IIP Czech Republic: Academy of Science - princeton.edu · IIP Czech Republic: Academy of Science...
Transcript of IIP Czech Republic: Academy of Science - princeton.edu · IIP Czech Republic: Academy of Science...
Nové Hrady andInstituteofMicrobiology•ExperimentalandModelingresearch•ParticipationintheannualVisegrad ConferenceandSummerSchool•GreatopportunitiestomeetresearchersfromEurope
TheCastle:bothlaboratoryandresidentialhall
Workresponsibilities•Reactionmechanismofhuman3’-phosphoadenosine5’-phosphosulfatesynthaseI(hPAPSSI)•ComputationalChemistry:ahybridquantummechanicsandmolecularmechanicsapproach(QM/MM)•AnalyticaltransitionstructuresearchusingSchrödingerBiologicalSuite StructureofhPAPSSI
BonafideTransitionstructure
Abriefdescriptionofcomputationchemistry• Usingmodelsofvaryingdegreesofaccuracytopredict
andunderstandmolecularbehavioratpico-secondtonano-secondscale
Impactontheorganization•Elucidationofbonafidetransitionstructure•Generatedadetailedapplicationnoteforcontinuationofthesameproject
•IntroducedapackagethatwasrarelyusedattheInstituteforfuturework(AmbermoleculardynamicsusingQM/MM)
•WinnerofBestPresentationAwardattheconclusionofsummerschool
Interactionbetweenligandandcriticalproteinresidues
VisegradConference•Posterpresentations
•Lecturesonexperimentalandmodelingwork
•NetworkingwithscholarsandresearchersalloverEuropeandbeyond
Impactonacademicsandcareerpath•Openedupanewwayformeinthefieldoftheoreticalstudies•Reaffirmedmydecisiontopursueacareerinmedicine•Motivatedmetostudybiologyinamorequantitativemanner
Sideprojectusingskillslearntfromwork:peptideembeddedinmembrane