Guided Progression Analysis™ (GPA)

The Future of Progression Tools for Structure and

Function

GPATM

progression tools can help

• Identify patients who:– Are progressing and may require a change in treatment– Are rapidly progressing and may truly need aggressive

therapy– Are stable and may need less monitoring and/or

treatment.

• Provide visual tools to educate patients– To drive compliance

A continuum of innovation in progression products

Future Releases:• Enhanced GPA Progression Analysis for HFA• GPA Progression Analysis for GDx • GPA Advanced Serial Analysis for Stratus OCT• GPA Progression Analysis for Stratus OCT

• MD rate of progression on HFA i

• GPA on the HFA (v4.0) 2005

1986 2008

• Glaucoma Change Probability Analysis 1989

The standard in progression: GPA for HFA

• Analyzes events and trends

• EMGT study criteria

• Common language terms

• Installed on 1000’s of HFAs

Likely Progression

•Simple to use:

•Default settings for seamless workflow

•Single page printout with GPA Summary

•Common language reporting

•Automatic baseline selection

GPA for HFA helps identify progression easily

GPA for HFA offers both “event” analysis and “trend” analysis

• Location of visual field changes – For correlating to imaging findings

• MD slope shows long term trends

– Choice of baseline exams can be verified

– Slope of MD values in dB is calculated

GPA SymbolsProgression at 95% significance level

Progressing point repeated in 2 consecutive exams

Progressing point repeated in 3 consecutive exams

GPA AlertTM

“Possible Progression”

Three in one exam

“Likely Progression”

Three in one exam

Intuitive GPA symbols make identifying progression fast and easy

Extending GPATM across structure and function

GPATM

tools integrate your structure and function analysis by using consistent terms and rules.

Under development … more innovations in GPA for HFA

• Improved metric of visual field loss

• New graphical trend display

• VF Index plotted against age

• Single page printout

• Available 2007

Under development…Visual Field Index

(VFI)

An improved metric for assessing rate of progression• Central points weighted more heavily than those on periphery

• Reduces cataract contribution to the measurement of VF loss

“ B”has more damaged central points and lower VFIand lower VFI than“A”.

A B

VFI = 90% VFI = 81%

Under development … more innovations in GPA for HFA

The Regression Graph The VFI Bar

• VF Index shows vision loss in terms of %’s

Under development … more innovations in GPA for HFA

Visual Field Index Bar

•Shows vision loss in terms of %

•Enhanced visual presentation

Under development … more innovations in GPA for HFA

100%

% loss to date

% loss in next 5 years

VF Index plotted against age:

• Characterizes trend significance over next 5 years

• Aids in interpretation & patient education

• Helps formulate individualized treatment decisions

Under development … more innovations in GPA for HFA