HPV pathology, the role of testing in cervical screening ... · 1-4 April 2014, Arena and...

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Transcript of HPV pathology, the role of testing in cervical screening ... · 1-4 April 2014, Arena and...

Page 1: HPV pathology, the role of testing in cervical screening ... · 1-4 April 2014, Arena and Convention Centre Liverpool THIRD JOINT CONFERENCE OF BHIVA AND BASHH 2014 Dr Anatole Menon-Johansson
Page 2: HPV pathology, the role of testing in cervical screening ... · 1-4 April 2014, Arena and Convention Centre Liverpool THIRD JOINT CONFERENCE OF BHIVA AND BASHH 2014 Dr Anatole Menon-Johansson

1-4 April 2014, Arena and Convention Centre Liverpool

THIRD JOINT CONFERENCE

OF BHIVA AND BASHH 2014

Dr Anatole Menon-JohanssonGuy’s and St Thomas’ NHS Foundation Trust, London

Page 3: HPV pathology, the role of testing in cervical screening ... · 1-4 April 2014, Arena and Convention Centre Liverpool THIRD JOINT CONFERENCE OF BHIVA AND BASHH 2014 Dr Anatole Menon-Johansson

1-4 April 2014, Arena and Convention Centre Liverpool

THIRD JOINT CONFERENCE

OF BHIVA AND BASHH 2014

Dr Anatole Menon-JohanssonGuy’s and St Thomas’ NHS Foundation Trust, London

COMPETING INTEREST OF FINANCIAL VALUE > £1,000:

Speaker Name Statement

Dr Anatole

Menon-Johansson

Date April 2014

Page 4: HPV pathology, the role of testing in cervical screening ... · 1-4 April 2014, Arena and Convention Centre Liverpool THIRD JOINT CONFERENCE OF BHIVA AND BASHH 2014 Dr Anatole Menon-Johansson

The BASHH national audit on

the management of

anogenital herpes

Dr Anatole S Menon-Johansson on behalf of the National Audit GroupClinical Lead, Guy’s & St Thomas‘ NHS Foundation Trust

Third Joint Conference of BHIVA with the BASHH3rd April, 2014

[email protected]

Page 5: HPV pathology, the role of testing in cervical screening ... · 1-4 April 2014, Arena and Convention Centre Liverpool THIRD JOINT CONFERENCE OF BHIVA AND BASHH 2014 Dr Anatole Menon-Johansson

Benchmark herpes audit

Page 6: HPV pathology, the role of testing in cervical screening ... · 1-4 April 2014, Arena and Convention Centre Liverpool THIRD JOINT CONFERENCE OF BHIVA AND BASHH 2014 Dr Anatole Menon-Johansson

Auditable outcome measures

All have a target of 100%

Virological confirmation should be attempted in all patients

At least one viral isolate should be typed

Patients presenting early in the course of first episode genital

herpes should be offered antiviral therapy

Patients with a diagnosis of genital herpes should be offered

counselling, support, and written information

Suppressive therapy should be offered to all patients with

more than six recurrences annually

If suppressive therapy is commenced, a clear plan of duration

of treatment should be entered in the notes & patient review

2012 UK National Guideline for the Management of Genital Herpes http://bit.ly/1cP4uN4

Page 7: HPV pathology, the role of testing in cervical screening ... · 1-4 April 2014, Arena and Convention Centre Liverpool THIRD JOINT CONFERENCE OF BHIVA AND BASHH 2014 Dr Anatole Menon-Johansson

Methods

• Each service reviewed forty clients seen

BEFORE 31 December 2013 and to submit

one form for each client http://bit.ly/17JLZLF

• Twenty clients with new anogenital herpes

(C10a) and 20 with a recurrent episode (C10b)

• Timeline 1st Feb – 28th March, 2014

• During the first form submission the auditor

was requested to add data about their service

Page 8: HPV pathology, the role of testing in cervical screening ... · 1-4 April 2014, Arena and Convention Centre Liverpool THIRD JOINT CONFERENCE OF BHIVA AND BASHH 2014 Dr Anatole Menon-Johansson
Page 9: HPV pathology, the role of testing in cervical screening ... · 1-4 April 2014, Arena and Convention Centre Liverpool THIRD JOINT CONFERENCE OF BHIVA AND BASHH 2014 Dr Anatole Menon-Johansson

Diagnosis status and testingWas this the first

episode?

Confirmatory testing

First

diagnosis

Number (%)

Recurrent

episode

Number (%)

Molecular test 2338 (94.8%) 718 (30.1%)

Culture & typing 93 (3.8%) 31 (13.0%)

No 16 (0.6%) 232 (9.7%)

Not recorded 5 (0.2%) 3 (0.1%)

Not applicable 1349 (56.6%)

Not specified 14 (0.6%) 50 (2.1%)

Grand Total 2466 2383

10 patients – diagnosis status not specified

Page 10: HPV pathology, the role of testing in cervical screening ... · 1-4 April 2014, Arena and Convention Centre Liverpool THIRD JOINT CONFERENCE OF BHIVA AND BASHH 2014 Dr Anatole Menon-Johansson

First diagnosis and time of treatmentWas treatment offered? Yes

Number (%)

No

Number (%)

Day 1 of episode 118 (4.8%)

Day 2 of episode 340 (13.8%)

Day 3 of episode 361 (14.6%)

Day 4 of episode 306 (12.4%)

Day 5+ of episode 769 (31.2%)

Duration not recorded 82 (3.3%)

Treatment started elsewhere 35 (1.4%)

No 251 (10.2%)

Not recorded 200 (8.1%)

Declined 4 (0.2%)

Page 11: HPV pathology, the role of testing in cervical screening ... · 1-4 April 2014, Arena and Convention Centre Liverpool THIRD JOINT CONFERENCE OF BHIVA AND BASHH 2014 Dr Anatole Menon-Johansson

Support, counselling and information

First episode Recurrent episode

Optimal management

of genital herpes

First episode

Number (%)

Recurrent episode

Number (%)

Support, counselling & information 1099 (44.5%) 403 (16.9%)

Not recorded 515 (20.8%) 1308 (54.9%)

Page 12: HPV pathology, the role of testing in cervical screening ... · 1-4 April 2014, Arena and Convention Centre Liverpool THIRD JOINT CONFERENCE OF BHIVA AND BASHH 2014 Dr Anatole Menon-Johansson

Number of recurrences in the last year

Page 13: HPV pathology, the role of testing in cervical screening ... · 1-4 April 2014, Arena and Convention Centre Liverpool THIRD JOINT CONFERENCE OF BHIVA AND BASHH 2014 Dr Anatole Menon-Johansson

Number of recurrences in the last year

227 with >6 episodes / year

Page 14: HPV pathology, the role of testing in cervical screening ... · 1-4 April 2014, Arena and Convention Centre Liverpool THIRD JOINT CONFERENCE OF BHIVA AND BASHH 2014 Dr Anatole Menon-Johansson

Offer of suppressive treatment

Optimal management of recurrent genital herpes Number (%)

Suppressive treatment offered 176 (77.5%)

Episodic treatment provided 28 (12.3%)

Page 15: HPV pathology, the role of testing in cervical screening ... · 1-4 April 2014, Arena and Convention Centre Liverpool THIRD JOINT CONFERENCE OF BHIVA AND BASHH 2014 Dr Anatole Menon-Johansson

Suppressive treatment details

Was it recorded? Duration

Number (%)

Follow up

Number (%)

Yes 554 (84.7%) 535 (81.8%)

No 38 (5.8%) 44 (6.7%)

Not recorded 62 (9.5%) 75 (11.5%)

Page 16: HPV pathology, the role of testing in cervical screening ... · 1-4 April 2014, Arena and Convention Centre Liverpool THIRD JOINT CONFERENCE OF BHIVA AND BASHH 2014 Dr Anatole Menon-Johansson

Comparison of the two audits on the management of genital herpes

Was treatment offered? 2006

(%)

2013

(%)

Molecular diagnostics 28% 95%

Virus culture 71% 4%

Evidence of counselling 85% 63%

Page 17: HPV pathology, the role of testing in cervical screening ... · 1-4 April 2014, Arena and Convention Centre Liverpool THIRD JOINT CONFERENCE OF BHIVA AND BASHH 2014 Dr Anatole Menon-Johansson

Summary• 19/20 are offered a molecular diagnostic test

at first presentation

• 8/10 were documented as treated at their first

episode

• Less than 5/10 were given support,

counselling and HSV information

• Nearly 8/10 with significant recurrences were

offered suppressive treatment

• 8/10 had the duration and follow up details for

their suppressive treatment documented

Page 18: HPV pathology, the role of testing in cervical screening ... · 1-4 April 2014, Arena and Convention Centre Liverpool THIRD JOINT CONFERENCE OF BHIVA AND BASHH 2014 Dr Anatole Menon-Johansson

AcknowledgementsPosition Name

Chair Hugo McClean

Vice Chair Chris Carne

Hon Sec Ann Sullivan

Director of Development Anatole Menon-Johansson

Co-opted David Daniels

BCCG Phillip Kell

BHIVA Ed Wilkins

Alison Roger

HPA Lynsey Emmett

Junior Doctors Derval Harte

Michael Rayment

NCSP Erna Buitndam

Public Health SIG Helen Ward

SSHA Jamie Hardie

Nicola Low

Region Name

Anglia Meena Gupta

Essex Martin Lechelt

Merseyside John Evans-Jones

N West Ashish Sukthanker

Northern Sarup Tayal

Northern Ireland Say Quah

Oxford Gill Wildman

Scotland Anthony Rae

South West Andrew DeBurgh-Thomas

Thames – North Vanessa Apea

Andy Williams

Thames – South East Amelia Hughes

Thames – South West Steve Estreich

Trent Jyoti Dhar

Wales Meena Sethupathi

Wessex Leela Sanmani

West Midlands William Spice

Yorkshire Maneh Farazmand

Page 19: HPV pathology, the role of testing in cervical screening ... · 1-4 April 2014, Arena and Convention Centre Liverpool THIRD JOINT CONFERENCE OF BHIVA AND BASHH 2014 Dr Anatole Menon-Johansson

Any questions?

Page 20: HPV pathology, the role of testing in cervical screening ... · 1-4 April 2014, Arena and Convention Centre Liverpool THIRD JOINT CONFERENCE OF BHIVA AND BASHH 2014 Dr Anatole Menon-Johansson