Honors Biology Chapter 12 Molecular Genetics
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Transcript of Honors Biology Chapter 12 Molecular Genetics
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Honors BiologyChapter 12
Molecular Genetics
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Identify key historical findings in the pursuit of the structure of DNA.
Draw and label a diagram of the molecular structure of DNA, showing the relationships between the six essential molecules that make up DNA: deoxyribose, phosphate, adenine, cytosine, guanine, thymine.
Apply knowledge of complementary base pairing to predict a DNA strand sequence given information about the other DNA strand.
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What IS the physical “factor” identified by
Mendel?How do “factors” produce phenotypes? What is the molecular basis for the “genetic code?”
Scientists could narrow it down to molecules found in the nucleus: DNA, RNA, or protein?
Most thought proteins, because they’re much more diverse and complex
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Griffith’s Transformati
onWorking with pneumonia in 1928, Griffith transformed or changed bacteria from one form to another.
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Avery’s ExperimentsWhat is the “transforming factor”?
Avery used enzymes to destroy molecules from the heat killed cells before transforming harmless cells.
Concluded: DNA is the transforming factor.
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Hershey-Chase Experiment
Alfred Hershey & Martha Chase: Radioactively label viral protein vs. DNA, let the phages infect bacteria, then separate them
Bacteria had the DNA trace, not the protein trace
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Rosalind Franklin & Photo 51
Franklin used X-ray diffraction to photograph crystallized DNA molecules.
Showed the helical shape and repeating structure of DNA
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The Double Helix
In 1953, James Watson and Francis Crick used scientific evidence reported by other scientists to suggest a model for the DNA structure as a double helix
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Nucleic Acids
Examples DNA
Deoxyribonucleic Acid
RNA Ribonucleic Acid
RNA
Information molecules
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DNADNA
Nucleic Acids Function:
genetic material stores information
blueprint for building proteins DNA RNA proteins
transfers informationblueprint for new cellsblueprint for next generation
proteinsproteins
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Nucleic acids
Building block = nucleotides
5 different nucleotides different nitrogen bases A, T, C, G, U
nucleotide – nucleotide – nucleotide – nucleotide
phosphate
sugar N base
Nitrogen basesI’m the
A,T,C,G or Upart!
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4 Types of Nitrogenous Bases in DNA
Purines: have 2 rings (Adenine and Guanine)
Pyrimidines: have 1 ring (Thymine and Cytosine)
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Complementary Base Pairing
Chargaff’s Base Pairing Rule: Chargaff determined that the amount of Adenine = amount of Thymine, and the amount of Guanine = the amount of Cytosine.The bases are connected to each other in the double helix by hydrogen bonds.
A pairs with T C pairs with G
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DNA Double strand twists into a double helix
Hydrogen bonds between nitrogen bases that join the 2 strands are weak
the two strands can separate and reattach
with relative ease
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Describe and model the process of DNA replication, including an explanation of why it produces identical copies of DNA.
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Copying DNA A dividing cell replicates (i.e. duplicates)
its DNA in S phase creates 2 copies of all DNA (sister
chromatids) separates the 2 copies to 2 daughter cells
nucleus
cell
DNA
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Copying DNA Matching bases allows
DNA to be easily copied
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DNA Replication Steps:
DNA starts as a double-stranded molecule matching bases (A:T, C:G)
Then the helix untwists and…
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DNA replication Strands “unzip” at the weak bonds
between bases Done by an enzyme, helicase
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DNA replication
DNA polymerase
Enzyme DNA polymerase
matches free-floating bases to exposed strand
DNA basesin nucleus
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New copies of DNA Get 2 exact copies of DNA to split between new
cells, thanks to complementary base pairing Each copy = one original strand, one new strand
DNA polymerase
DNA polymerase
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Copying DNA
DNA Replication-Review
• This process is responsible for the formation of sister chromatids, and their characteristic X shape
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double-strandedhuman chromosomesready for mitosis
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From Gene to Protein
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Compare and contrast DNA and RNA. Explain and model the overall process of protein synthesis (transcription and translation).
Apply knowledge of transcription to predict an mRNA sequence given information about a DNA sequence.
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DNA Proteins Cells Bodies
proteinscells
bodiesDNA gets all the glory,Proteins do all the work
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What do we know? DNA
DNA = instructions for proteins
Proteins proteins run living organisms enzymes
all chemical reactions in living organisms are controlled by enzymes (proteins)
structure all living organisms are built out of proteins
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Protein Synthesis: Part 1
So… How does the cell get the instructionsfrom the nucleus to the ribosomes?
DNA – stores info to make proteins
RIBOSOMES – where proteins are made
CYTOPLASM
NUCLEUS
Where are proteins made?Where are the instructions to make proteins?
CELL
It makes a copy to send called – messenger RNA
mRNA
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Flow of Genetic Information
1. A gene or segment of DNA is located on a chromosome
2. The cell uses transcription to copy the gene into a piece of mRNA
3. The mRNA leaves the nucleus and goes to a ribosome
4. The ribosome uses translation to direct the assembly of a protein
5. Gene is now expressed in the cell
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RNA = Ribonucleic Acid
Structure: Made of a single strand of nucleotides
Nucleotides use Ribose instead of Deoxyribose
Nitrogen base thymine is replaced by Uracil
Types:Messenger RNA (mRNA): single stranded- used to carry DNA code out of nucleus “working copy”
Transfer RNA (tRNA): binds to specific amino acids, used to build proteins
Ribosomal RNA (rRNA): makes up ribosomes along with proteins
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DNA vs. RNADNA
deoxyribose sugar nitrogen bases
G, C, A, T T = thymine
T : A C : G
double stranded
RNA ribose sugar nitrogen bases
G, C, A, U U = uracil
U : A C : G
single stranded
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DNA vs. RNA
DNA
DNARNA
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Transcription Making mRNA from DNA DNA strand is the
template (pattern) match bases
U : A G : C
Enzyme RNA polymerase
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Matching bases of DNA & RNA Double stranded DNA unzips
A G GGGGGT T A C A C T T T T TC C C CA A
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Matching bases of DNA & RNA Double stranded DNA unzips
A G GGGGGT T A C A C T T T T TC C C CA A
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Matching bases of DNA & RNA Match RNA bases to DNA
bases on one of the DNA strands
U
A G GGGGGT T A C A C T T T T TC C C CA A
U
UU
U
U
G
G
A
A
A C CRNA
polymerase
C
C
C
C
C
G
G
G
G
A
A
A
AA
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Matching bases of DNA & RNA U instead of T is matched to A
TACGCACATTTACGTACGCGGDNA
AUGCGUGUAAAUGCAUGCGCCmRNA
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Transcription Steps1. RNA Polymerase binds to the promoter (specific place
for polymerase to bind) on the DNA and begins transcription
2. DNA strands separate or unzip. 3. One of the original strands serves as a template. RNA
polymerase binds new RNA nucleotides to the template strand following base pairing rules. (A-U, C-G)
4. mRNA leaves the nucleus and carries the instructions to the ribosomes. The DNA “re-zips”.
A – T C – G G – C A – T C – G
T – A
A - - T C - - G G - - C A - - T C - - G T -
- A
A - U - T C - G - G G -
C - C A - U - T C - G - G T -
A - A
A – T U C – G G G – C C A – T U C – G G T – A A1 2 3 - 4 5
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Explain and model the overall process of protein synthesis (transcription and translation).
Apply knowledge of translation to predict a tRNA sequence given information about an mRNA sequence.
Apply knowledge of translation to predict an amino acid sequence given information about a tRNA sequence.
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RNA to protein But… building blocks are mismatched.
RNA “language” = 4 bases. Protein “language” = 20 amino acids.
aa aa aa aa aa aa aa aa
How do you convert from one language to another?
mRNA
U C CCCCCA A U G U G A A A A AG G G GU U
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But there’s still the 4 to 20 problem…
TACGCACATTTACGTACGCGGDNA
AUGCGUGUAAAUGCAUGCGCCmRNA
Met Arg Val Asn Ala Cys Alaprotein
?
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AUGCGUGUAAAUGCAUGCGCCmRNA
Solution: mRNA codes for proteins in triplets
TACGCACATTTACGTACGCGGDNA
AUGCGUGUAAAUGCAUGCGCCmRNA
Met Arg Val Asn Ala Cys Alaprotein
?
Codon block of 3 mRNA nucleotides
that “codes” for one amino acid
codons
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Now, how are the codons matched to amino acids?
TACGCACATTTACGTACGCGGDNA
AUGCGUGUAAAUGCAUGCGCCmRNA
aminoacid
tRNAanti-codon
codon
UAC
MetGCA
ArgCAU
Val
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ribosome
mRNA to protein = Translation The message -> mRNA The reader ribosome The transporter transfer RNA (tRNA) The product -> polypeptide/protein
aaaa
aa
tRNA
mRNAU C CCCCCA A U G U G A A A A AG G G GU U
GGU
aa
tRNA
U A C
aa
tRNA
GA C
tRNA
aa
A GU
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Transfer RNA
Transfer RNA (tRNA) A folded RNA chain, with
three exposed bases (anticodon) and an amino acid Which amino acid it
carries depends solely on the anticodon
Function: Carry amino acids to ribosome, assemble them in correct order
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Translation Steps1. Initiation: Ribosome attaches to the mRNA at the start
codon (AUG)2. tRNA with the complementary anti-codon (UAC) binds
to the mRNA codon, bringing the amino acid methionine with it.
3. Ribosome shifts down the mRNA to the next codon.4. Elongation: Another tRNA with the complementary anti-
codon binds to the mRNA codon. The amino acid from the tRNA binds to methionine.
5. The ribosome shifts again, another tRNA brings another amino acid to bind to the growing amino acid chain.
6. Termination: Process continues until the ribosome reads a stop codon, at which time it releases the finished amino acid chain (AKA: protein)
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In Animated Format
http://www-class.unl.edu/biochem/gp2/m_biology/animation/gene/gene_a3.html
http://learn.genetics.utah.edu/content/begin/dna/transcribe/
http://www.dnatube.com/video/5934/Basic-explanation-of-mRNA-Translation
http://highered.mcgraw-hill.com/sites/0072507470/student_view0/chapter3/animation__protein_synthesis__quiz_3_.html
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All life on Earth uses the same code
Due to common origin
Code is redundant several codons for
each amino acid “mutation
insurance!”
Start codon AUG methionine
Stop codons UGA, UAA, UAG
Genetic Code
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The Genetic Code
A map of CODONS, not ANTIcodons
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Recap of Protein Synthesis
A gene = a region of the chromosome that codes for one protein
mRNA is made in the nucleus using DNA as a template. (TRANSCRIPTION) mRNA travels to ribosome.
Protein is made at the ribosome by matching tRNA to mRNA. (TRANSLATION)
Amino acid sequence determines protein’s shape, protein shape determines its function.
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“Central Dogma” of Molecular Genetics
DNA -> RNA -> Protein -> Trait
Expanded version:DNA -> mRNA -> tRNA -> amino acid sequence -> protein
shape -> protein function -> trait
tran
scri
ptio
n
tran
slat
ion
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Mutations
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Distinguish between point/substitution and frameshift/insertion/deletion mutations, and predict their effects on an amino acid sequence.
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Mutations Mutations are changes in DNA sequences,
usually as errors in replication different DNA order = different RNA order =
different protein = different trait Human germ cell line averages 35
mutations per generation
Bb bbBB
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Mutations Point or Substitution
mutations single base change Ex: T instead of C Can be:
silent mutation no amino acid change
due to redundancy in code
missense change amino acid
nonsense change to stop codon
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Example: Sickle cell anemia
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Sickle cell anemia Autosomal codominant/recessive inheritance pattern Strikes 1 in 3 Subsaharan Africans, 1 in 500 African
Americans Sickle-shaped red blood cells carry less oxygen, easily
“clog” blood vessels
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Mutations Frameshift
shift in the reading frame changes everything
“downstream” Tends to have more
profound effects than point mutations
insertions adding base(s)
deletions losing base(s)
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THE RAA TAN DTH ECA TAT ETH ERE DBA T
Frameshift mutationsTHE RAT AND THE CAT ATE THE RED BAT
THE RTA NDT HEC ATA TET HER EDB AT
(Point)
THE RQT AND THE CAT ATE THE RED BAT
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Example: Cystic fibrosis
Primarily Northern and Western European descent strikes 1 in 2500 births
1 in 25 white Europeans are carriers (Aa) normal allele codes for a membrane protein
mutant channel limits movement of Cl- (& H2O) across cell membrane
thicker & stickier mucus coats cells in lungs, pancreas, digestive tract
without treatment children die before 5; with treatment can live past their late 20s
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Mutations
Mutation = not necessarily bad. As a phenomenon, is essential to genetic
diversity. And individual mutations… can be beneficial (ex: a fur color protein that
more closely matches environment) can be neutral (ex: silent mutations) can be detrimental (ex: cystic fibrosis) can be beneficial and detrimental! (ex: sickle
cell anemia protects against malaria)