History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life...
Transcript of History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life...
![Page 1: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/1.jpg)
History of Particle Therapy
Proton and Carbon Ion Beam
May 17, 2011
![Page 2: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/2.jpg)
Basis for Interest in 1H and 12CSuperior Distribution of
Biologically Effective Dose: Finite Range
May 17, 2011
Biologically Effective Dose: Finite Range
12C: High LET
![Page 3: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/3.jpg)
Interest in Particle Beam Therapy
May 17, 2011
![Page 4: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/4.jpg)
Particle Beam Centers Dec 2010
Status 1H 12C
Active 30 4
May 17, 2011
Active 30 4
Planned 17 4
![Page 5: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/5.jpg)
Particle Beam Treated Patients
Protons 67097C-ions 7151He 2054 Other Ions 1973
May 17, 2011
Other Ions 1973
Total 78275Jarmann 2011
![Page 6: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/6.jpg)
May 17, 2011
The Proton
![Page 7: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/7.jpg)
Protons: Dominant Particle of the Universe
∼∼∼∼1080+ Protons T1/2 ≥≥≥≥1035 yr
May 17, 2011
Age of Universe is ~10 -25 of T1/2
of Protons
![Page 8: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/8.jpg)
Creation of Protons
Quarks and Gluons at 10 -12 to -6 sec
Combined to Form Protons and
May 17, 2011
Combined to Form Protons and
Neutrons at 10 -6 to ∼∼∼∼1 sec
![Page 9: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/9.jpg)
Protons
Large Number of Quark Anti-quark
Pairs, Interacting with Gluons
May 17, 2011
Pairs, Interacting with Gluons
Life Span of Q Anti Q Pairs ∼∼∼∼ 10-23 sec
![Page 10: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/10.jpg)
1H: Nucleus of Hydrogen Atom
Constituent of Nucleus of All Atoms
Determines: Atomic Number
May 17, 2011
Determines: Atomic Number
Number of Electrons
Chemical Properties
![Page 11: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/11.jpg)
Wm Prout 1775 -1850 http://en.wikipedia.org/wiki/
May 17, 2011
![Page 12: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/12.jpg)
Prout Hypothesis
Atomic Weights are Whole -Number
Multiples of the Atomic Weight of
May 17, 2011
Multiples of the Atomic Weight of
Hydrogen. 1815, 1816
![Page 13: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/13.jpg)
Sir W. H. Bragg
May 17, 2011
![Page 14: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/14.jpg)
Bragg Peak
WM H Bragg 1904 Adelaide, Australia.
Determined Ionization Density of Air
May 17, 2011
Determined Ionization Density of Air
↑↑↑↑ at End of Range Ra αααα Rays
![Page 15: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/15.jpg)
W H Bragg 1912
May 17, 2011
![Page 16: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/16.jpg)
Proton Discovery
May 17, 2011
![Page 17: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/17.jpg)
Eugen Goldstein
Kanalstrahlen Particles 1886
Passing Through Holes in Cathode
May 17, 2011
Passing Through Holes in Cathode
∴∴∴∴Positive Charge
![Page 18: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/18.jpg)
May 17, 2011
![Page 19: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/19.jpg)
Wilhelm Wien
Kanalstrahalen 1898
Positive e/m~104
May 17, 2011
Positive e/m~104
![Page 20: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/20.jpg)
JJ Thomson
1907 and 1913
Confirmed Wien’s Report
May 17, 2011
Confirmed Wien’s Report
![Page 21: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/21.jpg)
Ernest Rutherford
May 17, 2011
![Page 22: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/22.jpg)
Rutherford 1899
Uranium 2 Radiations:
αααα Short Range in Air +
May 17, 2011
β Much Longer Range -
Cavendish Lab ER was 26 y/o
![Page 23: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/23.jpg)
Natural Alchemy 1903
Emission of αααα or β- Particles
Results in New Element with its
May 17, 2011
Results in New Element with its
Distinct Chemical Characteristics
![Page 24: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/24.jpg)
E Rutherford 1919
Nitrogen is Disintegrated by a Swift αααα
The Liberated H Atom was a
May 17, 2011
The Liberated H Atom was a
Constituent of the N Nucleus
![Page 25: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/25.jpg)
May 17, 2011
![Page 26: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/26.jpg)
PMS Blackett
1925 Wilson Cloud Chamber
1st Visualization of Disruption of an
May 17, 2011
1st Visualization of Disruption of an
Atomic Nucleus: αααα→ N →→→→ 17O + H+
![Page 27: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/27.jpg)
Blackett 1925
May 17, 2011
![Page 28: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/28.jpg)
Rutherford 1920
Proposed an Electrically Neutral
Particle and Named it Neutron
May 17, 2011
Particle and Named it Neutron
Chadwick Discovered Neutron 1932
![Page 29: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/29.jpg)
Transmutation of Li 1932
Cockcroft and Walton Accelerator
1st Artificial Alchemy
May 17, 2011
1st Artificial Alchemy
800 KeV H+ →→→→ Lithium →→→→ Two He
1st Splitting of an Atom
![Page 30: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/30.jpg)
Paul Dirac
May 17, 2011
![Page 31: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/31.jpg)
Paul Dirac
1928 Theoretical Basis for Anti Matter.
Symmetry in Nature
May 17, 2011
Symmetry in Nature
Predicted Positron and Anti Proton
Discovered 1932 1955
![Page 32: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/32.jpg)
May 17, 2011
![Page 33: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/33.jpg)
Lawrence, 1928
May 17, 2011
![Page 34: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/34.jpg)
184 MeV in Cyclotron LBL 1962
May 17, 2011
![Page 35: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/35.jpg)
1932
Radioactivity, αααα, ββββ, Electron, Alchemy,
Photon, Proton, Neutron, Positron,
May 17, 2011
Photon, Proton, Neutron, Positron,
Model of Atom, Splitting of Atom
![Page 36: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/36.jpg)
May 17, 2011
![Page 37: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/37.jpg)
Particle Radiation Therapy
May 17, 2011
![Page 38: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/38.jpg)
Robert Wilson
Proposed Protons and Heavier
Particles for Radiation Therapy
May 17, 2011
Particles for Radiation Therapy
SOBP 1946 Radiology
![Page 39: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/39.jpg)
May 17, 2011
![Page 40: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/40.jpg)
Spread Out Bragg Peak Koehler and Preston 1972
May 17, 2011
![Page 41: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/41.jpg)
1H and 12C SOBPWilkens GSI 2011
May 17, 2011
Wilkens and Oelfke 2008
![Page 42: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/42.jpg)
IMPT (GyRBE)IMXT (Gy)
May 17, 2011
![Page 43: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/43.jpg)
Particle RBE
May 17, 2011
![Page 44: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/44.jpg)
Proton RBE
Mean RBE for in vivo Studies
1.10
May 17, 2011
1.10
ICRU: Use 1.10 as a Generic RBE
![Page 45: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/45.jpg)
RB
E
1.5
2.0
2.5
In Vivo Paganetti, etal
May 17, 2011 Dose [Gy]
1 100.5
1.0
![Page 46: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/46.jpg)
12C ion RBE RBE is Quite VariableFunction of: LET
Dose, Dose Rate
May 17, 2011
Dose, Dose Rate Cell Line, TissuepO2
Depth
![Page 47: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/47.jpg)
High LET an Advantage?
An Intrinsic Differential RBE
Normal vs Tumor Cells at Defined pO ?
May 17, 2011
Normal vs Tumor Cells at Defined pO 2?
No Supporting Data
![Page 48: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/48.jpg)
May 17, 2011
Ando etal, Chiba
![Page 49: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/49.jpg)
Spinal Cord Injury
May 17, 2011 •Karger at al., 2006
![Page 50: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/50.jpg)
12C: RBEα/α vs. Remaining Range
5
6
7
8
9
C: R
BEα
/α
M10
SCC25
SQ20B
V79
May 17, 2011
0
1
2
3
4
0.11101001000
Remaining Range (mm)
12C
: RB
E
Belli et al 2008
![Page 51: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/51.jpg)
OERSF0.1 and RBESF0.1 vs. LET of HSG Human Cell
2
3
4
OERSF0.1 and RBESF0.1 vs. LET of HSG Human Cell
May 17, 2011
1
2
10 100 1000
LET (keV/µm)OER RBE
20 40 80 200 500
• Y.Furusawa et al., 2000
![Page 52: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/52.jpg)
RBE at Center of 12C SOBP
SOBP (mm) Clinical RBE30 2.840 2.6
May 17, 2011
40 2.660 2.480 2.3
100 2.2120 2.1
![Page 53: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/53.jpg)
Clinical Studies on Proton
Stereotactic Radiosurgery
May 17, 2011
Stereotactic Radiosurgery
1954-Present
![Page 54: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/54.jpg)
Stereotactic Proton Radiosurgery
UC Berkley 1955
Uppsala 1957
May 17, 2011
Harvard 1961
Dubna 1964
Moscow 1969
![Page 55: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/55.jpg)
C Tobias
May 17, 2011
![Page 56: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/56.jpg)
C Tobias LBL
1952 1st Rad Biol Study of ProtonsLD50 of Rat
May 17, 2011
1954 1st Proton RT of Pituitary of Dog
1957 1st Report of PRT of Humans
![Page 57: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/57.jpg)
Particle Beam Therapy
Carbon, Oxygen and Neon 1975
May 17, 2011
J Castro, T Phillips etal LBL
![Page 58: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/58.jpg)
Fractionated Dose Particle Therapy
1973-Present
May 17, 2011
Potentially Curable Cancer
Patients
![Page 59: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/59.jpg)
MGH Rad Oncology and HCL
1973. Commenced 1.8 -2.1
1973.GyRBE/Fraction
May 17, 2011
1973.GyRBE/Fraction
Single Variable: Dose distribution
![Page 60: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/60.jpg)
May 17, 2011
![Page 61: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/61.jpg)
May 17, 2011
![Page 62: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/62.jpg)
Checking Portal Film on 1 st
Patient Fractionated PRT
May 17, 2011
![Page 63: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/63.jpg)
May 17, 2011
![Page 64: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/64.jpg)
May 17, 2011
![Page 65: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/65.jpg)
May 17, 2011
Fig. 7. a, b and c
![Page 66: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/66.jpg)
Positive Aspects of Particles Gantry, Same Options as for Linac X
rays:
May 17, 2011
Beam NumberDirectionWeighting Modulation4D IGRT
![Page 67: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/67.jpg)
May 17, 2011
![Page 68: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/68.jpg)
Michael Goitein
Computer Based Treatment Planning
Dose Volume Histogram
May 17, 2011
Dose Volume Histogram
Beams Eye View
![Page 69: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/69.jpg)
Michael Goitein
Digital Reconstructed Radiograph
Uncertainty Band on CTV, GTV etc
May 17, 2011
Uncertainty Band on CTV, GTV etc
Correction for Density Heterogeneity
![Page 70: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/70.jpg)
G T Y Chen etal MGH
4 D CT
4D Image Guided Therapy
May 17, 2011
4D Image Guided Therapy
![Page 71: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/71.jpg)
Initial Study: March 2001
May 17, 2011 JHKFlat Couch Top
![Page 72: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/72.jpg)
Standard CT of Moving 6 cm Ball
May 17, 2011
![Page 73: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/73.jpg)
4D CT Lung Ca
May 17, 2011
![Page 74: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/74.jpg)
12C ion Therapy Less Late Morbidity than after Fast Neutron Therapy.
May 17, 2011
Superior Dose Distribution
Lower LET Higher OER 2.2 -2.6 vs 1.7
![Page 75: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/75.jpg)
Skull Base Chordoma 5 Yr LC
Beam # Pts BED Local RefControl
1H 42 72 81% Ares
May 17, 2011
1H 42 72 [38] 81% Ares
12C 84 75 [20] 63% Schulz12 96 100% Ertner19 89 [16] 100% Mizoe
![Page 76: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/76.jpg)
Sacral Chordoma 4-5 Yr LC
Beam # Pts BED Local RefControl
1H 9 77 87% De
May 17, 2011
1H 9 77 87% DeLaney
12C 95 113 88%
![Page 77: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/77.jpg)
Spinal Chordoma: Post Op Metallic Implants Local Failure
Yes 5/13
May 17, 2011
Yes 5/13
No 0/13p=0.03Rutz etal 2007
![Page 78: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/78.jpg)
Skull Base Chondrosarcoma4-5 yr LC
Beam # Pts BED Local RefControl
May 17, 2011
1H 200 70 99% Rosenberg
12C 54 75 90% SchulzErtner
![Page 79: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/79.jpg)
Uveal Melanoma
4505 Patients MGH PSI
Local Control 95% at 10 yrs
May 17, 2011
Retained Eye 94% at 5 yr
Chiba57 Patients LC 97% Eye Retained 95%
![Page 80: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/80.jpg)
Adenoid Cystic Ca
Beam #Pts BED LC Ref
1H + X 23 70 93% Pommier
May 17, 2011
H + X 23 70 93% Pommier3 yr
12C 90 70 79% Mizoe5 yr
29 72 78% Schultz -4 yr Ertner
![Page 81: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/81.jpg)
SCC H/N 5 yr LC
Beam #Pts BED LC Ref
1H + X 16 74 88% Slater
May 17, 2011
1H + X 16 74 88% Slater
12C 15 70 56% Mizoe
![Page 82: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/82.jpg)
Hepatocellular Ca 5 yr LC
Beam # Pts GyRBE Local RefControl
1H 162 72[16] 87% Chiba
May 17, 2011
H 162 72[16] 87% Chiba
12C 47 52.8 [4] 96% Imada
![Page 83: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/83.jpg)
Prostate Ca Beam # Pts GyRBE bDFS Ref1H 196 79[44] 83% Ziet-
T1b2b 10yr man
May 17, 2011
12C 295 84[20] 92% TsujiiT1-2 5 yr
Xray 785 Fav 81[46] 85% Zelef-924 Intmed 76% sky
8 yr
![Page 84: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/84.jpg)
70%
80%
90%
100%Lo
cal C
ontro
l at 5
yea
rs
Chordoma of Skull Base
May 17, 2011
40%
50%
60%
50 60 70 80 90 100
BED (α/βα/βα/βα/β=2)
Loca
l Con
trol a
t 5 y
ears
. . .12C 1H X
![Page 85: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/85.jpg)
70%
80%
90%
100%bN
ED
at 5
yea
rs
Prostate Carcinoma
May 17, 2011
40%
50%
60%
50 60 70 80 90 100
BED (α/βα/βα/βα/β=2)
bNE
D a
t 5 y
ears
. .12C 1H + X
![Page 86: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/86.jpg)
12C 1H Skull Base BED TCP
% BED TCP
% 75 63 72 81 Chordoma
Overlap of BED and TCP
May 17, 2011
75 63 72 81 Chordoma 70 60 68 59
75 90 70 99 Chond ro sarcoma 66 94
![Page 87: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/87.jpg)
Tumor 12C 1H BED] TCP% BED TCP% SCC [H/N] 70 56 74 88 ACC [H/N] 70 79 70 93
Overlap of BED and TCP
May 17, 2011
ACC [H/N] 70 79 70 93 74 81 84 88 HCC 67 86 83 87
![Page 88: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/88.jpg)
Special 12C Results Tsujii
Mucosal Malignant Melanoma 84%
Renal Cell Carcinoma 100%
May 17, 2011
Renal Cell Carcinoma 100%
Retroperitoneal Sarcoma 69%
![Page 89: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/89.jpg)
1H vs 12CHigher 12C TCPs Reflect Higher Doses
in an Important Fraction of Sites
May 17, 2011
in an Important Fraction of Sites
![Page 90: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/90.jpg)
May 17, 2011 Suit and Wolfgang
![Page 91: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/91.jpg)
May 17, 2011
![Page 92: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/92.jpg)
May 17, 2011
![Page 93: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/93.jpg)
May 17, 2011
![Page 94: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/94.jpg)
Depth Dose Curves for 1H and Xray Beams
May 17, 2011
![Page 95: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/95.jpg)
May 17, 2011A Trofimov 2010
![Page 96: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/96.jpg)
Particle Beam Centers
Proton LBL 1954Uppsala 1957
May 17, 2011
MGH/HCL 1961Moscow 1965Lenningrad 1967
![Page 97: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/97.jpg)
Particle Beam Centers
Pion Los Alamos 1974Triumf 1979
May 17, 2011
PSI [SIN] 1980
![Page 98: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/98.jpg)
Particle Beam Centers
12Carbon Ion LBL 1975Chiba 1994
May 17, 2011
Darmstadt 1997
![Page 99: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/99.jpg)
May 17, 2011
![Page 100: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/100.jpg)
6
8
10
12
Pen
umbr
a (9
5%-5
0%)
(mm
) 100 MeV Proton150 MeV Proton200 MeV Proton186 MeV/µ Carbon285 MeV/µ Carbon386 MeV/µ Carbon
6 MV x-ray
May 17, 2011
May 3 2011 May 3 2011 PRCOG Slides
0
2
4
0 5 10 15 20 25 30
Depth in Water Phantom(cm)
Pen
umbr
a (9
5%-5
0%)
(mm
)
![Page 101: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/101.jpg)
Lateral Scattered Dose
Proton (published Q), photon and carbon
10
100
Dos
e E
quiv
ale
nt (m
Sv/
Gy)
.
.
Proton PEM
Proton PBS
6MV IMXTCarbon
May 17, 2011
0.01
0.1
1
0 50 100 150 200
Distance from field edge (cm)
Dos
e E
quiv
ale
nt (m
Sv/
Gy)
.
.
Carbon
![Page 102: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/102.jpg)
May 17, 2011 Webber and Kraft,2009
![Page 103: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/103.jpg)
Patients Treated by 1H and 12C
60000
80000 P
atie
nts
1H
May 17, 2011
0
20000
40000
1994 1998 2002 2006 2010
Years
Pat
ient
s
12C Jarmann
![Page 104: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/104.jpg)
Alchemy
1903 Natural as in Radioactivity Decay
May 17, 2011
1919 αααα Particle Induced N →→→→ 17O
1932 Accelerated H + →→→→ Li →→→→ αααα + αααα
![Page 105: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/105.jpg)
Carl Anderson: Positron 1932
May 17, 2011
![Page 106: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/106.jpg)
Stockholm and Uppsala
Proton Radiation Therapy 1957
Stereotactic Radiosurgery
May 17, 2011
Stereotactic RadiosurgeryPhoton and Proton
Inverse Planning γγγγ50
![Page 107: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/107.jpg)
MGH Neurosurgery and HCL
1961
Stereotactic Radiosurgery of
May 17, 2011
Stereotactic Radiosurgery of
Intracranial Lesions
![Page 108: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/108.jpg)
Robt Stone and J Lawrence
May 17, 2011
![Page 109: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/109.jpg)
FN Therapy of T3 -4 H/N SCC
No Evident Gain in TCP
X ray TCP in 30 -50% Range
May 17, 2011
X ray TCP in 30 -50% Range
Steep Part of Dose Response Curve
![Page 110: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/110.jpg)
FN Therapy Rationale is High LET and RBE, viz
Lower OER
May 17, 2011
Flatter Age Response Function
A Potential Advantage in ↑↑↑↑TCP?
![Page 111: History of Particle Therapypeople.na.infn.it/~vaccaro/Erice2011/TalkContributions/Suit.pdf · Life Span of Q Anti Q Pairs ∼10-23 sec. 1H: Nucleus of Hydrogen Atom Constituent of](https://reader034.fdocuments.us/reader034/viewer/2022050510/5f9a993e28159a2918151955/html5/thumbnails/111.jpg)
FN Therapy in 2011
Nearly all Centers Closed
Unacceptable NTCP, No Gain
May 17, 2011
Unacceptable NTCP, No Gain
In TCP, Except for Low αααα/ββββ Tumors?
RBE Normal > RBE Tumor