I.Cancer Cancer cells evolve and accumulate traits that distinguish them from normal cells causing...
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![Page 1: I.Cancer Cancer cells evolve and accumulate traits that distinguish them from normal cells causing them to form tumors cancer cellnormal cell Matthew Saelzler.](https://reader035.fdocuments.us/reader035/viewer/2022062412/5a4d1ad97f8b9ab0599742aa/html5/thumbnails/1.jpg)
I. Cancer
Cancer cells evolve and accumulate traits that distinguish them from normal cells causing them to form tumors
cancer cellnormal cell
Matthew SaelzlerGraduate Student
MIT
![Page 2: I.Cancer Cancer cells evolve and accumulate traits that distinguish them from normal cells causing them to form tumors cancer cellnormal cell Matthew Saelzler.](https://reader035.fdocuments.us/reader035/viewer/2022062412/5a4d1ad97f8b9ab0599742aa/html5/thumbnails/2.jpg)
What is Cancer?
How does cancer evolve from a normal cell?
1. What causes the change in a normal cell to make it into a cancer cell?
2. How many changes does it take to make a cancer cell?
What do these changes incells do?
![Page 3: I.Cancer Cancer cells evolve and accumulate traits that distinguish them from normal cells causing them to form tumors cancer cellnormal cell Matthew Saelzler.](https://reader035.fdocuments.us/reader035/viewer/2022062412/5a4d1ad97f8b9ab0599742aa/html5/thumbnails/3.jpg)
DNA
mRNA
Protein
mutantDNA
mutantmRNA
mutantProtein
![Page 4: I.Cancer Cancer cells evolve and accumulate traits that distinguish them from normal cells causing them to form tumors cancer cellnormal cell Matthew Saelzler.](https://reader035.fdocuments.us/reader035/viewer/2022062412/5a4d1ad97f8b9ab0599742aa/html5/thumbnails/4.jpg)
The change into a cancer cell is not in one step.
There are several changes to become a cancer cell
normal
cancer cellnormal cell
cancer cell
Each box represents a mutation in the DNA of the cell.
![Page 5: I.Cancer Cancer cells evolve and accumulate traits that distinguish them from normal cells causing them to form tumors cancer cellnormal cell Matthew Saelzler.](https://reader035.fdocuments.us/reader035/viewer/2022062412/5a4d1ad97f8b9ab0599742aa/html5/thumbnails/5.jpg)
= normal cell
= cancer cell
![Page 6: I.Cancer Cancer cells evolve and accumulate traits that distinguish them from normal cells causing them to form tumors cancer cellnormal cell Matthew Saelzler.](https://reader035.fdocuments.us/reader035/viewer/2022062412/5a4d1ad97f8b9ab0599742aa/html5/thumbnails/6.jpg)
![Page 7: I.Cancer Cancer cells evolve and accumulate traits that distinguish them from normal cells causing them to form tumors cancer cellnormal cell Matthew Saelzler.](https://reader035.fdocuments.us/reader035/viewer/2022062412/5a4d1ad97f8b9ab0599742aa/html5/thumbnails/7.jpg)
Main Concepts
A. Cancer is caused by mutations in DNA.
B.The change from a normal to a cancer cell is the result of several mutations.
C.6 mutations give cancer cells abilities that normal cells lack
Normal Cell Cancer Cell
What do these changes in the normalcell do?
![Page 8: I.Cancer Cancer cells evolve and accumulate traits that distinguish them from normal cells causing them to form tumors cancer cellnormal cell Matthew Saelzler.](https://reader035.fdocuments.us/reader035/viewer/2022062412/5a4d1ad97f8b9ab0599742aa/html5/thumbnails/8.jpg)
What does the mutation cause the normal cell to do?
What happens next?
The first mutation induces the cell to divide.
![Page 9: I.Cancer Cancer cells evolve and accumulate traits that distinguish them from normal cells causing them to form tumors cancer cellnormal cell Matthew Saelzler.](https://reader035.fdocuments.us/reader035/viewer/2022062412/5a4d1ad97f8b9ab0599742aa/html5/thumbnails/9.jpg)
What does the second mutation do to the cell?
activate inhibit
What happens next?
The second mutation blocks the cell from stopping division.
![Page 10: I.Cancer Cancer cells evolve and accumulate traits that distinguish them from normal cells causing them to form tumors cancer cellnormal cell Matthew Saelzler.](https://reader035.fdocuments.us/reader035/viewer/2022062412/5a4d1ad97f8b9ab0599742aa/html5/thumbnails/10.jpg)
What does the third most likely do to the cell?
Normal Cell
Normal Cell Dies
Cancer Cell
Cancer Cell Lives
Uncontrolled Growth
Cancer cells can evade cell death (apoptosis).
This mutation allows cells to inhibit apoptosis
![Page 11: I.Cancer Cancer cells evolve and accumulate traits that distinguish them from normal cells causing them to form tumors cancer cellnormal cell Matthew Saelzler.](https://reader035.fdocuments.us/reader035/viewer/2022062412/5a4d1ad97f8b9ab0599742aa/html5/thumbnails/11.jpg)
What Makes a Cell a Cancer Cell?
1. Grow and divide without being told to do so.
2. Won’t stop growing and dividing when it should
3. It evades planned cell death
What happens next?
![Page 12: I.Cancer Cancer cells evolve and accumulate traits that distinguish them from normal cells causing them to form tumors cancer cellnormal cell Matthew Saelzler.](https://reader035.fdocuments.us/reader035/viewer/2022062412/5a4d1ad97f8b9ab0599742aa/html5/thumbnails/12.jpg)
What does the fourth mutation do to the cell?
The cells must become immortal to form a tumor.
Scientists have shown cells only divide a certain number of times. Once this is reached, they stop growing.The fourth mutation causes the cell to be
immortal.
![Page 13: I.Cancer Cancer cells evolve and accumulate traits that distinguish them from normal cells causing them to form tumors cancer cellnormal cell Matthew Saelzler.](https://reader035.fdocuments.us/reader035/viewer/2022062412/5a4d1ad97f8b9ab0599742aa/html5/thumbnails/13.jpg)
Angiogenesis -formation of new blood vessels
-the tumor releases molecules that recruit cells that form the blood vessel
-the recruited cells then form new blood vessels
VEGF is a molecule released by tumor cells to recruit endothelial cells
What is the fifth mutation required for a normal cell to progress to a cancer cell?
Tumors need oxygen and nutrients to survive, therefore they must have the ability to recruit blood vessels.
![Page 14: I.Cancer Cancer cells evolve and accumulate traits that distinguish them from normal cells causing them to form tumors cancer cellnormal cell Matthew Saelzler.](https://reader035.fdocuments.us/reader035/viewer/2022062412/5a4d1ad97f8b9ab0599742aa/html5/thumbnails/14.jpg)
What Makes a Cell a Cancer Cell?
1. Grow and divide without being told to do so
2. Won’t stop growing and dividing when it should
3. It evades cell death
4. It becomes immortal
5. It causes blood vessel formation
What is next in the evolution of a tumor?
![Page 15: I.Cancer Cancer cells evolve and accumulate traits that distinguish them from normal cells causing them to form tumors cancer cellnormal cell Matthew Saelzler.](https://reader035.fdocuments.us/reader035/viewer/2022062412/5a4d1ad97f8b9ab0599742aa/html5/thumbnails/15.jpg)
Metastasis -tumor cells move (spread) from one area of the body to another
1.Tumor cells grow at the primary site2.The cells breakthrough and invade nearby tissue3.The cells move into the bloodstream4.The cells move from bloodstream somewhere else.5.Tumor cells grow here into a tumor
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Metastasis
![Page 17: I.Cancer Cancer cells evolve and accumulate traits that distinguish them from normal cells causing them to form tumors cancer cellnormal cell Matthew Saelzler.](https://reader035.fdocuments.us/reader035/viewer/2022062412/5a4d1ad97f8b9ab0599742aa/html5/thumbnails/17.jpg)
What Makes a Cell a Cancer Cell?
1. Grow and divide without being told to do so
2. Won’t stop growing and dividing when it should
3. It evades cell death
4. It becomes immortal
5. It causes blood vessel formation
6. It can spread to other parts of the body
What Makes a Cell a Cancer Cell?
1. Self-sufficiency in growth signals
2. Insensitivity to anti-growth signals
3. Evading Apoptosis
4. Limitless replicative potential 5. Sustained Angiogenesis
6. Invasion and Metastasis
![Page 18: I.Cancer Cancer cells evolve and accumulate traits that distinguish them from normal cells causing them to form tumors cancer cellnormal cell Matthew Saelzler.](https://reader035.fdocuments.us/reader035/viewer/2022062412/5a4d1ad97f8b9ab0599742aa/html5/thumbnails/18.jpg)
Summary
A. Cancer is caused by mutations in DNA.
B.The change from a normal to a cancer cell is the result of several mutations.
C.Mutations give cancer cells abilities that normal cells lack
What do these changes in the normalcell do?