beinfluenced by external factors likediet, exercise, supplements, andlifestyle changes.
Disclaimer - The recommendations in this report have been carefully prepared and reviewed for you by your health and wellness provider, based on his or herreasoned medical judgment about your personal health needs. Be sure that you have shared with your health and wellness provider all relevant information aboutyour health, including any medications or dietary supplements you may be taking, and any medical conditions you may be experiencing, before you adopt any of theserecommendations. This test is performed via DNA sequencing. As with all genetic testing with the highest possible standards, the data generated during thelaboratory process will have a <99% sensitivity and specificity.
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How These Traits Affect You This page provides a high-level snapshot of the clinical significance of each trait within this panel. The results are intwo categories: traits that are ranked high, medium or low impact as well as traits for which there is an explicit result(i.e. categorical such as "yes" or "no"). At the end of this page are a summary of any non-reportable (NR) traits. Theresults for these traits are unable to be determined from the sample submitted. Recommendations are made for traitswith high or medium impact only.
Impact Traits Impact Learn More
1 Inflammation HIGH Page 11
2 Rheumatoid Arthritis MEDIUM Page 13
3 Hashimoto's Thyroiditis LOW
4 Multiple Sclerosis LOW
5 Psoriasis LOW
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High
Medium
Low
Impact Traits
Immune Panel
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SupplementsBelow is a list of the top recommended supplements curated specifically for you. These recommendations mayrepresent a subset of the total recommendations found within the Supplement sections of your report.Recommendations are listed in order of importance based on your individual genetic results. Theserecommendations have been reviewed by your healthcare provider. Please contact your provider if you have anyquestions.
Recommendation Name The Details Linked Traits
Curcumin Supplement with 250 - 2,000 mg of curcuminextract per day.
Inflammation, Rheumatoid Arthritis
Vitamin D3 Supplement with 3,000 IUs of vitamin D3 perday.
Inflammation, Rheumatoid Arthritis
Ashwagandha Supplement with 250 - 300 mg ofashwagandha per day.
Rheumatoid Arthritis
Betaine Hydrochloride(HCl)
Supplement with 1 - 2 g of betainehydrochloride (HCl) with meals for at least 6months.
Inflammation
Borage Oil Supplement with 2.7 g per day of borage oilper day.
Rheumatoid Arthritis
Cannabinoid Supplements Consider using cannabinoid supplements formanaging pain.
Rheumatoid Arthritis
Folate Supplement with 400 - 800 mcg of methyl-folate per day.
Inflammation
Multivitamin Supplement with a multivitamin that includesactivated B vitamins.
Inflammation
Omega-3 Supplement with 2 - 5 g of omega-3 fattyacid supplement that contains essential fattyacids DHA and EPA.
Rheumatoid Arthritis
Pomegranate Extract Supplement with 500 mg of pomegranateextract per day.
Rheumatoid Arthritis
Note - If you are taking any medications, consult with your practitioner before starting any new supplements as they may have adverseeffects with your medications.
Immune Panel Recommendations
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DietBelow is a list of the top dietary recommendations curated specifically for you. These recommendations mayrepresent a subset of the total recommendations found within the Diet sections of your report. Recommendationsare listed in order of importance based on your individual genetic results. These recommendations have beenreviewed by your healthcare provider. Please contact your provider if you have any questions.
Recommendation Name The Details Linked Traits
Mediterranean Diet Adopt a Mediterranean-style diet thatincludes a variety of antioxidant-rich foods,heart healthy fats, and complexcarbohydrates.
Inflammation, Rheumatoid Arthritis
Allergen Free Diet Eliminate common allergenic foods from thediet, including wheat, corn, dairy, shellfish,nuts, eggs, and soy.
Rheumatoid Arthritis
Anti-Inflammatory Diet Consume a diet rich in anti-inflammatoryfoods.
Inflammation
Dietary Fiber Increase dietary fiber intake to recommended25 g for females and 30 g for males.
Inflammation
Fruits and Vegetables Include fruits and vegetables at every meal toincrease levels of antioxidants in the body,especially strawberries, blueberries, broccoli,sprouts, and green leafy vegetables.
Inflammation
Juice Fasting Try a fruit and vegetable juice fast for 5 to 7days.
Rheumatoid Arthritis
Nut Consumption Consume a variety of nuts including almonds,walnuts, macadamia nuts, and brazil nuts.
Inflammation
Omega-3 Rich Foods Consume a diet rich in omega-3 fatty acids. Inflammation
Immune Panel Recommendations
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LifestyleBelow is a list of the top lifestyle recommendations curated specifically for you. These recommendations mayrepresent a subset of the total recommendations found within the Lifestyle sections of your report.Recommendations are listed in order of importance based on your individual genetic results. Theserecommendations have been reviewed by your healthcare provider. Please contact your provider if you have anyquestions.
Recommendation Name The Details Linked Traits
Cognitive BehavioralTherapy
Use cognitive behavorial therapy toreprogram responses to pain.
Rheumatoid Arthritis
Intermittent Fasting Try intermittent fasting (fasting for 14+ hoursdaily) or alternate day fasting (fasting for 24hours every other day).
Inflammation
Meditation Engage in 10 to 20 minutes of mindfulnessmeditation 2 or more times per week.
Rheumatoid Arthritis
Sleep Consistency Stick to a consistent sleep routinue thatconsists of going to sleep and waking up atapproximately the same time each day.
Inflammation
Use Natural Personal CareProducts
Use natural care products that do not containenvironmental toxins such as formaldehyde,phthalates, parabens, lead, mercury, triclosan,and benzophenone.
Rheumatoid Arthritis
Immune Panel Recommendations
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ExerciseBelow is a list of the top exercise recommendations curated specifically for you. These recommendations mayrepresent a subset of the total recommendations found within the Exercise sections of your report.Recommendations are listed in order of importance based on your individual genetic results. Theserecommendations have been reviewed by your healthcare provider. Please contact your provider if you have anyquestions.
Recommendation Name The Details Linked Traits
Cross Training Aim to perform cross training that includescardio, weight training, and sportsmovements performed twice per week.
Rheumatoid Arthritis
Immune Panel Recommendations
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Further TestingBelow is a list of the top further testing recommendations curated specifically for you. These recommendations mayrepresent a subset of the total recommendations found within the Further Testing sections of your report.Recommendations are listed in order of importance based on your individual genetic results. Theserecommendations have been reviewed by your healthcare provider. Please contact your provider if you have anyquestions.
Recommendation Name The Details Linked Traits
C-Reactive Protein (CRP) orhsCRP
Test levels of C-Reactive Protein (CRP) orhsCRP
Inflammation, Rheumatoid Arthritis
Erythrocyte SedimentationRate (ESR)
Test erythrocyte sedimentation rate (ESR) inblood
Inflammation, Rheumatoid Arthritis
Anti-MycoplasmaFermentans Antibodies
Test for Anti-mycoplasma fermentansantibodies
Rheumatoid Arthritis
Epstein-Barr Virus (EBV) Test for the Epstein-Barr Virus (EBV) Rheumatoid Arthritis
Fibrinogen Test fibrinogen levels in the body Inflammation
Folate Testing Test folate levels Inflammation
Food Sensitivity Testing Test for food sensitivities Rheumatoid Arthritis
Homocysteine Levels Check blood homocysteine levels Inflammation
IL-6 Testing Test for levels of IL-6 Inflammation
TNF-alpha Test for TNF-alpha Inflammation
Immune Panel Recommendations
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Trait Details
Appendix 1
Immune Panel
October 1, 2019
Demo ClientKit #1234ABCD5678
Inflammation People with similar genetic markers may be more likely to experience increased levels of inflammation, which is thebody’s natural response to an injury, wound, or infection.
Gene SNP Variant Impact
TNF-α rs1800629 +/+ High
IL6 rs1800795 +/+ High
TNF-α rs1799724 +/- Medium
PTPN22 rs2476601 +/- Medium
IL-10 rs1800872 +/- Low
TNF-α rs1799964 -/- Low
IL23R rs2201841 +/- Low
IL-10 rs3024505 -/- Low
Recommendations
These recommendations are based on the genetic findings in the chart above.
SUPPLEMENT • Multivitamin • Betaine Hydrochloride (HCl)
• Vitamin D3 • Folate
• Curcumin
DIET • Anti-Inflammatory Diet • Omega-3 Rich Foods
• Dietary Fiber • Mediterranean Diet
• Nut Consumption • Fruits and Vegetables
LIFESTYLE • Sleep Consistency • Intermittent Fasting
FURTHER TESTING • Homocysteine Levels • IL-6 Testing
• C-Reactive Protein (CRP) orhsCRP
• Erythrocyte SedimentationRate (ESR)
• Fibrinogen • Folate Testing
Immune Panel High Impact
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• TNF-alpha
Immune Panel High Impact
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Rheumatoid Arthritis People with similar genetic markers may be at a higher risk for developing rheumatoid arthritis.
Gene SNP Variant Impact
TNFAIP3 rs6920220 +/+ High
ANAPC4 rs3816587 +/+ High
PTPN22 rs1217410 +/+ High
PTPN22 rs2476601 +/- Medium
REL rs13031237 +/- Medium
STAT4 rs7574865 +/- Medium
CCR6 rs3093024 +/- Medium
NCF4 rs729749 +/- Medium
AFF3 rs10865035 +/- Medium
TNFAIP3 rs5029937 -/- Low
C6orf10 rs6910071 -/- Low
NOS3 rs2070744 -/- Low
CDK6 rs42041 -/- Low
TNFAIP3 rs2230926 -/- Low
TLR3 rs3775291 -/- Low
CD40 rs4810485 -/- Low
HLA-DRB1 rs615672 +/- Low
Recommendations
These recommendations are based on the genetic findings in the chart above.
SUPPLEMENT • Omega-3 • Vitamin D3
• Curcumin • Wormwood
• Borage Oil • Pomegranate Extract
• Ashwagandha • Cannabinoid Supplements
DIET • Mediterranean Diet • Juice Fasting
• Allergen Free Diet
Immune Panel Medium Impact
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LIFESTYLE • Use Natural Personal CareProducts • Meditation
• Cognitive Behavioral Therapy
EXERCISE • Cross Training
FURTHER TESTING • Anti-MycoplasmaFermentans Antibodies • Epstein-Barr Virus (EBV)
• Testing for Mold/Mildew • C-Reactive Protein (CRP) orhsCRP
• Erythrocyte SedimentationRate (ESR)
• Testing for Early Markers ofInflammation andAutoimmunity
• Food Sensitivity Testing
Immune Panel Medium Impact
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Recommenda�on
Detailed Appendix
Appendix 2
Immune Panel
October 1, 2019
Demo ClientKit #1234ABCD5678
Supplements
Recommendation Name The Details Linked Traits
Curcumin Supplement with 250 - 2,000 mg of curcumin extract per day. Inflammation, RheumatoidArthritis
Vitamin D3 Supplement with 3,000 IUs of vitamin D3 per day. Inflammation, RheumatoidArthritis
Ashwagandha Supplement with 250 - 300 mg of ashwagandha per day. Rheumatoid Arthritis
Betaine Hydrochloride(HCl)
Supplement with 1 - 2 g of betaine hydrochloride (HCl) with meals for atleast 6 months. Inflammation
Borage Oil Supplement with 2.7 g per day of borage oil per day. Rheumatoid Arthritis
CannabinoidSupplements Consider using cannabinoid supplements for managing pain. Rheumatoid Arthritis
Folate Supplement with 400 - 800 mcg of methyl-folate per day. Inflammation
Multivitamin Supplement with a multivitamin that includes activated B vitamins. Inflammation
Omega-3 Supplement with 2 - 5 g of omega-3 fatty acid supplement that containsessential fatty acids DHA and EPA. Rheumatoid Arthritis
Pomegranate Extract Supplement with 500 mg of pomegranate extract per day. Rheumatoid Arthritis
Wormwood Supplement with 30 g of wormwood per day. Rheumatoid Arthritis
Diet
RecommendationName
The Details Linked Traits
MediterraneanDiet
Adopt a Mediterranean-style diet that includes a variety of antioxidant-rich foods,heart healthy fats, and complex carbohydrates.
Inflammation,Rheumatoid Arthritis
Allergen Free Diet Eliminate common allergenic foods from the diet, including wheat, corn, dairy,shellfish, nuts, eggs, and soy. Rheumatoid Arthritis
Anti-InflammatoryDiet Consume a diet rich in anti-inflammatory foods. Inflammation
Dietary Fiber Increase dietary fiber intake to recommended 25 g for females and 30 g for males. Inflammation
Fruits andVegetables
Include fruits and vegetables at every meal to increase levels of antioxidants in thebody, especially strawberries, blueberries, broccoli, sprouts, and green leafyvegetables.
Inflammation
Juice Fasting Try a fruit and vegetable juice fast for 5 to 7 days. Rheumatoid Arthritis
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Nut Consumption Consume a variety of nuts including almonds, walnuts, macadamia nuts, and brazilnuts. Inflammation
Omega-3 RichFoods Consume a diet rich in omega-3 fatty acids. Inflammation
Lifestyle
Recommendation Name The Details Linked Traits
Cognitive BehavioralTherapy Use cognitive behavorial therapy to reprogram responses to pain. Rheumatoid
Arthritis
Intermittent Fasting Try intermittent fasting (fasting for 14+ hours daily) or alternate day fasting (fastingfor 24 hours every other day). Inflammation
Meditation Engage in 10 to 20 minutes of mindfulness meditation 2 or more times per week. RheumatoidArthritis
Sleep Consistency Stick to a consistent sleep routinue that consists of going to sleep and waking up atapproximately the same time each day. Inflammation
Use Natural PersonalCare Products
Use natural care products that do not contain environmental toxins such asformaldehyde, phthalates, parabens, lead, mercury, triclosan, and benzophenone.
RheumatoidArthritis
Exercise
RecommendationName
The Details Linked Traits
Cross Training Aim to perform cross training that includes cardio, weight training, and sportsmovements performed twice per week.
RheumatoidArthritis
Further Testing
Recommendation Name The Details Linked Traits
C-Reactive Protein (CRP) or hsCRP Test levels of C-Reactive Protein (CRP) or hsCRP Inflammation, RheumatoidArthritis
Erythrocyte Sedimentation Rate (ESR) Test erythrocyte sedimentation rate (ESR) inblood
Inflammation, RheumatoidArthritis
Anti-Mycoplasma Fermentans Antibodies Test for Anti-mycoplasma fermentans antibodies Rheumatoid Arthritis
Epstein-Barr Virus (EBV) Test for the Epstein-Barr Virus (EBV) Rheumatoid Arthritis
Fibrinogen Test fibrinogen levels in the body Inflammation
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Folate Testing Test folate levels Inflammation
Food Sensitivity Testing Test for food sensitivities Rheumatoid Arthritis
Homocysteine Levels Check blood homocysteine levels Inflammation
IL-6 Testing Test for levels of IL-6 Inflammation
TNF-alpha Test for TNF-alpha Inflammation
Testing for Early Markers of Inflammation andAutoimmunity
Testing for early markers of inflammation andautoimmunity Rheumatoid Arthritis
Testing for Mold/Mildew Test for mold/mildew exposure Rheumatoid Arthritis
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