HNP-1 - HuaBio · 2019-01-18 · HNP-1 Fig1: Western blot analysis of HNP-1 on rat spleen tissue...
Transcript of HNP-1 - HuaBio · 2019-01-18 · HNP-1 Fig1: Western blot analysis of HNP-1 on rat spleen tissue...
Background References
1. Ericksen B. et al. Antibacterial activity
and specificity of the six human
alpha-defensins. Antimicrob. Agents
Chemother. 49:269-275(2005).
2. Zou G. et al. Toward understanding the
cationicity of defensins. Arg and Lys
versus their noncoded analogs. J. Biol.
Chem. 282:19653-19665(2007).
Product Type: Mouse monoclonal IgG1, primary antibodies
Species reactivity: Human, Rat
Applications: WB, IHC
Molecular Wt.: 10 kDa
Clone number: 2D2
Description: Defensins are a family of antimicrobial and cytotoxic
peptides thought to be involved in host defense. They are abundant
in the granules of neutrophils and also found in the epithelia of
mucosal surfaces such as those of the intestine, respiratory tract,
urinary tract, and vagina. Members of the defensin family are highly
similar in protein sequence and distinguished by a conserved
cysteine motif. The protein encoded by this gene, defensin, alpha
1, is found in the microbicidal granules of neutrophils and likely
plays a role in phagocyte-mediated host defense. Several alpha
defensin genes are clustered on chromosome 8. This gene differs from
defensin, alpha 3 by only one amino acid. This gene and the gene
encoding defensin, alpha 3 are both subject to copy number
variation.
Immunogen:
Peptide.
Positive control:
Rat spleen tissue, human spleen tissue.
Subcellular location:
Secreted.
Database links:
SwissProt: P59665(Human)
Recommended Dilutions:
WB: 1:500-1:2,000 IHC: 1:50-1:200
Storage Buffer:
1*TBS (pH7.4), 1%BSA, 50%Glycerol. Preservative: 0.05% Sodium
Azide.
Storage Instruction:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C.
Avoid repeated freeze/thaw cycles.
Purity:
ProG affinity purified.
HNP-1
Fig1: Western blot analysis of HNP-1 on rat
spleen tissue lysates using anti-HNP-1
antibody at 1/500 dilution.
Fig2: Immunohistochemical analysis of
paraffin-embedded human spleen tissue using
anti-HNP-1 antibody. Counter stained with
hematoxylin.
rev. 01/03/18
Cat#: EM1701-52