HLA B27 Presentation

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Seronegative Spondyloarthropathies By Surijdei Amanda DeCruiz HLA –B27

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RA, Ankylosing Spondylitisis, UC, Crohn's, Still's Disease etc..

Transcript of HLA B27 Presentation

HLA B27

Seronegative Spondyloarthropathies

By Surijdei Amanda DeCruiz

HLA B27 HLA-B27Seronegative spondyloarthropathies HLA-B27 Human Leukocyte AntigenClass I Surface Antigen encoded in the B locus in MHC (Major Histocompatibility Complex) on Chr. 6p Blood test that detects proteins (HLA) located on the surface of WBCsFunction is to present the antigens to T-lymphocytesHLA proteins allows the body to distinguish between its own cells vs. foreign cellsPositive HLA-B27 = Abnormal = Increased Risk of developing Autoimmune DiseaseNegative for Rheumatoid factorPredilection for the Spine/Sacroiliac Joint, Enthesapothy, UveitisDo not Treat with Corticosteroids

HLA-B27 Seronegative spondyloarthropathies Ankylosing SpondylitisArthritis associated with Inflammatory Bowel Disease (Ulcerative Colitis and Crohns Disease) Psoriatic Arthritis Reactive Arthritis (Reiters syndrome)Juvenile Rheumatoid Arthritis (Adult Onset Stills Disease)

Ankylosing SpondylitisYoung Male (


« KIR3DL1 interaction with HLA-B27 is altered by ERAP1 and ... · « KIR3DL1 interaction with HLA-B27 is altered by ERAP1 and enhanced by MHC Class I cross-linking » « Hasan Abdullah

« KIR3DL1 interaction with HLA-B27 is altered by ERAP1 and ... · « KIR3DL1 interaction with HLA-B27 is altered by ERAP1 and enhanced by MHC Class I cross-linking » « Hasan Abdullah

Klebsiella'modifying HLA-B27+ B27 · lymphocytes of HLA-B27+ individuals and induce the appearance of new antigens, attempts weremadeto detect the bindingofklebsiella productsto HLA-B27+andB27-lymphocytesbya

Klebsiella'modifying HLA-B27+ B27 · lymphocytes of HLA-B27+ individuals and induce the appearance of new antigens, attempts weremadeto detect the bindingofklebsiella productsto HLA-B27+andB27-lymphocytesbya

[Type text] Page 1mykneemylife.org/PatientManual/ankylosingspondylitis-eBook.pdf · inflammation can be caused by many different health problems as well. Even test for HLA-B27 gene

[Type text] Page 1mykneemylife.org/PatientManual/ankylosingspondylitis-eBook.pdf · inflammation can be caused by many different health problems as well. Even test for HLA-B27 gene

ORAL TREATMENT WITH RECOMBINANT HUMAN INTERLEUKIN …jpet.aspetjournals.org/content/jpet/early/2003/10/20/jpet.103.058701... · HLA-B27 transgenic rats were used as a model of colitis

ORAL TREATMENT WITH RECOMBINANT HUMAN INTERLEUKIN …jpet.aspetjournals.org/content/jpet/early/2003/10/20/jpet.103.058701... · HLA-B27 transgenic rats were used as a model of colitis

Pojmovi i pojašnjenja SPONDILOARTRITISI · 6. Psorijaza 7. Inflamatorna bolest creva 8. Dobar odgovor na NSAIL 9. Porodično opterećenje 10. HLA-B27 pozitivnost 11. Povišen CRP

Pojmovi i pojašnjenja SPONDILOARTRITISI · 6. Psorijaza 7. Inflamatorna bolest creva 8. Dobar odgovor na NSAIL 9. Porodično opterećenje 10. HLA-B27 pozitivnost 11. Povišen CRP

Ankylosing spondylitis and HLA-B27: polymorphism sequencing › content › annrheumdis › 51 › 7 › 855.full.pdf · Ankylosing spondylitis and HLA-B27: restriction fragment length

Ankylosing spondylitis and HLA-B27: polymorphism sequencing › content › annrheumdis › 51 › 7 › 855.full.pdf · Ankylosing spondylitis and HLA-B27: restriction fragment length

HLA-B27 Modulates Intracellular Growth of Salmonella ......bacteria, e g. Salmonella and Yersinia [1]. The development and severity of ReA is strongly associated with the human leukocyte

HLA-B27 Modulates Intracellular Growth of Salmonella ......bacteria, e g. Salmonella and Yersinia [1]. The development and severity of ReA is strongly associated with the human leukocyte

SERONEGATIVE ARTHRITIS. A group of inflammatory conditions causing arthritis of the spine and peripheral joints, often associated with HLA B27, but without.

SERONEGATIVE ARTHRITIS. A group of inflammatory conditions causing arthritis of the spine and peripheral joints, often associated with HLA B27, but without.

Manisha Mehta, M - Uveitis€¦ · •HLA-B27 is associated with the pustular form of psoriasis •60-70% of cases with spondylitis associated psoriasis are HLA-B27 positive •3-4

Manisha Mehta, M - Uveitis€¦ · •HLA-B27 is associated with the pustular form of psoriasis •60-70% of cases with spondylitis associated psoriasis are HLA-B27 positive •3-4

GEN …€¦ · Web viewFor example, a child who inherits a maternal chromosome 6 with the HLA B27 allele is likely to inherit HLA A, C, and D alleles that reside on the same chromosome.

GEN …€¦ · Web viewFor example, a child who inherits a maternal chromosome 6 with the HLA B27 allele is likely to inherit HLA A, C, and D alleles that reside on the same chromosome.

Expression and immmunogenicity of HLA-B27 in high-transfection … · 2012. 5. 22. · Editorial Obituary R. Ceppellini * 19.01.1917 t05.06.1988 Original Articles Cyclosporin A mediated

Expression and immmunogenicity of HLA-B27 in high-transfection … · 2012. 5. 22. · Editorial Obituary R. Ceppellini * 19.01.1917 t05.06.1988 Original Articles Cyclosporin A mediated

Herpetic and HLA-B27 associated anterior uveitis Proefschrift L... · HLA-B27 associated anterior uveitis Human leukocyte antigen B27 (HLA-B27) is a class I surface antigen encoded

Herpetic and HLA-B27 associated anterior uveitis Proefschrift L... · HLA-B27 associated anterior uveitis Human leukocyte antigen B27 (HLA-B27) is a class I surface antigen encoded

ReaPan B27

ReaPan B27

HLA B27 Strip · aparición de precipitados en alguna de las soluciones (tampón de hibridación, tampones de lavado 1 y 2, conjugado). Estos precipitados se redisuelven al atemperar

HLA B27 Strip · aparición de precipitados en alguna de las soluciones (tampón de hibridación, tampones de lavado 1 y 2, conjugado). Estos precipitados se redisuelven al atemperar

CS229 Final Project Report Predicting Epitopes for …cs229.stanford.edu/proj2012/TuoZhao-PredictingEpitopes...subtypes—HLA-A01, HLA-A02, HLA-B27, and HLA-B08 from Immune Epitope

CS229 Final Project Report Predicting Epitopes for …cs229.stanford.edu/proj2012/TuoZhao-PredictingEpitopes...subtypes—HLA-A01, HLA-A02, HLA-B27, and HLA-B08 from Immune Epitope

IgA antibody klebsiella in ankylosing spondylitis measured ... · HLA-B27 positive subjects.8 9 It has been suggested that after exposure to Gramnegative bacteria AS is produced by

IgA antibody klebsiella in ankylosing spondylitis measured ... · HLA-B27 positive subjects.8 9 It has been suggested that after exposure to Gramnegative bacteria AS is produced by

HLA and antigen presentation

HLA and antigen presentation

HLA-B27 StripAssay - · PDF file04/2012 HLA-B27 StripAssay ® Instructions for use . I. INTENDED USE . Assay for the molecular typing of HLA-B27 based on polymerase chain reaction

HLA-B27 StripAssay - · PDF file04/2012 HLA-B27 StripAssay ® Instructions for use . I. INTENDED USE . Assay for the molecular typing of HLA-B27 based on polymerase chain reaction

Acute Anterior Uveitis with Hypopyon...14 Differential Diagnosis: HLA-b27 uveitis ´ HLA-b27 antigen is a class I major histocompatibility complex ´ Second most common noninfectious

Acute Anterior Uveitis with Hypopyon...14 Differential Diagnosis: HLA-b27 uveitis ´ HLA-b27 antigen is a class I major histocompatibility complex ´ Second most common noninfectious

Durham E-Theses The unfolded protein response and HLA-B27 … · 2016-07-27 · the folding capacity of the ER. The secretory pathway substrate HLA-B27 is highly associated with the

Durham E-Theses The unfolded protein response and HLA-B27 … · 2016-07-27 · the folding capacity of the ER. The secretory pathway substrate HLA-B27 is highly associated with the