IEG - Arc/Arg 3.1

Allatostatin receptor (AlstR)

+ 10 nM Alst

GFP controlled by Arc/Arg 3.1 gene promoterGenetical strategy for silencing a memory-encoding hippocampal cell assembly

Erasing and re-installing a hippocampus-dependent memory

Behavioural protocols and `high-cost decision point´

14-tetrode microdrive 64 channel Neuralynx Cheetah system

Extrafield firing at the high-cost decision point

Nonlocal representations at the choice point preferentially sweepforward of the animal

Nonlocal representations at the choice point sweep down the twochoices separately

Extrafield firing during error correction

Nonlocal representations are correlated but not defined by the orientation of motion

Nonlocal representations occur at locations of highly variable orientation of motion

Difference between histograms of reconstruction error distance during samples with variable orientation of motion and during the rest of the session.

High theta power at the choice points, no SW ripples.

The total amount of nonlocal reconstructedprobability decreased

multiple-T task

In contrast, on the cued-choice task, theforward component of the sweep maintained nonlocality.

Development of nonlocal representations with experienceSplitter cells – unindentified extrafield firing of place cells

hippocampus

ventral striatum

orbitofrontal cortex

(only the prediction component)

(reward anticipation)

(the value of potential choices)

prefrontal cortex

(decision making parameters)

“vicarious trial and error” (VTE) behaviors

behavioral “microchoices”

VTE

Hippocampal reevaluation in spatial navigation

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