Hepatitis C Is treatment in primary care possible/feasible (desirable)?
-
Upload
esperanza-hardisty -
Category
Documents
-
view
213 -
download
0
Transcript of Hepatitis C Is treatment in primary care possible/feasible (desirable)?
![Page 1: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/1.jpg)
Hepatitis C
Is treatment in primary care possible/feasible (desirable)?
![Page 2: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/2.jpg)
Objectives
• Understand the unique characteristics of HCV• Understand the complications of HCV
infection• Know who is at risk and who should be
screened• Describe treatment history and future options• Understand who should be treated and by
whom
![Page 3: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/3.jpg)
What is the Hepatitis C Virus?
• HCV was identified in 1989 – RNA virus– Prior: 90% of post transfusion ‘non A/non B’
hepatitis– Incubation rate for acute HCV 15-160 days but not
usually associated with acute symptoms or illness– Thought to be directly cytopathic to the
hepatocyte• HBV: T-lymphocytes are thought to mediate liver injury
![Page 4: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/4.jpg)
Hepatitis B vs C• HCV:– Up to 80% develop chronicity• The rest will likely continue to test HCV Ab+• BUT immunity is not inferred
• HBV:– if acquired as adult, only 20% develop acute
symptoms (can be severe)– Only 5-10% develop chronic virus• The remainder are immune
![Page 5: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/5.jpg)
• HCV is a diverse virus– 6 genotypes identified (with subtypes)• Genotype 1 most common in US• Genotype 2 - YEA! – He has genotype 2!!• Genotype 3 more in far east• Genotype 4 in Africa and middle east, increased
frequency in Europe• Genotype 5 in South Africa• Genotype 6 in Hong Kong, Vietnam and AustraliaGenotype 1 is the nemesis of treaters, researchers and pharmaceutical manufacturersIL28B genetic polymorphism? – Huh?
![Page 6: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/6.jpg)
Who Should Be Screened?• Persons born between 1945-1965• Persons who currently inject
drugs or who have injected drugs in the past, even once or in the distant past
• Recipients of clotting factor concentrates before 1990s
• Recipients of blood transfusion or donated organs before July 1992
• Long term hemodialysis patients
• Persons with known exposures to HCV (e.g., healthcare workers after needle sticks, recipients of blood or organs from a donor who later tested positive for HCV)
• HIV-infected persons• Children born to infected mothers • Patients with signs or symptoms
of liver disease (e.g., abnormal liver enzyme tests)
• Donors of blood, plasma, organs, tissues or semen
![Page 7: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/7.jpg)
Birth Cohort
• Per the CDC, anyone born between 1945 and 1965 should be screened, regardless of risk factor
• “According to data from 1999 to 2008, three fourths of patients in the United States living with HCV infection were born between 1945 and 1965” (US Preventative Task Force web site) – grade B recommendation
![Page 8: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/8.jpg)
Incidence of HCV
• Estimates in 2005: 185 million people globally infected(1)
• In United States, from a high of 250,000 new cases annually (1980s), down to 17,000 new cases annually(3)
– Per CDC, current overall incidence 0.3 per 100,000
• (1) Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence. Mohd Hanafiah K, Groeger J, Flaxman AD, Wiersma ST
• Hepatology. 2013;57(4):1333• (2) Surveillance for acute viral hepatitis--United States, 2006. Wasley A, Grytdal S, Gallagher K, Centers
for Disease Control and Prevention (CDC) MMWR Surveill Summ. 2008;57(2):1
![Page 9: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/9.jpg)
Why Do We Care
• New cases are declining• Infections from 1960s, 70s, 80s are suffering
the consequences and complications– Cirrhosis– Hepatocellular Carcinoma– Diminished quality of life
![Page 10: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/10.jpg)
Symptoms of HCV
• Typically asymptomatic • Symptoms often not attributed to HCV• Most common: fatigue– Along with anemia and thyroid issues, put HCV in
differential• Also nausea, anorexia, myalgias, arthralgias,
weakness• Rarely debilitating
![Page 11: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/11.jpg)
Quality of Life
• Even without specific symptoms of the virus, HCV diminishes health related quality of life(4)
• Successful treatment improves quality of life
• (3) Impact of hepatitis C on health related quality of life: a systematic review and quantitative assessment• Spiegel BM, Younossi ZM, Hays RD, Revicki D, Robbins S, Kanwal F Hepatology. 2005: 41(4): 790
![Page 12: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/12.jpg)
Extrahepatic manifestations of HCV
• A study of 321 patients with chronic HCV, 38% had extrahepatic manifestations (4)
– Dermatologic: purpura, porphyria cutanea tarda, psoriasis– Rheumatologic: arthropathies– Other: neuropathies, uveitis
– (4) Extrahepatic manifestations associated with hepatitis C virus infection. A prospective multicenter study of 321 patients. The GERMIVIC. Groupe d'Etude et de Recherche en Medecine Interne et Maladies Infectieuses sur le Virus de l'Hepatite C.
– Cacoub P, Renou C, Rosenthal E, Cohen P, Loury I, Loustaud-Ratti V, Yamamoto AM, Camproux AC, Hausfater P, Musset L, Veyssier P, Raguin G, Piette JC
– Medicine (Baltimore). 2000;79(1):47.
![Page 13: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/13.jpg)
Natural History of HCV Infection
Acute HCV
Chronic HCV55 to 85%
Stable75 to 95%
Cirrhosis5 to 25%
Stable
HCC or Decompensation
1-3% /yr
Resolved15 to 45%
![Page 14: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/14.jpg)
Complications of advanced liver disease
• Cirrhosis – once advanced fibrosis has developed, risk of progression to cirrhosis ~10% /year– Synthetic failure
• Hypoalbuminemia• Jaundice• Prolonged bleeding time
– Portal Hypertension• Ascites, peripheral edema• Varices and bleeding• encephalopathy
– Hepatocellular carcinoma
![Page 15: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/15.jpg)
Complications continued
• Hepatitis C accounts for nearly one-third of deaths annually from hepatocellular carcinoma in US
• Higher risk of death from complications of decompensated cirrhosis
![Page 16: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/16.jpg)
Factors associated with disease progression
• Acquiring the virus after age 40• Male• Blood transfusion may be a higher risk• Steatosis• ALCOHOL– Maintaining abstinence (hx of abuse) can improve
histology in the presence of chronic virus
![Page 17: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/17.jpg)
Burden of Disease
• In a study present at The Liver Meeting in 2011, the annual health care costs of a patient with hepatitis C (without cirrhosis) is nearly $18,000. (5)
• According to the United Network for Organ Sharing (UNOS)' Transplant Living Web site, the estimated U.S. average in 2011 of billed charges per liver transplant is $577,100. – ~$25,000 annually for anti-rejection drugs(5)Disease burden in patients with chronic hepatitis C virus (HCV) infection in a United States (US) private health insurance claims database analysis from 2003 to 2010 - (11/15/11) AASLD Nov 5-9 2011 SF, SC Gordon,1 PJ Pockros,2 NA Terrault,3 RS Hoop,4 A Buikema,5 D Nerenz,1 FM Hamzeh4 1Henry Ford Health System, Detroit, MI, USA; 2Scripps Clinic Torrey Pines, La Jolla, CA, USA; 3University of California at San Francisco, San Francisco, CA, USA; 4Genentech, South San Francisco, CA, USA; 5i3 Innovus, San Francisco, CA, USA
![Page 18: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/18.jpg)
Still wondering why we treat?
![Page 19: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/19.jpg)
Treatment objectives
• Sustained viral response (SVR) – CURE!• Avoid complications of cirrhosis and/or
hepatocellular carcinoma• Success measured by – No viremia– Normalized ALT – Improved histology • Decreased necroinflammatory action• Stable or improved level of fibrosis
![Page 20: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/20.jpg)
• Success measured by – No viremia– Normalized ALT – Improved histology – Decreased necroinflammatory action– Stable or improved level of fibrosis
![Page 21: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/21.jpg)
Evolution of Treatment(or how I have tortured 100s of unsuspecting
souls over the years)
![Page 22: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/22.jpg)
Medieval
• Standard interferon alpha, monotherapy– Mechanism of action: stimulates immune
response– FDA approved in 1991– Subcutaneous injection TIW• 50% respond with normalized ALT and undetectable
viral load but
– 24 week course ~ 12% success rate– 48 week course ~ 24% success rate
![Page 23: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/23.jpg)
Addition of Ribavirin
• 1998 FDA approval for combination therapy with interferon
• Mechanism of action: decreases replication by inhibiting pro (?)
• Ribavirin oral agent, interferon still TIW SQ• 35% cure rate – VERY exciting
![Page 24: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/24.jpg)
Pegylation
• Polyethylene glycol added to the interferon• Improved half-life• Allowed for weekly SQ combined with daily
ribavirin• Cure rates increased to ~40% in genotypes
1,4,5,6• ~70% in genotypes 2,3
![Page 25: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/25.jpg)
Side effects of Peg/RBV
![Page 26: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/26.jpg)
• Fatigue• Anemia
– May require Procrit or transfusion– Dose reductions decrease response
• pancytopenia• insomnia• Hyper somnolence• Alopecia (rarely irreversible(• Dyspnea• Cough• fatigue• Nausea• Diarrhea• Arthralgias• Depression• fatigue
• Anxiety• suicidal ideation• Exacerbation of autoimmune disease• Dry skin• Pruritus +/- rash• Thyroid dysfunction (+/- reversible)• Retinal hemorrhage• fatigue• uveitis• Leukocytoclastic vasculitis• Prophyria cutanea tarda• Migraine• Polyarteritis nodosum• Worsening of diabetes• Teratogenicity (RBV)
![Page 27: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/27.jpg)
Newer Agents
• Protease inhibitors approved May 2011• Direct Acting Anti-virals– Approved for genotype 1 only– NS 3/4A inhibitors with activity against HCV
encoded serine protease required for cleavage of viral polyprotein= no replication
– Telaprevir and Boceprevir: very similar efficacy– $$$$$– SVR increased to >70%
![Page 28: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/28.jpg)
Treatment regimens
• Boceprevir– Treatment course 28-48
wks depending on response
– 200 mg 4 every 7-9 hours (with food)
– RBV 200 mg 4-6 divided BID
– Pegylated interferon alfa• Weekly SQ
• Telaprevir– Treatment course 24-48
wks depending on response
– 375 mg 2 TID every 7-9 hours with 20g fat
– RBV 200 mg 4-6 divided BID
– Pegylated interferon alfa• Weekly SQ
![Page 29: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/29.jpg)
BUT more side effects
• More anemia• More pruritus• More fatigue• Dysgeusia• Anal/rectal complaints– Anal pruritus– Diarrhea (fire-rrhea)– Hemorrhoids– Anal pain
• More rash• Mild, moderate, severe• Serious: • SJS• TEN: Toxic Epidermal
Necrolysis• DRESS: Drug reaction
with eosinophilia and systemic symptoms
![Page 30: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/30.jpg)
Patient Selection
Your most important (and often most difficult) decision
![Page 31: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/31.jpg)
• Not everyone wants treatment
• Not everyone needs treatment
• Some patients should not be treated
• Everyone should be evaluated and know their status
![Page 32: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/32.jpg)
AASLD Recommendations(6)
• At least 18 years of age and• HCV RNA + and• Liver biopsy showing significant fibrosis and• Compensated liver disease and• Acceptable hematologic and biochemical
indices and• Willing to be treated and adhere to treatment
requirements
![Page 33: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/33.jpg)
AASLD continued
• Individualize Decision to Treat(6)
– Failed previous therapy– Current alcohol or illicit substance users– No or mild fibrosis by liver biopsy– Coinfection with HIV– Chronic renal disease– Decompensated cirrhosis– Liver transplant recipients
![Page 34: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/34.jpg)
Contraindications to HCV Therapy(7)
• Uncontrolled depressive illness, psychosis, or epilepsy• Untreated anemia• Autoimmune hepatitis or other autoimmune condition known
to be exacerbated by interferon• Untreated thyroid disease• Pregnancy or unwillingness to comply with adequate
contraception• Severe concurrent medical disease
• (7) Ghany MG, et al. Hepatology. 2009;49:1335-1374. EASL Clinical Practice Guidelines: Management of hepatitis C virus infection. June 2011.
![Page 35: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/35.jpg)
• Lab markers of concern:– Albumin <3.7 can predict decompensation on
treatment even if biopsy does not reflect cirrhosis– Platelets <75
![Page 36: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/36.jpg)
Preparing Patients for Therapy
• Clear understanding of treatment options• Review, explain, review, explain side effects and
management (consent form to treat?)• Clear description of treatment protocol, duration
and administration schedule for medications• Clear understanding of lab requirement and
office visit expectation– Free drug possible and no-charge office visit but labs
are not free
![Page 37: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/37.jpg)
• Job related issues• Support system• Clear understanding of prognosis, predicted
response per treatment protocol• Your expectations regarding alcohol, drug use• This is a two way discussion – treatment is
elective, no matter how necessary you think it is– Reluctant patients are not adherent to therapy
![Page 38: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/38.jpg)
New therapies on the horizon
• Will likely be multi-drug cocktails• Goals–High SVR–Pan genotypic–All oral–Clean SE profiles– Short duration of therapy– Smaller pill burden
![Page 39: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/39.jpg)
Specific treatment targets
• NS3/4 A protease inhibitors• NS3 protease inhibitors• NS5A nonnucleoside inhibitor• NS5B nonnucleoside polymerase inhibitors• NS5B nucleotide polymerase inhibitors• NS5A inhibitor
![Page 40: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/40.jpg)
American Companies
• Most with more than one compound– Gilead– Merck– AbbVie– Bristol-Myers Squibb– Janssen– Roche– Vertex– Kadmon
![Page 41: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/41.jpg)
The end is near!
![Page 42: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/42.jpg)
Final thoughts
• Screen per birth cohort/risk factor• If +HCV Ab – get genotype, viral load to
establish chronicity– If negative, repeat in 6 months to confirm– If positive and treatment not an option, don’t
check viral load yearly • HCV replicates 1 trillion virions daily: numbers fluctuate
dramatically and do not correlate with fibrosis or inflammation
![Page 43: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/43.jpg)
• “The temporary normalization of ALT levels should not be equated with improvement of disease nor should it be used as a justification for not seeking treatment.” Melissa Palmer, MD (Dr Melissa Palmer’s Guide to Hepatitis & Liver Disease)
![Page 44: Hepatitis C Is treatment in primary care possible/feasible (desirable)?](https://reader034.fdocuments.us/reader034/viewer/2022051819/551b86ff550346a6148b5a8b/html5/thumbnails/44.jpg)
Markers of deterioration
• Albumin dropping less than 3.7 indicates worsening fibrosis and synthetic function
• Watch platelets• Monitor synthetic function– Increasing INR, bilirubin