History A 50 y/o was referred for evaluation of azotemia. 10 yrs ago, he experienced sudden onset of...
5
History • A 50 y/o was referred for evaluation of azotemia. • 10 yrs ago, he experienced sudden onset of pain on his right big toe. His serum uric acid was elevated. He was diagnosed to have gout and was prescribed medication but he was poorly compliant. The gouty attacks recurred lately hence, he decided to undergo thorough check-up. He denies dysuria, flank pain or hesitancy. He has nocturia. Physical Exam • BP is 120/70 • Obese • numerous tophi in his metacarpo-phalangea l elbow joint • no edema Salient Features • A 50 y/o obese male diagnosed 10 years ago to have gout with gouty attacks recurring lately and was referred for evaluation of azotemia • Patient experiences nocturia but there is no dysuria, flank pain or hesitancy, and edema • BP is 120/70 • Numerous tophi in his metacarpo- phalangeal elbow joint
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Transcript of History A 50 y/o was referred for evaluation of azotemia. 10 yrs ago, he experienced sudden onset of...
History
• A 50 y/o was referred for evaluation of azotemia.• 10 yrs ago, he experienced sudden onset of pain
on his right big toe. His serum uric acid was elevated. He was diagnosed to have gout and was prescribed medication but he was poorly compliant. The gouty attacks recurred lately hence, he decided to undergo thorough check-up. He denies dysuria, flank pain or hesitancy. He has nocturia.
Physical Exam
• BP is 120/70• Obese• numerous tophi in his metacarpo-phalangea l
elbow joint• no edema
Salient Features
• A 50 y/o obese male diagnosed 10 years ago to have gout with gouty attacks recurring lately and was referred for evaluation of azotemia
• Patient experiences nocturia but there is no dysuria, flank pain or hesitancy, and edema
• BP is 120/70• Numerous tophi in his metacarpo-phalangeal
elbow joint
Clinical Impression
• Gouty nephropathy– Patients with prolonged forms of hyperuricemia
are predisposed to a more chronic tubulointerstitial disorder, often referred to as gouty nephropathy
– Distinctive feature: presence of crystalline deposits of uric acid and monosodium urate salts in kidney parenchyma
– Clinically, gouty nephropathy is an insidious cause of renal insufficiency.
– Early in its course GFR may be near normal despite focal morphologic changes in medullary and cortical interstitium, proteinuria and diminished urinary concentrating ability
Algorithm/Sequence of Events
Renal Deposition of Urates
Pelvic CalculiParenchymal Urate(microtophi)
Tubular Uric Acid(obstruction)
Gout
Renal Insufficiency
Differential Diagnosis
• Diabetic Nephropathy– Kimmelstiel-Wilson syndrome– a progressive kidney disease caused by angiopathy
of capillaries in the kidney glomeruli – characterized by nephrotic syndrome and diffuse
glomerulosclerosis.
Spectrum of Disease Diagram
Lower testing threshold Upper testing threshold
Pretest probability
Do nothing. Rule out the disease
Treat the patient without waiting for more information
Do additional diagnostic exams to confirm diagnosis (testing zone)
20 % 70% %
60%
