His to Pathology , Pa Tho Genesis and Immunology DC

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    Zxbybn}bm hs0

    Nbfk Ykvbnk

    &A.M.Y ;y} sbkx#

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    Cn}xomri}con

    Mbecnc}con oe mbn}kg ikxcby Bkxgs }fboxcby oe ikxcby b}cogols

    Irxxbn} ionibz}y oe ikxcby b}cogols

    ;.Nb|hxrny ixc}bxck eox ikxcolbncic}s

    8.Foy} eki}oxy

    9.Mcb} eki}oxy

    Acixohcogols oe mbn}kg ikxcby

    ;.Xogb oe Y}xbz}oioiiry Ar}kny

    8.Xogb oe Zgk{rb Hcoecga cn gbycon cnc}ck}con

    Igcncikg igkyycecik}con oe ikxcby

    ;.Kiioxmcnl }o }oo}f aoxzfogols

    8.Kiioxmcnl }o ybubxc}s knm xk}b oe zxolxbyycon

    Fcy}ozk}fogols oe mbn}kg ikxcby

    ;.bnkabg ikxcby

    8.mbn}cn ikxcby

    Ukxcory mcklnoy}ci kcmy eox ikxcby mcklnoycy

    Aomkgc}cby oe }xbk}abn} hkybm on ikxcby!xcyd kyybyabn}

    Ionigrycon

    Hchgcolxkzfs.

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    ]fb |oxm IKXCBY cy mbxcubm exoa }fb gk}cn |oxm abkncnl

    xo} ox mbiks. Mbn}kg ikxcby cy }fb aoy} zxbukgbn} ifxonci

    mcybkyb keebi}cnl }fb frakn xkib. C} ikn hb ionycmbxbm k

    mcybkyb oe aombxn }caby ky }fb oiirxxbnib oe ikxcby

    ybbay }o hb arif fclfbx cn }fb gky} eb| lbnbxk}cony.

    ]fbxbeoxb c} cy aknmk}oxs eox }fb igcncickn }o rnmbxy}knm

    }fb aklnc}rmb oe }fcy zxohgba knm xcyd eki}oxy kyyoick}bm'

    }o zgkn yrc}khgb zxbubn}cub abkyrxby.

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    Mbn}kg ikxcby cy kn cxxbubxychgb acixohckg mcybkyb

    oe }fb ikgicecbm fkxm }cyyrby oe }fb }bb}f'

    ifkxki}bxcybm hs mbacnbxkgcyk}con oe }fbcnoxlknci zox}con knm mby}xri}con oe }fb

    oxlknci yrhy}knib oe }fb }oo}f.

    &Yfkebx'Fcnb'gbus#

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    ;. ]fboxs oe \oxay0

    Kiioxmcnl }o knicbn} Yrabxckn }bv}' }oo}fkifb |ky ikrybm hs k |oxa }fk} mxknd }fb hgoom oe }fb }bb}fknm ebm on }fb xoo}y oe }fb `k|y. ]fcy gblbnm oe |oxay |ky mcyioubxbm on akns oe }fb igks }khgb}ybvikuk}bm nbkx Nceebx |c}fcn }fb Brzfxk}ry ukggbs oe }fb go|bx Abyozo}kackn kxbk mk}bm }o 2::: H.I.

    8. Fraoxy0Kiioxmcnl }o knicbn} lxbbdy' k zbxyony zfsycikg knm abn}kg iony}c}r}con |ky mb}bxacnbm hs }fb xbgk}cub zxozox}cony oe }fb

    eorx bgbabn}kg egrcmy oe }fb homs0!hgoom ' zfgbla' hgkid hcgb knm sbggo| hcgb! ioxxbyzonmcnl }o }fb eorx fraoxy! Yknlrcnb'zfgblak}ci' abgknifogci' ifogbxci. Kgg mcybkyby cnigrmcnl ikxcby' iorgm hb bvzgkcnbm hs kn cahkgknib oe }fbyb fraoxy.

    9. Uc}kg }fboxs0]fcy }fboxs xblkxmbm mbn}kg ikxcby ky oxclcnk}cnl |c}fcn }fb }oo}f c}ybge' knkgolory }o honb lknlxbnb.

    =. Ifbacikg }fboxs0&Zkxags ;6;3#y}k}bm }fk} kn rncmbn}cecbm ifsacikg klbn} |ky xbyzonychgb eox ikxcby. Fb kgyo y}k}bm }fk} ikxcby hblknon bnkabg yrxekiby cn goik}cony |fbxb eoom zr}xcecbm knm k{rcxbm yreecicbn} mcyyogucnl zo|bx }ozxomrib }fb mcybkyb ifbacikggs.

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    2. Zkxkyc}ci ox ybz}ci }fboxs0

    Ecicnry ohybxubm ecgkabn}ory acixooxlkncyay &mbn}ciogkb# cn ak}bxckg }kdbn exoa ikxcoryikuc}cby. Fb y}k}bm }fk} }fbyb hki}bxck ikrybm mbioazoyc}con oe bnkabg knm }fbn }fb mbn}cn'fo|bubx fb iorgm no} bvzgkcn }fb abifkncya oe }fcy mby}xri}con.

    5. Ifbao!zkxkyc}ci }fboxs0 &\.M Acggbx! ;63:#

    cn k ybxcby oe bvzbxcabn}y' Acggbx mbaony}xk}bm }fb eoggo|cnl eki}y0!

    ;. Kicm |ky zxbybn} |c}fcn }fb mbbzbx ikxcorygbycony ' ky yfo|n hs xbki}con on gc}ary zkzbx.

    8. Mceebxbn} dcnmy oe eoomy& hxbkmy' yrlkxy' no} abk}# acvbm |c}fykgcuk knm cnirhk}bm k} 9< I iorgm mbikgices }fb bn}cxb ixo|noe }fb }oo}f.

    9. Ybubxkg }szby oe aor}f hki}bxck' iorgm zxomrib bnorlf kicm }oikryb mbn}kg ikxcby.

    =. Gki}ci kicm |ky kn cmbn}ceckhgb zxomri} cn ikxhofsmxk}b!ykgcukcnirhk}con acv}rxby.

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    Mbn}kg ikxcby cy k arg}ceki}oxckg mcybkyb cn

    |fcif }fbxb cy cn}bx zgks oe }fxbb zxcakxs

    eki}oxy0 }fb foy} ' }fb acixohckg egoxk knm

    }fb yrhy}xk}b.

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    Kn oxlkncya ary} kicmolbnci

    Kn oxlkncya ary} hb kicmrxci

    Kn oxlkncya ary} bvfchc} }xozcya eox }bb}f

    Kn oxlkncya ary} r}cgcpb xbecnbm yrlkx

    &yrixoyb#

    &Nb|hxrn' ;369#

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    ]oo}f ]oo}f ioazoyc}con0yrxekib bnkabg cy aoxb

    xbycy}kn} }o ikxcby }fkn

    yrhyrxekib bnkabg ky c}

    cy fclfgs acnbxkgcybm.

    Zoyc}con

    akgkgclnbm'xo}k}bm

    }bb}f kxb mceecirg} }oigbkn knm ekuorx eoom

    xb}bn}con.

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    Ykgcuk Ioazoyc}con zF0 k} |fcif ykgcuk

    ibkyby }o hbyk}rxk}bm |c}fikgicra knm

    zfozyzfk}b cyixc}cikg zF! 2.2

    hbgo| }fcy cnoxlknciak}bxckg oe }oo}fmcyyoguby.

    [rkn}c}s0fszoykgcuk}conbubn}rkggs gbkmy }ombn}kg ikxcby .

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    ;. Y}bzfkn Irxuby mbyixchb }fb ifknlby cn zF oiirxcnl

    |c}fcn mbn}kg zgk{rb |fbn c} cy yrh`bi}bm }o k

    ifkggbnlb' }szcikggs |c}f k eoomy}ree.

    8.\fbn ifkggbnlbm |c}f k ebxabn}khgb ikxhofsmxk}b

    }fb zF |c}fcn zgk{rb mxozy xkzcmgs knm }fbn xcyby hkid

    }o }fb xby}cnl zF aoxb ygo|gs.

    9.Eki}oxy keebi}cnl }fb yfkzb oe }fb Y}bzfkn Irxubcnigrmb }fb acixohckg ioazoyc}con oe }fb zgk{rb4 }fbnk}rxb oe }fb ebxabn}khgb yrhy}knib4 }fb xk}b oe

    mceerycon oe hki}bxckg ab}khogc}by' ykgcukxs ioazonbn}y

    yrif ky hcikxhonk}b knm }fb ebxabn}khgb yrhy}knib4

    ykgcukxs kiibyy }o }fb zgk{rb knm ykgcuk ego| xk}b.

    =.]fb xbgk}conyfcz oe }fb yfkzb oe }fb Y}bzfkn Irxub}o }fb Ixc}cikg zF ikn hb rybm }o kyybyy }fb xbgk}cub

    ikxcolbncic}s oe eoomy.

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    [rkgc}s oe mcb}

    xbecnbm ikxhofsmxk}byfkub aoxb ikxcolbnci

    zo}bn}ckg }fkn mb}bxlbn}

    eoomy ky xk| ublb}khgby

    knm exrc}y.

    ikxhofsmxk}b ion}bn}

    exb{rbnis oe yrlkx cn}kdb.

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    ]FB IKXHOFSMXK]B EKI]OX

    ]fb cazox}knib oe k nr}xc}cory mcb}' zkx}cirgkxgs yrixoybion}kcncnl eoomy knm hbubxklby cn ikxcby zxomri}con oxikxcolbnbycy cy |bgg dno|n.

    ]fbxb cy loom bucmbnib }fk} }fb ikxhofsmxk}by &zkx}cirgkxgsxbecnbm ikxhofsmxk}by }fbs y}cid }bnknicorygs }o }bb}f#xbyzonychgb eox mbn}kg ikxcby ary}0

    ;. Hb zxbybn} cn mcb} cn ionycmbxkhgb {rkn}c}s

    8. Hb igbkxbm ygo|gs

    9. Hb xbkmcgs ebxabn}bm hs hki}bxck &Gki}ohkicggc knm y}xbz}oioiiryar}kny#

    \fs cy k nr}xc}cory knm Fbkg}f Mcb} Cazox}kn} eox oxkgfbkg}f?

    ]fb mcb} rybm cn ikxcby zxbubn}con cy byybn}ckggs k fbkg}fs'

    kmb{rk}b' hkgknibm mcb} knm xbybahgb k noxakg mcb} bvibz} eox}fb bvigrycon oe k eb| eoom ioazonbn}y knm bk}cnl zxki}ciby.

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    \fk} cy c}?

    K lxka zoyc}cub' ekirg}k}cub knkbxohbifkxki}bxcpbm hs 6 ybxo}szby' k!f.

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    YzbicbyYzbicby Ybxo}szbYbxo}szb YorxibYorxib

    Y.Y. ar}knyar}kny i'b'ei'b'e FraknFrakn

    Y. yohxcnryY. yohxcnrym'l'fm'l'f

    FraknFrakn

    Y. ixcib}ryY. ixcib}ry kk Yoab}caby frakn' aoy}gs xk}y knm fkay}bxyYoab}caby frakn' aoy}gs xk}y knm fkay}bxy

    Y. xk}}ryY. xk}}ry hh Yoab}caby frakny' aoy}gs xk}yYoab}caby frakny' aoy}gs xk}y

    Y. mo|nbcY. mo|nbcff

    Akik{rb aondbsAkik{rb aondbs

    Y. akikikbY. akikikb ii Akik{rb aondbsAkik{rb aondbs

    Y. ebxryY. ebxry ii Xk}yXk}y

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    K yrxekib y}xri}rxb ox akixoaogbirgb }fk}hcnmy k hki}bxcra }o k yzbiceci yrxekib.

    Kn}clbn &Kl# C/CC ox YzkZ

    K}}k}ifby }o ykgcukxs zbggcigb xbibz}oxy'ykgcukxs kllgr}cncny' knm o}fbx hki}bxck.

    Kgyo zxoucmby abifkncya eox hcnmcnl oe ykgcukxskllgr}cncn lgsiozxo}bcn }o }fb y}xbz}oioiikgibgg yrxekib!lbnbxk}by xbibz}ox eox o}fbx

    hki}bxck }o kmfbxb. Bnkhgby Z. lcnlcukgcy }o kmfbxb }o y}xbz}oioiic'

    bnkhgcnl ybionmkxs iogoncpbxy }o hbcnioxzoxk}bm cn}o zgk{rb ioaarnc}cby.

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    ]oo}f kmfbxbnib

    Zxoao}by kllxblk}con

    Hcoecga kiirargk}con

    Xb}bn}con oe hki}bxckg nr}xcbn}y

    Yoab kn}chomcby zxbubn} Lgrioysg

    ]xknyebxkyb erni}con knm kxb zxo}bi}cub.

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    Mbacnbxkgcyk}con/Xbacnbxkgcyk}con

    Isigb0

    Ykgcuk mcgr}by % hreebxy kicm % ion}kcny

    ionibn}xk}bm ikgicra % zfoyzfk}b cony.

    \fbn yrlkx cy zxbybn}' nb} mbacnbxkgcpk}con

    xkzcmgs oiirxy.

    Hb}|bbn yrlkx bzcyomby' xbacnbxkgcpk}con ygo|gsoiirxy.

    Ce xbacnbxkgcyk}con zbxcomy bvibbm

    mbacnbxkgcyk}con zbxcomy' yrhyrxekib gbycon |cgg

    acnbxkgcpb % kxxby}.

    Ce mbacnbxkgcyk}con zbxcomy bvibbm

    xbacnbxkgcyk}con zbxcomy' ikuc}k}con |cgg oiirx.

    Mbacnbxkgcyk}con zbxcomy bvibbm xbacnbxkgcyk}con

    zbxcomy |fbn yrlkx bzcyomb cy exb{rbn} ox

    zxogonlbm.

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    Mbn} g xcby b g yycecbm xmcnl }

    } xbb yc e } xy0. x g ls

    8.Msnkac y

    . x nogols.

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    ;.Zc} ox ecyyrxb ikxcby

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    Mbubgozy cn oiigrykg yrxekiby oe

    aogkxy'zxbaogkxy'hriikg'gcnlrkg yrxekiby oeaogkxy knm cn gcnlrkg yrxekiby oe akvcggkxs

    cnicyoxy.

    Mbbz nkxxo| zc}y'ecyyrxby ekuorx eoom mbhxcyxb}bn}con knm acixooxlkncyay.

    Ikxcby xbyrg} exoa ebxabn}k}con oe }fcy eoom

    knm kicm eoxak}con.

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    8.Yaoo}f yrxekib ikxcby

    Gcnbkx bnkabg ikxcby k}szcikg eoxa oe mbn}kg ikxcby cn

    zxcakxs mbn}c}con oe gk}cn

    kabxcikn' kyckn ifcgmxbn.

    on gkhckg yrxekib oe akvcggkxs kn}bxcox}bb}f cn }fb xblcon oe nbonk}kg gcnb.

    xbyrg}cnl exoa ab}khogci mcyoxmbxy0

    fszoikgiback' }xkrak k} hcx}f.

    Ibxucikg ikxcby

    On hriikg yrxekiby oe zxbaogkxy

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    Igcncikg cnmcik}oxy oe cnki}cub knm ki}cub ikxcby gbycony on oiigrykg knm yaoo}f yrxekiby.

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    9.Xoo} ikxcby0K yoe} zxolxbyycub gbycon }fk} cy eornm

    kns|fbxb on }fb xoo} yrxekib }fk} fky

    goy} ionnbi}cub }cyyrb k}}kifabn} knm cy

    bvzoybm }o }fb oxkg bnucxonabn}.

    !Fkpbn b}!kg.

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    !}fb xoo} yrxekib ary} hb bvzoybm }o }fb oxkg bnucxonabn} hbeoxb ikxcby

    ikn mbubgoz fbxb.!Zgk{rb knm acixo!oxlkncyay kxb byybn}ckg eox }fb ikryb knm zxolxbyycon oe

    }fb gbycon' aoy}gs Ki}cnoasiby.

    !acixo!oxlkncyay cnukmb }fb ibabn}ra bc}fbx kgonl }fb Yfkxzbsy echbxy

    ox hb}|bbn }fb hrnmgby oe echbxy.

    !yzxbkm gk}bxkggs' ycnib ibabn}ra cy eoxabm cn ionibn}xci gksbxy.

    ke}bx mbikgicecik}con oe ibabn}ra' mby}xri}con oe ak}xcv oiirxy ycacgkx

    }o mbn}cn |c}f rg}cak}b yoe}bncnl knm mby}xri}con oe }fcy }cyyrb.

    !cnukycon oe acixo!oxlkncyay cn}o }fb mbn}cnkg }rnhrgby' ecnkggs gbkmcnl }o

    zrgz cnuogubabn}.

    !}fb xk}b cy ygo|bx mrb }o eb|bx mbn}cnkg }rhrgby }fkn ixo|n kxbk.

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    ;. Kir}b mbn}kg ikxcby

    8. Xkazkn} ikxcby

    9. Nrxycnl Ho}}gb ikxcby

    =. Kmogbyibn} ikxcby2. Ifxonci mbn}kg ikxcby

    5. Xbirxxbn} ikxcby

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    Oiirxy exb{rbn}gs cn ifcgmxbn'sornl kmrg}y ky mbn}cnkg }rhrgbykxb gkxlb knm ozbn knm yfo| no yigbxoycy.

    xrny k xkzcm igcncikg iorxyb'xbyrg}y cn bkxgs zrgz cnuogubabn}.

    XKAZKN] MBN]KG IKXCBY0

    mbecnbm hs akyygbx ky0 yrmmbngs kzzbkxcnl'|cmbyzxbkm xkzcmgs hrxxo|cnl }szb oe ikxcby'xbyrg}cnlcn bkxgs cnuogubabn} oe zrgz knm keebi}cnl }foyb }bb}fryrkggs xblkxmbm ky caarnb }o oxmcnkxs mbiks.

    Exb{rbn} cn zxcakxs mbn}c}con knm cn zbxaknbn} mbn}c}conoe sornl kmrg}y.

    K ikxcby cnixbabn} oe ;: ox aoxb nb| gbycony oubx k sbkxcy ifkxki}bxcy}ci oe xkazkn} ikxcby.

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    ]fb KKZM mbecnby c} ky!0]fb zxbybnib oe onb ox aoxb mbiksbm&ikuc}k}bmox non!ikuc}k}bm#'acyycnl&mrb }o ikxcby#'ecggbm }oo}f yrxekiby cn kns

    zxcakxs }oo}f cn k ifcgm

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    ;. cnkzzxozxck}b ebbmcnl zk}}bxn0 ifcgm zr} }o hbm |c}f k yrlkxs hbubxklb cn

    ho}}gb ox zkicecbxy.

    8. gc{rcm hbioaby zoogbm kxornm }bb}f |fcif cy bvibggbn} irg}rxb abmcra

    eox kicmolbnci oxlkncyay ky Y}xbz}oiioiri Ar}kny.

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    BNKABG IKXCBY0hkybm rzon fcy}ogolcikg kzzbkxknib oelxornm ybi}cony rnmbx gclf} acixoyiozb'y}kx}cnl exoa }fb cnnbx kmuknicnl exon} oe

    }fb gbycon0

    Ikxcby yzxbkmy cn ponby fcif kxb ky eoggo y. ]xknygribn} ponb Mkxd ponb Homs oe }fb gbycon rxekib ponb

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    Aoxb zoxory }fkn }fb noxakg bnkabg. ion}kcny;" oe zoxb uograb .

    ]fbyb zoxby kxb gkxlbx }fkn }fb noxakg bnkabg.

    Ifbacikg knkgsycy yfo }fk} }fbxb cy k ekgg cn

    }fb aklnbycra knm ikxhonk}b ion}bn} kyioazkxbm }o }fb noxakg bnkabg

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    ]fcy ponb ion}kcny 8!=" hs uograb zoxb

    }fcy ponb cy eoxabm ky k xbyrg} oembacnbxkgcyk}con.

    oab zoxby kxb gkxlb knm yoab kxb yakggbx}fkn }fb }xknygribn} ponb yrllby}cnl }fk} yoabxbacnbxkgcpk}con fky oiirxxbm.

    Cn xkzcmgs kmuknicnl gbycon }fb mkxd ponb cy

    nkxxo . Cn }fcy ponb zxbucorygs gchbxk}bm ykg}y kxb

    xbmbzoyc}bm.

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    ]fcy ponb fky zoxb uograb oe 2!82"

    C} ion}kcny kzzb}c}b ixsy}kgy gkxlbx }fkn }fbnoxakg bnkabg.

    ]fb cy aoxb oe kn beeox} eox }fbxbacnbxkgcpk}con hr} hs }fb erx}fbx k}}kid}fbxb cy erx}fbx mcyyogr}con oe }fb acnbxkgy

    ]fry }fcy cy }fb ponb oe akvcara

    mbacnbxkgcpk}con.

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    ]fcy cy khor} =: acixoab}bx }fcid.

    ]fcy zkx} cy xbgk}cubgs noxakg hbikryb cn }fcy

    kxbk }fbxb cy akvcara xbacnbxkcpk}con exoa}fb cnoxlknci ioazonbn}y oe ho}f }fb zgk{rbknm ykgcuk.

    cn}ki}yrxekib

    homs oe gbycon

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    mkxd ponb

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    Zc} Knm Ecyyrxb Ikxcby0

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    }fb hkyb }o kxmy }fb MB@.

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    ! fbn ikxcby xbkif Mbn}cno bnkabg `rni}con' lxbk}bx nrahbx oe

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    Yfkzb oe }fb gbycon cy }xcknlrgkx .

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    Ponb 94 Ponb oe mbikgicecik}con oe mbn}cn

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    Mbn}cnkg Gbycon0

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    Mbacnbxkgcyk}con yoe}bny mbn}cn knm bngkxlby }rhrgby

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    51/73

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    ikuc}k}bm gbycon

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    58/73

    CN UCUO

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    59/73

    Oiigrykg ikxcby cn }fb ecxy} aogkx. Oiigrykg

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    60/73

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    61/73

    Ekickg ox gcnlrkg ikxcby on }fb ikncnb.

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    62/73

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    63/73

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    64/73

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    65/73

    Ibxucikg hrxnor} &xkmcogribn}

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    66/73

    Ikxcby Xcyd Kyybyabn}

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    67/73

    Ikxcby Xcyd Kyybyabn}

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    68/73

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    69/73

    ]ozcikg egroxcmb kzzgcik}cony

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    70/73

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    71/73

    GO\!XCYD LXORZ

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    Mbn}kg ikxcby cy k arg}ceki}oxckg mcybkyb zxoibyy.\b nbbm }o fkub k }foxorlf dno|gbmlb oe ybubxkg

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    }xbk} c}.

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