History of Contrast agents in medical imaging Jalal Jalal Shokouhi-MD Jamejam and kourosh medical...
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![Page 1: History of Contrast agents in medical imaging Jalal Jalal Shokouhi-MD Jamejam and kourosh medical imaging centers jalaljalalshokouhi@hotmail.comjalaljalalshokouhi@hotmail.com.](https://reader036.fdocuments.us/reader036/viewer/2022081514/56649ebf5503460f94bca2e9/html5/thumbnails/1.jpg)
History of Contrast agents in medical imaging
Jalal Jalal Shokouhi-MD Jamejam and kourosh medical imaging [email protected] www.medimage.irBehrouz Taheri-MD Arad hospital medical imaging center
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• Teichmann`s paste a mixture of Ca++ and vermilion and vaseline used in cadavre amputated hand vessels by hadschek and lindenthal, plaster by morton and hammer
• Thorotrust the first contrast agent used in medicine• First classic medical contrast agent ,1927
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Today is:99 years after the safe contrast agent in
medicine= sulfate barium and 114 years after X-ray discovery by W. C. Rontgen
(1895) in Wurzburg, Germany
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I am talking aboutI am talking about
transparent human bodytransparent human body
Today we can see any part, inside of our body by natural contrast, density and artificial contrast agents
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• Contrast medias had discovered before X-ray discovery = Co2, O2, Air, Nitrogen (as negative contrast agents)
• Positive contrast agentsoral: sulfate barium candidate (1895
sehrwald)GI-Barium studies: 1910 Berlin krause
By mid-1920s in Berlin: search for I.V contrast agents
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By 1871 a green pharmacist, Ernst christian friedrich schering (1824-1889) founded a company in the north of Berlin
1925: systematic research under the direction of prof. Walter scholler
1930: the first urinary contrast media (uroselectan) is the father of renal contrast media (from anti inflamantory drug for cows and pigs)
Quickly, uroselectan changed to uroselectan-B with two iodine atoms
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Almost 150 years ago in Berlin Green Pharmacy in 1871
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By 1940 biliselection was used as an oral contrast agent for billiary system (O.C.G)
By early 1950s di-iodinated pyridine changed to tri-iodinated benzonic acid
1953 urographin is born and amidotriazoates served for angiography
By 1954 biligraphin is made accidentaly for billiary system during a research for urographin
By 1965-1968 non-ionic contrast agents are found (they truly began by amipaque in 1977)
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1970 X-ray CT scan invented by sir N.G. Hansfield in England
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1985 ultravist developed by schering and isovist a non-ionic, dimeric in 1987
Isovist was special for myelography but you can use ultravist 300 as well as Isovist
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Gadolinium DTPA started in 1988 for MRI (magnevist)1991 echovist-300 is introducted for U.S studiesBy 1988 first new and non-ionic contrast agents used in
defense ministry hospital (omnipaque was the first non-ionic contrast agent used by early 1980 in Loghman hospital)
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The basis of today`s water-soluble CM is the triiodinated benzene
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By 2005 vasovist innovated for more detail visualization of the vessles (DSA, cardiac angiography, X-ray, CTA)
Future: target specific contrast agents, biomolocular imaging contrast medias and for optical mammography with application of fluorescent dye and laser light
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Thank you for your attentionThank you for your attention