Hypothyroidism By Farshid Mokhberi
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Hypothyroidism By: Farshid Mokhberi Medical Student at: Shahid Beheshti University of Medical Sciences and Health Services
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Transcript of Hypothyroidism By Farshid Mokhberi
- 1. By: Farshid Mokhberi Medical Student at: Shahid Beheshti University of Medical Sciences and Health Services
- 2. Anatomy of Thyroid Gland
- 3. Histology
- 4. Transfering from cell to blood
- 5. Mechanism of action
- 6. Regulation of synthesis
- 7. Functions Carbohydrate metabolism Cholesterol metabolism Growth Skeletal muscle Heart CNS Calorigenic action
- 8. Hypothyroidism: Hypothyroidism is a common endocrine disorder resulting from deficiency of thyroid hormone.
- 9. Risk Factors woman older than age 60 Have an autoimmune disease Have a close relative autoimmune disease Have been treated with radioactive iodine or anti- thyroid medications Received radiation to your neck or upper chest Have had thyroid surgery (partial thyroidectomy) Have been pregnant or delivered a baby within the past six months
- 10. SKIN Cool and pale Sweating is decreased Yellowish tinge Hyperpigmentation Coarse hair Hairloss Non pitting edema Cold intolerance Dry skin
- 11. Eyes Periorbital edema
- 12. Cardiovascular Decreased heart rate Decreased cardiac output Pericardial effusion Diastolic hypertension Hypercholesterolemia hyperhomocystinemia
- 13. Respiratory Fatigue Shortness of breath on exertion Hypoventilation Sleep apnea Hoarseness of voice
- 14. Gastrointestinal Constipation Ascites Weight gain Gastric atrophy
- 15. Reproductive Oligorrhea Amenorrhea Menorrhagia Decreased fertility Early abortion
- 16. Neurologic Mental slowing Myxedema coma Mental retardation
- 17. Myxedema coma The condition occurs in patients with long-standing, untreated hypothyroidism. mental status, including lethargy stupor delirium(acute confusional state) coma
- 18. Musculoskeletal Joint pains Aches stiffness
- 19. Metabolic Hyponatremia Hyperlipidemia Increased homocystine
- 20. Normal values TSH 0.4- 5.0 mU/L Total T4 4.6-11.2 mcg/dl Total T3 75-195 ng/dl Free T4 0.8-1.8 ng/dl Free T3 2.3-4.2 pg/ml
- 21. Treatment INITIAL DOSE Young healthy-1.6mcg/Kg wt Elderly-50mcg TIMING OF DOSE Half an hour before food SIDE EFFECTS-Rare Allergy to dye in the tablets
- 22. MONITORING Every 6 weeks If TSH is not with in normal range increase the dose by 12.5-25mcg If TSH normal ,monitor TSH once a year
- 23. Refrences