H.Gaub / SS 2007BPZ§4.31 All pore-forming ion channels are similar in structure.
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Transcript of H.Gaub / SS 2007BPZ§4.31 All pore-forming ion channels are similar in structure.
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H.Gaub / SS 2007 BPZ§4.3 1
All pore-forming ion channels are similar in structure
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H.Gaub / SS 2007 BPZ§4.3 2
Struktur des K-Kanals
Rod MacKinnon
Chemie Nobelpreis 2003
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H.Gaub / SS 2007 BPZ§4.3 3
Crystal is defined and stabilized by Antibodies
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H.Gaub / SS 2007 BPZ§4.3 4
Chemistry of Ion Coordination and Hydration Revealed by a K+ Channel-Fab Complex at 2.0 Angstrom Resolution; MacKinnon, R., et al.; Nature, Vol. 414; January 1, 2001
Potassium Channel Receptor Site for the Inactivation Gate and Quaternary Amine Inhibitors; MacKinnon, R., et al.; Nature, Vol. 411; March 8, 2001
Energetic Optimization of Ion Conduction Rate by the K+ Selectivity Filter; MacKinnon, R., et al.; Nature, Vol. 414; November 1, 2001
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H.Gaub / SS 2007 BPZ§4.3 5
Ionenselektivität des Natriumkanals
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H.Gaub / SS 2007 BPZ§4.3 6
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H.Gaub / SS 2007 BPZ§4.3 7
Alternative Stacking of K+ (Green) and Water (red)
High K+ Concentration (2M)
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H.Gaub / SS 2007 BPZ§4.3 8
Gating by conformational changes of the tetramer