Seattle, Washington, USA^

Images of the Twenty-First CenturyProceedings of the Annual International Conference

of the

IEEE Engineering in Medicine and Biology SocietyVolume 11:1989

Seattle, Washington • November 9-12, 1989

EDITED BY

Yongmin Kim

Francis A. Spelman

89CH2770-6

UNIVERSITATSBIBUOTHEKHANNOVER

TECHNISCHE

IMFORMATlOMSBtBLlOTHEK

Part 4/6

Track 6. Biosensors

Track 7. Electromagnetic Interactions

Track 8. Lasers & Electro-optics

Track 9. Bioelectric Potentials

Track 15. Molecular Electronics

2

Images ofthe Twenty-FirstCentury

TABLEOFCONTENTS

Part 4/6

THIS PART CONTAINS:

Track 6. Biosensors

Track 7. Electromagnetic Interactions

Track 8. Lasers & Electro-optics

Track 9. Bioelectric Potentials

Track 15. Molecular Electronics

Track 6: BiosensorsChair: Peter Cheung

Session 6.01: Current Status of Biosensor TechnologySession Chair: Peter Cheung, University of Washington

1. Overview ofBiosensor Design and Fabrication JCPatton, Digene Diagnostics, Inc., 1081

Silver Spring, MD

2. Modern Sensors of 4 Recent pH and Blood Gas Analyzers B Gouget, Meaux 1082

Hospital, France; Y Gourmelin, A Feuillu, A Truchaud

3. Chemical Response ofSi3N4/Si02/Si Structures Used in pH Microelectronic Sensors 1084

M Moinpour, University of Washington; PW Cheung, E Liao, CY Aw, ED Weiler

4. Present Day Bio Sensors and Associated Signal Processing WV Subbarao, Florida 1086

International University; F Wu

Session 6.02: Oximetry and Glucose Sensors

Session Chair: Tom Horbett, University ofWashington

1. A Smart Sensor for Biomedical Applications W Sansen, Katholieke Universiteit, 1088

Leuven, Belgium; A Claes, D De Wachter, L Callewaert, M Lambrechts

IEEE EMBS 1989—iii

2. Pathlength Independent Spectrophotometry: Measurement ofHemoglobin in Solution 1090

DLDickensheets, University ofWashington; PW Cheung

3. Simultaneous Measurement ofPercent Carboxyhemoglobin And Functional Oxygen 1092

Saturation JCSLee, University of Washington; PW Cheung, DR Marble, MA

Kenny, D Landicho

4. Transcutaneous Measurement of Bio-Substances by Suction Effusion Fluid from Skin 1094

SKayashima, National Defense Medical College, Japan; T Arai, M Kikuchi, N

Nagata, O Takatani, S Miyamoto, S Shinohara, N Ito, J Kimura, T Kuriyama

5. Application ofthe Kubelka Munk Equation to Characterizing a Reflectance Pulse 1095

Oximeter CDavies, Cleveland Clinic Foundation; S Takatani, N Sakakibara, YNose

6. Computer Modelling of a Glucose-Sensitive Membrane Device LAKlumb, 1098

University ofWashington; TA Horbett

Session 6.03: Ultrasonic and Optical SensorsSession Chair: Paul Yager, University ofWashington

1. Digital Imaging Fluorescence Microscopy: Analytical Purpose and Low Light Level 1100

Intensity JM Salmon, University ofPerpignan, France; J Vigo, S Lahmy, P

Viallet

2. Waveguide Parameter for Waveguide-Binding Fiber Optic Biosensors RB Thompson, 1102

Naval Research Laboratory, Washington, DC; L Kondracki

3. Development of a Fluorescence-Based Fiber Optic Sensor for Rapid Detection of 1104General Anesthetics and Other Lipid-Soluble Chemicals SL Merlo, UniversityofWashington; L Burgess, P Yager

4. Implantable Doppler Ultrasonic Vessel Patency Monitor PFK Read, University of 1106

Washington; RW Martin, EH Albrecht, AH Proctor

5. Acoustic Plate-Wave Biosensing BJCostello, University ofCalifornia, Berkeley; 1108BA Martin,RM White

6. A Wide-Band Stagger-Tuned Transducer Used for Pulsed Ultrasonic Doppler 1110Flowmeter Y Zhang, Shaanxi Teachers University, China; Q Chen, X Zang, ZHou

Session 6.04: Position Sensors and Mechano SensorsSession Chair: Peter Cheung, University ofWashington

1. The Silicon Microphysiometer: A Biosensor That Detects Cell-Affecting Agents JC 1112Owicki, MolecularDevices Corp., Menlo Park, CA

2. Noninvasive Monitoring of Uterine Contractility in Pregnant Patients Using Multiple 1114Tocodynamometers MR Neuman, Case Western Reserve University

3. Thin Film Sensor for Infant Respiration TG Mclntyre, Case Western Reserve 1115University; MR Neuman

4. A Conductive Polymer Pressure Sensor Array NMaalej, University ofWisconsin - 1116Madison; JG Webster, WJ Tompkins, JJ Wertsch

iv—IEEE EMBS 1989

5. A Fiber Optic Angular Sensor for Biomedical Applications JC Jensen, Rutgers 1118

Unviersity; JKJ Li, G Sigel, Jr.

Session 6.05: Novel Biosensor Fabrication TechnologySession Chair: Mansour Moinpour, University ofWashington

1. Flavoenzyme-Based Biosensors with Redox Polymer Electron Relays PD Hale, 1120

BrookhavenNationalLaboratory; T Inagaki, HI Karan, HS Lee, Y Okamoto, TASkotheim

2. Beetle Luciferases as Transducers of Biochemical and Genetic Events KVWood, 1122

University ofCalifornia, San Diego

3. Neuron-Based Sensors for Biochemical Quantitation WSKisaalita, Washington 1124

State University; RS Skeen, BJ Van Wie, CD Barnes, SJ Fung, WC Davis

4. Identifying Proteins for Microbiosensor Applications CE Furlong, University of 1126

Washington; EB Weiler, JA Sundstrom, PW Cheung, EW Voss, Jr.

5. Development of a Polyimide Based Potassium Ion-Selective Membrane for ISFET 1128

Sensor ELiao, University ofWashington; CY Aw, M Moinpour, C Morgan, PW

Cheung

6. Fabrication and Electrochemical Treatment of the Carbon Fiber Electrode in the 1130

Neurotransmitters Measurement MS Young, National Cheng-Kung University,Taiwan; MTHo.MTLin

Track 7: Electromagnetic InteractionsChair: Charles Polk

Session 7.01: Biological Effects of High Peak-Power Electromagnetic RadiationSession Chair: Ronald L. Seaman, Louisiana Tech University

1. Analysis of EMP Induced Currents in Human Body by NEC Method of Moments 1132

AW Guy, University ofWashington

2. A Biological Effects Exposure Facility Utilizing an 800 MWPeak Power Pulsed 1134

Microwave Source F Bates, ERC BioServices Corp., Rockville, MD; HBassen

3. Comparison of the Efficacy ofPulsed Versus CWMicrowave Feilds in Evoking Body 1136

Movements HWachtel Walter Reed Army Inst, ofResearch

4. Behavioral Recovery from Hyperthermia Induced by High Peak Power Microwave 1138

Pulses Y Akyel, ERC BioServices Corp., Rockville, MD; EL Hunt, CA Vargas, Jr.

5. Behavioral Effects of 1300 MHz High Peak-Power Microwave Irradiation DL 1140

Hjeresen, Los AlamosNational Laboratory; KOUmbarger

6. Microwave Ablation for Tachycardia JC Lin, University ofIllinois at Chicago; KJ 1141

Beckman, RJ Hariman

IEEE EMBS 1989—V

Session 7.02: Microwave HyperthermiaSession Chair: A. W. Guy, University ofWashington

1. Resonant Inductive Applicator for Neck Hyperthermia DA Christensen, 1143

University of Utah; BM Roberts, CH Durney, JA Shaw

2. Analysis and Measurement ofa Microstrip Array Applicator for Hyperthermia 1145

Therapy HR Underwood, University ofIllinois; AF Peterson, RL Magin

3. Design ofInterstitial Ring-Slot Applicator for Microwave Hyperthermia T Terakawa, 1147

Chiba University, Japan; K Ito, K Ueno, M Hyodo, H Kasai

4. A Multichannel Interstitial Capacitive Hyperthermia System as an Adjunct to 1148

Brachytherapy MNadi, Faculte de Science, Nancy, France; GPrieur, C

Marchal, J Mabire

5. Microwave Interstitial Hyperthermia Controlled by Microwave Radiometry: 1150

Technical Aspects, Animal Experiments and First Clinical Results JJ Fabre,

Universite des Sciences et Techniques de Lille, France; E Playez, M Chive, B

Prevost, A Demaille, J Rohart, M Plancot

6. Thermal Profile Reconstruction in the Steady State During Microwave Hyperthermia 1151

Based on Microwave Radiometry Measurements: Bidimensional Aspects L

Dubois, Universite des Sciences et Techniques de Lille, Framce; JJ Fabre, M Chive

Session 7.03: Thermography and Thermal ImagingSession Chair: M. Anbar, State University of New York, Buffalo

1. A Multi-WavelengthThermal Imaging System S Hejazi, State University ofNew 1153

York, Buffalo; RASpangler

2. Detector Systems for Thermal Imaging—A Critical Overview RLeftwich, 1155

Magnavox Electro-optical Systems, Mahwah, NJ

3. Advanced Technology Developments in Quantitative Thermography for Space Science 1156

RR Hale, JR., Jet Propulsion Lab

4. Study of Regulation of Skin Temperature Using Dynamic Digital Thermal Imaging J 1158

Montoro, State University ofNew York, Buffalo; KH Lee, M Anbar

5. Digital Thermal Imaging System Compatible with Standard AKutas, Dorexlnc, 1160

Orange, CA

Session 7.04: Exposure to Low-Intensity Electromagnetic FieldsSession Chair: C. Polk, University of Rhode Island

1. Neurological Effects of Low-Level Microwaves Mediated by Endogenous Opioids H 1161

Lai, University ofWashington; A Horita, AWGuy

2. Microwave-Triggered Liposomal Drug Delivery: Investigation of a Model Drug 1163

Delivery System RPLiburdy, Lawrence Berkeley Laboratory; DdeManincor,CQ Sheeler, B Fingado

3. Power-Frequency Magnetic Fields from Electric Blankets HKFlorig, Carnegie 1165Mellon University; JF Hoburg

Vi—IEEE EMBS 1989

4. Measurement ofMagneticalUy Induced Current Density in Saline and In Vivo GTay, 1167

Medical College ofWisconsin; M Chilbert, J Battocletti, A Sances, Jr., T Swiontek,

CKurakami

5. Brain Cortex Stimulation by Using Magnetic Pulses: Analysis of the Induced Current 1169

Distribution MGuidi, Universita diAncona, Italy; 0 Scarpino, F Angeleri, R

Antili, R De Leo

Track 8: Lasers & ElectroopticsChair: Ronald Waynant

Session 8.01: Tissue Welding and UV Ablation

Session Chair: R. Waynant, Center for Devices and Radiological Health, EDA

1. An Automated Approach to Laser Tissue Welding: The Exoscope System JS Sauer, 1172

LaserSurge, Inc., Rochester, NY; KP McGuire

2. Electrophysiological and Histological Studies ofLaser and Suture Anastomosis in Rat 1174

Sciatic Nerve TA Benke, Rice University; JW Clark, PJ Wisoff, SA Shehab, S

Schneider, B Chidambaram, H Hawkins, JLaurent

3. A Theoretical Description of Ultraviolet Laser Ablation of Organic Materials GH 1176

Pettit, Rice University; R Sauerbrey

4. Thrombolysis by Excimer Laser Photoablation GH Pettit, Rice University; IS 1178

Saidi, FK Tittel, R Sauerbrey, J Cartwright, R Farrell, C Benedict

5. Research for Photo-Dissociative Effect on Atherosclerotic Plaques Using a Solid Laser 1179

C Boissier, Universite J. Monnet, France; H Damany, JC SabaJier, J Liang, CH'

Veyret,XBarral

Session 8.02: Laser Imaging Velocimetry and Optical DiagnosticsSession Chair: Barry Sullivan, Northwestern University

1. Modeling and Analysis of CCI Holography BJ Sullivan, Northwestern University; 1181

JA Hayes

2. Focussed and Unfocussed Laser Heating of a TLD Layer for Medical Imaging: A 1183

Comparison Case ME Grupen-Shemansky, Arizona State University; KJKearfott

3. Evaluation ofCochlear Blood Flow Measurement by Laser Doppler Flowmetry T 1185

Tamura, Tokyo Medical and Dental University, Japan; A Okamoto, N Kobayashi,K Yokoyama, M Hasegawa, T Togawa

4. Laser and Dosimetry in Photodynamic Therapy SDiebold, Centre de Recherche 1187

enAutomatique de Nancy-ENSEM-GBM, Nancy, France; Y Granjon, E Yvroud, F

Guillemin

IEEE EMBS 1989~vii

Session 8.03: Fiber OpticsSession Chair: Michael Aita, Advanced Cardiovascular Systems, Santa Clara, CA

1. A Novel Delivery System for Laser Thermal Recanalization H Hussein, 1190

Trimedyne, Inc., Tustin, CA

2. Angioscopy-Design Considerations and Preliminary Results with the ACS Angioscope 1192

G Samson, Advanced Cardiovascular Systems, Santa Clara, CA; M Aita, T Doyle,MB Michaels, C White, S Ramee

3. Excitation and Detection ofAction Potential Induced Fluorescence Changes Through 1194

a Single Monomode Optical Fiber CC Davis, University ofMaryland; TA

Bowmaster, V Krauthamer

4. Novel Fiber Optic Pulsed Photo-Thermal Radiametry for Transluminal Tissue 1196

Characterization TArai, National Defense Medical College, Japan; SInazaki,M Nakagawa, A Suda, M Kikuchi, Y Daidoh,Y Komine, H Nakamura, K Mizuno

5. Evaluation of Sapphire Fibers for Laser Medical Application MN Ediger, FDA 4-AP-1

Centerfor Devices and RadiologicalHealth; RW Waynot, NI Djeu, Y Shimoji,RSF Chang

Session 8.04: Optics of Tissue I

Session Chair: Massoud Motamedi, Wayne State University, Detroit

1. Diffusion of Light in Tissues A Ishirnaru, University of Washington 1197

2. Thermally Induced Changes in Optical Properties of Heart SL Jacques, University 1199

ofTexas M.D. Anderson Cancer Center, Houston; MO Gaeeni

3. Optical Fiber Probe Monitor for Neonatal Bilirubinemia ISaidi, University of 1201

Texas M.D. Anderson Cancer Center, Houston; SL Jacques, M Keijzer, FK Tittel

4. Optical Trapping of Microspheres as a Model for Biological Cells WH Wright, 1203

University ofCalifornia, Irvine; GJ Sonek, MWBems

5. Medical Diagnostics Using Digitized Optical Imaging RE Benner, University of 1205

Utah; AL Eatchel, RW McClane, RC Straight

Session 8.05: Optics of Tissue H - Thermal Considerations

Session Chair: Massoud Motamedi, Wayne State University, Detroit

1. Thermodynamic Considerations in Laser Irradiation and Ablation of Tissue S 1207

Rastegar, TexasA&M University

2. The Effect ofWavelength on Ablation Mechanisms DuringCW Laser Irradiation: 1209

Argon Versus Nd:YAG (1.32um) GL LeCarpentier, University ofTexas, Austin;M Motamedi, LP McMath, AJ Welch

3. Detection of Tissue Thermal Damage Using Quantitative Histology SThomsen, 1211

University of TexasMD. Anderson Center, Houston; JA Pearce, WF Cheong

4. Kinetic Models of Tissue Thermal Damage JA Pearce, University of Texas, Austin 1213

5. Nd:YAG Laser-Induced Interstitial Hyperthermia MPanjehpour, Thompson 1215Cancer Center, Knoxville, TN; AJ Milligan, BF Overholt

Viii—IEEE EMBS 1989

Track 9: Bioelectric PotentialsChair: YongminKim

Session 9.00: Biolectric Potentials I

Session Chair: B. 0. Familoni, Memphis State University

1. Equivalent Dipole Tracing of Human Alpha Activities B He, Tokyo Institute of 1217

Technology; WYe, TMusha

2. Lissajous Figures and Visual Electrograms by Colored Modulated Stimulation E 1219

Albuisson, Faculty ofMedicine, Clermont-Ferrand, France; R Alfieri, JY Boire

3. Three-Dimensional Display and Reconstruction for Neuromagnetic Source 1221

Localization JS George, Los Alamos National Laboratory; PS Jackson, DMRanken, ER Flynn

4. Determining Gastrointestinal Location by Means ofElectrical Control Activity 1223

Frequencies Detected with an Intraluminal Probe HA Puryear, Ross

Laboratories, Columbus, OH; RM Isaac, RA Cannon

5. Small Intestine Slow Wave Signals Measured with anIntraluminal Probe RM 1226

Campbell, Ohio State University; RP Stradley, CS Weng, DN Yetkinler

6. A Model of Abnormal Gastric Electrical Activity BO Familoni, Memphis State 1228

University; TL Abell, P Praturu, S Katragadda, P Sabourin

Session 9.01: ImpedanceSession Chair: James J. Ackmann, Medical College of Wisconsin

1. Finite Element Analysis ofImpedance Models JH Battocletti, Medical College of 1230

Wisconsin

2. Impedance Measurements During Simulated Blood Flow LLHause, Medical 1232

College ofWisconsin; FA Gayon, ME Aleksza

3. Instrumentation Considerations for Complex Impedance Measurements JJ Ackmann, 1233

Medical College ofWisconsin

A. Current Distribution in a 3-D Thorax Model for Impedance Cardiography DW Kim, 1235

Yonsei University, Korea; NH Kim, WK Kim, SH Park

5. Mapping the Cardiogenic Impedance Signal on the Thorax R Patterson, University 1237

ofMinnesota; L Wang, B Raza, G McVeigh, R Bums

6. Determination of Cardiac Geometry from Impedance Measurements PD Wolf, 1239

Duke University; WM Smith, TC PilMngton

Session 9.02: Bioelectric Potentials n

Session Chair: James J. Ackmann, Medical College of Wisconsin

1. Electrical Behavior ofBiological Materials MASeitz, Marquette University 1241

2. Measurement ofIntracellular Electrical Activity from Two Smooth Muscle Layers PJ 1243

Sabourin, University ofAlberta; YJKingma, KL Bowes

IEEE EMBS 1989—ix

3. Evaluation of a Heuristic Approach to Estimate Motor Conduction Velocity 1245

Distributions ofPeripheral Nerves M Slawnych, University ofBritish Columbia;C Laszlo, C Hershler

4. A Modified K-Means Clustering Algorithm for Classification of Neurophysiological 1247

Waveforms (Slow Waves) B Kocsis, Michigan State University; KDembowsky,GL Gebber

5. Estimation of the Conduction Velocity Distribution of Motor Unit Action Potentials 1250

(MUAPS) YChen, University ofBritish Columbia; CA Laszlo, C Hershler

Session 9.03: NeuromagnetismSession Chair: Dominique Durand, Case Western Reserve University

1. Induced Electric Fields by Magnetic Stimulation in Non-Homogeneous Conducting 1252

Media D Durand, Case Western Reserve University; AS Ferguson, T Dalbasti

2. Optimization of Coil Design for Neuronal Excitation by Magnetic Stimulation AS 1254

Ferguson, Case Western Reserve University; D Durand, T Dalbasti

3. New Approaches to Source Localization in MEG CW Crowley, Biomagnetic 1256

Technologies Inc., San Diego, CA; RE Greenblatt, I Khalil

4. Studies of3-Dimensional Voltage Distributions Induced in Homogeneous Media 1259

Volume Conductors PJMaccabee, SUNY-Health Science Center at Brooklyn; LEberle, VE Amassian, RQ Cracco, A Rudell

Session 9.04: Bioelectric ModelsSession Chair: Craig Henriquez, Duke University

1. Study of Conduction in a New Model ofthe Myelinated Nerve Fiber JA Halter, 1261

Baylor College ofMedicine; JW Clark, Jr.

2. A Transmembrane Current Model in a Stylized Form T Ihara, Duke University; 1263

RCBarr

3. Modeling Propagation in 2D Cardiac Muscle Using Interconnected Cables LJLeon, 1264

University ofMontreal

4. A Bidomain Model for Simulating Propagation in Multicellular Cardiac Tissue CS 1266

Henriquez, Duke University; R Plonsey

5. Electric Field Model for Electric Interactions Between Cells: An Alternative 1267

Mechanism for Cell-to-Cell Propagation N Sperelakis, University ofCincinnati;J Picone

6. A Filtering Approach to the Two-Dimensional Volume Conductor Forward and 1269Inverse Problems TG Xydis, University ofMichigan; AE Yagle

Session 9.05: Bioelectric Potentials m

Session Chair: Lee Baker, University of Texas, Austin

1. Relationship of the K-Complex to the O Wave: A Study Using Averaging Techniques 1271JL Vamer, University ofNebraska-Lincoln; JW Rohrbaugh, RJ Ellingson, SRPaige

X—IEEE EMBS 1989

2. Spatial Patterns Underlying the Human Electroencephalogram ZJ Koles, 1273

University ofAlberta; MS Lazar, A Kasmia, Z Zhou

3. Complex Pattern Visual Evoked Potentials in Controls and Multiple Sclerosis Patients 1275

JMitchell-DePew, Rutgers University; E Micheli-Tzanakou

4. A Personal Computer-Based System for Auditory Evoked Potential and 1277

Psychoacoustic Experiments WT Gumming, University ofWisconsin-Madison;JG Wells

5. Visual Evoked Potentials and Reaction Times: Dependence on Alpha Activity C 1279

Baedeker, UNI-BWMunich, FRG; WWolf,UAppel

Session 9.06: Neural ModelingSession Chair: Dominique Durand, Case Western Reserve University

1. Modeling of Electric Field Effects on the Excitability ofMyelinated Motor Nerve JD 1281

Sweeney, Case Western Reserve University; K Deng, E Warman, JT Mortimer

2. Comparison of Passive Cable Model Predictions and Physiologic Measurements in 1283

CA1 Hippocampal Neurons DA Turner, University ofMinnesota

3. Neuronal System Identification: The Passive Electrical Properties BL Bardakjian, 1284

University ofToronto

4. Desynchronization of Epileptiform Activity by Phase Resetting E Warman, Case 1286

WesternReserve University; D Durand

5. Collective Oscillations in the CA3 Region of the Guinea Pig Hippocampal Slice RD 1288

Traub, IBM TJ. Watson Research Center

Session 9.07: Bioelectric PotentialsIV

Session Chair: Lee Baker, University ofTexas

1. The Use ofM Pulse Sequences in the Study of Nonlinearities in the Brainstem 1289

Auditory Evoked Response YShi, University ofWisconsin-Madison; KE

Hecox

2. Gradient of Surface Potential on a Homogeneous Sphere: Lateral Hemispheric Mean 1291

Magnitude RP Gaumond, Penn State University; M Psaltikidou

3. Use of Superconducting Plates and Shells to Deflect Magnetic Noise Fields: 1293

Application to MEG. WC Overton, Jr., Los Alamos NationalLaboratory; DB

van Hulsteyn, ER Flynn

4. Altered Neural Circuit Activity: Prenatal Protein Malnutrition and the Paired Pulse 1295

Response JDBronzino, Trinity College; RJ Austin-LaFrance, RJ Francesctuni, PJ

Morgane

5. Method for Modelling the Potential Sensed by a Concentric Multi-Ring Electrode Set 1297

from a Moving Depolarization Wave WF Poole, University ofMiami; PP Tarjan

IEEE EMBS 1989—xi

Track 15: Molecular ElectronicsChair: Felix T. Hong

Session 15.01: Conjugated Polymers and Novel Molecular Electronic Materials

Session Chair: R. S. Fotember, Johns Hopkins University

1. "Synthetic Metals": A Novel Role for Organic Polymers AG MacDiarmid, 1299

University ofPennsylvania; AJ Epstein

2. Controlling Light with Light in Organic Molecular Solids: Applications of 1300

Conjugated Polymers in Photonics PD Townsend, Bell Communications

Research

3. Molecular-Based Optical Devices RSPotember, Johns Hopkins University; RC 1302

Hoffman, KR Speck, KAStetyick

4. Diacetylenic Phosphatides: A New Class of Biomaterials A Singh, Naval Research 1304

Laboratory, Washington, DC; PE Schoen, BP Gaber, JM Schnur

5. Langmuir-Blodgett Films ofElectroactive Polymers TASkotheim, Brookhaven 1306

National Laboratory; XQ Yang, J Chen, HS Lee, Y Okamoto, MF Rubner

Session 15.02: Organic Thin Films

Session Chair: M. Sugi, Electrotechnical Laboratory, Tsukuba, Japan

1. Molecular Electronic Device Based on Biological Electron Transport System SIsoda, 1308

Mitsubishi Elect. Corp., Japan; S Ueyama,HKawakubo, Y Hanazato,M Maeda

2. LB Films of Dye-Derivatives as a Model System for Molecular Electronics MSugi, 1310

Electrotechnical Laboratory, Tsukuba, Japan; K Ikegami, S Kuroda, K Saito, M

Saito

3. Vibrational Spectroscopy ofSupermolecular Assemblies DJ Walls, University of 1311

Illinois; K Hughes, PWBonn

4. ESR and ENDOR Characterization of Molecular Electronic Materials S Kuroda, 1313

Electrotechnical Laboratory, Tsukuba, Japan; K Ikegami, K Saito, M Saito, M

Sugi, H Shirakawa

5. Metalioproteins Thin Films RMargalit, Jet Propulsion Lab; RPVasquez 1315

6. Defects in Langmuir-Blodgett Films and TheirInfluence on Electric Properties Y 1317

Wei, Southeast University, China; C Lin, Z Lu

Session 15.03: Electron Transfers and Ion Transports I

Session Chair: S. G. Boxer, Stanford University

1. Artificial Photosynthetic Reaction Center by Molecular Assemblies M Fujihira, 1318

Tokyo Institute ofTechnology, Japan

2. Effects of Electric Fields on Electron Transfer in Photosynthetic Reaction Centers 1320

SG Boxer, Stanford University

3. Ultrasmall Memories Based on ElectronTransfer Reactions DNBeratan, Jet 1322

Propulsion Lab; JJ Hopfield, JN Onuchic

Xii—IEEE EMBS 1989

4. Viologen-Mediated Transmembrane Oxidation-Reduction BC Patterson, Oregon 1323

Graduate Center; E Kuhn, JK Hurst

5. Phthalocyanines in Molecular Electronic Devices B Simic-Glavaski, Case Western 1325

Reserve University

Session 15.04: Retinal Proteins

Session Chair: H. G. Smith, EG & G Mason Research Institute, Worcester, MA

1. Some Methods for Irreversible Write-Once Recording in "Biochrom" Films NN 1327

Vsevolodov, USSR Academy ofSciences; TV Djukova, AB Druzhko

2. Ordering of Cationic Amphiphiles on Two-Dimensional Lattice ofBacteriorhodopsin 1328

T Katsura, Research Institutefor Polymers & Textiles, Tsukuba, Japan

3. Surface-Bound Biomembrane Assemblies HG Smith, E G& G Mason Research 1329

Institute, Worcester, MA; J Li, NW Downer, LW DeLuca

4. Photoreceptor Ion Channels Reconstituted in Bilayer Lipid Membranes M Takagi, 1331

Osaka University, Japan

5. Signal Modulation Via Interfacial Processes in Molecular Optoelectonic Devices S 1333

Michaile, Wayne State University; FT Hong

Session 15.05: Electron Transfers and Ion Transports HSession Chair: M. A. Cusanovich, University of Arizona

1. Photogating of Ionic Currents Across the Lipid Bilayer CM Drain, Rockefeller 1336

University; B Christensen, D Mauzerall

2. Approach to Artificial Mitochondria and Highly Functional Artificial Organ Devices 1337

T Akaike, University ofAgriculture & Technology, Tokyo; T Daido, Y Tanaka, K

Yamamoto, T Suzuki

3. Cytochrome C3, An Oriented Iron Wire MA Cusanovich, University ofArizona; H 1339

Akutsu, JH Hazzard

4. Membrane Electronics of Reconstituted Thermophilic Proteins THamamoto, 1341

Jichi Medical School, Japan; H Hirata, Y Kagawa

5. Membrane Enzyme as Transducer of Electric Energy: Mechanism of Enforced 1342

Conformational Oscillations TY Tsong, University ofMinnesota

Session 15.06: Tissues, Cells and CytoskeletonsSession Chair: S. R. Hameroff, University of Arizona

1. Stimulated Volume Changes in Mammalian Outer Hair Cells WEBrownell, 1344

JohnsHopkins University; JB Imredy, W Shehata

2. Interfacing Excitable Cells with Integrated Devices M Grattarola, Biophysical & 1346

Electronic Engrg. Dept., Genoa, Italy; G Arnaldi, A Cambiaso, S Martinoia, G

Massobrio

3. Dynamic Biomolecular Assemblies as Molecular Devices H Hotani, ERATO, 1348

Research Dev. Corp., Japan; T Bceda

IEEE EMBS 1989—xiii

4. Scanning Tunneling Microscopy ofMicrotubules SHameroff, University of 1350

Arizona; Y Simic-Krstic, D Korugal, M Kelley, R McCuskey, M Krasovich, C

Schneiker

5. Molecular Correlates of Neural Network in C. Elegans SSiddiqui, Toyohashi 1352

University ofTechnology, Japan

6. Chemical Oscillations and Waves in Perception by a Cell T Ueda, Hokkaido 1353

University, Japan; K Matsumoto

Session 15.07: Neuromolecular Computing I

Session Chair: K. Matsuno, Technological University ofNagaoka, Japan

1. Self-Assembly as a Mechanism ofMolecular Computing M Conrad, Wayne State 1354

University

2. A Molecular Computing in Developmental Process K Matsuno, Technological 1356

University ofNagaoka, Japan; T Suzuki

3. Learning Parameters for Molecular Memory Control R Trenary, Western 1357

Michigan University; P Moss

4. Information Processing in the Lorenz-Turing Neuron KGKirby, Wright State 1358

University

5. Bridging the Gap Between Molecular Electronics and Biocomputing K Akingbehin, 1360

University ofMichigan - Dearborn

Session 15.08: Neuromolecular Computing HSession Chair: D. Rakovic, University ofBelgrade, Yugoslavia

1. Signal Processing System Using a Neural Network for Laser-Doppler Velocimetry Y 1362

Fukuoka, Keio University, Japan; Y Nakajyo, E Okada,H Matsuki, H Minamitani

2. Molecular Networks and Neuroengineering D Koruga, University ofBelgrade, 1364

Yugoslavia

3. Molecular Electronics and Neural Networks: Significance of Ionic Structure D 1366

Rakovic, University ofBelgrade, Yugoslavia; D Koruga, Z Martinovic, G

Stanojevic

4. Emergent Computation in Microtubule Model Networks S Rasmussen, University 1368

ofArizona; H Karampurwalo, R Vaidyanath, S Hameroft

5. Biological Codes for Stretch W Craelius, SUNY Health Science & VA Medical 1370

Centers, Brooklyn

Session 15.09: Molecular Electronic Sensor TechnologySession Chair: J. M. Schnur, Naval Research Laboratory, Washington, DC

1. Multiple Applications of the Light Addressable Potentiometric Sensor JW Parce, 1372

Molecular Devices Corp., Menlo Park, CA

2. Bio/Technological & Biomaterial Applications of Self Assembly JM Schnur, Naval 1373

Research Laboratory, Washington, DC; J Calvert, M Peckerar, P Schoen, C

Martian, R Price, A Singh, A Rudolph, J Georger,W Stockton, C Dulcey, M Testoff

Xiv—IEEE EMBS 1989

3. An Approach to the Stabilization of Lipid Bilayers Incorporating Ion Channels for 1375

Biosensing Applications T Osborn, University ofWashington; JJ Person, P Yager

4. An Electrical Characterization ofDPPE/ValinomycinFilms on Platinum Surfaces TL 1377

Fare, NavalResearch Laboratory, Washington, DC; E Chang

5. Sensors on Surfaces PESchoen, Naval Research Laboratory, Washington, DC; T 1379

Fare, SK Bhatia, LC Shriver-Lake, FS Ligler

6. A Planar Conductimetric Sensor for Continuous Monitoring of Haemodialysis W 1381

Sansen, Katholieke University Leuven, Belgium; P Jacobs, A Claes, M Lambrechts

Special Workshop on Molecular ElectronicsChair: Felix T. Hong, Wayne State University

1 Current Status of Molecular Electronics AAviram, IBM TJ. Watson Research 1385

Center;

2 Molecular Electronic Technology for Biosensors MAizawa, Tokyo Institute of 1387

Technology

3 Molecular Monoelectronics PILazarev USSR Academy ofSciences 1388

Additional Papers 4-AP-l

Authors' Index ai

Keywords Index ki

IEEE EMBS 1989--XV