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H O KB I O M E D I C A L + T R A N S L AT I O N A L H E A LT H FA C I L I T I E S

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“ We interviewed many experienced fi rms for the IRC (now WIMR) project. In the end, we selected HOK because we were not only impressed with the fi rm’s breadth of experience, but also with the team’s personal approach to project delivery. We have not been disappointed.”

- Mr. Mark Wells

Assistant Dean of Facilities

University of Wisconsin - Madison

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B I O M E D I C A L + T R A N S L AT I O N A LH E A LT H FA C I L I T I E SA S A M P L E O F O U R P R O J E C T S F O C U S E D O N T R A N S L A T I O N A L A N D

B I O M E D I C A L R E S E A R C H

WIMR

University of Wisconsin, Wisconsin Institutes for Medical Research

CEDARS

Cedars-Sinai Medical Center, Advanced Health Sciences Pavilion

CRICK

The Francis Crick Institute

TCMC

The Commonwealth Medical College

OSU

The Ohio State University Med. Ctr. Cancer Hospital and Critical Care Tower

UMB

University of Maryland, Baltimore Health Sciences Facility III

EMORY

Emory Univ. Whitehead Biomedical Research Building

U. FLORIDA

University of Florida, Lake Nona Academic and Research Center

U. BUFFALO

University at Buffalo School of Medicine and Biomedical Sciences

RIMED

Fondazione RiMED Biomedical Research & Biotechnology Center

The new model of health sciences is changingfrom a focus on treatment of

disease to a focus on health.

The increasing convergence

of knowledge and capability at

the most fundamental level of

biological sciences and systems

requires moving away from

reparative medicine and nursing

to a new model of predictive and

proactive public health.

An interdisciplinary model for

education, research, and the

practice of medicine is at the

forefront of design for health

sciences.

HOK develops innovative design

solutions which create aligned

vision and bring translational

models to fruition for academic

medical centers.

Present day function and future

fl exibility that allow for growth and

renewal are the tip of the iceberg.

Evolving trends in medicine and

treatment, including translational

medicine, genomic medicine and

research, proteomics, and evolving

patient-centered care models are

shaping today’s academic medical

centers.

Environments for academic

medical research and education

must be ready to accommodate

tomorrow’s innovation. HOK

designs buildings that maximize

opportunities for researchers and

physicians to share knowledge.

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If the goal of academic medical centers engagedin translational research is

creating novel, basic scientifi c

discoveries that translate

into clinical applications, then

collaboration, technology and its

critical infrastructure are what

enables development of bench-to-

bedside therapies.

The design of these facilities

must enhance the communication

link between research scientists

and physicians vital to cutting-

edge research that connects

basic research to patient care.

Translational techniques are

a core competency central to

comprehensive cancer care,

emphasizing the bench-to- bedside

potential. Facility design must

enable the development and

application of new technologies

for the patient-driven environment,

including early patient testing and

evaluation using traditional and

genomic techniques.

By building partnerships

that facilitate the interaction

between basic research and

both clinical medicine and clinical

trials, innovation can fl ourish

because information can fl ow

freely between researchers and

clinicians. Many major medical

centers are looking to of predictive

medicine to identify biological

markers to identify individuals

at high risk for developing

diseases using techniques such

as genomics, proteomics, and

cytomics.

T R A N S L AT IO N A L R ES E A RC H FACI L I T I ES

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S IZ E469,000 sq. ft.

C O M P L E T I O N 2008

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U N I V E R S I T Y O F W I S C O N S I N , W I S C O N S I N I N S T I T U T E S F O R M E D I C A L R E S E A R C H

The new Wisconsin Institutes

for Medical Research (WIMR) is

the centerpiece of the Medical

School’s efforts at creating

the world’s preeminent cancer

research institute.

The seven-story East Tower is

the first of WIMR’s three planned

interdisciplinary research towers

to house researchers in

highly interactive spaces

designed to cultivate

collaboration.

Madison, Wisconsin

UW researchers from a wide range of backgrounds occupy the WIMR, working together to study the underlying mechanisms of cancer, identifying potential treatments and cures then rapidly translating their discoveries into promising new therapies for patients at the adjacent clinic/hospital. Adjacent to UW Hospitals and Clinics, WIMR scientists can easily interact with clinicians and are within sight of the patients whose lives they hope to improve.

The East Tower, eliminates laboratory walls, places office areas close to labs, allows rapid sharing of complex equipment and facilities and includes interaction space on every floor. Alternate floors are also joined by two-story atriums to further enhance communication and collaboration.

The Advanced Imaging and Radiation center, with walls and

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U N I V E R S I T Y O F W I S C O N S I N

ceilings more than eight feet thick, is designed to be vibration-free. Equipment includes every imaging modality for human and animal research at the molecular level as well as a 30-ton cyclotron for production of short-lived imaging agents and computerized chemical synthesis. Complete facilities are provided for the development of state-of-the-art, three-dimensional radiation oncology application development.The first floor and basement also house one of the nation’s largest rodent and primate vivaria.

Lab floors are organized to support the multi-disciplinary approach to research, so that all parties involved in a specific research area are located on the same floor. Teams that require additional space can overflow onto another floor via the two-story atria without losing the ability to interact.

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C E D A R S - S I N A I M E D I C A L C E N T E RA D VA N C E D H E A LT H S C I E N C E S PAV I L I O N

Cedars-Sinai is dedicated to

providing the best possible care

for its patients.

HOK guided project planners

at Cedars to realize the path

to profound change in their

organization would come

through a translational facility

that would combine patient

care, clinical offices, research,

physician education and training.

Los Angeles, California

Utilizing an incredibly flexible model, the facility was planned and designed to provide outpatient procedure services in Cardiac Care and Neuroscience.

Attracting and retaining the “triple-threat” physicians (educator/researcher/physician) is a primary mission of Cedars-Sinai.The facility provides for procedure suites, clinic/office space, and research facilities, as well as a training center with a simulation center and debrief rooms. Every doctor who is assigned to this facility will be an active researcher and practicing physician, and

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will be able to directly apply their research into highly personalized patient care.

A connected link to the main hospital facility will allow for inpatients to benefit from procedures in the state-of-the-art procedure suites, and be transferred back to their rooms in the hospital.

The building will also house a fully functioning pharmacy, Imaging center (including MRI and CT), and a centralized conferencing facility to allow for maximum interaction of physicians.

C E D A R S - S I N A I M E D I C A L C E N T E R

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T H E F R A N C I S C R I C K I N S T I T U T E

HOK designed what will become

one of the world’s major

research centers, covering

research in a broad range of

biomedical sciences including

translational research.

Six leading UK research

organizations have come

together to build this hub for

research into the development,

prevention and treatment of

significant diseases.

S IZ E635,000 sq. ft.

C O M P L E T I O N 2014

London, United Kingdom

HOK designed what will become one of the world’s major research centers, covering research in a broad range of biomedical sciences including translational research.

Six leading research organizations - The Medical Research Council, Cancer Research UK, The Wellcome Trust, UCL (University College London), Imperial College London and King’s College London - have come together to build the Francis Crick Institute: the hub for research into the development, prevention and treatment of diseases such as cancer, heart disease/stroke, infections, and neurodegenerative diseases.

The laboratories are arranged over four floors, with each floor consisting of four interconnected blocks which will bring together staff working in different fields.

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T H E F R A N C I S C R I C K I N S T I T U T E

The laboratories are designed to be adaptable to change as new scientific opportunities emerge in the future.

This facility will support highly translational research as it is equipped with high-performance IT infrastructure for virtual collaboration, integrated analysis and bedside decision support as well as a state-of-the-art imaging center to further promote human subject translational research. More than 7,500 sq. ft. of biocontainment space (at BSL-3 or higher) will allow for world-leading research into diseases such as influenza, malaria, tuberculosis and HIV.

A state-of-the-art, 85,000 sq. ft. barrier research facility includes: SPF (Specific Pathogen Free), EXP (Experimental Barrier), BSL-3, UHS (Unknown Health Status), Aquatics and Imaging.

S IZ E194,263 sq. ft.

C O M P L E T I O N 2011

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T H E C O M M O N W E A LT H M E D I C A L C O L L E G E

HOK worked with The

Commonwealth Medical

College to create their vision of

a freestanding medical school

with no university affiliation.

Within this independent

structure, TCMC is able to

partner with health science

programs throughout the region,

offering students a variety

of educational experiences;

preparing them to become

community physicians practiced

in evidence-based medicine.

Scranton, Pennsylvania

The west research wing and east educational wing surrounds a shared courtyard. The linkage between the two buildings acts as the central hub where students can gather and socialize at the grand porch, courtyard and café. To the east, public ground floor spaces include additional student common areas, a bookstore and lobby for the 250 seat auditorium.

The Research space is 63,929 square feet and can support 16 Principal Investigators (PIs) for wet research and 4 PIs for bioinformatics. In 35 laboratories, researchers can focus on diseases that are relevant to the area, including issues with aging as well as cancers of the colon, breast and lung. The state of the art flexible labs, stairways and common areas offer ample daylight and promote interaction and collaboration. A 5,000 sq.

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T H E C O M M O N W E A LT H M E D I C A L C O L L E G E

ft. vivarium and cagewash, as well as imaging facilities, support biomedical research for students and faculty.

The ground floor of the north structure contains a simulation facility with 12 mock exam rooms for standardized patients (actors portraying patients) and several suites for simulated surgical procedures using high-fidelity robotics, as well as breakout rooms and small group work areas. The gross anatomy lab is also included in this area. All simulation spaces offer high definition video for real time viewing by professors or other students, or for later review.

The new buildings incorporate principals of sustainable development and should garner the facility LEED Certification.

S IZ E1,100,000 sq. ft.

C O M P L E T I O N 2014

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T H E O H I O S TAT E U N I V E R S I T Y M E D I C A L C E N T E R , J A M E S C A N C E R H O S P I TA L A N D C R I T I C A L C A R E T O W E R

As part of the University

Medical Center’s South Campus

Master Plan Implementation

this project includes growth

and replacement of the Arthur

G. James Cancer Hospital

and associated translational

research facilities, critical care

beds, surgery and imaging

to create The Ohio State’s

Comprehensive Cancer Center

- James Cancer Hospital and

Solove Research Institute.

Columbus, Ohio

S IZ E198,000 sq. ft.

C O M P L E T I O N 2009

4 L E E D - N C S I LV E R

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U N I V E R S I T Y O F C E N T R A L F L O R I D A S C H O O L O F B I O M E D I C A L S C I E N C E

Providing quality undergraduate

and graduate programs in the

biomedical sciences to build

robust research programs

focused on cancer and

cardiovascular, neurological,

and infectious diseases is the

mission of the Burnett School

of Biomedical Sciences.

HOK’s design creates the

cornerstone facility of the

new research quadrant.

Orlando, Florida

As envisioned in HOK’s campus masterplan, this facility is the first of several buildings that will ultimately create a biomedical cluster; providing UCF with key health partnerships to allow for the rapid translation of laboratory findings into new patient cures.

The School is committed to its role in developing technology-based industry in Florida.Innovative partnerships formed with the College of Optics and Photonics and the NanoScience Technology Center facilitate interdisciplinary research and education programs in the application of photonics, bioinformatics and nanoscience to biomedical problems.

HOK designed this facility to support the new undergraduate curriculum in biomedical sciences; updated to better prepare students for admission to medical/health profession schools

“ (HOK are) the fi rst architects I have worked with

that listened to our issues, and responded with

contemporary and cost effective solutions.”

Robert N. Gennaro, PhDBurnett College of Biomedical Sciences

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U N I V E R S I T Y O F C E N T R A L F L O R I D A

and graduate programs in the biomedical sciences.

The research center includes four levels of labs and investigator offices, specialty core support labs, a transgenic animal facility (vivarium), faculty offices and administrative suite. Core lab areas include space for two Electron Microscopes, two Confocal Microscopes and associated image processing; large x-ray crystallography suite; multiple rooms for light and fluorescence microscopy, as well as conventional dark rooms. Containment space is an enhanced BSL-3, with HEPA filtration of all exhaust air, and shower-out ability.

HOK worked closely with UCF to include sustainable features such as FSC Certified lab casework and wood materials; as well as energy recovery on general lab exhaust.

S IZ E325,000 sq. ft.

C O M P L E T I O N 2001

4 L EED -2 .0 S I LV ER

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E M O R Y U N I V E R S I T Y W HIT EHE A D BIOMEDICA L RESE A RCH BUIL DING

This eight-story interdisciplinary

biomedical research facility for

genetics, cell biology, physiology

and neuroscience research

includes special facilities such

as animal housing, tissue culture,

and environmental health and

safety support facilities. It

supports BSL-2 and BSL-3

research activities.

Atlanta, Georgia

S IZ E330,000 sq. ft.

C O M P L E T I O N2017

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This new facility for the

University’s Medicine, Dentistry

and Pharmacy Schools is

the third phase of the Health

Science Facility at UMB, and is

expected to help advance UMB’s

position as academic research

leaders, and to recruit the best

faculty, students and staff. The

building is sited among the three

schools’ existing facilities to

maximize interactions and the

sharing of resources.

U N I V E R S I T Y O F M A R Y L A N D , B A LT I M O R E H E A LT H S C I E N C E S FA C I L I T Y 3

Baltimore, Maryland

S IZ E100,000 sq. ft.

C O M P L E T I O N2012

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This new academic and research

facility will complement the Lake

Nona “Medical City” institutions.

The UF College of Pharmacy,

including the newly established

pharmacometrics and systems

pharmacology initiative in the

interdisciplinary Institute of

Therapeutic Innovation, will

relocate its Orlando campus to

this vibrant new building.

U N I V E R S I T Y O F F L O R I D A A C A D E M I C A N D R E S E A R C H C E N T E R AT L A K E N O N A

Orlando, Florida

Sited on approximately five acres directly adjacent to the Sanford Burnham Institute, the new center takes a dramatic form to represent the innovative, collaborative and life changing activities housed inside.

The research areas include two floors of open laboratories consisting of large, ballroom plan island bench areas with mobile sinks and casework, supported by fume hood and BSC alcoves and other support functions at either side, and are located to maximize the views of the wooded preserve to the south. A glass wall along the inboard side of the research laboratories provides a visual connection to the office zone for faculty and graduate students.

One floor is devoted specifically to research conducted in enhanced environments.

“ All of the HOK team have been extremely

responsive to the needs of the faculty and the Lake

Nona development. We have been impressed with

their BIM capabilities, their team approach with the

Construction Manager and the willingness to meet

the goals of UF for a minimum Gold LEED building.”

Carol J. Walker, Assistant Vice PresidentUF Facilities Planning & Construction

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U N I V E R S I T Y O F F L O R I D A

The first floor of the building accommodates a state of the art conference center, consisting of a large, media-rich auditorium, break out conference rooms, and a large media-equipped lobby capable of accommodating social, academic and student events. Amenities are centrally located to support and connect the laboratories and offices.

The remainder of the first floor is clinical research space operated by the Institute on Aging, an interdisciplinary group involved in the areas of research, education and health care across all UF Colleges and Departments.

Passive and active design strategies through the building led the facility to a LEED Platinum Certification.

S IZ E?

C O M P L E T I O N ?

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F O N D A Z I O N E R I . M E D B I O M E D I C A L R E S E A R C H A N D B I O T E C H N O L O G Y C E N T E R

Carini, Sicily

This new Biomedical Research

and Biotechnology Center is

designed to be a new center for

translational research pairing

scientific researchers with

practicing clinicians on a common

campus.

The master plan is comprised

of a large research complex, a

future 300-bed hospital and

common shared elements such

as an auditorium, employee café,

administration complex and

gardens.

S IZ E538,000 sq. ft.

C O M P L E T I O N 2014

S IZ E500,000 sq. ft. (Phase I)

C O M P L E T I O N 2016

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U N I V E R S I T Y AT B U F FA L O , S C H O O L O F M E D I C I N E A N D B I O M E D I C A L S C I E N C E S

Located at the center of the

region’s emerging bio-sciences

corridor, this new medical school

development will anchor a

mixed-use district on campus

and bring 1,200 students,

faculty and staff downtown.

The new center will create

connections that allow students,

faculty, biomedical researchers

and clinicians to move easily

from classroom to bedside

to lab.

Buffalo, New York

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