HIV INFECTION OUTBREAK AMONG IDUS IN...

HIV INFECTION OUTBREAK

AMONG IDUS IN MINSK

Prof. Vladimir Eremin MD, PhD, Dr. Elena Gasich PhD,

Dr.Sviataslau Sasinovich PhD

Republican Research & Practical Center for Epidemiology & Microbiology,

Minsk, Republic of Belarus

[email protected]

Ljubljana, Slovenia 27-28 September 2017

HIV/AIDS IN THE REPUBLIC OF BELARUS, AS OF 01.01.2017

0

5000

10000

15000

20000

25000

20 11 12 14 12 21 10 5 8

1021653 554 410 525 549

947 713 779 750 733 990 881 1,072 1069 1087 1196 1223 1533 1391 1633 1811

2305 2391

31 43 57 69 90 100 105 113

1134 17872341

27513276

3825

47725485

62647014

7747

8737

9618

10,690

11759

1284612955

14178

15711

17102

17,34417522

19,827

22,218

cases

years

per yeartotal

Population: 9 498 700 as of 01.01.2016

Svetlogorsk outbreak May-July 1996


HIV/AIDS IN BELARUS, AS 01.01.2017

As of January 1, 2017, 22 218 HIV/AIDS cases registered in the Republic of Belarus. In 2016,

2,391 HIV-infected patients were detected. The incidence rate was 25.2 per 100 thousand

population (in 2015 - 24.3).

The total number of cases of HIV infection in the age group 15-49 years is 20 699 people (the

proportion in the overall structure of HIV-positive - 93.2%). For 2016 - In the age group 15-49

years, 2 099 cases (87.8%) were registered.

According to the cumulative data (1987-01.01.2017) 37.5% (8,330 people) were infected

parenterally (with intravenous injection of drugs), the proportion of people who became

sexually infected was 60.2% (13 385 cases).


HIV/AIDS CASES IN REGIONS, N=22218

1376 (6,2%)

3265 (14,7%)

980 (4,4%)

9603 (43,2%)

1196 (5,4%)

4085 (18,4%)

1713 (7,7%)

Mogiliov region Minsk region Grodno region Gomel region Vitebsk region Minsk Brest region

Mn1

7-A

AY50

0393

Rus

sia

Con

sens

us ID

U-A

HE6

5746

0-M

n1-A

HE6

5747

9-G

r13-

A

HE6

5750

2-M

n20-

AH

E657

493-

Mg1

-A

HE6

5751

0-M

nObl

-09A

1

Mn1

3-A

Mn3

5-A-

Det

HE5

7761

4-M

nObl

-02A

1HE

6574

56-M

n12-

AM

nObl

-45A

1

MnO

bl-6

0A1

Mn3

2-A

Mn2

5-A-D

et

Mn-

38-A

Br27-A

Mn33-A

Br21-A

Vit4-A

-168Det

HE657505-Br1

9-A-D

et

HE657486-Gr1

1-A

MnObl-38A1

Mn-36-A

Mn34-A

HE657478-Gr1-A

Gr17-AHE657538-G

r15-A

HE657539-Gr7-A

HE657482-Gr5-A

MnObl-36A1

HE657480-Gr2-A

HE657487-Gr10-A

HE657481-Gr4-A

HE657477-Gr14-A

HE657518-MnObl-32A1

Mn10-AHE657511-MnObl-20A1

HE657499-MnObl-39A1

HE657542-MnObl-33A1HE657537-Br4-AMn19-A

HE657459-Mn11-AHE657529-MnObl-17A1

MnObl-52A1Mn24-AMnObl-56A1

MnObl-48A1

MnObl-47A1

MnObl-50A1MnObl-40A1

HE657526-MnObl-31A1MnObl-44A1

HE657523-MnObl-16A1MnObl-37A1

MnObl-43A1

HE657527-MnObl-10A1

MnObl-58A1MnObl-53A1

HE657517-MnObl-07A1Mn7-A-Det

HE657520-MnObl-08A1

HE657471-Br10-A

HE657509-MnObl-21A1

HE657462-Mn6-A

Mn-40-A

HE657531-MnObl-13A1

MnObl-57A1

MnObl-59A1

HE577616-MnObl-04A1

HE657512-MnObl-22A1

HE657513-MnObl-19A1

MnO

bl-65A1

HE657540-MnO

bl-34A1

HE657522-MnO

bl-25A1

MnO

bl-25A1-12

MnO

bl-49A1M

nObl-51A1

HE657436-Gom

19-A

HE657435-Gom

20-A

HE657507-Br17-A

Mn27-A-D

et

HE657524-M

nObl-29A1

AF413987 Ukraine

Mn28-A-D

et

HE657504-G

om22-A

HE657473-Br12-A

HE657472-Br6-A

HE657468-Br5-A

HE6

5751

5-M

nObl

-23A

1

Mn2

6-A-

Det

MnO

bl-6

2A1

HE6

5750

3-G

om21

-A

HE6

5746

3-M

n2-A

HE6

5747

4-Br

9-A

HE6

5745

7-M

n18-

A

Vit7

-A-1

93

HE6

5744

5-G

om5-

AH

E657

446-

Gom

6-A

HE6

5745

0-G

om10

-AH

E657

448-

Gom

25-A

HE6

5753

2-G

om18

-AH

E657

494-

Mg7

-A

HE6

5749

5-M

g6-A

HE6

5749

6-M

g5-A

HE6

5745

4-M

n16-

A

HE6

5743

7-G

om13

-A

HE6

5744

4-G

om15

-A

Gom

-31A

1

MnO

bl-5

4A1

MnO

bl-6

8A

HE657

500-

Mn3

-A

HE6574

38-G

om14

-A

HE6574

51-G

om4-

A

HE6574

33-G

om26

-A

HE6574

30-G

om17

-A

Mn3

0-A

Br22-

A

MnO

bl-67URF

Mn29-A

HE657434-Gom23-A

Gom-2

9A1

HE657489-Vit2

-A

Mn31-AHE657514-MnObl-1

8A1

HE657516-MnObl-3

0A1

HE657447-Gom2-A

HE657530-MnObl-1

2A1

HE657541-MnObl-3

5A1

HE577613-MnObl-0

1A1

HE657488-Gr9-A

HE577615-MnObl-0

3A1

Gom-30A1

Br28-AMn23-A-Det

HE657441-Gom12-A

HE657442-Gom11-A

HE657475-Br11-A

HE577617-MnObl-05A1

Br29-AHE577618-MnObl-06A1

HE657521-MnObl-26A1

MnObl-64A1HE657528-MnObl-11A1

MnObl-63A1

Mn-41AHE657519-MnObl-14A1

HE657483-Gr16-AHE657465-Br13-A

HE657497-Mg4-AHE657484-Gr12-AMnObl-66A1HE657452-Mn4-AHE657498-Mg2-A

HE657449-Gom16-AHE657466-Br1-A

HE657470-Br2-AHE657506-Br15-A

HE657476-Br16-ABr25-A

HE657469-Br14-AHE657536-Br18-ABr23-A

HE657535-Br7-ABr24-A

MnObl-46A1

HE657467-Br3-A

Br26-AMnObl-55A1

Br20-A

HE657439-Gom24-A

HE657443-Gom7-A

HE657440-Gom8-A

HE657432-Gom1-A

HE657534-Gom3-A

HE657525-MnObl-24A1

HE657533-Gom9-A

MnObl-42A1

Vit5-A-167

HE657461-Mn5-A

HE657431-Gom27-AFN995656-M

n21-URF

AF004885 A Kenya

U88823 Rwanda

HE657501-Mn22-C

Mn-39-C

U52953 C Brazil

AY158534 South Africa

AF067159 India

AY772535 Cameroon

AF084936 G DRC

HE657492-Mg3-GAF190127 H Belgium

AF082394 J

AF077336 F DRC

AJ249235 KFR686468-M

nObl-28cpx

FR686469-M

nObl-27cpx

DQ

400856 Russia

AY535660 Estonia

FR729474-M

g8-A/BFR

729475-MnO

bl-15A/B

AF414006 AB Belarus

AF193276 AB KAL153

FR773523-G

r3-A/BH

E657485-Gr8-A/B

MnO

bl-61A/B

K03454 D

HE657453-M

n14-B

AY682547Russia

HE657464-M

n8-B

Mn-37B

HE657458-M

n15-BD

Q823364 U

kraine

Vit-6-B

HE657455-M

n9-B

DQ

207943 Georgia

AY819715 Russia

AY835766 USA

K03455 B (HXB2)

A1

CRF03_AB

B

CRF06_cpxCRF02_AG, G

C

The HIV / AIDS epidemic in the

Republic of Belarus consists of a

number of local outbreaks and is

supported by a HIV-1 subtype

A1> 93%


THE SVETLOGORSK OUTBREAK IS

A UNIQUE SINGLE-SOURCE OUTBREAK AMONG >1,000 INDIVIDUALS

Svetlogorsk outbreak


A1

Unique Svetlogorsk outbreak with a single source

env region

cons_BLR VMIRSENITDNGKIIIVQLTEPVNITCIRPGNNTRTSIRIGPGQTFYATGDVIGDIRKAYCNVSRAAWNSTLQKISTQLRKYFNNKTIIFKN

A974696 ------------------------------------------------------------------------------------------..

A974697 ------------------------------------------------------------------------------------------..

A974698 ------------------------------------------------------------------------------------------..

A974699 ------------------------------------------------------------------------------------------..

A974700 ------------------------------------------------------------------------------------------..

A974701 ---------N--------------------------------------------------------------------------------..

A904703 ------------------------------------------------------------------------------------------..

A974704 ------------------------------------------------------------------------------------------..

A974705 ------------------------------------------------------------------------------------------..

A974706 -----K--------------------------------------------G---------------------------------------..

A974707 -----------------------------------------------------------H------------------------------..

A974708 ------------------------------------------------------------------------------------------..

A974709 ------------------------------------------------------------------------------------------..

A974710 -----K------------------------------------------------------------------------------------..

A974711 ------------------------------------------------------------------------------------------..

A974712 ------------------------------------------------------------------------------------------..

A974713 -----K---E---------N----------------------------------------------------------------------..

A974714 I----K-------T------------------------------------A-T------H---------R--------------------..

A974715 -----K--------------------------------------------A---------------------------------------..

A974724 ------------------------------------------------------------------------------------------..

1996 1997Ljubljana, Slovenia 27-28 September 2017

gag region

cons_BLR VWASRELERFALNPSLLETSEGCQQILEQLQPTLKTGSEELKSLYNTVATLYCVHQRIEIKDTKEALDKIEEIQNKSKQKTQQAATGTGSSSKVSQNYPIVQNAQGQMTH

A974696 -------D----------SA------------------------------------------------------------------------------------------

A974697 --------------------------------------------------------------------------------------------------------------

A974699 --------------------------------------------------------------------------------------------------------------

A964700 --------------------------------------------------------------------------------------------------------------

A974701 -------D------------------------------------------------------------------------------------------------------

A974703 --------------------------------------------------------------------------------------------------------------

A974704 --------------------------------------------------------------------------------------------------------------

A974705 ------------------------------------------------------------R-------------------------------------------------

A974706 --------------------------------------------------------------------------------------------------------------

A974707 --------------------------------------------------------------------------------------------------------------

A974724 -------D------------------------------------------------------------------------------------------------------

cons_BLR QSMSPRTLNAWVKVIEEKAFSPEVIPMFSALSEGATPQDLNMMLNIVGGHQAAMQMLKDTINEEAAEWDRLHPAQAGPFPPGQMREPRGSDIAGTTSTLQEQIGWMT

A974696 -----------------------------------------------------------------------------------------------------------

A974697 ---------------------------------------------------------------------------------------------R-----------T-

A974698 ---------------------------------------------------------------------------------------------------------T-

A974699 -----------------------------------------------------------------------------------------------------------

A964700 -----------------------------------------------------------------------------------------------------------

A974701 -----------------------------------------------------------------------------------------------------------

A974703 -----------------------------------------------------------------------------------------------------------

A974704 ---------------------------------------------------------------------------------------------R-----------T-

A974705 ---------------------------------------------------------------------------------------------R-------------

A974706 ---------------------------------------------------------------------------P-------------------------------

A974707 -----------------------------------------------------------------------------------------------------------

A974724 ---------------------------------------------------------------------------------------------R-------------

1996 1997

Unique Svetlogorsk outbreak with a single

source


CHANGE OF TACTICS OF A DRUG

PREPARATION

In the beginning of 1996

IDUs the Gomel region

began to be supplied

ready for use drug prepared

from poppy straw

in clandestine laboratories

south of Russia and Ukraine,

delivered in pre-packaged

bottles from under Coca-Cola


HIV INFECTION BY AGE GROUPS OF IDUS FROM GOMEL OBLAST, 1996

0

50

100

150

200

250

300

350

400

450

3

223

435

191

435

40

HIV

/AID

S c

ases

age

0-14

15-19

20-24

25-29

30-34

35-39

40 и старше


HIV / AIDS IN THE REGIONAL CENTERS AND THE CAPITAL-MINSK

0

500

1000

1500

2000

2500

3000

3500

Brest Vitebsk Gomel Grodno Mogilov Minsk

224

348

1129

158215

3379

70.497.8

226.346.7

57.8

184.7

cases

cities

Chart Title

HIV/AIDS cases per 100nd. popul as 01.12.2015 Ljubljana, Slovenia 27-28 September 2017

HIV / AIDS CASES IN MINSK (2006-2016)

996

12261297

1347

1477

1665

1852

2033

2255

2642

3433

230

71 50130

188 187 181 222

387

791

0

500

1000

1500

2000

2500

3000

3500

4000

01/01/2006 01/01/2007 01/01/2008 01/01/2009 01/01/2010 01/01/2011 01/01/2012 01/01/2013 01/01/2014 01/01/2015 01/01/2016

HIV

/AID

S c

ase

s

years Ljubljana, Slovenia 27-28 September 2017

PHYLOGENETICAL ANALYSIS ON GAG (P17 / P24) REGION (N=70)

A1.U

Z.2

002.0

2U

Z698.A

Y829206

A1.U

Z.2

002

.02

UZ

74

0.A

Y82

92

08

A1.U

Z.2

002

.02

UZ

06

72

.AY

82

92

12

A1.U

Z.2

002.0

2U

Z652.A

Y829203

A1.U

Z.2

002.0

2U

Z694.A

Y829205

A1.U

Z.2

002.0

2U

Z0667.A

Y829211

A1.U

Z.2

002.0

2U

Z0659.A

Y829209

A1.U

A.2

001.0

1U

AP

ol2

94.D

Q823356

A1.U

A.2

001.0

1U

AP

ol2

93.D

Q823359

A1.U

A.2

001.0

1U

AP

ol3

03.D

Q823360

03_A

B.R

U.1

997.K

AL153_2.A

F193276

03_A

B.R

U.1

998.R

U98001_98R

U001.A

F193277

A1.B

Y.1

997.9

7B

L006.A

F193275

A1.R

U.2

003.0

3R

U20_06_13.A

Y500393

A1.U

A.2

000.9

8U

A0116.A

F413963

A1.

CY

.200

5.C

Y05

8.E

U67

3426

A1.

CY.2

005.

CY05

7.EU

6734

25

A1.

CY.2

005.

CY05

7.FJ3

8890

699

96

A1.

KZ.2

002.

02KZY

UZ3

0041

3.EF5

8904

0

A1.

KZ.

2002

.02K

ZYUZ3

0042

5.EF5

8904

1

A1.

KZ.2

002.

02KZP

AV30

0497

.EF58

9039

A1.

RU.2

005.

RU_5

60_1

125_

JA.J

Q29

2895

A1.CY.2

006.

CY17

3.EU

6734

42

A1.CY.2

006.CY173.F

J388951

99

03_AB.BY.2

000.98BY10443.A

F413992

03_AB.BY.2

000.98BY10443.A

F414006

99

03_AB.BY.2000.9

8BY10443.AF413991

03_AB.BY.2000.98BY10443.A

F413993

A1.KZ.2002.02KZKAR300435.E

F589042

515HIV03_AB.SE.2010.THS-28.JQ229744

A1.RU.2006.RU_915_1035.JQ292897

A1.RU.2006.RU_915_1016.JQ292896

A1.RU.2006.RU_SP_B_049.JQ292900

A1.KZ.2002.02KZPAV300480.EF589043

A1.UZ.2002.02UZ0663.AY829210

A1.UA.2001.01UAKV254.DQ823361

A1.UA.2001.01UAOD89.DQ823367

191PV-Mn

199PV

265PV99

253PV190PV-Mn

241PV-Mn81 231PV240PV-Mn232PV200PV196PV237PV-Mn203PV255PV

9972A1.RU.2002.RU01029.JQ292892

A1.RU.2010.10RU6617.JX500696195PV

A1.RU.2010.10RU6792.JX500695

A1.CY.2007.CY213.JF683763

A1.CY.2008.CY231.JF683780

95

193PV-Mn

242PV

98

A1.RU.2008.RUA007.JQ292894

A1.RU.2007.Irkutsk_5.JQ292891

219PV248PV

507HIV

508HIV

99

226PV

236PV

239PV

91

204PV

98

222P

V

627R

es-G

om

Obl

208P

V

267P

V

100

252P

V502H

IV

98

98

183P

V-M

n

192P

V-M

n

251P

V

228P

V266P

V186P

V-M

n

214P

V25

4P

V

97

22

5P

V1

00

20

7P

V20

2P

V20

6P

V247P

V212P

V215P

V205P

V238P

V246P

V

94 8

1

A1.U

A.2

001.0

1U

AD

N139.D

Q823357

A1.C

Y.2

006.C

Y171.E

U673440

A1.C

Y.2

006.C

Y171.F

J388950

100

486M

S

487M

S

100

227P

V

264P

V

234P

V

209P

V

211P

V21

3PV

217P

V-M

n

249P

V25

0PV

100 10

0

521HIV

210PV

263PV

B.US.1998.9

8USHVTN8229c6.A

Y560109

B.CA.-.B

CCFE_HOMER_HIV_GAG_3063.E

U242120

B.CA.-.B

CCFE_HOMER_HIV_GAG_3011.EU242068

224PVB.CA.-.BCCFE_HOMER_HIV_GAG_3177.EU242234

B.US.2007.pt13t1s135.HQ249700

B.US.2008.pt13t2s024.HQ250035

B.US.2008.pt13t3s057.HQ250435

B.US.2007.pt13t1s039.HQ249685

B.US.2007.pt13t1s048.HQ249692

B.US.2008.pt13t2s020.HQ250149

B.US.2008.pt13t3s124.HQ250727

93

B.KR.2004.04KJin8_1955.DQ295195B.US.1989.gag210.KF701833

B.US.-.S5571TOB8U.GQ371605B.US.2006.630865_timepoint_2.GU561301B.CA.1998.CANB5FULL.AY779555

B.FR.2012.D.KC899335

B.DK.1996.6_bPI_pre.AM933529

B.CA.-.BCCFE_HOMER_HIV_GAG_2956.EU242013


B.US.1988.gag167.KF701795

B.US.1984.gag287.KF701891

B.US.1987.gag116.KF701749

B.US.1987.gag102.KF701736

B.US.1984.gag335.KF701926

B.US.1988.gag145.KF701776


B.US.1989.gag192.KF701817

B.US.1989.gag194.KF701818

B.US.2007.502_0287_LH2.JF320400

B.US.2007.502_2586_LH07.JF320132

B.US.2007.502_2586_LH01.JF320133

B.US.2007.502_2586_LH03.JF320137

B.US.2007.502_2586_LH06.JF320139

100

B.US.2006.22.HM116823

B.TH.1997.97TH

50.AF196648

B.US.2007.07U

S_SAJ_NVS55.JF689893

B.U

S.1986.gag71.K

F701709

B.U

S.1986.gag72.K

F701710

B.Z

A.1985.R

84.FJ647145

B.U

S.1984.gag281.K

F701886

B.U

S.1986.A

D87_A

DA.A

F004394

B.U

S.-.9C

P_1031.A

Y786866

B.U

S.1

985.g

ag27.K

F701669

B.U

S.1

998.W

C3_0498_2.E

F175210

B.U

S.1

998.W

C3_0498_4.E

F175212

B.U

S.1

993.W

C3_1093.E

F121388

B.U

S.1

992.W

C3_0892.E

F121386

B.U

S.1

993.W

C3_0393.E

F121387

767399

100

0.02

Age:

m - 33,7±4,4

f – 32,8±6,2


A1.

UZ

.200

2.02

UZ

652.

AY

8292

03A

1.U

Z.2

002.

02U

Z06

72.A

Y82

9212

A1.

UZ

.200

2.02

UZ

694.

AY

8292

05A

1.U

Z.2

002.

02U

Z74

0.A

Y82

9208

A1.

KZ

.200

2.02

KZ

PA

V30

0497

.EF

5890

39

A1.

KZ

.200

2.02

KZ

YU

Z30

0413

.EF

5890

40

A1.

CY

.200

7.C

Y21

3.JF

6837

63

A1.

RU

.200

2.R

U01

029.

JQ29

2892

A1.

RU

.200

3.03

RU

20_0

6_13

.AY

5003

93

A1.

KZ.

2002

.02K

ZYU

Z300

425.

EF5

8904

1

A1.

UZ.

2002

.02U

Z065

9.A

Y82

9209

A1.

UZ.

2002

.02U

Z698

.AY

8292

06

A1.

UZ.

2002

.02U

Z066

7.AY82

9211

219P

V22

2PV

A1.RU.2

008.

RUA00

1.JQ

2928

93

A1.RU.2

010.

10RU67

92.J

X5006

95

A1.RU.2

007.Irku

tsk_

5.JQ

292891

190PV

189PV

94

195PV

A1.RU.2006.R

U_915_1038.JQ292898

239PV

253PV

231PV

232PV

237PV

240PV

194PV9792

193PV

241PV99

A1.RU.2006.RU_915_1016.JQ292896

A1.RU.2006.RU_915_1041.JQ292899

230PV

261PV

188PV226PVA1.RU.2006.RU_915_1035.JQ292897242PV198PV

100

487MS486MS100

A1.UA.2001.01UADN139.DQ823357

A1.CY.2006.CY171.FJ388950

A1.CY.2009.CY255.JF683798

A1.UZ.2002.02UZ0663.AY829210

A1.UA.2001.01UAKV254.DQ823361

A1.KZ.2002.02KZPAV300480.EF589043

A1.KZ.2002.02KZPAV300502.EF589044

100

A1.UA.2000.98UA0116.AF413968

A1.UA.2000.98UA0116.AF413987

89

A1.UA.2000.98UA0116.AF413967

99

A1.UA.2000.98UA0116.AF413966

75

A1.GE.1999.99G

EMZ011.DQ

207944

A1.RU.2011.11RU6950.JX500694

03_AB.RU.1997.KAL153_2.AF193276

A1.UA.2001.01U

AOD10.D

Q823365

A1.UA.2001.01U

ADN121.D

Q823358

A1.K

Z.2002.02KZK

AR300435.E

F589042

A1.U

A.2001.01U

APol294.D

Q823356

A1.U

A.2001.01U

AP

ol303.DQ

823360

80

A1.U

A.2001.01U

AP

ol293.DQ

823359

81

03_AB

.RU

.1998.RU

98001_98RU

001.AF193277

A1.B

Y.1997.97B

L006.AF

193275

03_AB

.BY

.2000.98BY

10443.AF

413994

03_AB

.BY

.2000.98BY

10443.AF

413996

80

03_AB

.BY

.2000.98BY

10443.AF

413995

03_AB

.BY

.2000.98BY

10443.AF

414006

93 A1.U

A.2001.01U

AO

D89.D

Q823367

210PV218P

V

A1.

RU

.200

8.D

EM

A10

8RU

004.

KF

7164

92

182P

V21

7PV

201P

V

99

206P

V207P

V

215P

V

91

248P

V

246P

V

247P

V

185P

V

202P

V

187P

V

259P

V

184P

V

212P

V

82

98

227P

V

251PV

225PV228PV

186PV183PV243PV 71 77 87221PV235PV244PV

99

252PVB.ES.2010.R7.KT200356

224PVB.US.2008.HIV_US_BID-V3114_2007.JQ403074

B.ES.2009.S61_D1p21.HM469972

B.ES.2009.S61_D1_5p21.HM469974

B.ES.1989.D1_5p11.GQ386776B.ES.1989.D1p11.GQ386775B.ES.1989.D1p1.GQ386774B.ES.1989.S61D15.AF256205

B.ES.2009.S61_D2p21.HM469973

B.ES.1989.D2p11.GQ386778

B.ES.1989.D2p1.GQ386777

B.ES.1989.S61D1.AF256211

100

B.US.2005.L8249.DQ886037

B.US.2005.L8249.FJ469746

100

B.US.1986.AD87_ADA.AF004394

B.US.1993.5127_93.AY835776

B.CN.2007.07CNHB_ES17.HQ198023

B.FR.1985.NL4_3_LAI_NY5_pNL43_NL43.U26942

B.FR.1985.HIV_US_BID-V4141_pNL43.JQ403040

B.-.-.pIIIB.EU541617

B.FR.1985.NL43E9_LAI_IIIB_NY5.AF070521

89

B.US.2006.CR0222X.FJ469709

99

B.US.1986.5127_86.AY835774

B.DE.1986.D31.U43096

B.US.1986.YU-10.M93259

B.US.1986.5113_86.AY835757

B.KR.2004.04KM

K5.JQ316126

B.KR.2003.03KD

E11.JQ316128

B.KR.2004.04KYR

8.DQ295196

B.KR.2002.02O

SG1.JQ

429433

B.K

R.1992.H

P-6_03JH

J2-3477.KJ140251

85

B.K

R.1993.H

P-17_02LS

P11-2268.K

J140262

B.K

R.2003.03Y

GS

3.JQ316135

B.K

R.2003.H

P-15_03LS

W3_6491.K

J140260

B.K

R.1992.H

P-7_96LS

M10-3474.K

J140252

B.K

R.1992.H

P-16_12JIS

11-6075.KJ140261

100

0.02

PHYLOGENETICAL ANALYSIS GENE pol region


PHYLOGENETICAL ANALYSIS BY THE GENE ENV, GP120 V3 LOOP REGION

A1.

EE

.200

5.S

21A

1.R

U.2

008

.SA

L2

1

A1.R

U.2

007.R

U_56_07_C

2_7

A1.

RU

.2008

.SA

L14

A1.

RU

.201

1.R

U_Y

EK

B26

588

A.C

Z.-

.CZ

7679

9

A1.

LV.2

002.

02LV

_HE

T02

9_20

02_V

3

70

A1.

RU

.200

7.R

U_2

1_07

_A10

A1.

LV.2

003.

03LV

_HE

T05

7_20

03_V

3

A.C

Z.-.

CZ79

990

A1.

CY

.200

8.C

Y23

1

A1.

UZ.

2002

.02U

Z066

7

A.R

U.-.

patie

nt_2

082

A1.

AU.-.

AUS_1

A1.LV

.200

3.03

LV_I

DU01

1_19

97_V

3

A1.RU.2

003.

03RU10

62

191PV-Mn

236PV

230PV

99

A1.RU.2007.Y

AK_1393

A1.RU.2008.S

AL24

A1.LV.2003.03LV_MSM023_2003_V3

A1.LV.1998.98LV_IDU018_1998_V3

A1.LV.1998.98LV_MSM015_1998_V3

A1.LV.1999.99LV_HET003_1999_V3

81

A1.LV.2001.01LV_IDU007_1998_V3

A.RU.1996.RU1175_c14

A.LV.2001.01LV_B251

A.LV.2001.01LV_K612

A.LV.2001.01LV_R135

A.SE.2000.SE_P35.21525

A1.RU.2007.RU_41_07_A9_2A1.RU.2008.RUA004gA1.RU.2008.RUA004iA1.RU.2008.RUA004k95

99A1.RU.2008.SAL10

A1.RU.2007.YAK_1380

A1.KZ.2002.02KZKAR300435

A1.LV.2005.05LV_IDU_S2110_2005_v3_A1

A1.LV.2001.01LV_N0731

03_AB.RU.2002.2002_2828_6

A1.RU.2006.06_RU_SP_R392_IV_tH9

A1.RU.2006.06_RU_SP_R392_IV_2F8

99

A1.KZ.2002.02KZPAV300502

A1.LV.2005.05LV_IDU_S2144_2005_v3_A1208PV252PV

99

486MS

487MS

93

A1.C

Y.2005.C

Y058

A1.C

Y.2005.C

Y057

A1.C

Y.2005.C

Y057

9986

A1.U

A.2001.01U

AKV254

230PV

A1.C

Y.2006.C

Y169

195PV

-Mn

186PV

-Mn

A1.LT

.-.123

82

617Res

190PV

-Mn

196P

V25

3P

V23

7P

V23

9P

V23

2P

V25

5PV

231PV

240PV

99

03_A

B.R

U.2

002.

2002

_273

2

A1.

RU

.200

6.R

U_S

P_B

_049

A1.

RU

.200

7.07

_RU

_SP

_R52

6_V

_A01

A1.

RU

.200

7.07

_RU

_SP

_SC

3208

_VI_

F12

218P

V-M

n

213P

V-M

n

258P

V

71

249P

V

250P

V

82

94

182P

V-Mn

99

234PV235PV

210PV

189PV-Mn

242PV99

99

184PV-Mn185PV-M

n 94

207PV-Mn

206PV247PV 81215PV-Mn217PV97

79

188PV-Mn248PV202PV-Mn

246PV212PV-Mn

187PV-Mn

259PV

78

94

81

193PV-Mn

241PV99

A1.RU.2006.RU_915_1080_G4

A1.RU.2006.RU_915_1080_A4_4

99

226PV

183PV-Mn

225PV-Mn

214PV-Mn

227PV

192PV-Mn

228PV

7476

99

219PV-Mn

221PV-Mn

223PV-Mn

224PV

B.FR

.2005.DEM

B05FR

001

B.N

L.1987.19663_9G6

B.U

S.2005.05U

S_S

AJ_N

VS8

B.S

E.-.2242_64_8

B.S

E.-.2242_64_1

99

B.C

H.2005.Z

PH

I78_31

B.C

H.2005.Z

PH

I78_32

9999

99

0.02


COMPARATIVE ANALYSIS OF HIV-1 OF GENE GAG (P17 / P24) REGION

10 20 30 40 50 60 70 80 90 100

....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|

183PV-Mn GTATGGGCAAGCAGGGAGTTGGAAAGATTCGCGCTTAACCCTGGCCTTTTAGAAAACTCAGAAGGATGTCAGCAAATATTAGAACAATTACAACCAACTC

186PV-Mn ....................................................................................................

192PV-Mn ....................................................................................................

214PV ....................................................................................................

228PV .........................................................C..........................................

254PV ......................................................................................C.............

266PV ....................................................................................................

110 120 130 140 150 160 170 180 190 200

....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|

183PV-Mn TCAAGACAGGATCAGAGGAAGTTAAATCATTATATAATACAGTAGCAACCCTTTATTGTGTACATCAAAGGATAGAAATAAGAGACACCAAGGAAGCTTT

186PV-Mn ....................A...............................................................................

192PV-Mn ....................................................................................................

214PV ....................A...............................................................................

228PV .....................................................................A..............................

254PV ...........................................G........................................................

266PV .....................................................................A..............................

210 220 230 240 250 260 270 280 290 300

....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|

183PV-Mn AGATAAAATAGAGGAACTACAAAATAAGAGCAAGCAAAAGACCCAACAGGCAGCGGCTGGCACAGGAAGCAGCAGCAAGGTCAGTCAAAATTACCCCATA

186PV-Mn ....................................................................................................

192PV-Mn ....................................................................................................

214PV ......................................................A.............................................

228PV ....................................................................................................

254PV ..........................................................................................C.........

266PV ..................G.................................................................................

310 320 330 340 350 360 370 380 390 400

....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|

183PV-Mn GTGCAAAATGCACAAGGGCAAATGACATACCAGTCCATGTCACCTAGGACTTTGAATGCATGGGTGAAAGTAATAGAAGAAAAGGCTTTCAGCCCAGAAA

186PV-Mn ....................................................................................................

192PV-Mn ....................................................................................................

214PV ............................................................................................Y.......

228PV ....................................................................................................

254PV ....................................................................................................

266PV ............................................A.......................................................

410 420 430 440 450 460 470 480 490 500

....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|

183PV-Mn TAATACCCATGTTTTCAGCATTATCAGAAGGAGCCCCCCCACAAGATTTAAACATGATGCTGAACGTAGTAGGGGGACACCAGGCAGCTATGCAAATGTT

186PV-Mn ....................................................................................................

192PV-Mn ....................................................................................................

214PV .............C.....................A............................T...................................

228PV ....................................................................................................

254PV ....................................................................................................

266PV ....................................................................................................

510 520 530 540 550 560 570 580 590 600

....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|

183PV-Mn AAAAGATACCATCAATGAGGAAGCTGCTGAATGGGATAGGTTACATCCAGCACAGGCCGGGCCTTATCCACCAGGGCAGCTGAGAGAACCAAGGGGAAGT

186PV-Mn ....................................................................................................

192PV-Mn ....................................................................................................

214PV ....................................................................................................

228PV ....................................................................................................

254PV ....................................................................................................

266PV ....................................................................................................

610 620 630 640 650

....|....|....|....|....|....|....|....|....|....|.

183PV-Mn GACATAGCAGGAACTACTAGTACCCTTGAAGAACAAGTAAGGTGGATGACA

186PV-Mn ...................................................

192PV-Mn ...................................................

214PV ...................................................

228PV ...................................................

254PV ......................A................G.A.........

266PV ...................................................


COMPARATIVE ANALYSIS OF HIV-1 SEQUENCES FOR THE GENE ENV, GP120 V3 LOOP REGION

10 20 30 40 50 60 70 80 90 100....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|

183PV-Mn GGCAGTCTAGCAGAAGAAGATGTAATGATTAGATCTGAAAATATCACAGACAATAGCAAAACCATAATAGTACAGCTTAATGAGCCTGTAAACATCACTT

192PV-Mn ....................................................................................................

214PV-Mn ....................................................................................................

225PV-Mn .........................................C..........................................................

227PV ....................................................................................................

228PV ....................................................................................................

110 120 130 140 150 160 170 180 190 200....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|

183PV-Mn GTATCAGACCTGGCAACAATACAAGAACAAGTATACGTATAGGACCAGGACAAACCTGGTATGCAACAGGTGCTATAACAGGGGACATACGAAAAGCACA

192PV-Mn ..........................................................................G.........................

214PV-Mn ..........................................................................G.........................

225PV-Mn ..........................................................................G.........................

227PV ..........................................................................G.........................

228PV ..........................................................................G.........................

210 220 230 240 250 260 270 280....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|...

183PV-Mn TTGTGAGGTCAACAGTACAGAATGGAATAGCTCTTTATACAAGATAAGTGAACAATTAAGAAAATACTTTATTAACAAAACAA

192PV-Mn ...C.............................................A.C......G........................

214PV-Mn ...............................A.................A........G........................

225PV-Mn ...............................A..........................G........................

227PV .................................................A........G........................

228PV .......................A.........................A........G........................


SLOW/LOW, M-, CCR5-TROPIC10 20 30 40 50 60 70 80

....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|

189PV-Mn VMIRSKNITDNSKIIIVQLPTPVNITCIRPGNNTRTSVRIGPGQAFFATGDIIGNPRKAHCNVNRTAWNEALQKISIQLKKYFPN

193PV-Mn .I...E..S....T...H.NET...............I......T.Y.......DI.......S.....ST.E..KT..AT..K.

196PV .....X.....X.......NN................I......T.Y.......DI.......S.AE..N......K..R...N.

210PV ...............................................................SK....NT.....K..RT..N.

231PV ...........G.......KD................I......T.Y.......DI.......S.AE..NT.....E..X...N.

232PV ...........G.......KD................I......T.Y.......DI.......S.AE..NT.....E..R...N.

236PV .....E.......N.....TE..S......A......Y......T.Y....V..D....Y...SKA...NT........R...D.

237PV ....X..............KD................I......T.Y.......DI.......S.AE..NT.....E..R...N.

239PV ...........G.......KD................I......T.Y.......DI.......S.AK..NT.....E..R...N.

226PV ...................NE..I.....N.......IP....R..Y....V.RDI.....E....E..ST.....AK.GX..NK

230PV .....E.F.....T.....A.H.K..X...N......IH.......Y....V..DI.......SKAE..N..YX..T..REH.K.

240PV ...........G.......KD................I......T.........DI.......S.AE..NT.....E..R...N.

242PV ...........................................................................T.........

208PV .....E.......V.....NKT...S...........I......T.Y....VT.DT......ISK.E..R...E..T..RES.K.

252PV .....E.......V.....NKT...S...........I......T.Y....VT.DT......ISKAE..G...E..KE.R.H.E.

253PV ...........G.......KD................I......T.Y.......DI.......S.AE..NT.....E..R...T.

255PV ...........G.......KD................I......T.Y.......DI.......S.AE..NT.....E..R...N.

AF061590 A904703 .....E.....G.......TE................I......T.Y....V..DI...Y...S.A...ST.....T..R...N.




11/S 25/D


PHYLOGENETICAL ANALYSIS BY THE GENE GAG (P17 / P24)

(SAMPLES FROM MINSK AND SVETLOGORSK, 1996)

183P

V-M

n19

2P

V-M

n

25

1P

V228P

V266P

V

186P

V-M

n

214P

V254P

V97

225P

V99

207P

V202P

V205P

V212P

V206P

V215P

V24

7PV 23

8PV

246P

V

93

73

208P

V26

7PV

99

252P

V50

2HIV

98

96

627R

es-G

omO

bl

AY8704

93 A

A04_0

530

222P

V

204PV

236PV

239PV

9997

AY870492 AA04_0496

A1.KZ.2002.0

2KZKAR300435.EF589042

515HIV03_AB.S

E.2010.THS-28.JQ229744

AY870506 AA04_0730

A1.RU.2006.RU_915_1035.JQ292897

A1.RU.2006.RU_SP_B_049.JQ292900

A1.RU.2006.RU_915_1016.JQ292896

03_AB.BY.2000.98BY10443.AF413993

03_AB.BY.2000.98BY10443.AF413991

03_AB.BY.2000.98BY10443.AF413992

03_AB.BY.2000.98BY10443.AF414006

98

A1.CY.2006.CY173.EU673442

A1.CY.2006.CY173.FJ388951

96AY870491 AA04_0491

AY870497 AA04_0624

AY870498 AA04_0625

92507HIV

508HIV98

226PVAY870499 AA04_0685AY870505 AA04_072383

AY870509 AA04_0775AY870509 AA04_077599

A1.UA.2001.01UAPol294.DQ823356

A1.UA.2001.01UAPol293.DQ823359

A1.UA.2001.01UAPol303.DQ823360

A1.UZ.2002.02UZ0663.AY829210

A1.UA.2001.01UAKV254.DQ823361

A1.KZ.2002.02KZPAV300480.EF589043

AY870490 AA04_0488

AY870504 AA04_0721

A1.KZ.2002.02KZYUZ300413.EF589040

A1.KZ.2002.02KZYUZ300425.EF589041

A1.KZ.2002.02KZPAV300497.EF589039

A1.RU.2005.RU_560_1125_JA.JQ292895

A1.RU.2002.RU01029.JQ292892

A1.RU.2010.10RU6617.JX500696

AY870494 AA04_0537

AY870500 AA04_0686

03_AB.RU.1997.KAL153_2.AF193276

03_AB.RU.1998.RU98001_98RU001.AF193277

A1.UZ.2002.02U

Z698.AY829206

A1.UZ.2002.02U

Z740.AY829208

A1.U

Z.2002.02UZ0659.A

Y829209

A1.U

Z.2002.02UZ0667.A

Y829211

A1.U

Z.2002.02UZ652.A

Y829203

A1.U

Z.2002.02UZ694.A

Y829205

A1.U

Z.2002.02U

Z0672.A

Y829212

A1.U

A.2000.98U

A0116.A

F413963

A1.R

U.2003.03R

U20_06_13.A

Y500393

A1.B

Y.1997.97B

L006.AF193275

A1.C

Y.20

05.C

Y05

8.EU

6734

26

A1.C

Y.2

005.C

Y057.E

U673425

A1.C

Y.2

005.C

Y057.F

J388906

99

95

193P

V-M

n

242P

V

99

A1.R

U.2

008.R

UA

007.JQ

292894

AY

870495 A

A04_0595

A1.R

U.2

007.Irku

tsk_5.JQ

292891

219P

V248P

V

AY

870496 A

A04_0604

A1.U

A.2

001.0

1U

AD

N139.D

Q823357

A1.C

Y.2

006

.CY

17

1.E

U67

34

40

A1.C

Y.2

006

.CY

17

1.F

J38

89

50

99 A1.U

A.2

001

.01

UA

OD

89

.DQ

82

33

67

19

1P

V-M

n

19

5P

V

A1.R

U.2

010

.10

RU

67

92

.JX

50

06

95

A1.C

Y.2

007.C

Y213.J

F683763

A1.C

Y.2

008.C

Y231.J

F683780 9

0

213P

V

217P

V-M

n249P

V

250P

V

99

209P

V

211P

V

99

AY

870502 A

A04_0700

234P

V

199P

V

265P

V

99

253P

V

190P

V-M

n

241P

V-M

n23

1PV

240P

V-M

n

196P

V

237P

V-M

n

200P

V

232P

V

203P

V255PV 99

89

227PV264PV486M

S487MS

99

521HIV

210PV

263PV

B.US.1998.98USHVTN8229c6.AY560109


224PVB.CA.-.B

CCFE_HOMER_HIV_GAG_3177.EU242234

AY870507 AA04_0735

B.US.-.S5571TOB8U.GQ371605


B.US.2007.pt13t1s135.HQ249700

B.US.2008.pt13t2s024.HQ250035

B.US.2007.pt13t1s039.HQ249685

B.US.2008.pt13t3s057.HQ250435

B.US.2007.pt13t1s048.HQ249692B.US.2008.pt13t2s020.HQ250149B.US.2008.pt13t3s124.HQ250727

92


AY870503 AA04_0708

B.KR.2004.04KJin8_1955.DQ295195

B.US.2006.22.HM116823

B.US.1986.gag71.KF701709

B.US.1985.gag27.KF701669

B.US.1986.gag72.KF701710

B.ZA.1985.R84.FJ647145

B.TH.1997.97TH50.AF196648

B.US.2007.07US_SAJ_NVS55.JF689893

B.US.-.9CP_1031.AY786866

B.US.1984.gag287.KF701891

B.US.1998.WC3_0498_2.EF175210

B.US.1998.WC3_0498_4.EF175212

B.US.1993.WC3_1093.EF121388

B.US.1992.WC3_0892.EF121386

B.US.1993.WC3_0393.EF121387

747199

B.US.1984.gag281.KF701886

B.US.1986.AD87_ADA.AF004394

B.US.1989.gag210.KF701833

B.US.2006.630865_timepoint_2.G

U561301

B.CA.1998.CANB5FULL.AY779555

B.DK.1996.6_bPI_pre.AM

933529

B.US.1987.gag116.KF701749

B.FR.2012.D

.KC899335

B.C

A.-.B

CCFE

_HOM

ER_H

IV_GAG_3175.EU

242232

B.U

S.2007.502_0287_LH

2.JF320400

B.U

S.2007.502_2586_LH

03.JF320137

B.U

S.2007.502_2586_LH

06.JF320139

B.U

S.2007.502_2586_LH

01.JF320133

B.U

S.2007.502_2586_LH

07.JF320132

99

B.U

S.1989.gag192.K

F701817

B.U

S.1989.gag194.K

F701818

B.U

S.19

88.ga

g167

.KF70

1795

B.C

A.-.B

CC

FE

_H

OM

ER

_H

IV_G

AG

_3103.E

U242160

B.U

S.1

988.g

ag145.K

F701776

B.U

S.1

987.g

ag102.K

F701736

B.U

S.1

984.g

ag335.K

F701926

99

0.01


PHYLOGENETICAL ANALYSIS OF GENE ENV, GP120 V3 LOOP (SAMPLES FROM MINSK AND SVETLOGORSK, 1996)

A1.E

E.2

005.S

21

A1.R

U.2

006

.RU

_9

15

_1

00

5_

C2

A1.R

U.2

008

.SA

L2

1

A1.R

U.2

006.R

U_S

P_B

_049

A1.R

U.2

006.0

6_R

U_S

P_R

163_Io

rII_

44

A1.R

U.2

011.R

U_Y

EK

B26588

03_A

B.R

U.2

002.2

002_2732

A1.R

U.2

002.0

2_R

U_S

P_H

408_IV

_B

08

A.R

U.-

.patie

nt_

2082

AY

870470 A

A04_0624

AY

870471 A

A04_0625

98

186P

V-M

n

A1.

LT.-.1

23

85

A1.

UZ.2

002.

02U

Z06

67

AY87

0469

AA04

_060

4

AY87

0464

AA04

_049

6

AY87

0486

AA04

_073

0

AY8704

75 A

A04_0

685

A1.LV.2

001.01LV_N0731

AY870474 AA04_0684

A1.AU.-.

AUS_1

AY870481 AA04_0706

AY870463 AA04_0492

AY870467 AA04_0590

189PV-Mn

242PV

100

210PV

100A1.RU.2003.03RU1062

191PV-Mn

236PV

230PV

99A1.LV.1998.98LV_MSM015_1998_V3

A.RU.1996.RU1175_c14

AY870483 AA04_0715AY870461 AA04_0488A.LV.2001.01LV_K612

A.SE.2000.SE_P35.21525AY870465 AA04_0506

A.CZ.-.CZ76799

A1.LV.2002.02LV_HET029_2002_V3

A.RU.-.patient_2080

AY870466 AA04_0537

AY870476 AA04_0686

AY870472 AA04_0645

AY870473 AA04_0683

80

A1.RU.2007.RU_21_07_A10

A.CZ.-.CZ79990

A1.CY.2008.CY231

A1.LV.2003.03LV_MSM

023_2003_V3

A1.LV.2003.03LV_HET043_2003_V3

A1.LV.2005.05LV_IDU_S2144_2005_v3_A1

AY870488 A

A04_0739

AY870489 A

A04_0775

AY870468 A

A04_0595

AY870485 A

A04_0723

A1.R

U.2008.R

UA

004g

195P

V-M

nA

1.U

A.2

001.0

1U

AK

V254

231P

V

255P

V

232P

V

240P

V

239P

V

237P

V253P

V196P

V

99

61

7R

es

A1.K

Z.2

002

.02

KZ

PA

V30

05

02

19

0P

V-M

n

AY

87

04

80

AA

04

_0

70

0

235P

V234P

V 182P

V-M

n213P

V-M

n

258P

V

72

249P

V250P

V

80

93 1

00

208P

V

252P

V

100

230P

V

AY87

0462

AA04

_049

1

486M

S

487M

S

89

A1.

CY.2

005.

CY05

8

A1.CY.2

005.

CY05

7

218P

V-Mn

AY870484 AA04_0721

184PV-Mn

185PV-Mn

93

207PV-Mn

206PV247PV 88215PV-Mn217PV

96

70188PV-Mn248PV212PV-Mn202PV-Mn187PV-Mn246PV259PV

70

89

79

A1.KZ.2002.02KZKAR300435226PV

A1.RU.2008.08_RU_SP_R053_V_D5

AY870477 AA04_0687

A1.RU.2006.RU_915_1080_A4_4193PV-Mn

241PV

99

183PV-Mn

225PV-Mn

214PV-Mn

227PV

192PV-Mn

228PV

7478

100

219PV-Mn

221PV-Mn

99

223PV-Mn

224PV

B.FR

.2005.DEM

B05FR

001

AY870478 A

A04_0690

AY870482 A

A04_0708

AY870479 A

A04_0692

B.N

L.1987.19663_9G6

B.C

H.2005.Z

PH

I78_32

B.U

S.2

005.0

5U

S_S

AJ_

NV

S8

AY

870487 A

A04_0735

B.S

E.-.2

242_63_2_6

B.S

E.-.2

242_64_1

97

98

0.05


PHYLOGENETICAL ANALYSIS OF HCV AT GENE CORE / E1 REGION

AF

165053 1

bA

F16

50

54

1b

10

0

AF

165055 1

b

93

KL-1

42

HC

V-1

378-M

nH

CV

-1435-M

nM

S-1

56-M

n

185P

V

1459

AH

CV

_Mn

KL-

102-

Mn

HC

V-1

374-

Mn

HCV-1

374a

-Mn

100

188P

V

1452HCV_M

n

99

MS-2

30-Mn

MS-1

05-Vit

AY045702 HCR6

AF165052 1b

AF165051 1b

100239PV

D50480 HCV-1b

1456HCV_Mn

HCV-1369a

HCV-1398-Mn

MS-226-Mn

199PV

208PV1454HCV_Mn247_PV_MnHCV-1427-Mn

97

100AF139594 1b264MS_Mn

76

300MS_GrObl

303MS_Mn

289MS_Gm

301MS_Mn

302MS_M

n

301aMS_M

n

338MS_M

n

98

226PV

490MS

100184P

V

82

187PV

189P

V

99

M67463 1

a

83

209P

V

233P

V

230P

V

237P

V

23

4P

V

24

0P

V

10

0

73

100

100

25

0_

PV

_M

n

JX227971 4

g

NC

_009825 4

JX227979 4

o

EF

589161 4

f

78

10

0

NC

_009826 5

EF424628 6

l

EF42

4629

6c

84

NC

_009

827

6

DQ

4805

12 6

a

DQ

4805

13 6

a 100

97

100

JX22

795

3g

JX22

7955

3i

81

192PV206PV

198PV190PV202PVHCV-1394-Mn

200PV194PV

228PV91HCV-1397-Mn

441MS191PV_Mn

486MS

AB691595 3a

D28917 3a

258PV

HCV-1401-MnObl

252_PV_Mn

JX826592 3a-2a

NC_009824 3

87

9796 99

JX227952 2k/1b

JX227953 2k

100

JX227968 2m

JX227951 2c

80

AF238486 2b

AB690461 2a

NC_009823 2

AF238485 2a

AF238484 2a

AF238482 2a

AF238483 2

aA

F238481 2

a

98100

100

0.05


PHYLOGENETICAL ANALYSIS OF HCV AT NS5 GENE REGION

182P

V23

9M

S_M

n

200P

V

232P

V

183P

V

265P

V97

190P

V26

0PV

228P

V19

2PV

1648

HCV

191P

V

202PV1431_HCV-U

KR

1421_HCV-MnObl

91 1394_Mn

217PV

223PV

1397_Mn

198PV

AB691595 3a

23MS_Mn

24MS_Mn96

186PV

96

251PV

205PV248PV

78

NC_009824 31382_Mn12MS_Mn213PV1460HCV_Mn195PV

1401_MnObl-Sol238PV266PV

83

258PV

D28917 3a

100

JX227979 4o

JX227971 4g

EF589161 4f

250PV

NC

_009825 4

80100

86

EF

424628 6l

EF

424629 6c

NC

_009827 6

DQ

4805

12 6a

DQ

48

05

13

6a

10

0

85

7195

79

32

MS

_M

n

AF

13

95

94

1b

72

JX22

7952

2k/

1bA

F16

5052

1b

AF

1650

51 1

b 99

199P

V

D50

480

HC

V-1

b

AY

0457

02 H

CR

6

AF1

6505

5 1b

AF1

6505

3 1b

AF1

6505

4 1b 99

36M

S_Mn

1374_Mn

1408_Mn

100

187PV

264PV184PVM67463 1a4

90MS

76233PV244PV

71

209PV237PV

236PV230PV

255PV

212PV

240PV

1440_HCV-Mn

234PV

246PV

91

100

98

NC_009826 5

AF238486 2b

JX227951 2c

JX227953 2k

90

JX227968 2m

NC_009823 2

JX826592 3a-2a

AB690461 2a

AF238485 2a

AF238484 2a

AF238481 2a

AF238483 2a

AF

238482 2a

99

93

100

0.05


HIV-INFECTED PATIENTS WERE INFECTED WITH THE HEPATITIS C VIRUS

BEFOREenv region HIV-1

HCV 1a

HCV 3a


0

5

10

15

20

25

30

1a 1b 3a 4d

15

6

30

1

ca

ses

subgenotypes

HCV subgenotypes distribution in HIV-infected patients, n=52


PHYLOGENETIC ANALYSIS OF HBV GENES S AND P REGION

196P

V20

3P

V

87

AB

109475 D

ayw

3

75

EU

594429 D

2

489M

S489M

S

98

709H

BV

-Mn

EU

594427 D

2G

Q477452 D

269

2-G

om46

5MS

-Vit

742H

BV

-Gom

466M

S-V

it

467M

S-V

it

72

738H

BV-M

n

774H

BV-Gom

Zhl

773H

BV-Mn

745HBV-Mn

695-Mn

736HBV-Mn

775HBV-MnObl

460MS-Vit

734HBV-Mn

748HBV-Gom

JX125384 D2

80708HBV-Mg

GQ377589 D1 ayw2 J145

AB263404 MonB04-009E

JQ518287 D1

AB104709 D ayw2 EG64

AY796032 ayw D

776HBV-Ukr

706HBV-Mn464MS-Vit

73

JX470760 D3AY233291 D ayw2746HBV-Mn

749HBV-Mn-Det730HBV-Mn148KL149KL698-Gom

697

EU594382 D3 3798-91488MS

488MS

95

693

732HBV-M

n

740HBV-M

n

771HBV

-Mn

71

81

FJ904394 D7 DQ

995846 D pol

HE974373 D

4

FJ692533 D

4

8377

96

421MS

-Vit

AF297620_A

D

83 AM

494689 E

Africa

X75664 E

, Kou

GQ

161755 E

GU

1694

AB

194948 E

CM

R936

AB

091256 E

AB

I-212

EU

239217 E

G2451

AP

00

72

62

E H

B-JI4

11F

100

AB

37

51

65

G M

EX

ICO

8-G

DQ

20

77

98

G N

28

29

AB

05

65

13

G U

SG

17

88

GQ

325762 G

pol

EF

464097 G

06hac

10

0

FJ0

23664 I_M

04-0

026

GQ

486349 I p

ol

AB

231908 I H

BV

-VH

24 93

92

AB

367392 C

LA

Mr

Pt

GQ

3257

82 C

2

GQ

3775

28 C

adw

1 J2

9

70

GQ

4862

41 C

(po

l)

72

FJ0

2364

7 C

AB11

7758

C H

BV-C

B10

99

DQ

0897

56 C

HK75

AB64

4282

B-C

Jap

an

9811

1HBV_M

g

95

GQ

486038 B p

ol

AB073833 B H

BV-Chi5

9

82

GQ325779 B

AB493827 B 2

5UC

FJ023631 B2

U87747 B adw2

AB205122 B HBV-VH69-1

100FJ692555 A5

GQ486194 A GS159 pol

FM199974 A 45021

DQ315784 adw2 Aa EI03101

FJ692558 A1

79694-Mn

AY707087 adw A426_MS_MnAB116076 A HBV-USA1911

479MS

750HBV-Mn

AB116079 A HBV-TR1

471MS-Vit

462MS-Vit98

744HBV-Mn

737HBV-Mn

696-Gom

GQ477460 A

741HBV-Mn

747HBV-Mn

87

95

92

10

0

AB375159 H MEX8-H

AB064315 H US1122

AB179747 H HB-JBDH1

AY090457 H 2928Nic

GQ

486268 H pol

100

AB064316 F US2573

EU670260 F 453

81

AB116654 F JP

NTA

KA

100

AY311369 F

BD

4139

X69798 F

adw4

AY

090455 F 1889N

ic

98

AB

116549 F P

AN

AM

5

AB

365446 F

BO

L3

X75658 F

Fou

100

76

80

98

0.01


CONCLUSION:

- THE OUTBREAK OF HIV INFECTION IN MINSK WAS ASSOCIATED

WITH NEW SYNTHETIC DRUGS WITH AN INTRAVENOUS ROUTE OF

ADMINISTRATION;

- THE HIV OUTBREAK IN MINSK IS CAUSED BY THE “DOMESTIC"

A1 SUBTYPE;

- AT LEAST SEVEN DIFFERENT SOURCES OF INFECTION HAVE BEEN

IDENTIFIED;

- ALL HIV-INFECTED ARE CO-INFECTED WITH THE HEPATITIS C

VIRUS;

- IN MOST OF THE ANALYZED CASES, HIV-INFECTED PATIENTS

WERE INFECTED WITH THE HEPATITIS C VIRUS BEFORE;

- TWO PATIENTS WERE INFECTED WITH THE SAME D2

SUBGENOTYPE OF HEPATITIS B VIRUS;Ljubljana, Slovenia 27-28 September 2017

HIV INFECTION OUTBREAK AMONG IDUS IN...

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