Horst Bruning Exxim Animage Stanford May409
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EXXIM - all you need for cone beam tomography
Dr. Horst Bruning
CEO, Animage LLC and Exxim Computing
Stanford School of Engineering
May 4 2009
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European – Silicon Valley
Entrepreneurship
• What can we learn from European
entrepreneurs (if anything)?
• Personal story
• Exxim and Animage
• What’s European about it?
• What is Silicon Valley specific?
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The Personal StoryBackground in Germany and SwitzerlandStudied Physics at Universities of Erlangen/Nurnberg and
Freiburg/Germany
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The Personal Story -2
PhD work at CERN in Geneva, Switzerland:
Charm quarks, neutral currents, PSI-particles 3.1 GeV/c
Competition with SLAC and MIT/Brookhaven
Do something of fundamental importance
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Personal Story - 3
• SIEMENS Healthcare in Erlangen Germany
• CT, Angiography, cross-modality work
• VP Engineering
• Head of Basic Research
• Concept Intrapreneurship
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Personal Story - 4Founding of Exxim Computing Corporation
in 2002 (Extreme X-ray IMaging)
– 3 people, 2 products:
• COBRA software and
• LIDO active pixel array for detectors
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Exxim. Our team
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Calculates tomographic slices from a set of 2-D projection
images: Cone Beam Tomography
COBRA supports a wide spectrum of scanner hardware
configurations
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Clockwise: transaxial slice, surface
rendered insect, sagittal cut into
volume rendered head image
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Can be setup on a wide spectrum of computer hardware:
laptops, desktops, desktops with powerful graphics cards (nVidia
Geforce), and network (Cobra Cluster Solutions)
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Based on Feldkamp’s algorithm
Air raw (bright field)
projection
Raw (intensity values)
projection
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First step of Feldkamp’s algorithm: converting
input data to attenuation projections
+
=
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Second step of Feldkamp’s algorithm:
filtering attenuation projections
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Third step of Feldkamp’s algorithm:
backprojecting and accumulation
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Incorporates correction
algorithms making
output images more
accurate and visually
pleasant:
- post-reconstruction
noise reduction,
- metal artifact
reduction,
- water-level density
auto-calibration
Noise reduction
when different
factors applied
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Iterative metal artifact reduction (MAR)
Important for dental
applications
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water-level density auto-calibration
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Useful optional features:
- DICOM output,
- Arbitrary output volume size (cubes even bigger
than 4096x4096x4096 can be reconstructed),
- Output volume origin offset and volume flips,
- Built-in geometry calibration utility,
- Accepting input projections containing intensity
or logged attenuation values
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Cobra performance
Dual-core 3 GHz PC
nVidia Geforce 285 GTX installed
Windows 64-bit platform
Input data Output Volume Reconstruction time
512x512
512 projections
512x512x512 < 20 sec
960x768
600 projections
640x640x576 60 sec
1024x1024
700 projections
1024x1024x1024 180 sec
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Cobra software architecture
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char company[] = "YourCompanyName";
char serialNumber[] = "YourLicense";
DWORD result = 0;
// ************ Init ************
result = CobraDispatcher_Init(company, serialNumber);
result = CobraDispatcher_Communicate();
result = CobraDispatcher_SetReconMode(
BPMODETAG_CONEBEAM | MODE_OFFLINE);
// ************ Set parameters from file ************
CobraDispatcher_SetParametersByFile(cParFileName);
// ************ Reconstruct ************
result = CobraDispatcher_TerminateReconstruction();
result = CobraDispatcher_ResetReconstruction();
result = CobraDispatcher_StartReconstruction();
Cobra SDK
Flexible and easy to integrate
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Version 7. New look. Built-in visualization
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Version 7.
Scan database. Full DICOM interface
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Exxim is dedicated to continuous
improvement of Volume CT software
- Increase performance
- Add functionality
- Mitigate artifacts
- Open for the future
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Founding of Animage, LLC in 1/2008
Serves the veterinary radiology market with a
multi-modality x-ray imager
– Volume CT
– Digital Radiography
– Digital Fluoroscopy
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Conclusions
• Personal goals
• Deep expertise in at least one field
• Sufficient knowledge of all other fields of
the corporate world
• Access to venture capital questionable
• A bit of luck