HIV Testing and Considerations for Prevention
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Transcript of HIV Testing and Considerations for Prevention
Bernard M. Branson, M.D.
Associate Director for Laboratory DiagnosticsDivisions of HIV/AIDS Prevention
National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention
Centers for Disease Control and Prevention
HIV Testing andConsiderations for Prevention
Percent of Persons Ever Tested and Percent of Persons Ever Tested and Tested in the Preceding 12 Months Tested in the Preceding 12 Months
- NHIS 2002-2006- NHIS 2002-2006
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2006
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Ever tested Preceding 12 months
- MMWR August 8, 2008
Early Indications of Progress:National Health Interview
SurveyEver Tested Last 12 months
2005 70,036,336 (39.9%)
18,042,610 (10.44%)
2006 71,468,420 (40.4%)
17,775,006 (10.39%)
2007 73,848,002 (41.3%)
18,791,895 (10.67%)
2008 80,172,602 (44.6%)
19,055,402 (10.74%)
Change since 2006:
8.7 million 1.3 millionSource: National Health Interview
Survey
Estimated Cases of HIV/AIDS, by year of diagnosis
(based on 34 States with Confidential HIV Reporting)
2004 37,164
2005 36,640
2006 37,193
2007
Change:
42,655
5462 (15%)
Source: HIV/AIDS Surveillance Report, 2007
CDC’s Expanded Testing Initiative
Test 1.5 million persons per year among populations disproportionately affected by HIV, primarily African-Americans.
Identify 20,000 new HIV infections
Funded September 2007
Progress: Total Tests
Cumulative Tests
Avg Tests/Month
Oct-Mar 2008 87,038 14,506
Apr-Sept 2008 446,503 37,209
Oct – Mar 2009 859,882 47,771
April 2009 932,157 49,061
May 2009 1,027,059 51,353
June 2009 1,136,067 54,098
July 2009 1,221,680 55,531
Percentage of Tests and New HIV+ Tests
by Venue, Sept 2007 through March 2009
34
1.4 1
26
13
1.1 1.2
18
5.3
39
1 0.7
22
14
0.9 0.7
16
5.6
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Total Tests HIV+ Tests
HIV Testing Among IDU
HIV Testing Survey, 1998-1999• 90% previously tested
5 cities, 1998 – 2002*
• 93% previously tested• 69% tested within previous year
- Kellerman et el, JAIDS 2002- Heimer et al, AJPH 2007
*Chicago IL, Hartford CT, New Haven CT, Oakland CA, Springfield MA
HIV Testing Among MSM
Young MSM study, 1998-2000• 88% previously tested, 54% in previous year
National HIV Behavioral Surveillance 2003-2005:• 92% previously tested, 77% in previous year
57,131 MSM visits to STD clinics, Denver, DC, San Francisco, Seattle• 94% previously tested• Median inter-test interval 243 days
- MacKellar et al, Sex Transm Diseases 2006 - CDC, MMWR Surveillance Summaries 2006 -Helms et al, JAIDS 2009
Total Tested
HIVPrevalence
No. %
Unrecognized HIV Infection
No. %Age Group (yrs) 18-24 410 57 (14) 45 (79)25-29 303 53 (17) 37 (70)30-39 585 171 (29) 83 (49)40-49 367 137 (37) 41 (30) ≥ 50 102 32 (31) 11 (34)
Race/EthnicityWhite 616 127 (21) 23 (18)Black 444 206 (46) 139 (67)Hispanic 466 80 (17) 38 (48)Multiracial 86 16 (19) 8 (50)Other 139 18 (13) 9 (50)
Total 1,767 450 (25) 217(48)
HIV Prevalence and Proportion of Unrecognized HIV Infection Among 1,767 MSM, by Age Group and Race/Ethnicity
NHBS, Baltimore, LA, Miami, NYC, San Francisco
MMWR June 24, 2005
Pooled RNA Screening for Acute HIV Infection
1 Master Pool
1-Stage Pooling
16 Specimens A B C D E F G H I J
CDC Acute HIV Infection Study
K L M N O P
Yield from Pooled RNA Screening after EIA
SiteNumber tested
HIV Ab+
RNA+/ Ab-
Florida – 2006-08
54,948 663 (1.2%)† 9 (0.02%)
L.A. - 2006-08
37,012 427 (1.2%)* 35 (0.09%)
†Screened with Bio-Rad 1-2 Plus O *Screened with Vironostika EIA
- Patel et al, CDC , Archives Int Med 2010
Yield from Pooled RNA Screening after EIA
SiteNumber tested
HIV Ab+
RNA+/ Ab-
Florida – 2006-08
54,948 663 (1.2%)† 9 (0.02%)
L.A. - 2006-08
37,012 427 (1.2%)* 35 (0.09%)
L.A. - 2006-08
37,012 441 (1.2%)† 18 (0.05%)
†Screened with Bio-Rad 1-2 Plus O *Screened with Vironostika EIA
- Patel et al, CDC , Archives Int Med 2010
Yield from Pooled RNA Screening after Rapid Test
SiteNumber tested
HIV Ab+
RNA+/ Ab-
Florida 604 17 (2.8%) 1 (0.2%)
New York 6,547 29 (0.4%) 7 (0.1%)
- Patel et al, CDC , Archives Int Med 2010
Yield from Pooled RNA Screening after Rapid Test
SiteNumber tested
HIV Ab+
RNA+/ Ab-
Florida 604 17 (2.8%)* 1 (0.2%)Florida 604 17 (2.8%) † 1 (0.2%)
New York 6,547 29 (0.4%)* 7 (0.1%)
New York 6,547 35 (0.5%) † 1 (0.02%)
* Screened with OraQuick †Screened with BioRad 1-2 Plus O
- Patel et al, CDC , Archives Int Med 2010
Acute HIV Screening: 99,111 tested
EIA-RR/WB+ 1,136 (1.1%)
NAAT+ 1,094 (96.3%)
NAAT- 42 (3.7%)
EIA-RR/WB-ind 30 (0.03%)
NAAT+ 3 (10.0%)
NAAT- 27 (90.0%)
EIA-neg/NAAT+ 52 (0.05%)
Acute HIV 48 (92%)
False-pos NAAT
4 (8%)
- Patel et al, Archives Int Med 2010
Acute HIV Screening: 99,111 tested
EIA-RR/WB+ 1,136 (1.1%)
NAAT+ 1,094 (96.3%)
NAAT- 42 (3.7%)
EIA-RR/WB-ind 30 (0.03%)
NAAT+ 3 (10.0%)
NAAT- 27 (90.0%)
EIA-neg/NAAT+ 52 (0.05%)
Acute HIV 48 (92%)
False-pos NAAT
4 (8%)
- Patel et al, Archives Int Med 2010
Acute HIV Screening: 99,111 tested
EIA-RR/WB+ 1,136 (1.1%)
NAAT+ 1,094 (96.3%)
NAAT- 42 (3.7%)
EIA-RR/WB-ind 30 (0.03%)
NAAT+ 3 (10.0%)
NAAT- 27 (90.0%)
EIA-neg/NAAT+ 52 (0.05%)
Acute HIV 48 (92%)
False-pos NAAT
4 (8%)
- Patel et al, Archives Int Med 2010
Acute Infections in MSM detected by NAAT
0.3% of 14,005 frequently tested MSM in Seattle STD clinic; represent 20% of all HIV infections detected
26 (74%) of 35 AHI cases detected in LA at MSM clinic; 25% of all HIV infections detected
0.08% of 21,425 STD clinic patients in New York City; represent 9% of all HIV infections detected; 94% were MSM
- Stekler et al, Clin Infect Dis 2009
- Shepard et al, MMWR 2009- Patel et al, Archives Int Med 2010
4th Generation vs. RNA
RNA+/ 3rd gen-negative specimens detected by 4th generation EIA:
• 38 of 46 (83%) – Australia*• 10 of 14 (71%) – CDC AHI study**• 51 of 61 (84%) – CDC panel***
• 4 days after RNA – 9 seroconversion panels***
* Cunningham P, HIV Diagnostics Conf 2007 ** Patel P, CROI 2009*** Owen M, CROI 2009
Potential Prevention Research Questions
Indications for and frequency of retesting
Role of acute infection in sustaining the epidemic
Community trial of structured serosorting intervention