BEIS(Boost efficiency IS)-High sensitivity ion source for GC-MS/MS-

MS Business Unit, Analytical & Measuring Instruments Division

Market trend of GC-MS/MS In the past, Dioxins in food had been analyzed by GC-HRMS

Recently, GC-MS/MS was also confirmed as official method (EU589/2014)

The market will grow in Europe, Asia and Africa where export food to Europe

Trend of regulation for POPs analysis by GC-MS/MS

China・Dioxins in food and feed sample・Dioxins in environmental sample

Taipei・Dioxins in food and feed sample・Dioxins in environmental sample

EU・Dioxins in food and feed sample・Dioxins in environmental sample

Not published yet2

Background

Confidential

Market trend of Dioxin analysis (in EU) ML is getting lower and lower

3

Background

Confidential

Food and FeedMaximum level

Conc. in sample Conc. in vial

Pigs fat 1,00 pg/g fat 0.06 pg/uL

Vegetable oils 0,75 pg/g fat 0.04 pg/uL

Foods for infants and young children 0,10 pg/g wet weight 0.04 pg/uL

About competitors situation Release new ion source for Dioxin analysis and improving spec. (IDL)

Make the technical document for Dioxin analysis

TSQ9000

Company Model Spec.

SHIMADZU TQ8050NX OFN：IDL < 0.5fg

Thermo TSQ9000 OFN：IDL < 0.4fg

Agilent 7010B OFN：IDL < 0.5fg

Improve the structure of ion source Diameter of electron gun was optimized

Ionization efficiency was much improved

4

Features of BEIS(Boost efficiency IS)

Confidential

e-

e-e- e

-e-e

-

e-

e-e-

e-

e-

e-

e-

e-

e-

e-e-

e-

e-

e-

e-

e-

e-e

-

e-e-e-e-

e-

e-

e-

e-

e-

e-

e-

e-

Improve

Previous NEW!!

1. Boost up sensitivity of your analysis

2. Realize high reliable analysis for Dioxins

Increase the sensitivity for 3 – 4 times

5

Boost up sensitivity of your analysis

Confidential

Analysis result of DXNs Analysis result of OFN

Company Model Spec.

SHIMADZU TQ8050NX OFN：IDL ≦ 0.3fg

Thermo TSQ9000 OFN：IDL < 0.4fg

Agilent 7010B OFN：IDL < 0.5fg

3.900 3.925 3.950

1000

2000

3000

4000

5000

6000

7000

8000

Octafluoronaphthalene (1 fg)

Comparison of spec. (IDL)

1,2,3,7,8-Pentachlorodibenzo-p-dioxin (0.05 pg/uL)

20.0 21.00.0

0.5

1.0

1.5

2.0

2.5(x1,000)

353.90>290.90355.90>292.90

20.0 21.00.0

0.5

1.0

1.5

2.0

2.5(x1,000)

353.90>290.90355.90>292.90

BEIS Prev.

4 times

15.0 16.00.0

1.0

2.0

3.0

4.0(x1,000)

305.90>242.90303.90>240.90

15.0 16.00.0

1.0

2.0

3.0

4.0(x1,000)

305.90>242.90303.90>240.90

2,3,7,8-Tetrachlorodibenzofuran (0.05 pg/uL)

BEIS Prev.

Confidential

6

Realize high sensitivity analysis even if use low emission current

Realize high reliable analysis for Dioxins

36.5 37.0 37.5 38.00.00

0.25

0.50

0.75

1.00

1.25

1.50(x10,000)

443.80>380.80441.80>378.80

28.0 28.5 29.0 29.50.0

1.0

2.0

3.0

4.0

5.0

6.0

(x1,000)

391.80>328.90389.80>326.90

27.0 27.5 28.0 28.50.0

1.0

2.0

3.0

4.0

5.0

6.0

(x1,000)

391.80>328.90389.80>326.90

20.5 21.0 21.5 22.00.00

0.25

0.50

0.75

1.00

(x10,000)

337.90>274.90339.90>276.90

36.0 36.5 37.0 37.50.00

0.25

0.50

0.75

1.00

1.25

1.50(x10,000)

443.80>380.80441.80>378.80

15.5 16.0 16.5 17.00.00

0.25

0.50

0.75

1.00

1.25

(x10,000)

305.90>242.90303.90>240.90

16.5 17.0 17.5 18.00.00

0.25

0.50

0.75

1.00

1.25

(x10,000)

305.90>242.90303.90>240.90

2,3,7,8-Tetrachlorodibenzofuran

BEIS with 150uA Prev. with 300uA

2 times !

1,2,3,7,8,9-Hexachlorodibenzo-p-dioxin

BEIS Prev.

1,2,3,7,8-Pentachlorodibenzofuran Octachlorodibenzofuran

BEIS Prev.BEIS Prev.

19.5 20.0 20.5 21.00.00

0.25

0.50

0.75

1.00

(x10,000)

337.90>274.90339.90>276.90

Keep the sensitivity over than 500 injection in Dioxin analysis

7

Realize high reliable analysis for Dioxins

Confidential

0.00

0.20

0.40

0.60

0.80

1.00

1.20

1.40

1.60

1.80

2.00

0 50 100 150 200 250 300 350 400 450 500

2,3,7,8-TeCDD 1,2,3,7,8-PeCDD 1,2,3,4,7,8-HxCDD 1,2,3,6,7,8-HxCDD 1,2,3,7,8,9-HxCDD 1,2,3,4,6,7,8-HpCDD OCDD

Transition of the sensitivity of STD (0.05 pg/uL)

STDTest

sample

Ratio (

-)Are

a o

f each I

.N.

/ Are

a o

f First

Inje

ction

Transition of Peak Area (PCDD)

Sales Strategy

Proposes high reliable analysis for Dioxins Promotes to customers who want to start or replace GC-HRMS for Dioxins analysis

Sales targets

BEISDioxin method package

Counterworks against competitor’s proposals

・Usability such as AART function

・Cover many compounds such as

PCBs, BFRs

Confidential

・High sensitivity at low conc.

・High durability (enables

analyze hundreds of sample)

Europe：18 unit Taiwan：4 unit China：＊＊*Depending on the regualtion

8

Lifetime of Filament

9

Confidential

Note

e-e-e-e-

e- e-e-e-e- e

-

e-

e-e-

e-

e-

0.00

0.20

0.40

0.60

0.80

1.00

1.20

1.40

0 100 200 300 400 500 600

2,3,7,8-TeCDD 1,2,3,7,8-PeCDD OCDD

Injection number 537

Ratio (

-)Are

a o

f each I

.N.

/ Are

a o

f First

Inje

ction

Transition of Peak Area (PCDD)

Filament make much

more electron than

previous when use the

same emission current

Lifetime of filament may be shorter

・BEIS is suitable for POPs analysis especially Dioxins.

・For other applications (such as pesticides in food), the sensitivity is enough even if use

current ion source. We should recommend current ion source because of filament lifetime.