IBUPROFENProperties & Biological Effects

By

Ononiwu Ikenna George

STRUCTURE

IUPAC Name: (RS)-2-(4-(2-methylpropyl)phenyl)propanoic acid

Aim: To study the biological, negative and positive effects of

Ibuprofen.

Formula:

Molar Mass: 206.29 g/mol

Melting Point: 76 °C (169 °F)

Market Names: Advil, Brufen, Motrin, Nurofen, etc.

Solubility in Water: Practically Insoluble

INTRODUCTION

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID).

NSAIDs are drugs that provide analgesic and antipyretic (fever-

reducing) effects, and in higher doses, anti-

inflammatory effects. Ibuprofen works by reducing hormones

that cause inflammation and pain in the body. Ibuprofen is used

to reduce fever and treat pain or inflammation caused by many

conditions such as headache, toothache, back pain, arthritis,

menstrual cramps (in females), or minor injury.

Why The Confusion About Addiction Potential?

Some people may take medications which contain addictive medicines IN

COMBINATION with ibuprofen. And they want to measure the addiction

liability of each. Generic and brand name pain pills that combine ibuprofen

with either hydrocodone or oxycodone have fairly high addiction liability.

Drugs that contain hydrocodone or oxycodone should be used for short term

relief of pain, and are often not prescribed for longer than 7 days for the

treatment of acute pain. This is because hydrocodone and oxycodone are some

of the most abused and addictive medications in many advanced countries

today. How addictive is hydrocodone or oxycodone?  Very, especially if used to

feel high.

What health conditions might Ibuprofen be applicable?

Dental Pain

Fever

Headache

Migraine

Mild Pain

Myalgia etc.

Serious Side Effects of Ibuprofen

Chest pain, weakness, shortness of breath, slurred speech, problems with

vision or balance.

Black, bloody, or tarry stools, coughing up blood or vomit that looks like

coffee.

Swelling or rapid weight gain.

severe headache, neck stiffness, chills, increased sensitivity to light, and/or

seizure (convulsions).

fever, sore throat, and headache with a severe blistering, peeling, and red skin

rash etc.

Less Serious Side Effects

Upset stomach, mild heartburn, diarrhea, constipation

Dizziness, headache, nervousness

Skin itching or rash

Blurred vision

Ringing in the ears etc.

What substances should be avoided while taking Ibuprofen?

• Do not take in ibuprofen if you are taking aspirin in order to prevent stroke

or heart attack. Ibuprofen can make aspirin less effective in protecting your

heart and blood vessels. If you must use both medications, take the ibuprofen

at least 8 hours before or 30 minutes after you take the aspirin.

• Ask a doctor or pharmacist before using any other cold, allergy, or pain

medicine. Ibuprofen and other NSAIDs are contained in many combination

medicines.

•Avoid drinking alcohol. It may increase your risk of stomach bleeding.