HRCT Low attenuation pattern
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HRCT Low attenuation pattern
DR SAKHER-ALKHADERICONSULTANT RADIOLOGIST AMC
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Low Attenuation pattern
Emphysema
Lung cysts (LAM, LIP, Langerhans cell histiocytosis)
Bronchiectasis
Honeycombing
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Emphysema
Emphysema typically presents as areas of low attenuation without visible walls as a result of parenchymal destruction.
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EMPHYSEMA Permanent, abnormal enlargement of air spaces distal to the terminal bronchiole and accompanied by the destruction of the walls of the involved air spaces.
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Most common type Irreversible destruction of alveolar
walls in the centrilobular portion of the lobule
Upper lobe predominance and uneven distribution
Strongly associated with smoking.
Centrilobular (proximal or centriacinar) emphysema
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Centrilobular (proximal or centriacinar) emphysema
Found most commonly in the upper lobes Manifests as multiple small areas of low attenuation without a perceptible wall, producing a punched-out appearance. Often the centrilobular artery is visible within the centre of these lucencies.
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Centrilobular emphysema due to smoking. The periphery of the lung is spared (blue arrows). Centrilobular artery (yellow arrows) is seen in the center of the hypodense area.
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PANLOBULAR EMPHYSEMA Affects the whole secondary lobule Lower lobe predominance In alpha-1-antitrypsin deficiency, but
also seen in smokers with advanced emphysema
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PANLOBULAR EMPHYSEMA Affects the entire secondary pulmonary lobule and is more pronounced in the lower zonesComplete destruction of the entire pulmonary lobule.Results in an overall decrease in lung attenuation and a reduction in size of pulmonary vessels
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PANLOBULAR EMPHYSEMA
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Panlobular emphysema
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Paraseptal (distal acinar) emphysema
Affects the peripheral parts of the secondary pulmonary lobuleProduces subpleural lucencies.
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Paraseptal emphysema
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Cystic lung diseaseLung cysts are defined as radiolucent areas with a wall thickness of less than 4mm.
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There is proliferation of Langerhans cells in the bronchiolar and bronchial epithelium, forming granulomas. It is postulated that as these cellular granulomas evolve, peripheral fibrosis forms resulting in traction on the central bronchiole which becomes cyst-like 3. This explains the presumed evolution from nodule, through cavitating nodule and thick walled cysts, to the 'stable' thin-walled cysts 3
CT : nodules:more pronounced early in the diseasemay range in number from a few to innumerable1-10 mm in diameter (typically 1-5 mm 4)centrilobular distributionusually irregular marginsurrounding lung parenchyma appears normalmay cavitate and become cysts
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Cysts : more pronounced later in the diseaseusually less than 10 mm in diametermay measure up to 2-3 centimetres in sizethe extreme bases may be preservedusually thin-walled, but on occasion may be up to a few millimetres thick
Other common findings include 1,3:ground-glass opacities:emphysemamosaic attenuationDifferential diagnoses
-granulomatous diseaseWegener granulomatosissarcoidosis
-metastases-miliary tuberculosis-lymphangiomyomatosis (LAM)
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The disease is characterised by the persistence of dilated lymphatics and interstitial proliferation of abnormal smooth muscle that in turn can obstruct venules, lymphatics, and small airways.
HRCTthin walled cysts of variable sizes surrounded by normal lung parenchyma can be seen throughout the lunginterlobular septal thickeningmay show a dilated thoracic ducthaemorrhages may be seen as areas of increased attenuation
Differential diagnosisFor pulmonary manifestations, the primary differential to be considered is Langerhans cell histiocytosis (LCH) which tends to happen in children and young adults with history of heavy cigarette smoking. It has a mid to upper lobe distribution with preservation of costophrenic angles. In addition, the cysts in LCH tend to be more irregular in contour. LCH has much more favourable prognosis compared with LAM.
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Lymphangiomyomatosis complicated by pneumothorax
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Lymphocytic interstitial pneumonia is a benign lymphoproliferative disorder characterized by a diffuse and exquisitely interstitial proliferation of small lymphocytes and plasma cells (1). Lymphocytic interstitial pneumonia occurs most commonly in patients who have Sjögren syndrome, autoimmune thyroid disease, acquired immunodeficiency syndrome (AIDS), or Castleman disease
LIP
Radiology findings : ground-glass attenuation, airspace consolidation, parenchymal nodules, interlobular septal thickening, thickening of bronchovascular bundles, and cystic airspaces
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BronchiectasisBronchiectasis is defined as localized irreversible
bronchial dilatation. bronchial wall thickening lack of normal tapering with visibility of airways in the peripheral lung mucus retention in the bronchial lumen associated atelectasis and sometimes air trapping
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SubtypesAccording to macroscopic morphology, three types have been described, which also represet a spectrum of severity 8:cylindrical bronchiectasis
bronchi have a uniform calibre, do not taper and have parallel walls (tram track sign and signet ring sign)commonest form 14
varicose bronchiectasisrelatively uncommonbeaded appearances where dilated bronchi have interspersed sites of relative narrowing
cystic bronchiectasissevere form with cyst-like bronchi that extend to the pleural surfaceair-fluid levels are commonly present
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ABPA: glove-finger shadow due to mucoid impaction in central bronchiectasis in a patient with asthma.
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Signet-Ring Sign
A signet-ring sign represents an axial cut of a dilated bronchus (ring) with its accompanying small artery (signet).
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Tram Tracks
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Bronchial dilation with lack of tapering . Cystic bronchiectasis
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HONEYCOMBINGDefined as - small cystic spaces with irregularly thickened walls composed of fibrous tissue.
Predominate in the peripheral and subpleural lung regions
Subpleural honeycomb cysts typically occur in several contiguous layers. D/D- paraseptal emphysema in which subpleural cysts usually occur in a single layer.
Indicates the presence of “END stage” disease regardless of the cause.
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HoneycombingHoneycombing is defined by the presence of small cystic spaces with irregularly thickened walls composed of fibrous tissue.
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Causes
Lower lobe predominance : 1. UIP or interstitial fibrosis 2. Connective tissue disorders 3. Hypersensitivity pneumonitis 4. Asbestosis 5. NSIP (rare)
Upper lobe predominance : 1. End stage sarcodosis 2. Radiation 3. Hypersensitivity Pneumonitis 4. End stage ARDS
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Honeycombing
HRCT showing honeycobing
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Honeycombing and traction bronchiectasis in UIP.
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Typical UIP with honeycombing and traction bronchiectasis in a patient with idiopathic pulmonary fibrosis (IPF)
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THE END