ICA TriNova, LLC A marketing and development company seeking to commercialize new technologies...

ICA TriNova, LLCICA TriNova, LLC

ICA TriNova, LLC

• A marketing and development company seeking to commercialize new technologies

• Founded in 1999 and headquartered in Atlanta GA

• Privately held

• Specializing in solid phase chemical release systems for ClO2, CO2, H2O2, etc


Impregnate Technology Platformcarrier mediacarrier media

Chemistry AChemistry A Chemistry BChemistry B

MixingMixing ActivationActivation

Controlled Controlled reaction / releasereaction / release

Desired absorption Desired absorption or oxidationor oxidation


Chlorine Dioxide

• Formula - ClO2

• CASRN 10049-04-4

• Mol. Wt - 65.5

• Highly Soluble in Water (>Chlorine)

• Stable Free Radical

• Strong oxidizer and biocide

• Works over broad pH range, 2 - 10

• Does not react with ammonia

• Effective against biofilms

• Does not substitute onto organics

• Highly soluble in water

• Cannot be Shipped - Made on site


ClO2 Chemistry• Sodium Chlorite - NaClO2

- Acids +/or Reducing Species

- Chlorine

- Fast Kinetics

- HCl, H2SO4, Citric, Acetic, etc.

- Example

4ClO2- + 4H+ ---> 2ClO2 + ClO3

- + Cl- + 2H+ + H2O


Traditional ClO2 Technologies


ICA ClO2 Technology

• Z-Series Solids

- mg- kg/day

- Controlled Activation

- Efficient Chemistry

- Easy to use

- Safe

- Solutions, Gas, Powders


-50

0

50

100

150

200

250

-50 0 50 100 150 200

Effect of Activator -Z : NaClO2-Z Ratio

on ClO2 generation at 79F

Sample 1Sample 2Sample 3Sample 4

Mic

rom

ols

ClO

2 p

er g

m Z

-mate

rial

Time, hr

Ratio0.000.100.201.00


ClO2 Solution Delivery System


ClO2 Gas Delivery System


Data Collection Programs

** Government, Universities, Customers, and Partners** Government, Universities, Customers, and Partners

ProgramProgram

ProduceProduce

WaterWater

Poultry & MeatPoultry & Meat

HorticultureHorticulture

AgricultureAgriculture

Indoor Air QualityIndoor Air Quality

Pest ManagementPest Management

Bio/Chem ThreatBio/Chem Threat

Study FocusStudy Focus

Food Safety & Shelf LifeFood Safety & Shelf Life

Disinfection & OxidationDisinfection & Oxidation

Food Safety & Animal HealthFood Safety & Animal Health

Shelf Life & OxidationShelf Life & Oxidation

Food Safety & YieldsFood Safety & Yields

Odor Control & MoldOdor Control & Mold

Mosquitoes, Ticks, FleasMosquitoes, Ticks, Fleas

Anthrax, VirusAnthrax, Virus


ClO2 for Drinking Water

ICA technology overcomes the major disadvantages of ClO2 Generation for small water systems

Advantages*Advantages*

Lowers halogenated DPDsLowers halogenated DPDs

Improved taste/odorImproved taste/odor

Improved CT over broader pH Improved CT over broader pH rangerange

Better Giardia/Crypto controlBetter Giardia/Crypto control

Historical Disadvantages*Historical Disadvantages*

Specialized EquipmentSpecialized Equipment

Chemical Handling/AvailabilityChemical Handling/Availability

Chemical EfficiencyChemical Efficiency

More Skilled Operators NeededMore Skilled Operators Needed

*Source: ClO2 Handbook *Source: ClO2 Handbook


Drinking Water Disinfection:10 minute ClO2 Exposure

0

20

40

60

80

100

1 5 10

ClO2 Solution Conc. (ppm)

% K

ill

E-coli

Cholera


ClO2 for Industrial Water TreatmentChlorine dioxide is used for disinfection and oxidation in

industrial, food, and point of use water applications

• Major Applications:– Cooling Towers– Rinses for raw ag. Products– Flume waters disinfection– Waste Water disinfection– Drip Irrigation– Hospital Water– Hotel Water– Industrial waste water for phenol, cyanide destruction


ClO2 Gas Treatments

• ClO2 solution is great but Gas has exciting new possibilities

• ClO2 gas has long been know as a sanitizer/disinfectant/sterilant but has had limited use due to a lack of easy generation technology

• ClO2 gas forms a rapid equilibrium with water - brings ClO2 to the problem

ICA technology = practical, simple and predictability = $$$


ClO2 Gas Treatments of Tomatoes


ClO2 Gas Treatment of Tomatoes for Soft Rot

0.0% 0.0%

24.0%

88.0%

100.0%

0.0%

10.0%

20.0%

30.0%

40.0%

50.0%

60.0%

70.0%

80.0%

90.0%

100.0%

Chamber 1 Chamber 2 Ch 2 in bag 100 ppm HOCl UntreatedControl

0.75ppm ClO2(g)


ClO2 Gas Treatments of Raw Ag.


ClO2 Gas Sanitizing of Food Tanks


800 1600 1000 1200 1000 1600

0.26 0.53 0.22 0.26 0.17 0.26

4 4 1 4 4 4

N N N Y N N

N N Y N N N

72.8 37.0 78.2 67.1 73.6 64.5

100.0 82.0 100.0 75.5 100.0 83.5

6.5 6.3 7.1 6.3 6.5 6.3

7.1 6.4 6.9 6.4 7.1 6.4

Top <1.3 <1.3 4.3 <1.3 <1.3 <1.3

Btm <1.3 <1.3 5.1 <1.3 <1.3 <1.3

Top 5.3 5.1 >5.4 3.2 5.7 3.2

Btm 1.9 5.5 >5.4 3.5 5.7 <1.3

Top >5.2 >5.0 2.8 >5.0 >5.2 >5.0

Btm >5.2 >5.0 2.0 >5.0 >5.2 >5.0

Top 1.8 1.3 <1.5 3.2 1.4 3.2

Btm 5.2 0.9 <1.5 2.9 1.4 >5.1

37

Fan used (Y/N?)

Leakage of ClO2 (Y/N?)

38 37Blade spin rate (RPM)

Co

nd

itio

ns

6060

Average ClO2 conc. (mg/L)

Ctr

lL

og

re

du

cti

on

Lb4005

Ca30

Ca30Lo

g(

No

. o

f S

urv

ivo

rs ) Lb4005

Temperature (0F)

Relative humidity (%)

Bacteria inoculum

Yeast inoculum

Total ClO2 over time (mg)

Exposure time (h)

3030 4540Volume of Tank (L)

ClO2 Gas Treatment of 800, 1200 & 1600 Gallon Tanks


Powder - ClO2 Gas ReleaseControl Treatment with ClO2

-releasing powderSterilization determination

Long pilecarpet

Short pilecarpet

Spore strips

AutoclavedSpore Strip

Control

ClO2-treatedspore strip

B

A C

D

E

F

Fig 4. Exposure of carpet with Bacillus species endospores to ClO2 -releasing powderSections of carpet (232.3 cm2, duplicates) with both long (10 mm, A & C) and short pile (4 mm , B & D) were tested with sterility strips with Bacillus subtilis and B. stearothermophilus (2x106 spores, each was cut into four equal lengths spores) embedded on edge into the pile of the carpets. The con trolled-release ClO2 powder was applied to both pre-moistened (10 ml sterile, deionized water) and dry carpet sections both at 7.8 mg/cm 2 or 38.8 mg/cm2. Spore strips were recovered from the carpet after 2 h and 24 h and cultured in Tryptic Soy broth (TSB) fortified with 0.3% sodium thiosulfate, and were monitored visually for

growth in comparison with control strips in the same me dia. Bacillus spp. were recovered from only 2 of 8 strips from moistened carpets and none from dry carpets after 24 h at the 38 .8 mg/cm2 concentration.


ClO2 Gas Hospitality


Chlorine Dioxide for Medical/Biothreat

•Advantages:- low concentration sterlilant (< 25 mg/L)- exhaust gas easy to destroy- low temperature (25-30C)- rapid cycle

•Limitations:- limited penetrability- gas must be generated on site- pre-humidification- corrosive to some metals


Medical Sterilization


ClO2 ATEK Concept• Simple, shelf-stable, first-line responder

kit containing ClO2 gas, solution and powder generation materials

• Puts established best available chemical in the field where there is a gap in response capability

• Products put ClO2 close to problem statement = faster response, greater efficacy, minimizes collateral damage, and garners more control over personnel exposure issues

• Complements large scale generator approach

• Capitalizes on government investment in ICA TriNova Products


Equipment Decon


Why ICA Z-Series CO2 is Unique

• Dry powder to gas CO2 production

• Controlled generation of gas CO2 - extended low level or rapid high level gas release

• Patented substrate and reaction chemistries-10 patents, 2 patents applications filed

• Uncomplicated, safe and reliable


-0.05

0

0.05

0.1

0.15

0.2

0.25

0.3

0.35

-20 0 20 40 60 80 100 120

Fig 2: Carbon dioxide release from sachetscontaining ICA Z-materials

P1 ; R1 ; S1P1 ; R2 ; S1P1 ; R3 ; S1P2 ; R1 ; S2P2 ; R2 ; S2P2 ; R3 ; S2

To

tal

CO 2,

Lit

ers

(Ref.

25C

) p

er g

m P

in

gred

ien

t

Time, hr

P = precursor ingredientR = precursor/activator formulationS = precursor size designation


CDC/Army/USDA Study Results

Stimulant 1Stimulant 1

Ave % AttractedAve % Attracted

COCO22 2121

COCO2 2 SachetSachet 9696

ActivatorActivator 5151

COCO22 Sachet Sachet 9393




Stimulant 2Stimulant 2

Ave % AttractedAve % Attracted

BlankBlank 00

Blank Blank 0 0

Blank Blank 0 0

COCO22 2 2

COCO22 1212


Activator & COActivator & CO22 2626


Mosquito Surveillance/Control


ICA CO2 in Food Preservation • Patents cover critical aspects of CO2 generation

• Patents cover the combined generation of CO2 and ClO2

• Technology is scalable - package applications to ship board containers

• ICA technology provides more design flexibility because of impregnation and chemistry choice

• ICA platform provides other benefits with respect to humidification, antimicrobials and other atmospheric gases


ICA Value

• Products for gas, solution and powder release of ClO2

• Products for gas release of CO2

• Applications know-how in critical markets

• Technology platform - Leveraged R&D and new product concepts

ICA TriNova, LLC A marketing and development company seeking to commercialize new technologies...

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