VOLUME 56^

1988

INTERNATIONALJOURNAL OF LEPROSYAnd Other Mycobacterial Diseases

Official Organ of theINTERNATIONAL LEPROSY ASSOCIATION

(Association Internationale contre la Lcpre)(Asociación Internacional de la Lepra)

Contents

INTERNATIONAL JOURNAL OF LEPROSYand Other Mycobacterial Diseases

Official Organ of the International Leprosy Association

President: Wayne M. Meyers, M.D., Ph.D., Chicf,Microbiology Division, Armed ForcesInstitute of Pathology, Washington,D.C. 20306-6000, U.S.A.

Secretary: Dr. Yo Yuasa, Executive and MedicalDirector, Saskawa Memorial HealthFoundation, The Sasakawa Hall, 6F3-12-12 Mita, Minato-ku, Tokyo 108, Japan

Treasurer: Dr. W. F. Ross, One Broadway,Elmwood Park, New Jersey 07407, U.S.A.

EDITORIAL OFFICEGillis W. Long Hansen's Disease Center

Carville, Louisiana 70721, U.S.A.

Editor: ROBERT C. HASTINGS, Carville, LouisianaAssistant Editor: DEE D. GOODMAN, Carville, Louisiana

BUSINESS AND CIRCULATION OFFICEExecutive OJfcer: W. FELTON Ross, One Broadway

Elmwood Park, New Jersey 07407, U.S.A.

BOARD OF DIRECTORSDr. Wayne M. Meyers (President, ILA), ChairmanDr. Thomas H. Rea^Dr. M. F. R. WatersDr. W. Felton Ross^Dr. Yo Yuasa

CONTRIBUTING EDITORSArgentina: Dr. J. E. Cardama

(Buenos Aires)Australia: Dr. J. C. Hargrave (Darwin)Brazil: Dr. L. M. Bechelli (São Paulo)France & Fr. Terr.: Dr. D. Wallach

(Paris)índia (North): Dr. L. K. Bhutani

(New Delhi)índia (South): Dr. G. Ramu

(Kumbakonam)Israel: Dr. L. Levy (Jerusalem)Japan: Dr. M. Abe (Tokyo)Malaysia & SE Asia: Dr. J. H. S.

Pettit (Kuala Lumpur)

Mexico: Dr. A. Saúl (Mexico, D.F.)Netherlands: Dr. D. L. Leiker (Amsterdam)People's Republic of China:

Dr. Ye Gan-yun (Taizhou)Philippines: Dr. R. M. Abalos (Cebu City)Spain: Dr. J. Terencio delas Aguas (Fontilles)U.K.: Dr. R. J. W. Rees (London)U.K.: Dr. M. F. R. Waters (London)U.S.A.: Dr. P. W. Brand (Seattle)U.S.A.: Dr. Thomas H. Rea

(Los Angeles)U.S.S.R.: Dr. A. A. Juscenko (Astrakhan)Venezuela: Dr. J. Convit (Caracas)West Africa: Dr. M. Nebout (Bamako)

This JOURNAL iS indexed in CURRENT CONTENTS/LIFE SCIENCES, BIOLOGICAL ABSTRACTS,

CIIEMICAL ABSTRACTS, EXCERPTA MEDICA/SECTION 51 LEPROSY, TROPICAL DISEASES

BULLETIN, and INDEX MEDICUS-MEDLINE DATA BASE. Microform available from UniversityMicrofilms International, Ann Arbor, Michigan 48106, U.S.A. or London WC1R 4EJ, U.K.

The INTERNATIONAL JOURNAI. OF LEPROSY (ISSN 0148-916X) is published quarterly for $70.00 peryear for members and S100.00 per year for subscribers by Allen Press, Inc., 1041 New HampshireSt., Lawrence, Kansas 66044, U.S.A. Second-class postage paid at Elmwood Park, New Jersey andadditional mailing office. POSTMASTER: Send address changes to INTERNATIONAI. JOURNAI. 01

LEPROSY, Business and Circulation Office, One Broadway, Elmwood Park, NJ 07407, U.S.A.

INTERNATIONAL JOURNAL OF LEPROSYand Other Mycobacterial Diseases

CONTENTSVolume 56, Number 1, March 1988

Original Articles^ PageKatoch, Kiran, Sreevatsa, Ramanathan, Usha, and Ramu, Gopal.

Pyrazinamide as a Part of Combination Therapy for BL and LL Patients—a Pre-liminary Report. 1

Pieters, Frans A. J. M., Woonink, Frits, and Zuidema, Jan. A Field Trial AmongLeprosy Patients in Nigeria with Depot Injections of Dapsone and Monoacetyl-dapsone. 10

Marks, Sandy C., Jr. and Grossetete, Gerard. Facies Leprosa: Resorption ofMaxillary Anterior Alveolar Bone and the Anterior Nasal Spine in Patients withLepromatous Leprosy in Mali. 21

Chirmule, Narendra B., Chaturvedi, Ramesh M., and Deo, MadhavG. lmmunogenic "Subunit" of the ICRC Antileprosy Vaccine. ^27

Gill, Harvindar Kaur, Mustafa, Abu Salim, and Godal, Tore. Vaccination ofHuman Volunteers with Heat-killed M. leprae: Local Responses in Relation to theInterpretation of the Lepromin Reaction. 36

Sengupta, Utpal, Sinha, Sudhir, Ramu, Gopal, Lavania, Ravinder K., and Gup-ta, Chhitar M. Soluble Antigen of M. leprae Coupled with Liposomes ElicitsBoth "Early" and "Late" Delayed Hypersensitivity Skin Reactions 45

Wu, Qin -Xue, Ye, Gan -Yun, and Li, Xin -Yu. Serological Activity of Natural Dis-accharide Octyl Bovine Serum Albumin (ND-O-BSA) in Sera from Patients withLeprosy, Tuberculosis, and Normal Controls. ^50

Jacob, Mary and Mathai, Rachel. Diagnostic Efficacy of Cutaneous Nerve Biopsyin Primary Neuritic Leprosy. ^56

Gormus, Bobby J., Wolf, Robert H., Baskin, Gary B., Ohkawa, Susumu, Gerone,Peter J., Walsh, Gerald P., Meyers, Wayne M., Binford, Chapman H., andGreer, William E. A Second Sooty Mangabey Monkey with Naturally AcquiredLeprosy: First Reported Possible Monkey-to-Monkey Transmission. 61

EditoriaisNutrition in Leprosy: A Review. (Ray L. Foster, Albert L. Sanchez, Wilfred Stuy-

vesant, Frances N. Foster, Carrol Small, and Benjamin H. S. Lau) ^66The 1987 JOURNAL-a Continuing Perspective. (Robert C. Hastings) ^82

CorrespondenceSkin Smears and the Bacterial Index (BI) in Multiple Drug Therapy Leprosy

Control Programs: An Unsatisfactory and Potentially Hazardous State ofAffairs. (George D. Georgiev and A. Colin McDougall) ^101

Treatment Regimens in Paucibacillary Leprosy. (William H. Jopling) ^104Dr. Katoch's Response. (Kiran Katoch) ^105Allergy and Immunity in Leprosy: Are These Concepts Becoming Obso-

lete? (Michael G. Corcos) ^106Photoactivated Topical 8-Methoxypsoralen in Repigmentation of a Tuber-

culoid Leprosy Lesion. (C. R. Srinivas) ^109A Family with Histoid Leprosy. (Malkit Singh, Fatma H. Shahat, M. S. Belhaj, and

E. A. Manghoush) ^110Lupus and Lepros. (John M. Grange) ^111Determination of the o and L Configuration of Phenolic Glycolipids of M. leprae

and M. bovis. (Tsuyoshi Fujiwara) ^112Effect of Shipment of Skin-biopsy Specimens to a Distant Laboratory on

Viability of Mycobacterium leprae. (Mario Baras and Louis Levy) ^115News and Notes ^119

Book Reviews ^127

Current Literature ^131

Special Grantors and Sustaining Members ^162

Index to Volume 55 ^163

CONTENTS

Volume 56, Number 2, June 1988

Original Articles^ PageSirumban, P., Kumar, Ashok, and Neelan, P. N. Healing Time in Untreated

Paucibacillary Leprosy: A Cross-sectional Study ^223Hodes, Richard M. and Teferedegne, Befekadu. Tetanus in Leprosy Patients:

Report of Five Cases ^228Neylan, Thomas C., Nelson, Kenrad E., Schauf, Victoria, and Scollard, David

M. Illness Beliefs of Leprosy Patients: Use of Medical Anthropology in ClinicaiPractice ^231

Suryawanshi, Nivrutti and Richard, J. Cataract Surgery on Leprosy Patients ^238Fine, Paul E. M., Ponnighaus, Jorg M., Burgess, Peter, Clarkson, Jacqueline

A., and Draper, Christopher C. Seroepidemiological Studies of Leprosy inNorthern Malawi Based on an Enzyme-linked Immunosorbent Assay Using Syn-thetic Glycoconjugate Antigen 243

Petchclai, Bencha, Khupulsup, Kalayanee, Hiranras, Supaporn, Sampatavan-ich, Surasak, Sampoonachot, Prasert, and Leelarusamee, Amorn. APassive Hemagglutination Test for Leprosy Using a Synthetic DisaccharideAntigen 255

Grosset, Jacques H., Guelpa -Lauras, Claire -Cecile, Perani, Evelyne G., andBeoletto, Corinne. Activity of Ofloxacin Against Mycobacterium leprae in theMouse ^259

Mustafa, Abu Salim. Identification of T-cell-activating Recombinant Antigens SharedAmong Three Candidate Antileprosy Vaccines, Killed M. leprae, M. bovis BCG,and Mycobacterium w 265

Vadiee, Abdul R., Shannon, Edward J., Gillis, Thomas P., and Hastings, RobertC. Partial Characterization of Antigens from M. leprae Evoking IgG and IgMAntibodies in Armadillos 274

Cowley, Sally A., Butter, Colin, Verghese, Susan, Curtis, Jill, and Turk, JohnL. Nerve Damage Induced by Mycobacterial Granulomas in Guinea Pig SciaticNerves 283

Job, Charles K., Sanchez, Rita M., and Hastings, Robert C. LepromatousMeningoencephalitis in the Nine-banded Armadillo (Dasypus novemcinctus) ^291

Cree, lan A., Srinivasan, T., Krishnan, S. A. R., Gardiner, Carol A., Mehta, Jal,Fisher, Crispin A. H., and Beck, J. Swanson. Reproducibility of Histology inLeprosy Lesions 296

Meyers, Wayne M., McDougall, A. Colin, Fleury, Raul N., Neves, Rene, Reyes,Oscar, and Binford, Chapman H. Histologic Responses in Sixty MultibacillaryLeprosy Patients Inoculated with Autoclaved Mycobacterium leprae and LiveBCG 302

EditoriaisLeprosy Vaccine—a Reappraisal (Noshir H. Antia and Tannaz J. Birdi) ^310Leprosy: The Immunologist and the Patient (Robert N. Mshana and Rune Nil-

sen) ^314Obituaries

Bopp, Clovis ^323Klingmüller, Georg ^324Madarang, Monina G. ^325

CorrespondenceDapsone Susceptibility of Mycobacterium leprae lsolated Before 1977. (Ji

Baohong, E. C. de la Cruz, L. Levy, S. R. Pattyn, and R. J. W. Rees) ^326An Electronic Device for Repetitive Auditory Cues. (J. Devasundaram) ^328Leprous Neuritis, Classification of Leprosy, and Multidrug Therapy. (Yo-

hannes Negesse) ^329News and Notes ^331Current Literature ^342Special Grantors and Sustaining Members ^381

CONTENTSVolume 56, Number 3, September 1988

Original Articles^ PageRea, Thomas H. A Comparative Study of Testicular Involvement in Lepromatous

and Borderline Lepromatous Leprosy ^383Dhand, Upinder K., Kumar, Bhushan, Dhand, Rajiv, Chopra, Jagjit S., and Kaur,

Surrinder. Phrenic Nerve Conduction in Leprosy ^389Agusni, Indropo, Beck, J. Swanson, Potts, Robert C., Cree, lan A., and lulas,

M. Ibeni. Blood Flow Velocity in Cutaneous Lesions of Leprosy ^394Thangaraj, Harry, Laal, Suman, Thangaraj, Irene, and Nath, Indira. Epidermal

Changes in Reactional Leprosy: Keratinocyte la Expression as an Indicator of Cell-mediated Immune Responses 401

Boerrigter, Gjalt, Ponnighaus, Jorg M., and Fine, Paul E. M. Preliminary Ap-praisal of a WHO-recommended Multiple Drug Regimen in Paucibacillary LeprosyPatients in Malawi 408

Jesudasan, Kumar, Pannikar, Vijaykumar, and Christian, Melville. Infectivityof Secondary Dapsone-resistant Cases ^418

Vadiee, Abdul R., Shannon, Edward J., Gillis, Thomas P., Mshana, Robert N ,and Hastings, Robert C. Armadillo IgG and IgM Antibody Responses to Phe-nolic Glycolipid-I During Experimental Infection with M. leprae 422

Rojas-Espinosa, Oscar, Vega, Rosario, Oltra, Antonina, Arce, Patricia, andNunez, Augustin. Transitory Macrophage Activation in the GranulomatousLesions of Mycobacterium lepraemurium-induced Lepromatoid Leprosy in theMouse 428

Job, Charles K., Jacobson, Robert R., and Hastings, Robert C. SimultaneousUpgrading Reaction and Erythema Nodosum Leprosum in a Patient with Lepro-matous Leprosy 437

Malaty, Raga, Meyers, Wayne M., Walsh, Gerald P., Binford, Chapman H ,Zimmerman, Lorenz E., Baskin, Gary B., Gormus, Bobby J., Martin, LouisN., and Wolf, Robert H. Histopathological Changes in the Eyes of MangabeyMonkeys with Lepromatous Leprosy 443

Smida, Jan, Kazda, Jindrich, and Stackebrandt, Erko. Molecular-Genetic Evi-dence for the Relationship of Mycobacterium leprae to Slow-growing PathogenicMycobacteria 449

EditorialImmunological Approach for Control of Mycobacterium avium-intracellulare

Infections in AIDS—an Hypothesis (M. G. Deo) ^455

CorrespondenceIncreased Pigmentation of Skin Along Course of Superficial Veins of Lower

Limbs in Chronic Plantar Ulceration of Leprosy Patients (M. K. SiddalingaSwamy and C. Ratnakar) 464

Vibration Sensation in Leprosy Patches (Paul Klenerman and Christopher Ham-mond) ^466

Isolation of Mycobacteria from Healthy Persons' Stools (Françoise Portaels,Lennart Larsson, and Pascale Smeets ^468

Comedones Induced by Coconut Oil in a Borderline Tuberculoid Lesion (C.R. Srinivas, Ambrish Padhee, C. Balanchandran, S. D. Shenoy, Sandhya Acharya,and K. Ramnarayan) 471

News and Notes ^473Book Reviews ^479Current Literature ^481Statement of Financial Condition ^517Special Grantors and Sustaining Members ^521

CONTENTSVolume 56, Number 4, December 1988

Original Articles^ PageJob, Anand and Chacko, Chinoy J. G. Reactional States in the Nasal Mucosa: A Clinicai

and Histopathological Study ^523Agis, Frantz, Schlich, Pascal, Cartel, Jean -Louis, Guidi, Claude, and Bach, Marie-

Anne. Use of Anti-M. leprae Phenolic Glycolipid-I Antibody Detection for Early Diagnosisand Prognosis of Leprosy ^527

Gormus, Bobby J., Ohashi, David K., Ohkawa, Susumo, Walsh, Gerald P., Meyers, WayneM., Brennan, Patrick J., and Trygg, Cynthia. Serologic Responses to Mycobacteriumleprae-specific Phenolic Glycolipid-I Antigen in Sooty Mangabey Monkeys with ExperimentalLeprosy 537

ShivRaj, Lalita, Patil, Shripad A., Girdhar, Anita, Sengupta, Utpal, Desikan, K. V. andSrinivasan, H. Antibodies to HIV - 1 in Sera from Patients with Mycobacterial Infections ^546

Lai A Fat, Rudy F. M., Harboe, Morten, Chan Pin Jin, Jimmy C., Diesselhoff -den Dulk,Martina M. C., and van Furth, Ralph. In Vitro Synthesis of Antimycobacterial Antibodieswith Different Specificities in Various Tissues of Leprosy Patients ^552

Chakrabarty, Asit K., Kashyap, A., Sehgal, V. N., and Saha, Kunal. Solubilization ofPreformed lmmune Complexes in Sera of Patients with Type 1 and Type 2 Lepra Reactions^559

Courtright, Paul D. Defining the Magnitude of Ocular Complications from Leprosy: Problemsof Methodology ^566

Roy, B. and Das, R. K. Cytogenetic Effect of Dapsone, an Antileprotic Drug, in the Mouse inVivo System ^574

Portaels, Françoise, Fissette, Krista, De Ridder, Karin, Macedo, Paula M., De Muynck,Aimé, and Silva, Manuel T. Effects of Freezing and Thawing on the Viability and theUltrastructure of in Vivo Grown Mycobacteria 580

Harris, Eugene B., Franzblau, Scott G., and Hastings, Robert C. Inhibition of PhenolicGlycolipid-I Synthesis in Extracellular Mycobacterium leprae as an Indicator of AntimicrobialActivity 588

Reddi, Prabhakara P., Talwar, G. P., and Khandekar, Pramond S. Repetitive DNA Se-quence of Mycobacterium tuberculosis: Analysis of Differential Hybridization Pattern withOther Mycobacteria 592

Al -Mohaya, Suleiman A., Coode, Peter E., Alkhder, Abdullah A., and Al -Suhaibani,Mohammed O. Renal Granuloma and Mesangial Proliferative Glomerulonephritis in Leprosy^599

EditoriaisBlister Calendar Packs—Potential for lmprovement in the Supply and Utilization of

Multiple Drug Therapy in Leprosy Control Programs (George D. Georgiev and A. ColinMcDougall) ^603

A Review of Health Education in Leprosy (Jeffrey L. Lennon) ^611

CorrespondenceNerve Damage in Leprosy (Vanaja P. Shetty and Noshir H. Antia) ^619Pyrazinamide as a Part of Combination Therapy for BL and LL Patients —a Preliminary

Report (Louis Levy) ^621Reply to Dr. Levy (Kiran Katoch) ^622Thalidomide and Exfoliative Dermatitis (A. Salafia and R. D. Kharkar) ^625A Large Hypoanesthetic Patch in Borderline Tuberculoid Leprosy (Kader N. Mohamed)^625Arthus-like Phenomenon and Lepromin A—a Case Report (A. Salafia and R. D. Kharkar)^627Skin Smears and Bacterial Index in Multiple Drug Therapy (M. N. Agrawal and D. Porichha)^628Search for Leprous Infection in Some Small Wild Animais of Louisiana (Charles K. Job,

Joe L. Allen, and Robert C. Hastings) ^630Psychrophilic Mycobacteria in M. leprae-infected Tissues (Laszlo Kato) ^631Multiplication of Armadillo-derived M. leprae in Murine Dissociated Schwann Cell Cul-

tures (Noshir H. Antia, Nerges F. Mistry, and Varsha C. Kulkarni) ^632News and Notes ^636Book Reviews ^644Current Literature ^647U.S.-Japan Cooperativa Medical Science Program, Twenty-Third Joint Leprosy Research

Conference, Nara, Japan, 1988 ^673Reviewers ^692Special Grantors and Sustaining Members ^693Statement of Ownership ^694