I S A ISA - CLARA · Fragment-based drug design Identification, quantification, quality control....

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Thématique SANTE Innovative analysi S for improving human heAlth ISA Isabelle KRIMM [email protected]

Transcript of I S A ISA - CLARA · Fragment-based drug design Identification, quantification, quality control....

Page 1: I S A ISA - CLARA · Fragment-based drug design Identification, quantification, quality control. Isabelle KRIMM Isabelle.krimm@isa-lyon.fr Fragment-BasedDrug Design Chimiothèquede

ThématiqueSANTE

InnovativeanalysiS forimprovinghumanheAlthISA

[email protected]

Page 2: I S A ISA - CLARA · Fragment-based drug design Identification, quantification, quality control. Isabelle KRIMM Isabelle.krimm@isa-lyon.fr Fragment-BasedDrug Design Chimiothèquede

METHODS andTOOLSforbiomedicalDIAGNOSTIC

BIOMARKERclinicalevaluationandquantification

CHARACTERISATIONof

BIOLOGICS,LIPIDSandDRUGS

METHODS forsmall-molecule

DRUGDISCOVERY

SciencesforHealthatISA

ProteomicsMetabolomics

Micro/NanoBiotechnologies,Biosensors

MRIcontrastagents

StructuralBiologybyNMR

Fragment-baseddrugdesign

Identification,quantification,qualitycontrol

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[email protected]

Fragment-Based DrugDesign

Chimiothèque defragmentsMassemolaire<250g/mol

CriblageRMN Modélisation,RMNX-ray

Synthèse

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[email protected]

Fragment-Based DrugDesign

Pouroptimiserlesmolécules

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[email protected]

Fragment-Based DrugDesignunexemple:

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Conceptiondenouvellesmolécules

MéthodesRMN

Fragments

Versducriblagediscriminant

VersdesinhibiteursallostériquesdeRCPG

Versdenouveauxantibiotiques

IsabelleKRIMMThématiquesderecherche

Versdenouveauxanticancéreux

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IsabelleKRIMM

ü Identification,validationdeligands

ü Étudesstructuralesü FBDD,criblageü InteractionHSA-molécule

NécessiteuneCIBLEthérapeutiqueidentifiéeetpurifiée

Expertises

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IsabelleKRIMM

ü Chimistesavecinhibiteursàcaractériser/modifier

ü Biologistesstructurauxsouhaitantdévelopperdesmolécules

ü Biologistesaveccibles

Collaborationsrecherchées…


Ontological description of Indian art music for knowledge ... · Suddha Gandhara Sadharana Gandhara Antara Gandhara Chatussruti Rishaba..... Suddha Rishaba isA isA isA isA isA isA

Ontological description of Indian art music for knowledge ... · Suddha Gandhara Sadharana Gandhara Antara Gandhara Chatussruti Rishaba..... Suddha Rishaba isA isA isA isA isA isA

Sentence vs-fragment

Sentence vs-fragment

ISA BRANCH ISA NO ISA STATE First Name Surname MOBILE E ...isaweb.in/pdf/ISA FBF Voters List 2019.pdf · ISA BRANCH ISA NO ISA STATE First Name Surname MOBILE E-MAIL KAKINADA C0108

ISA BRANCH ISA NO ISA STATE First Name Surname MOBILE E ...isaweb.in/pdf/ISA FBF Voters List 2019.pdf · ISA BRANCH ISA NO ISA STATE First Name Surname MOBILE E-MAIL KAKINADA C0108

Fragment sculptural

Fragment sculptural

Small Fragment & Large Fragment Application Notes for ...

Small Fragment & Large Fragment Application Notes for ...

Antro Fragment

Antro Fragment

FRAGMENT LIBRARIES

FRAGMENT LIBRARIES

 · ISA AMES eloisapmes.com . E ISA AMES eloisajames.com . E ISA AMES eloisajames.com

 · ISA AMES eloisapmes.com . E ISA AMES eloisajames.com . E ISA AMES eloisajames.com

Fission Fragment Generator

Fission Fragment Generator

Integrating ISA 88 and ISA 95

Integrating ISA 88 and ISA 95

12. Procedures & Stacks · 6.004 Computation Structures L10: Beta ISA, Procedures and Stacks, Slide #2 Procedures: A Software Abstraction • Procedure: Reusable code fragment that

12. Procedures & Stacks · 6.004 Computation Structures L10: Beta ISA, Procedures and Stacks, Slide #2 Procedures: A Software Abstraction • Procedure: Reusable code fragment that

Fragment ..

Fragment ..

Sentence fragment

Sentence fragment

ISA&feature=related ISA&feature=related.

ISA&feature=related ISA&feature=related.

ARB Fragment Program

ARB Fragment Program

Android Fragment-Awesome

Android Fragment-Awesome

Romeo&juliet - fragment

Romeo&juliet - fragment

Menander Fragment

Menander Fragment

Isabelle Krimm | FBDD 2014 | NMR Applications in FBDD regarding fragment binding mode and fragment-induced protein conformational change

Isabelle Krimm | FBDD 2014 | NMR Applications in FBDD regarding fragment binding mode and fragment-induced protein conformational change

Fragment III

Fragment III