HEART FAILURE - University of Mosulmedicinemosul.uomosul.edu.iq/files/pages/page_2181505.pdf ·...
Transcript of HEART FAILURE - University of Mosulmedicinemosul.uomosul.edu.iq/files/pages/page_2181505.pdf ·...
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HEART FAILURE
غفران أجياد ثامر
فرح عماد
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HEART FAILURE
A state that develops when the heart fails
to maintain an adequate cardiac output to
meet the demands of the body
characterized by:
1. Diminished cardiac output (forward
failure)
2. Damming back of blood in the venous
system (backward failure) or Both .
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TYPES OF HEART FAILURE
*Left sided ,right sided & biventricular heart
failure
*Acute &chronic heart failure
*Compensated & decompensated heart
failure
* Forward & backward heart failure
* Systolic & diastolic dysfunction
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Pathophysioylogy
Before reaching H.F we have many mechanisms that is compensatory mechanisms :Adaptive mechanismsby which the CVS maintains arterial pressure & perfusion of vital organs :
.1The Frank-Starling mechanism : >preload of dilation helps to sustain cardiac performance by enhancing contractility.
.2Myocardial structural change : Augmented muscle mass (hypertrophy) with or without cardiac chamber dilatation.
.3Activation of neurohumoral system :Release of norepinephrine – >heart rate—augments myocardial contractility.Activation of renin – angiotensin – aldosterone system.Release of atrial natriuretic peptide.
of H.F
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Pathophysiology
Failure of adaptive mechanisms
Heart
failure
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Pathophysiology
Systolic dysfunction:
Progressive detoriation of myocardial contractile function.
Occurs in cases of Ischemic injury, pressure or volume overload and DCM.
E.g. IHD and HTN.
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Diastolic dysfunction:
Inability of the heart chamber to relax, expand, and fill sufficiently during diastole to accommodate an adequate ventricular blood volume.
E.g. Massive LVH, myocardial fibrosis, deposition of amyloid, or constrictive pericarditis.
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PathophysiologyCardiac The onset of HF is preceded by
compensatory response of :hypertrophythe myocardium to > mechanical work.
The stimuli > the rate of protein synthesis, the amount of protein in each cell, size of myocytes, numbers of sacromeres & mitochondria : the mass & size of heart.
Also accompanied by selective up regulation of several immediate early response gene & embryonic forms of contractile& other proteins.
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Schematic representation of the sequence of events in cardiac hypertrophy and its
progression to heart failure, emphasizing cellular and extracellular changes
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LEFT SIDED HEART FAILURE
Progressive damming of the blood within the
pulmonary circulation and the consequence
of diminished peripheral BP and flow.
CAUSES :
* IHD
* SYSTEMIC HTN
* MI
* VALVULAR DISEASE
* Non_ischemic myocardial disease
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MORPHOLOGY OF LEFT SIDED
HEART FAILUREHEART:
LEFT VENTRICLE is usually hypertrophied and often dilated
Secondary enlargement of the left atrium
LUNG:
Pressure in the pulmonary veins are transmitted retrograde to the capillaries and arteries
Pulmonary congestion & edema
Heavy wet lung
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Kidney:
Decrease cardiac output
Reduction in renal perfusion
Activation of renal – angiotensin –aldosterone
System
Retention of salt & water with consequent expansion of the interstitial fluid and blood volumes
Pulmonary edema in lungs
Brain:
Hypoxic encephalopathy
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Congestion & edema
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Pulmonary congestion with dilated capillaries and leakage of blood into alveolar
spaces leads to an increase in hemosiderin-laden macrophages,
as seen here.
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RIGHT SIDED HEART FAILURE
* Usually as a consequence of right sided
heart failure
* Cor pulmonale :chronic severe
pulmonary hypertension due to
increased resistance within the
pulmonary circulation.
* Other causes : multiple pulmonary emboli
& valvular disease
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MORPHOLOGY OF RIGHT SIDED
HERTE FAILURE
HEART:
Hypertrophy and dilation are generally confined to right ventricle and atrium.
LIVER AND PORTAL SYSTEM:
* Passive congestive hepatomegaly(nutmeg liver)
* Centrilobular necrosis along with the sinusoidal congestion
* Congestive splenomegaly
* Ascites
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Here is an example of a "nutmeg" liver seen with chronic passive congestion of the liver.
Note the dark red congested regions that represent accumulation
of RBC's in centrilobular regions. the natural nutmeg is at right.
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