HYPOGLYCAEMIC AND HYPOGLYCAEMIC EFFECT OF MORINDA CITRIFOLIA.ppt

7/27/2019 HYPOGLYCAEMIC AND HYPOGLYCAEMIC EFFECT OF MORINDA CITRIFOLIA.ppt

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HYPOGLYCAEMIC ANDHYPOCHOLESTEROLAEMIC

EFFECT OF MORINDACITRIFOLIA(NONI) SYRUP

ON FEMALE NIDDMSUBJECTSBY

DR CHANDRA VENKATASUBRAMANIAN &

K.PRIYAREADER AND ADDITIONAL HEAD , DEPARTMENT OF HOME

SCIENCE , QUEEN MARYS COLLEGE, CHENNAI - 4


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Introduction

Diabetes mellitus is emerging as oneof the main threats to human health.The prevalence of this condition and

its mortality rate has increased fromfive percent to 20 percent. India isreported to be the world capital for

Diabetes mellitus.


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Certain foods have functional properties

which are beneficial in controlling theblood sugar levels. In India herbalplants used for Diabetes mellitus have

shown to possess anti diabetic propertyMorinda Citrifolia (NONI) known as theIndian Mulberry has been used for food

and medicinal purposes for more than2000 years.


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The Indian mulberry fruit(NONI) contains

phytochemicals, organicacids, terpenes, sterols,glycosides, amino acids,anthroquinones, phenoliccompounds and alkaloids

High amount of calcium,potassium, phosphorusand magnesium

Due to its high nutritient

content the fruit is used asa health drink throughoutthe world.


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Noni syrup is consideredimportant due to its unique

Therapeutic

Antiviral and Antitumour

Anti helmintic,Analgesic andHypotensive potential

Anti inflammatory and

immune enhancing Hypocholesterolaemic

and Hypoglycaemic

effect


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Thus the present study was carriedout to find out its Hypoglycaemic and

Hypocholesterolaemic effect on

selected middle aged female NonInsulin Dependent Diabetes Mellitus

(NIDDM) subjects.


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Methodology

Hundred middle aged female NIDDM subjectswere randomly selected and their nutritionalstatus was assessed by anthropometry,biochemical examination and diet survey

Biochemical parameters such as FBS,PPBS,HBA1C and Lipid profile were recorded.

Only co operative subjects were selected for thestudy

Eight subjects each formed the experimentalgroup (those who were administered the NONIsyrup)and control group (those who were notadministered the NONI syrup)


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The Criteria used for the selection ofthe study subjects were -

Women in the age group of 35 to 55 years

Fasting blood glucose >130 mg/dl

Serum total cholesterol > 230 mg/dl

Should be co operative for entire study period

Should donate blood at the beginning and endof the study period (60 days).


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This study was planned for 90 daysand conducted for a period of 60

days only from december 2007 tofebruary 2008

The experimental group was given 30

ml of NONI syrup in two equal doses of15 ml each in the morning beforebreakfast and at bedtime beforedinner.

This is the standard dose prescribedby Dr P.I. Peter in his Monographs onNONI, 2008.


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Periodic visits by the researcher wastaken up to ensure that the subjectsunder study adhered to the dietary

regimen and were taking NONI syrup

regularly.The anthropometric measurementssuch as height and weight were

measured and the blood sample wasdrawn from the selected subjects on0 day and day 60 of the study period.


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Results and Discussion

Anthropometric measurements of experimental

group

Anthropometricmeasurements

ExperimentalGroup

0 Day

Mean

S.D

ExperimentalGroup

60th Day

Mean

S. D

t Value

Weight 67.25 13.49 64.75 13.69 1.832 **

Body Mass Index 27.21 5.75 26.20 5.85 11.769****Significant atone percentlevel


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Results and Discussion

Anthropometric measurements of Control group

Anthropometricmeasurements

Control Group

0 Day

Mean S.D

Control Group

60th Day

Mean S. D

t Value

Weight 74.13 10.64 74.80 11.48 1.132 NS

Body Mass Index 30.69 5.01 30.97 5.00 1.288 NS

NSnot significant


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Statistical analysis revealed that

when comparing the weight andBody Mass Index of experimentaland control groups, there was a

highly significant lowering ofweight and Body Mass Index of theexperimental group as compared to

the control at one percent level.


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Blood parameters (glucose andHBA1C) of the experimental group

Blood parameters Experimentalgroup

0 Day

Experimentalgroup

60th Day

t Value

Fasting bloodglucose(mg/dl)

165.71 21.66 120.25 19.83 8.348**

Post prandialblood

glucose(mg/dl)

269.25 28.01 171.13 21.81 22.294**

HBA1C 8.14 0.86 7.18 0.65 7.773**

**Significant atone percentlevel


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Blood parameters (glucose andHBA1C) of the Control group

Bloodparameters

Experimentalgroup

0 Day

Experimentalgroup

60th Day

t Value

Fasting bloodglucose(mg/dl)

74.13 10.64 74.8 11.48 1.251 NS

Post prandialblood

glucose(mg/dl)

30.69 5.01 30.97 5.27 0.068 NS

HBA1C 8.44 0.79 8.44 0.71 0.729 NS

NS not significant


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Statistical analysis revealed thatwhen comparing the mean fastingblood glucose, post prandial bloodglucose and HBA1C values of the

experimental and the controlgroup, there was a highlysignificant lowering of the above

in the experimental group ascompared to the control at one

percent level.


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Serum lipid profile ofexperimental group

Blood parameters Experimentalgroup

0 Day

Experimentalgroup

60 Day

t Value

Serum totalcholesterol

(mg/dl)

248.25 17.98 195.50 15.84 9.254**

Serum triglyceride(mg/dl)

285.75 48.85 190.73 23.27 6.678**

HDL cholesterol(mg/dl)

47.13 9.49 47.88 9.28 0.513 NS

LDL cholesterol(mg/dl)

140.50 20.51 109.50 18.72 3.870**

VLDL cholesterol(mg/dl)

56.88 9.98 38.13 4.55 6.180**

**Significant

at one percentlevel


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Serum lipid profile of Control groupBlood parameters Control group

0 Day

Control group

60 Day

t Value

Serum totalcholesterol (mg/dl)

251.50 18.00 255.98 21.21 0.361 NS

Serum triglyceride(mg/dl)

298.25 53.58 300.33 44.27 0.488 NS

HDL cholesterol(mg/dl)

33.42 9.66 33.81 7.26 2.861 NS

LDL cholesterol(mg/dl)

158.38 20.26 166.63 57.58 1.754 NS

VLDL cholesterol(mg/dl)

59.75 10.67 60.00 8.72 0.557 NS

Not significant


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Statistical analysis revealed that

in the experimental group therewas a highly significant

reduction in the serum total

cholesterol, serum triglyceride,LDL and VLDL cholesterol at one

percent level as compared to thecontrol group


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ConclusionThus it can be concluded that Morinda

Citrifolia/NONI/Indian Mulberry syrup is avery good Hypo glycaemic andhypocholesterolaemic agent.


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Thus it can be confidently stated thatwhen the effect of NONI is so

statistically sound for short termstudies then how mind blowing the

results should be for long term

studies of six months or so


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Thank you

HYPOGLYCAEMIC AND HYPOGLYCAEMIC EFFECT OF MORINDA CITRIFOLIA.ppt

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