Hematopoiesis Simplified: Part 1 Erythropoiesis Larry Johnson Texas A&M University.
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Transcript of Hematopoiesis Simplified: Part 1 Erythropoiesis Larry Johnson Texas A&M University.
Hematopoiesis Simplified: Part 1 Erythropoiesis
Objectives are to:• Identify the developmental cells of
erythropoiesis•Characterize developmental changes in the cytoplasm and nucleus of these cells
Bone marrow
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Blood vessel
Erythrocytes
Reticulocytes
Orthochromatophilicerythroblasts
Polychromatophilic erythroblasts
Basophilic erythroblasts
Proerythroblasts
No nucleus and red cytoplasm
No nucleus and blue - grey cytoplasm
Dark, small, spherical nucleusblue – grey cytoplasm
Darkening, fractured ,spherical nucleus and mixed pools of grey and blue cytoplasm
Fractured, spherical nucleus andthin rim of dark blue cytoplasm
Uniformly light, spherical nucleus with thin rim of medium to dark blue cytoplasm
Erythropoiesis
Orthochromatophilic erythroblasts
Erythrocytes
Polychromatophilic erythroblasts
Basophilic erythroblasts
Proerythroblasts
Reticulocytes
Erythropoiesis
Erythropoiesis
Orthochromatophilic erythroblast
Erythrocyte
Polychromatophilic erythroblast
Basophilic erythroblast
Proerythroblast
Reticulocytes
Erythropoiesis
Orthochromatophilic erythroblast
Erythrocyte
Polychromatophilic erythroblast
Basophilic erythroblast
Proerythroblast
Reticulocytes
Erythropoiesis
Orthochromatophilic erythroblast
Erythrocyte
Polychromatophilic erythroblast
Basophilic erythroblast
Proerythroblast
Reticulocytes
Erythropoiesis
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Polychromatophilic erythroblast
Orthochromatophilicerythroblasts
Basophilic erythroblast
Proerythroblast
Late polychromatophilic erythroblast
Eosinophil orbasophil
RBCs
platelets
Reticulocyte
Erythrocytes
Hematopoiesis Simplified: Part 2 Granulopoiesis
Objectives are to:• Identify the developmental cells of granulopoiesis•Characterize developmental changes in the cytoplasm and nucleus of these cells
Bone marrow32583
Neutrophilicmetamyelocytes
Neutrophils
Neutrophilic myelocytes
Promyelocytes
Neutrophilic band or stab cells
Lobulated, dark nucleus, mature grey cytoplasm with small granules
Horse-shoe shaped, darkening nucleus, grey mature cytoplasm
Oval to kidney bean-shaped, indented nucleus, grey mature cytoplasm with a weak blue tent
Large, oval, non-indented nucleus, large amount of cytoplasm with specific and non-specific granules
Large, oval, non-indented nucleus,large amount of sky blue cytoplasm with non-specific granules
Granulopoiesis
Neutrophilicband cells
Neutrophils
Neutrophilic myelocytes
Promyelocytes
Neutrophilic metamyelocytes
Granulopoiesis
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Neutrophilic myelocytes
Neutrophilic metamyelocyte
Neutrophil
Eosinophil orbasophil
Platelets
Neutrophilic metamyelocytes
Neutrophilicband cells
Neutrophils
Neutrophilic myelocytes
Promyelocytes
Neutrophilic metamyelocytes
Granulopoiesis
Neutrophilic metamyelocytes
Neutrophilicband cellsLymphocytes Neutrophilic
myelocytes
Lymphocytes
Neutrophilic band cell
Unknown nuclei Promyelocyte
Neutrophilic myelocytes
Neutrophilic metamyelocytes
Neutrophilicband cells
Neutrophilic metamyelocytes
Proerythroblast
Neutrophilic myelocytes
Neutrophilic metamyelocytes
Orthochromatophilicerythroblasts
Orthochromatophilicerythroblasts
Unknown nuclei
Eosinophils or basophils
Neutrophilicband cells