HISTIDIN

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PHD ST : NABEE

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CHEMISTR

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OUTLINES

• GENERAL INFORMATION i. WHAT IS HISTIDINE ii. IMPORTANCE AND FUNCTIONS iii. SOURCES • METABOLISM OF HISTIDINE • DISORDERS

WHAT IS HISTIDINE Histidine is both an essential amino acid and non-essential amino acid, has as a positively charged imidazole functional group. The imidazole makes it a common participant in enzyme catalyzed reactions. The unprotonated imidazole is nucleophilic and can serve as a general base, while the protonated form can serve as a general acid. The residue can also serve a role in stabilizing the folded structures of proteins.

FUNCTIONS • It develop and maintain healthy tissues in all parts of the body . • It may be useful for treatment of mental disorders as well as certain types of sexual

dysfunction. • Histidine levels in the body must be balanced to ensure good mental and physical

health. • Histidine is important to normal sexual functioning. • Histamine is also needed to help the immune system know when the body is

experiencing an allergic reaction, and for the production of gastric juices needed for normal digestion.

• Research suggests that Histidine also acts as a natural detoxifier, protecting against radiation damage, and removing heavy metals from the system. It may even help prevent the onset of AIDS

• Histidine is crucial to the production of both red and white blood cells.

IMPORTANCE • Histidine facilitates the growth and repair of all body

tissue. • It manufactures white and red blood cells. • It is key in the manufacture and maintenance of oligo-

dendrocytes that wrap around nerves forming myelin, a protective sheath, thus preventing unintended impulses that lead to spinal cord and brain defects.

• Histidine removes surplus heavy metals and protects from radiation.

• It aids in digestion by producing gastric juices.

SOURCES

METABOLISM OF

HISTIDINE

DISORDERS

• Plasma histidine concentrations were significantly lower in CKD patients.

• Plasma histidine was negatively associated with age

• a low histidine concentration was associated with all-cause mortality

• the association between low histidine and mortality remained significant (hazard ratio: 1.55; 95% CI: 1.02, 2.40; P < 0.05).

CHRONIC KIDNEY DISEASE CKD

Histidine acts as an inhibitory neurotransmitter, boosting the activity of soothing alpha waves in the brain and supporting resistant to the effects of anxiety and stress. In cases of histidine deficiency, there is an unbalancing effect on alpha rhythms, leading to greater beta wave production. Beta waves are responsible for brain activity leading to anger and tension.

REFRENCES https://en.wikipedia.org/wiki/Histidine

http://www.slideshare.net/DJ4SDM/histidine-metabolism

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC239417/

http://www.biology.arizona.edu/biochemistry/problem_sets/aa/histidine.html

https://pubchem.ncbi.nlm.nih.gov/compound/L-histidine#section=Pharmacology-and-Biochemistry

https://upload.wikimedia.org/wikipedia/commons/4/4c/WP514_85639.svg

https://homepages.rpi.edu/~bellos/new_page_2.htm