Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
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Transcript of Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
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Humansin
2020Ramez Naam
@ramez
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Three Ingredients
Motive Opportunity Means
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•Why Would We Transform Humans?
•Why Even Invest in the R&D?
Motive•Wh
at’s Possible to Change?
Opportunity
•How Do We Actually Change a Human?
Means
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Motivation is Medical
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Human Baseline
Acceptable
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Human Baseline
Questionable!
?
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External != Internal
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Human Baseline
?
?
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The Power to Heal=
The Power to Enhance
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Our Population is Aging
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A Worldwide Phenomenon
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Disability as a Function of Age
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Lost With Age
Mental
Memory
Speed
Problem Solving
Learning Rate
Physical
Strength
Cardio Fitness
Recovery
Metabolism
Appearance
Fertility
Sensory
Eyesight
Hearing
Touch
Taste
Balance
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A Very Large Motivator
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Order: Trillions of $’s
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Ten Thousand Dollars
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One Million Dollars
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One Billion Dollars
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One Trillion Dollars
You Are Here
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So What?
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Opportunity?
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Knowledge
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Understanding
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Human Construction
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Goal: 100,000 Genomes by 2020
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2020: $100 Genome
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Millions of Genomes Sequenced
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Millions of Individual Humans
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Every Mammalian Species
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Lots of Data to Mine
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What Will We Find?Trait Genetic Component in USA
Height 87%
Skin, Eye, Hair Color 90+%
Weight, Body Fat, Obesity 50%
Muscular Strength 35-55%
Longevity 25-30%
IQ 52%
Extroversion/Introversion 53%
Openness to Experience 61%
Conscientiousness 41%
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Knowing is Half the Battle
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The Other Half is Doing
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If the Genome is Digital
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Can We Edit It?
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Sometimes
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Some Challenges
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Immune Response
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Cancer (from retroviral vectors)
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Number of Cells Changed
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Progress
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Strength & Endurance: IGF-1, Myostatin, PPAR-Delta
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Oxygen Capacity: EPO
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“About half the emails I get now are from athletes” - Gene Therapy Researcher Lee Sweeney
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More Provocative Changes are Likely Possible
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In Summary
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We Are Approaching the Day of the Editable Genome
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•Huge Medical Needs and Market in an Aging Population
Motive
•Will Become Evident from the Digitization of Biology
Opportunities
•Printing Genes, and Editing Through Gene Therapy (The Hard Part)
Means
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Humansin
2020Ramez Naam
@ramez