Hormones and cancer final ppt
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Transcript of Hormones and cancer final ppt
HORMONES AND CANCER
HORMONES AND CANCER Richin john koshy
OVERVIEW: HORMONES HORMONE DEPENDENT CANCER RISK FACTORS CAUSING CANCER PATHOPHYSIOLOGY THERAPEUTIC MEDICATIONS CONCLUSION
Hormones are peptide or a steroid which is produced by a tissue and conveyed to the bloodstream to the target organs for maturation
Hormones are involved in growth and development of an individual
HORMONE DEPENDENT CANCERS: Hormones share a strong bond in cancer and
its progression and the role in which hormones play in cancer are seen in breast ,prostate and ovaries
RISK FACTORS : BREAST CANCER
Null ParityEarly Menarche Late MenopauseHormone Replacement TheraphyHigh Fat Diet Oral Contraceptive Pills ? DEBATE
RISK FACTORS: PROSTATE CANCER
Ethnic groupAndrogen receptor
PATHOPHYSIOLOGY
ANTI ANDROGENS :Bicalutamide and Nilutamide which block the binding of androgen to receptors are commonly used as a hormonal therapy
GNRH AGONIST :Leuprolide acetate or Goserelin
acetate can be given which eventually leads to chemical castration
• Testosterone hormone stimulates the growth of cancerous cells and it
is the fuel for cancerous growth
•Luteinising hormone from the anterior pituitary stimulates the release of
testosterone from the testes and hormonal therapy in prostate cancer is
androgen deprivation which can be accomplished surgically by
orchidectomy (castration ) as the body's source of testosterone is removed
Conclusion Breast and Prostate tumours have a common
feature in that at some stage in their evolution they were hormone dependent cancers, and therefore hormone therapy is an intuitively obvious therapeutic approach
Refrences
Risbridger ,G.P et al.Breast and prostate cancer more similiar than diffrent .Nature (2010) Ricke, W. A. et al. Prostatic hormonal carcinogenesis ismediated by in situ estrogen
production and estrogen trial. J. Urol. 176, 965–970 (2006) Ma, X. J., Dahiya, S., Richardson, E., Erlander, M. &Sgroi, D. C. Gene expression profiling of
the tumor microenvironment during breast cancer progression.Breast Cancer Res. 11, 7 (2009).