Zio AT Final Report for

Report, Sample #2Patient IDDate of Birth

12/12/67 (49 yrs)GenderFemale

Prescribing ClinicianDr. E. Physician

Managing LocationiNCC Lincolnshire

Primary Indication (I48.0)Paroxysmal atrial fibrillation

Enrollment Period

12/21/16, 01:34pm to01/04/17, 12:43pm

13 days 23 hoursAnalysis Time13 days 23 hours(after artifact removed)

Heart RateOverall Max 204 bpm 09:57pm, 12/24

Min 36 bpm 01:17am, 01/03

Avg 86 bpm

Sinus Max 85 bpm 03:20am, 12/25

Min 36 bpm 01:17am, 01/03

Avg 54 bpm

Patient EventsTriggeredEvents: 5

Findings within ± 45 sec of Triggers:Atrial Fibrillation

DiaryEntries: 2

Findings within ± 45 sec of Entries:Atrial Fibrillation

Fastest AF (HR Range 113-204 bpm, Avg 166 bpm)

AF Burden35%Longest Duration1 d 9 hHR Range64-204 bpmAvg145 bpm

Atrial Fibrillation

None found

Fastest SVT (HR Range 169-190 bpm, Avg 180 bpm)

Episodes6HR Range95-190 bpmAvg137 bpm

Supraventricular Tachycardia (4 beats or more)

None found

AV Block (2nd° Mobitz II, 3rd°) None found

Ventricular Tachycardia (4 beats or more)

Fastest VT (HR Range 135-197 bpm, Avg 164 bpm)

Episodes1HR Range135-197 bpmAvg164 bpm

None found

Longest Pause (4.8 s, 12 bpm)

Episodes6Range3.0-4.8 s

Pauses (3 secs or longer)

None found

Ectopics Rare<1%

Occasional1% to <5%

Frequent5%+

Supraventricular Ectopy (SVE/PACs)IsolatedCoupletTriplet

Occasional 265791.5%Rare 964<1.0%Rare <1.0% 47

Ventricular Ectopy (VE/PVCs)IsolatedCoupletTriplet

Rare <1.0%Rare <1.0%0

0 sLongest Ventricular Bigeminy Episode0 sLongest Ventricular Trigeminy Episode

SIGNATURE

Final InterpretationPreliminary FindingsPatient had a min HR of 36 bpm, max HR of 204 bpm, and avg HR of 86 bpm. Predominant underlying rhythm was Sinus Rhythm. 1 run of Ventricular Tachycardia occurred lasting 4 beats with a max rate of 197 bpm (avg 164 bpm). 6 Supraventricular Tachycardia runs occurred, the run with the fastest interval lasting 4 beats with a max rate of 190 bpm, the longest lasting 6 beats with an avg rate of 120 bpm. Atrial Fibrillation occurred (35% burden), ranging from 64-204 bpm (avg of 145 bpm), the longest lasting 1 day 9 hours with an avg rate of 130 bpm. Atrial Fibrillation was detected within +/- 45 seconds of patient triggered/diary event. 6 Pauses occurred, the longest lasting 4.8 secs (12 bpm). Isolated SVEs were occasional (1.5%, 26579), SVE Couplets were rare (<1.0%, 964), and SVE Triplets were rare (<1.0%, 47). Isolated VEs were rare (<1.0%), VE Couplets were rare(<1.0%), and no VE Triplets were present. MD notification criteria for First Documentation of Atrial Fibrillation met - notified Dr. E Physician on 22 Jan 2017 at 9:12 am CT. MD notification criteria for Pauses met -notified Dr. E. Physician on 02 Jan 2017 at 02:42 pm CT. MD notification criteria for Rapid Atrial Fibrillation met - notified Dr. E. Physician on 24 Jan 2017 at 01:20 pm CT.

iRhythm TechnologiesTel: (888) 693-2401www.zioreports.com

S/N:A123456789 2018 iRhythm Technologies, Inc. Page 1 of 26

HR(bpm)

020000

410

Patient diary events Patient triggered PVT, VF, TdP VT SVT Pauses % AF burden AV Block Unanalyzable ECG

Days 1 & 2

HR per 20 min period:

Max/Min Avg

6am noon 6pm midnight 6am noon 6pm

000001

350

Patient diary events Patient triggered PVT, VF, TdP VT SVT Pauses % AF burden AV Block Unanalyzable ECG

Days 3 & 46am noon 6pm midnight 6am noon 6pm

000010

170

Patient diary events Patient triggered PVT, VF, TdP VT SVT Pauses % AF burden AV Block Unanalyzable ECG

Days 5 & 66am noon 6pm midnight 6am noon 6pm

Events

Patient: Report, Sample #2 S/N:A123456789 2018 iRhythm Technologies, Inc. Page 2 of 26

HR(bpm)

11

0110

690

Patient diary events Patient triggered PVT, VF, TdP VT SVT Pauses % AF burden AV Block Unanalyzable ECG

Days 7 & 8

HR per 20 min period:

Max/Min Avg

6am noon 6pm midnight 6am noon 6pm

01000040

Patient diary events Patient triggered PVT, VF, TdP VT SVT Pauses % AF burden AV Block Unanalyzable ECG

Days 9 & 106am noon 6pm midnight 6am noon 6pm

000021

260

Patient diary events Patient triggered PVT, VF, TdP VT SVT Pauses % AF burden AV Block Unanalyzable ECG

Days 11 & 126am noon 6pm midnight 6am noon 6pm

Patient: Report, Sample #2 S/N:A123456789 2018 iRhythm Technologies, Inc. Page 3 of 26

HR(bpm)

110024

600

Patient diary events Patient triggered PVT, VF, TdP VT SVT Pauses % AF burden AV Block Unanalyzable ECG

Days 13 & 14

HR per 20 min period:

Max/Min Avg

6am noon 6ammidnight6pm noon 6pm

000000

180

Patient diary events Patient triggered PVT, VF, TdP VT SVT Pauses % AF burden AV Block Unanalyzable ECG

Day 156am noon 6ammidnight6pm noon 6pm

Patient: Report, Sample #2 S/N:A123456789 2018 iRhythm Technologies, Inc. Page 4 of 26

PatientEvents

Patient Triggered EventsNote: Triggered Event strips cover 45 seconds before and after the button press.

= Patient Triggered Marker = Vertical Zoom

12/21/16 09:29:09pm AF (152-187 bpm) 2.5x, 90 s

12/22/16 06:58:20pm AF (152-177 bpm) 2.1x, 90 s

12/28/16 12:22:55am AF (102-151 bpm) 2.3x, 90 s

12/30/16 08:31:25pm AF (148-187 bpm) 2.1x, 90 s

01/02/17 02:02:51pm AF (147-188 bpm) 2.8x, 90 s

Patient: Report, Sample #2 S/N:A123456789 2018 iRhythm Technologies, Inc. Page 5 of 26

Patient Diary EntriesNotes: iRhythm cannot verify the accuracy of the patient-reported information provided below.

Patient Diary strips cover 45 seconds before and after the patient's stated diary entry time.

= Patient Triggered Markers captured within the Patient Diary ECG = Vertical Zoom

Date Time Symptoms Duration Activity

moving furniture1/ /16 02:06pm skipped/irregular beat(s)

Findings: AF (1 -1 bpm) 2.1x, 90 s

Patient: Report, Sample #2 S/N:A123456789 2018 iRhythm Technologies, Inc. Page 6 of 26

1 minDate Time Symptoms Duration Activity

05:21pm skipped/irregular beat(s)12/27/16 walking around house

Findings: AF (135-165 bpm) 2.1x, 90 s

Date Time Symptoms Duration Activity

02:06pm skipped/irregular beat(s)01/02/17 moving furnitureless than 1 min

Findings: AF (127-175 bpm) 3.2x, 90 s

Episode Heart Rates

HeartRate(bpm)

day (6am - 10pm)night (10pm - 6am)unanalyzable ECG VT

Ventricular Tachycardia(4 beats or more)

Number of episodes

1Average heart rate

164 bpmHeart rate range

135-197 bpm

Note: Heart rates are calculatedusing single, beat-to-beat intervals.

HeartRate(bpm)

VT with Fastest Heart Rate2 s07:56:50pm 135-197 bpm12/28/16

Range:

164 bpmAverage:Duration: Pt Triggered?

YES NO

# Beats:

41

VT with Fastest Avg. Heart Rate Range:Average:Duration: Pt Triggered?

YES NO

# Beats:2

Patient: Report, Sample #2 S/N:A123456789 2018 iRhythm Technologies, Inc. Page 7 of 26

Longest VT Episode Range:Average:Duration: Pt Triggered?

YES NO

# Beats:3

Patient: Report, Sample #2 S/N:A123456789 2018 iRhythm Technologies, Inc. Page 8 of 26

Number of Pauses per hour

Pauses(No./hr)

day (6am - 10pm)night (10pm - 6am)unanalyzable ECG Pauses

(3 secs or longer)

Number of episodes

6Maximum Pauses per hour

1Maximum duration

4.8 secs (12 bpm)Range

3.0-4.8 secs

Pauses(No./hr)

Longest Pause4.8 s (12 bpm)12:12:13pm01/02/17Duration: Pt Triggered?

YES NO

1

Second Longest Pause4.1 s (14 bpm)01:21:05pm12/23/16Duration: Pt Triggered?

YES NO

2

Patient: Report, Sample #2 S/N:A123456789 2018 iRhythm Technologies, Inc. Page 9 of 26

Third Longest Pause4 s (15 bpm)05:39:59pm01/02/17Duration: Pt Triggered?

YES NO

3

Patient: Report, Sample #2 S/N:A123456789 2018 iRhythm Technologies, Inc. Page 10 of 26

AF Burden & Heart Rate Averages

Time(hr) inAF per day

Heart Rate(bpm)

% AF of Analyzable ECG

Time in AFUnanalyzable Time

AFSinus/Other

3h 10m13h 35m

10h 57m0h 2m

13h 9m0h 1m

3h 30m0h 7m

2h 9m0h 3m

5h 57m0h 2m

21h 27m0h 1m

30% 46% 55% 15% 9% 25% 89%

11h 52m0h 1m50%

Heart Rate(bpm)

% AF of Analyzable ECG

Time in AFUnanalyzable Time

0h 0m0h 3m

1h 45m0h 3m

8h 45m0h 2m

3h 48m0h 4m

18h 4m< 1 min

10h 52m0h 3m

2h 15m11h 18m

0% 7% 36% 16% 75% 45% 18%

AF Duration

% of AFEpisodes (30s+)

Episodes

Avg. Duration

30 - <60s 1 - <6m 6 - <10m 10 - <60m 1 - <12h 12 - <24h 1d+

7 13 1 14 18 0 1

45s 2m 0s 8m 22s 32m 59s 4h 13m 0 1d 9h

Total Episodes (30s+)

54Episodes of 6 mins or longer

34Longest Duration

1 d 9 h

1 AF with Fastest Heart Rate Average: Range:

12/24/16 09:57:41pm 166 bpm 113-204 bpm

Pt Triggered?

YES NO

AFAtrial Fibrillation

Total AF during enrollment

35%Average heart rate

145 bpmHeart rate range

64-204 bpm

Note: Heart rates are calculatedusing a sliding window of 8 beatintervals.

Patient: Report, Sample #2 S/N:A123456789 2018 iRhythm Technologies, Inc. Page 11 of 26

2 AF with Slowest Heart Rate Average: Range:

12/23/16 09:15:34am 127 bpm 64-185 bpm

Pt Triggered?

YES NO

3 AF with Fastest Avg. Heart Rate Average: Range:

01/03/17 10:22:47pm 171 bpm 132-203 bpm

Pt Triggered?

YES NO

4 Longest AF Episode Duration: Average: Range:

12/27/16 02:32:03am 1 d 9 h 130 bpm 65-184 bpm

Pt Triggered?

YES NO

TERMINATIONONSET FASTEST

5 Second longest AF Episode Duration: Average: Range:

12/23/16 01:34:22am 11 h 47 m 127 bpm 64-185 bpm

Pt Triggered?

YES NO

TERMINATIONONSET FASTEST

Patient: Report, Sample #2 S/N:A123456789 2018 iRhythm Technologies, Inc. Page 12 of 26

Episode Heart Rates

HeartRate(bpm)

day (6am - 10pm)night (10pm - 6am)unanalyzable ECG SVT

Supraventricular Tachycardia(4 beats or more)

Number of episodes

6Average heart rate

137 bpmHeart rate range

95-190 bpm

Note: Heart rates are calculatedusing single, beat-to-beat intervals.

HeartRate(bpm)

SVT with Fastest Heart Rate1.5 s02:54:33pm 169-190 bpm01/03/17

Range:

180 bpmAverage:Duration: Pt Triggered?

YES NO

# Beats:

41

SVT with Fastest Avg. Heart Rate Range:Average:Duration: Pt Triggered?

YES NO

# Beats:2

Patient: Report, Sample #2 S/N:A123456789 2018 iRhythm Technologies, Inc. Page 13 of 26

Longest SVT Episode2.9 s10:08:19pm 110-125 bpm12/25/16

Range:

120 bpmAverage:Duration: Pt Triggered?

YES NO

# Beats:

63

Patient: Report, Sample #2 S/N:A123456789 2018 iRhythm Technologies, Inc. Page 14 of 26

Number of Beats per Hour

SVE Beats(No./hr)

1189 1478 1483 2615 3791 2034 518 15002.2% 1.0% 1.1% 2.7% 4.1% 1.9% 0.3% 1.3%

Daily SVEs:Daily % SVEs:

day (6am - 10pm)night (10pm - 6am)unanalyzable ECG SVEs

Supraventricular Ectopics(PACs)

Isolated Ectopics

1.5% 26579, Occasional

Couplets

<1.0% 964, Rare

Triplets

<1.0% 47, Rare

3548 2087 777 3382 526 2275 13894.7% 2.3% 0.6% 3.2% 0.3% 1.5% 2.6%

Daily SVEs:Daily % SVEs:

SVE Beats(No./hr)

None found

Isolated SVE03:24:56am01/04/17

1

None found

SVE Couplet08:21:40am12/26/16

2

Patient: Report, Sample #2 S/N:A123456789 2018 iRhythm Technologies, Inc. Page 15 of 26

None found

SVE Triplet02:21:15am12/25/16

3

Patient: Report, Sample #2 S/N:A123456789 2018 iRhythm Technologies, Inc. Page 16 of 26

AdditionalStrips

1 Minimum Sinus Rate (36 bpm)01:17:00am01/03/17

2 Maximum Sinus Rate (85 bpm)03:20:19am12/25/16

3 Atrial Fibrillation (154-186 bpm)12/21/16 09:29:08pm Associated with patient triggered event

Patient: Report, Sample #2 S/N:A123456789 2018 iRhythm Technologies, Inc. Page 17 of 26

4 Initiation of Atrial Fibrillation (87-158 bpm)01:34:18am12/23/16

5 Atrial Fibrillation (64-98 bpm)09:15:22am12/23/16

Patient: Report, Sample #2 S/N:A123456789 2018 iRhythm Technologies, Inc. Page 18 of 26

6 Termination of Atrial Fibrillation (135-168 bpm), Pause (4.1 seconds)01:20:31pm12/23/16

7 Atrial Fibrillation (163-204 bpm)09:57:33pm12/24/16

Patient: Report, Sample #2 S/N:A123456789 2018 iRhythm Technologies, Inc. Page 19 of 26

8 Atrial Fibrillation (166-194 bpm)11:43:09pm12/24/16

Patient: Report, Sample #2 S/N:A123456789 2018 iRhythm Technologies, Inc. Page 20 of 26

9 Initiation of Atrial Fibrillation (115-155 bpm)02:32:00am12/27/16

10 Atrial Fibrillation (138-165 bpm)05:20:45pm Associated with patient diary event (accuracy of times reported by

patient cannot be guaranteed)12/27/16

Patient: Report, Sample #2 S/N:A123456789 2018 iRhythm Technologies, Inc. Page 21 of 26

11 Termination of Atrial Fibrillation (93-137 bpm)11:52:26am12/28/16

12 Sinus (47 bpm), Supraventricular Tachycardia (95-119 bpm)01:48:44am12/31/16

Patient: Report, Sample #2 S/N:A123456789 2018 iRhythm Technologies, Inc. Page 22 of 26

13 Sinus (53 bpm), Supraventricular Tachycardia (104-171 bpm)09:13:07pm01/01/17

14 Atrial Fibrillation (151-195 bpm)10:22:13am01/02/17

Patient: Report, Sample #2 S/N:A123456789 2018 iRhythm Technologies, Inc. Page 23 of 26

15 Termination of Atrial Fibrillation (141-160 bpm), Pause (4.0 seconds)11:56:04am01/02/17

16 Termination of Atrial Fibrillation (129-155 bpm), Pause (4.8 seconds)12:11:55pm01/02/17

Patient: Report, Sample #2 S/N:A123456789 2018 iRhythm Technologies, Inc. Page 24 of 26

17 Atrial Fibrillation (148-183 bpm)01/02/17 02:02:28pm Associated with patient triggered event

18 Termination of Atrial Fibrillation (162-167 bpm), Pause (4.0 seconds)05:39:41pm01/02/17

Patient: Report, Sample #2 S/N:A123456789 2018 iRhythm Technologies, Inc. Page 25 of 26

19 Termination of Atrial Fibrillation (147-172 bpm), Pause (3.1 seconds)01:03:10am01/03/17

20 Atrial Fibrillation (157-204 bpm)09:50:17pm01/03/17

21 Sinus (38 bpm), VE(s)02:21:00pm12/22/16

2018 iRhythm Technologies, Inc. Page 26 of 26Patient: Report, Sample #2 S/N:A123456789

MKT0006.02