Supplemental*Figure*1:*Guide&to&ranking&of&TRPV6&staining&in&biopsies*IHC Score

Intensity of Staining (Brief description)

Representative Image Specimen Source (Ovarian tumor type and Grade)

0 No staining of tissue

Normal ovarian tissue

1 Very weak staining; Majority of cells negative for staining with weak staining of some cells

Normal ovarian tissue

2 Weak staining of majority of cells

Serous papillary adenocarcinoma Grade I

2 Weak staining of majority of cells

Mucinous papillary adenocarcinoma Grade II-III

3 Light staining of majority of cells

&

Serous papillary adenocarcinoma Grade II&

3 Light staining of majority of cells

&

Mucinous papillary cystadenocarcinoma Grade II&

4 Moderate staining of majority of cells

&

Serous papillary adenocarcinoma Grade II

4 Moderate staining of majority of cells

&

Mucinous papillary adenocarcinoma Grade III&

5 Intense staining of majority of cells

&

Serous papillary adenocarcinoma Grade II

5 Intense staining of majority of cells

&

Mucinous papillary cystadenocarcinoma Grade II&

&&&

SupplementalTable1:PathologyofcDNAarraysusedforTRPV6mRNAmeasurementHORT-101

Panel Well Sample Diagnosis Tumorgrade Stage101 C1 Normal Adenocarcinomaofendometrium,papillaryserous FIGOG3:Poorlydifferentiated 0101 C2 Normal Carcinomaofcervix,squamouscell FIGOG3:Poorlydifferentiated 0101 C3 Normal Abscessoftissue NotReported 0101 C4 Normal Endometriosis NotReported 0101 C5 Normal Endometriosis NotReported 0101 C6 Normal Endometriosis NotReported 0101 C7 Normal Endometriosis NotReported 0101 C8 Tumor Carcinomaofovary,endometrioid FIGOG2:Moderatelydifferentiated I101 C9 Tumor Adenocarcinomaofovary,papillaryserous FIGOG2:Moderatelydifferentiated IA101 C10 Tumor Tumorofovary,papillaryserous,borderline AJCCGB:Borderlinemalignancy IA101 C11 Tumor Tumorofovary,papillaryserous,borderline AJCCGB:Borderlinemalignancy IA101 C12 Tumor Carcinomaofovary,endometrioid FIGOG1:Welldifferentiated IA101 D1 Tumor Tumorofovary,serous,borderline AJCCGB:Borderlinemalignancy IA101 D2 Tumor Tumorofovary,borderline AJCCGB:Borderlinemalignancy IA101 D3 Tumor Tumorofovary,mucinous,borderline AJCCGB:Borderlinemalignancy IA101 D4 Tumor Adenocarcinomaofovary,mucinous FIGOG3:Poorlydifferentiated IB101 D5 Tumor Adenocarcinomaofovary,endometrioid FIGOG3:Poorlydifferentiated IB101 D6 Tumor Tumorofovary,borderline NotReported IB101 D7 Tumor Tumorofovary,mucinous,borderline AJCCGB:Borderlinemalignancy IC101 D8 Tumor Tumorofovary,serous,borderline AJCCGB:Borderlinemalignancy IC101 D9 Tumor Tumorofovary,serous,borderline AJCCGB:Borderlinemalignancy IC101 D10 Tumor Adenocarcinomaofovary,mucinous FIGOG2:Moderatelydifferentiated IC101 D11 Tumor Adenocarcinomaofovary,endometrioid,squamousfeatures FIGOG2:Moderatelydifferentiated IC101 D12 Tumor Adenocarcinomaofovary,serous FIGOG3:Poorlydifferentiated IIB101 E1 Tumor Adenocarcinomaofovary,endometrioid FIGOG3:Poorlydifferentiated IIB101 E2 Tumor Adenocarcinomaofovary,endometrioid FIGOG1:Welldifferentiated IIC101 E3 Tumor Adenocarcinomaofovary,papillaryserous FIGOG2:Moderatelydifferentiated III101 E4 Tumor Adenocarcinomaofovary,serous FIGOG3:Poorlydifferentiated III101 E5 Tumor Carcinomaofovary,endometrioid FIGOG2:Moderatelydifferentiated IIIA

101 E6 Tumor Tumorofovary,serous,borderline AJCCGB:Borderlinemalignancy IIIA101 E7 Tumor Adenocarcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IIIB101 E8 Tumor Adenocarcinomaofovary,serous FIGOG2:Moderatelydifferentiated IIIB101 E9 Tumor Adenocarcinomaofovary,endometrioid FIGOG3:Poorlydifferentiated IIIB101 E10 Tumor Adenocarcinomaofovary,papillaryserous FIGOG2:Moderatelydifferentiated IIIB101 E11 Tumor Adenocarcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IIIB101 E12 Tumor Tumorofovary,serous,borderline NotReported IIIB101 F1 Tumor Adenocarcinomaofovary,metastatic NotReported IIIB101 F2 Tumor Adenocarcinomaofovary,papillaryserous FIGOG1:Welldifferentiated IIIC101 F3 Tumor Adenocarcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IIIC101 F4 Tumor Adenocarcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IIIC101 F5 Tumor Adenocarcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IIIC101 F6 Tumor Adenocarcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IIIC101 F7 Tumor Carcinomaofovary FIGOG3:Poorlydifferentiated IIIC101 F8 Tumor Adenocarcinomaofovary,papillaryserous NotReported IIIC101 F9 Tumor Adenocarcinomaofovary,serous NotReported IIIC101 F10 Tumor Adenocarcinomaofovary,papillaryserous FIGOG2:Moderatelydifferentiated IV101 F11 Tumor Adenocarcinomaofovary,metastatic NotReported IV101 F12 Tumor Adenocarcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IV

HORT102

Panel Well Sample Diagnosis Tumorgrade Stage102 C1 Normal Leiomyomaofmyometrium NotApplicable 0102 C2 Normal Leiomyomaofmyometrium NotApplicable 0102 C3 Normal Leiomyomaofmyometrium NotApplicable 0102 C4 Normal Endometrium,secretory NotApplicable 0102 C5 Normal Noresidualmalignancy NotApplicable 0102 C6 Normal Cystofovary,follicular NotApplicable 0102 C7 Normal Endometriosis NotApplicable 0102 C8 Normal Endometriosis NotApplicable 0102 C9 Tumor Carcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IA

102 C10 Tumor Adenocarcinomaofovary,papillaryserous FIGOG2:Moderatelydifferentiated IA102 C11 Tumor Adenocarcinomaofovary,clearcell NotReported IA102 C12 Tumor Adenocarcinomaofovary,endometrioid FIGOG1:Welldifferentiated IB102 D1 Tumor Adenocarcinomaofovary,endometrioid FIGOG3:Poorlydifferentiated IB102 D2 Tumor Adenocarcinomaofovary,endometrioid,papillaryserous FIGOG3:Poorlydifferentiated IB102 D3 Tumor Carcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IC102 D4 Tumor Carcinomaofovary,endometrioid FIGOG2:Moderatelydifferentiated IC102 D5 Tumor Adenocarcinomaofovary,papillaryserous FIGOG2:Moderatelydifferentiated IIA102 D6 Tumor Carcinomaofovary,papillaryserous FIGOG2:Moderatelydifferentiated IIA102 D7 Tumor Adenocarcinomaofovary FIGOG3:Poorlydifferentiated IIA102 D8 Tumor Adenocarcinomaofovary,serous FIGOG2:Moderatelydifferentiated IIB102 D9 Tumor Adenocarcinomaofovary,serous FIGOG2:Moderatelydifferentiated IIB102 D10 Tumor Adenocarcinomaofovary,endometrioid FIGOG3:Poorlydifferentiated IIB102 D11 Tumor Adenocarcinomaofovary,papillaryserous FIGOG2:Moderatelydifferentiated IIB102 D12 Tumor Adenocarcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IIC102 E1 Tumor Adenocarcinomaofovary,serous FIGOG2:Moderatelydifferentiated IIC102 E2 Tumor Adenocarcinomaofovary,serous FIGOG2:Moderatelydifferentiated III102 E3 Tumor Adenocarcinomaofovary,serous FIGOG3:Poorlydifferentiated III102 E4 Tumor Adenocarcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated III102 E5 Tumor Adenocarcinomaofovary,endometrioid FIGOG3:Poorlydifferentiated IIIA102 E6 Tumor Adenocarcinomaofovary,serous FIGOG3:Poorlydifferentiated IIIA102 E7 Tumor Adenocarcinomaofovary,mucinous FIGOG2:Moderatelydifferentiated IIIA102 E8 Tumor Adenocarcinomaofovary,serous FIGOG2:Moderatelydifferentiated IIIA102 E9 Tumor Adenocarcinomaofovary,serous NotReported IIIB102 E10 Tumor Adenocarcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IIIB102 E11 Tumor Carcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IIIB102 E12 Tumor Adenocarcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IIIB102 F1 Tumor Adenocarcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IIIC102 F2 Tumor Adenocarcinomaofovary,papillaryserous FIGOG2:Moderatelydifferentiated IIIC102 F3 Tumor Carcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IIIC102 F4 Tumor Adenocarcinomaofovary,papillaryserous FIGOG2:Moderatelydifferentiated IIIC102 F5 Tumor Adenocarcinomaofovary,serous FIGOG3:Poorlydifferentiated IIIC102 F6 Tumor Adenocarcinomaofovary,endometrioid,papillaryserous FIGOG3:Poorlydifferentiated IIIC102 F7 Tumor Adenocarcinomaofovary,serous,metastatic NotReported IV

102 F8 Tumor Adenocarcinomaofovary,endometrioid,papillaryserous FIGOG3:Poorlydifferentiated IV102 F9 Tumor Adenocarcinomaofovary,serous FIGOG3:Poorlydifferentiated IV102 F10 Tumor Adenocarcinomaofovary,serous FIGOG3:Poorlydifferentiated IV102 F11 Tumor Adenocarcinomaofovary,papillaryserous,metastatic NotReported IV102 F12 Tumor Adenocarcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IV

HORT103

Panel Well Sample Diagnosis Tumor grade Stage103 C1 Normal Endometriosis NotApplicable 0103 C2 Normal Leiomyomaofmyometrium NotApplicable 0103 C3 Normal Carcinomaofbladder,urothelial NotApplicable 0103 C4 Normal Endometriosis NotApplicable 0103 C5 Normal Endometriosis NotApplicable 0103 C6 Normal Endometriosis NotApplicable 0103 C7 Tumor Adenocarcinomaofovary,serous FIGOG3:Poorlydifferentiated IA103 C8 Tumor Adenocarcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IA103 C9 Tumor Adenocarcinomaofovary,clearcell FIGOG3:Poorlydifferentiated IA103 C10 Tumor Adenocarcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IA103 C11 Tumor Adenocarcinomaofovary,endometrioid FIGOG1:Welldifferentiated IA103 C12 Tumor Adenocarcinomaofovary,endometrioid,squamousfeatures FIGOG1:Welldifferentiated IA103 D1 Tumor Carcinomaofovary,endometrioid FIGOG2:Moderatelydifferentiated IA103 D2 Tumor Adenocarcinomaofovary,endometrioid FIGOG1:Welldifferentiated IA103 D3 Tumor Adenocarcinomaofovary,endometrioid FIGOG2:Moderatelydifferentiated IA103 D4 Tumor Adenocarcinomaofovary,endometrioid,mucinous FIGOG1:Welldifferentiated IB103 D5 Tumor Adenocarcinomaofovary,endometrioid FIGOG2:Moderatelydifferentiated IB103 D6 Tumor Adenocarcinomaofovary,endometrioid FIGOG3:Poorlydifferentiated IC103 D7 Tumor Adenocarcinomaofovary,serous FIGOG3:Poorlydifferentiated IC103 D8 Tumor Carcinomaofovary,clearcell FIGOG3:Poorlydifferentiated IC103 D9 Tumor Adenocarcinomaofovary,serous FIGOG2:Moderatelydifferentiated II103 D10 Tumor Adenocarcinomaofovary,serous FIGOG2:Moderatelydifferentiated IIB103 D11 Tumor Adenocarcinomaofovary,mucinous FIGOG1:Welldifferentiated IIB103 D12 Tumor Adenocarcinomaofovary,serous FIGOG3:Poorlydifferentiated IIB

103 E1 Tumor Adenocarcinomaofovary,endometrioid FIGOG3:Poorlydifferentiated IIC103 E2 Tumor Adenocarcinomaofovary FIGOG3:Poorlydifferentiated III103 E3 Tumor Adenocarcinomaofovary,serous FIGOG3:Poorlydifferentiated IIIA103 E4 Tumor Adenocarcinomaofovary,papillaryserous FIGOG2:Moderatelydifferentiated IIIA103 E5 Tumor Adenocarcinomaofovary,serous FIGOG2:Moderatelydifferentiated IIIA103 E6 Tumor Adenocarcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IIIB103 E7 Tumor Adenocarcinomaofovary,serous FIGOG3:Poorlydifferentiated IIIB103 E8 Tumor Adenocarcinomaofovary,serous FIGOG2:Moderatelydifferentiated IIIB103 E9 Tumor Adenocarcinomaofovary,serous FIGOG3:Poorlydifferentiated IIIB103 E10 Tumor Adenocarcinomaofovary FIGOG3:Poorlydifferentiated IIIB103 E11 Tumor Carcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IIIB103 E12 Tumor Adenocarcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IIIC103 F1 Tumor Adenocarcinomaofovary,endometrioid FIGOG2:Moderatelydifferentiated IIIC103 F2 Tumor Carcinomaofovary FIGOG3:Poorlydifferentiated IIIC103 F3 Tumor Carcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IIIC103 F4 Tumor Carcinomaofovary,papillaryserous NotReported IIIC103 F5 Tumor Adenocarcinomaofovary,serous FIGOG3:Poorlydifferentiated IIIC103 F6 Tumor Adenocarcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IIIC103 F7 Tumor Adenocarcinomaofovary,serous FIGOG2:Moderatelydifferentiated IIIC103 F8 Tumor Adenocarcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IIIC103 F9 Tumor Adenocarcinomaofovary,endometrioid FIGOG3:Poorlydifferentiated IIIC103 F10 Tumor Adenocarcinomaofovary,clearcell FIGOG3:Poorlydifferentiated IIIC103 F11 Tumor Adenocarcinomaofovary,endometrioid,papillaryserous FIGOG3:Poorlydifferentiated IIIC103 F12 Tumor Adenocarcinomaofovary,clearcell FIGOG3:Poorlydifferentiated IV

HORT104

Panel Well Sample Diagnosis Tumor grade Stage104 C1 Normal Nopathologicdisease NotApplicable 0104 C2 Normal Cystofovary,endometrial NotApplicable 0104 C3 Normal Adenocarcinomaofovary,serous NotApplicable 0104 C4 Normal Adenocarcinomaofmesosalpinx,endometrioid NotApplicable 0104 C5 Normal Adenocarcinomaofovary,papillaryserous NotApplicable 0

104 C6 Normal Endometriosis NotApplicable 0104 C7 Tumor Adenocarcinomaofovary,clearcell FIGOG3:Poorlydifferentiated IA104 C8 Tumor Adenocarcinomaofovary,endometrioid FIGOG2:Moderatelydifferentiated IA104 C9 Tumor Carcinomaofovary,endometrioid FIGOG1:Welldifferentiated IA104 C10 Tumor Adenocarcinomaofovary,endometrioid FIGOG1:Welldifferentiated IA104 C11 Tumor Adenocarcinomaofovary,endometrioid FIGOG2:Moderatelydifferentiated IA104 C12 Tumor Adenocarcinomaofovary,clearcell NotReported IB104 D1 Tumor Adenocarcinomaofovary,clearcell,papillaryserous FIGOG3:Poorlydifferentiated IC104 D2 Tumor Adenocarcinomaofovary,papillaryserous FIGOG2:Moderatelydifferentiated IIB104 D3 Tumor Adenocarcinomaofovary,endometrioid FIGOG3:Poorlydifferentiated III104 D4 Tumor Adenocarcinomaofovary,metastatic NotReported III104 D5 Tumor Adenocarcinomaofovary,serous FIGOG3:Poorlydifferentiated IIIA104 D6 Tumor Adenocarcinomaofovary,serous,metastatic FIGOG3:Poorlydifferentiated IIIA104 D7 Tumor Adenocarcinomaofovary,serous FIGOG3:Poorlydifferentiated IIIA104 D8 Tumor Adenocarcinomaofovary,endometrioid,serous FIGOG2:Moderatelydifferentiated IIIA104 D9 Tumor Adenocarcinomaofovary,papillaryserous,metastatic NotReported IIIB104 D10 Tumor Adenocarcinomaofovary,endometrioid,serous FIGOG3:Poorlydifferentiated IIIB104 D11 Tumor Adenocarcinomaofovary,papillaryserous FIGOG2:Moderatelydifferentiated IIIB104 D12 Tumor Adenocarcinomaofovary,serous FIGOG2:Moderatelydifferentiated IIIB104 E1 Tumor Adenocarcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IIIB104 E2 Tumor Carcinomaofovary,papillaryserous FIGOG2:Moderatelydifferentiated IIIB104 E3 Tumor Adenocarcinomaofovary,serous FIGOG2:Moderatelydifferentiated IIIC104 E4 Tumor Adenocarcinomaofovary,papillaryserous NotReported IIIC104 E5 Tumor Adenocarcinomaofovary,serous FIGOG1:Welldifferentiated IIIC104 E6 Tumor Adenocarcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IIIC104 E7 Tumor Adenocarcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IIIC104 E8 Tumor Adenocarcinomaofovary,serous FIGOG2:Moderatelydifferentiated IIIC104 E9 Tumor Adenocarcinomaofovary,serous FIGOG3:Poorlydifferentiated IIIC104 E10 Tumor Adenocarcinomaofovary,mucinous NotReported IIIC104 E11 Tumor Adenocarcinomaofovary,serous FIGOG3:Poorlydifferentiated IIIC104 E12 Tumor Adenocarcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IIIC104 F1 Tumor Adenocarcinomaofovary,serous FIGOG2:Moderatelydifferentiated IIIC104 F2 Tumor Adenocarcinomaofovary,papillaryserous FIGOG2:Moderatelydifferentiated IIIC104 F3 Tumor Adenocarcinomaofovary,clearcell,papillaryserous FIGOG3:Poorlydifferentiated IIIC

104 F4 Tumor Carcinomaofovary,endometrioid FIGOG2:Moderatelydifferentiated IIIC104 F5 Tumor Adenocarcinomaofovary,papillaryserous FIGOG2:Moderatelydifferentiated IIIC104 F6 Tumor Adenocarcinomaofovary,endometrioid FIGOG3:Poorlydifferentiated IIIC104 F7 Tumor Adenocarcinomaofovary,serous FIGOG3:Poorlydifferentiated IIIC104 F8 Tumor Adenocarcinomaofovary,papillaryserous FIGOG3:Poorlydifferentiated IIIC104 F9 Tumor Adenocarcinomaofovary,serous FIGOG3:Poorlydifferentiated IIIC104 F10 Tumor Carcinosarcomaofovary FIGOG3:Poorlydifferentiated IIIC104 F11 Tumor Adenocarcinomaofovary,clearcell FIGOG3:Poorlydifferentiated IIIC

104 F12 Tumor Adenocarcinomaofovary,papillaryserous,metastatic NotReported IV

SupplementalTable2PathologyofTissueMicroarraysforImmunohistochemicalassessmentofTRPV6Array Position Patient Age Pathology Diagnosis Grade Staging OV483 A1 62 Mucinous papillary cystadenocarcinoma 1 T1NxM0 OV483 A2 52 Mucinous papillary cystadenocarcinoma 1 T1N0M0 OV483 A3 42 Mucinous papillary cystadenocarcinoma 1 T1N0M0 OV483 A4 48 Mucinous papillary cystadenocarcinoma 1 T3aN1M1 OV483 A5 23 Mucinous papillary cystadenocarcinoma 1 T1cNxM0 OV483 A6 34 Mucinous papillary cystadenocarcinoma 1 T1bNxM0 OV483 A7 43 Mucinous cystadenocarcinoma 1 T3cNxM0 OV483 A8 51 Mucinous papillary cystadenocarcinoma 1 OV483 B1 38 Mucinous papillary cystadenocarcinoma 1 T2bNxM0 OV483 B2 37 Mucinous papillary cystadenocarcinoma 1 T1aN0M0 OV483 B3 40 Mucinous papillary adenocarcinoma 2 T2NxM0 OV483 B4 51 Mucinous papillary adenocarcinoma 2 T1aN0M0 OV483 B5 64 Mucinous papillary cystadenocarcinoma 1 T1aN0M0 OV483 B6 65 Mucinous papillary cystadenocarcinoma 2 TxN0M0 OV483 B7 29 Mucinous papillary cystadenocarcinoma 2 T1cNxM0 OV483 B8 64 Mucinous papillary cystadenocarcinoma 2 T1N0M0 OV483 C1 51 Mucinous papillary adenocarcinoma 2 T3cN1M0 OV483 C2 34 Mucinous papillary adenocarcinoma 2 T2cN1M0 OV483 C3 47 Mucinous papillary adenocarcinoma 2 T1N0M0 OV483 C4 50 Mucinous papillary adenocarcinoma 2-3 T3cN1M0 OV483 C5 51 Mucinous papillary adenocarcinoma 3 T1NxM1 OV483 C6 56 Mucinous papillary adenocarcinoma 3 T1cNxM0 OV483 C7 46 Mucinous papillary adenocarcinoma 2 T4NxM3 OV483 C8 40 Serous papillary adenocarcinoma 1 T1N0M0 OV483 D1 30 Serous papillary adenocarcinoma 1 T1N0M0 OV483 D2 43 Serous papillary adenocarcinoma 2 T3cN1M0 OV483 D3 70 Serous papillary adenocarcinoma 2 T1aN0M0 OV483 D4 63 Serous papillary adenocarcinoma 2 T2N0M0 OV483 D5 59 Serous papillary adenocarcinoma 2 T3aN0M0 OV483 D6 50 Serous papillary adenocarcinoma 2 T3aN1M0 OV483 D7 47 Serous papillary adenocarcinoma 1-2 T3cN1M0

OV483 D8 61 Serous papillary adenocarcinoma 2 T3N1M0 OV483 E1 60 Serous adenocarcinoma 2 T2N0M0 OV483 E2 52 Serous adenocarcinoma 3 T1N0M0 OV483 E3 43 Serous adenocarcinoma 3 OV483 E4 56 Serous adenocarcinoma 3 T2N1M0 OV483 E5 68 Clear cell carcinoma T1N0M0 OV483 E6 70 Transitional cell carcinoma T1N0M0 OV483 E7 45 Endometrioid adenocarcinoma T2N0M0 OV483 E8 40 Endometrioid adenocarcinoma T2N1M0 OV483 F1 21 Normal ovarian tissue OV483 F2 21 Normal ovarian tissue OV483 F3 41 Normal ovarian tissue OV483 F4 14 Normal ovarian tissue OV483 F5 18 Normal ovarian tissue OV483 F6 15 Normal ovarian tissue OV483 F7 21 Normal ovarian tissue OV483 F8 21 Normal ovarian tissue

OV802 A1 40 Clear cell carcinoma OV802 A2 57 Serous papillary carcinoma 2 OV802 A3 48 Clear cell carcinoma OV802 A4 57 Serous papillary carcinoma 2 OV802 A5 43 Serous papillary carcinoma 3 OV802 A6 54 Serous papillary carcinoma 1 OV802 A7 63 Serous papillary carcinoma 3 OV802 A8 46 Serous papillary carcinoma 3 OV802 A9 54 Serous papillary carcinoma 3 OV802 A10 56 Hyperplastic fibrous tissue OV802 B1 44 Granular cell tumor OV802 B2 49 Serous papillary carcinoma 3 OV802 B3 18 Immature teratoma OV802 B4 15 Endodermal sinus carcinoma OV802 B5 38 Metastatic adenocarcinoma 3 OV802 B6 39 Serous papillary carcinoma 3

OV802 B7 24 Endodermal sinus carcinoma OV802 B8 42 Serous papillary carcinoma 3 OV802 B9 50 Serous papillary carcinoma 3 OV802 B10 49 Serous papillary carcinoma 3 OV802 C1 62 Serous papillary carcinoma 3 OV802 C2 53 Mucinous papillary carcinoma 1 OV802 C3 38 Metastatic adenocarcinoma 3 OV802 C4 43 Clear cell carcinoma OV802 C5 26 Serous papillary carcinoma 1 OV802 C6 47 Serous papillary carcinoma 1 OV802 C7 62 Squamous cell carcinoma 3 OV802 C8 35 Dysgerminoma OV802 C9 41 Dysgerminoma OV802 C10 47 Serous papillary carcinoma 3 OV802 D1 42 Clear cell carcinoma OV802 D2 39 Metastatic adenocarcinoma 1 OV802 D3 66 Metastatic adenocarcinoma 3 OV802 D4 48 Malignant follicular theca cytoma OV802 D5 51 Serous papillary carcinoma 1 OV802 D6 33 Metastatic signet-ring cell carcinoma OV802 D7 18 Mixed germ cell tumor OV802 D8 40 Metastatic signet-ring cell carcinoma OV802 D9 43 Granular cell tumor OV802 D10 55 Serous papillary carcinoma 3 OV802 E1 46 Serous papillary carcinoma 3 OV802 E2 57 Serous papillary carcinoma 3 OV802 E3 75 Serous papillary carcinoma 3 OV802 E4 69 Serous papillary carcinoma (sparse) 3 OV802 E5 30 Serous papillary carcinoma 3 OV802 E6 42 Serous papillary carcinoma 2 OV802 E7 48 Clear cell carcinoma OV802 E8 22 Serous papillary carcinoma 1 OV802 E9 50 Clear cell carcinoma OV802 E10 32 Serous papillary carcinoma 2

OV802 F1 48 Serous papillary carcinoma (sparse) 2 OV802 F2 50 Serous papillary carcinoma 2 OV802 F3 65 Serous papillary carcinoma 3 OV802 F4 38 Serous papillary carcinoma 3 OV802 F5 31 Metastatic adenocarcinoma 3 OV802 F6 55 Metastatic adenocarcinoma 3 OV802 F7 51 Serous papillary carcinoma 3 OV802 F8 65 Serous papillary carcinoma 2 OV802 F9 26 Serous papillary carcinoma 2 OV802 F10 55 Serous papillary carcinoma 2 OV802 G1 49 Serous papillary carcinoma 3 OV802 G2 48 Metastatic signet-ring cell carcinoma OV802 G3 46 Serous papillary carcinoma 3 OV802 G4 63 Serous papillary carcinoma 3 OV802 G5 37 Serous papillary carcinoma 2 OV802 G6 35 Malignant tumor (sparse) OV802 G7 12 Dysgerminoma OV802 G8 55 Serous papillary carcinoma 2 OV802 G9 20 Malignant tumor cell (sparse) OV802 G10 55 Serous papillary carcinoma 2

OV802 H1 40 Cancer adjacent normal ovarian tissue of No. A1

OV802 H2 22 Cancer adjacent normal ovarian tissue OV802 H3 30 Cancer adjacent normal ovarian tissue OV802 H4 39 Cancer adjacent normal ovarian tissue

OV802 H5 32 Cancer adjacent normal ovarian tissue of No. E10

OV802 H6 63 Normal ovarian tissue OV802 H7 17 Normal ovarian tissue OV802 H8 29 Normal ovarian tissue OV802 H9 14 Normal ovarian tissue OV802 H10 20 Normal ovarian tissue BCN721 G1 56 Serous cystadenocarcinoma 3 BCN721 G2 49 Serous cystadenocarcinoma 2-3

BCN721 G3 59 Serous cystadenocarcinoma 3 BCN721 H1 53 Cancer adjacent normal ovarian tissue BCN721 H2 39 Cancer adjacent normal ovarian tissue BCN721 H3 31 Cancer adjacent normal ovarian tissue

T112 A1 52 Serous papillary adenocarcinoma with necrosis 1 T1N0M0 T112 A2 52 Serous papillary adenocarcinoma 2 T1bN0M0 T112 A3 43 Serous papillary adenocarcinoma 2 T1aN0M0 T112 A4 41 Mucinous adenocarcinoma 1 T1aN0M0 T112 B1 42 Mucinous adenocarcinoma 1-2 T1bN0M0 T112 B2 49 Clear cell carcinoma - T1N0M0 T112 B3 68 Clear cell carcinoma - T1N0M0 T112 B4 43 Endometroid adenocarcinoma 1-2 T1bN0M0 T112 C1 40 Endometroid adenocarcinoma 2 T2N1M0 T112 C2 38 Granular cell tumor - T1N0M0 T112 C3 20 Normal ovarian tissue - - T112 C4 15 Normal ovarian tissue - -