Heart Failure - Bristol-Myers Squibb - Global ... · Acute decompensated heart failure is a sudden...
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BMS is committed to identifying and developing new treatment options for patients with heart failure. Learn more about our cardiovascular research: https://www.bms.com/researchers-and-partners/areas-of-focus.html What is Heart Failure? Heart failure is a progressive, debilitating disease characterized by a deterioration of heart function and supply of blood to critical organs. 1 Acute decompensated heart failure is a sudden worsening of heart failure symptoms. 2 1 "Heart Failure." American Heart Association. Accessed June 27, 2017. http://watchlearnlive.heart.org/CVML_Player.php?moduleSelect=hrtflr. 2 Joseph, Susan M., MD, Ari M. Cedars, MD, Gregory A. Ewald, MD, and Douglas L. Mann, MD. "Acute Decompensated Heart Failure." Texas Heart Institute Journal 36, no. 6 (2009): 510-20. Accessed June 27, 2017. 3 "Warning Signs of Heart Failure." American Heart Association. May 8, 2017. Accessed June 14, 2017. http://www.heart.org/HEARTORG/Conditions/HeartFailure/WarningSignsforHeartFailure/Warning-Signs-of-Heart-Failure_UCM_002045_Article.jsp#.WUFqKVXyuos. 4 "Heart Failure Symptoms." Mayo Clinic. March 7, 2017. Accessed June 29, 2017. http://www.mayoclinic.org/diseases-conditions/heart-failure/basics/symptoms/con-20029801 5 Ponikowski et al. ESC Heart Fail. 2014;1:4–25. 6 "Who Is at Risk for Heart Failure?" National Heart Lung and Blood Institute. June 22, 2015. Accessed June 27, 2017. https://www.nhlbi.nih.gov/health/health-topics/topics/hf/atrisk 7 Heart Failure Complications." Mayo Clinic. March 07, 2017. Accessed June 19, 2017. http://www.mayoclinic.org/diseases-conditions/heart-failure/basics/complications/con-20029801. 8 Zaya, Melody. "Predictors of re-hospitalization in patients with chronic heart failure." World Journal of Cardiology 4, no. 2 (February 26, 2012): 23-30. Accessed February 13, 2018. doi:10.4330/wjc.v4.i2.23." 9 "Living with Heart Failure and Managing Advanced HF." American Heart Association. Accessed June 19, 2017. http://www.heart.org/HEARTORG/Conditions/HeartFailure/LivingWithHeartFailureAndAdvancedHF/Living-with-Heart-Failure-and-Managing-Advanced-HF_UCM_477835_Article.jsp#.WUfXrVXyuos. 10 Katz JN,Waters SB, Hollis IB, Chang PP. Advanced Therapies For End-Stage Heart Failure. Current Cardiology Reviews. 2015; 11(1):63-72. doi:10.2174/1573403X09666131117163825. 11 "Common Tests for Heart Failure." American Heart Association. Accessed June 19, 2017. http://www.heart.org/HEARTORG/Conditions/HeartFailure/DiagnosingHeartFailure/Common-Tests-for-Heart-Failure_UCM_306334_Article.jsp#.WUfcU1UrKos. Heart Failure Diagnosis There is no one test that can diagnose heart failure, so physicians consider family history, signs and symptoms, a physical exam, and tests to diagnose. Tests include: 11 • Chest X-ray • Electrocardiogram (EKG) • Echocardiography • Exercise stress test • Blood test Treatment Half of patients have no approved evidence-based therapy. Current treatment options for heart failure are limited and there is a need for medications that help patients live longer, feel and function better and have fewer safety risks. Normal Heart Failure Ischemia Hypertension Arrhythmia Chronic Insult Heart muscle pumps blood normally Abnormal left ventricle pumps blood ineffectively Prevalence Approximately 26 MILLION people worldwide have been diagnosed with heart failure. 5 Heart failure is most common in people who are 65 OR OLDER. 6 Impact Heart failure is a serious condition that can have a significant impact on lives: Heart failure is a leading contributor to hospitalizations, re-admissions and healthcare costs worldwide. In the U.S. alone, hospitalizations related to heart failure cost >$30B and are projected to increase to $70B in 2030. In the U.S., approximately 50% of patients with diagnosed heart failure are re-hospitalized within 6 MONTHS 8 About HALF of all heart failure patients will die within 5 YEARS of diagnosis If not treated properly, heart failure can result in SERIOUS COMPLICATIONS, including kidney damage or failure, heart valve problems, arrhythmias, and liver damage 7 Around 10% of heart failure patients in the U.S. are at risk for advanced heart failure and require advanced therapies (e.g., transplants, defibrillators, continuous IV medications, or assist devices) 9,10 Signs and symptoms of heart failure can include: 3,4 Nausea or lack of appetite Confusion or impaired thinking Increased or irregular heart rate Fatigue Persistent coughing or wheezing Swelling/ excess fluid Shortness of breath ? ??? Z Z Z
Transcript of Heart Failure - Bristol-Myers Squibb - Global ... · Acute decompensated heart failure is a sudden...
BMS is committed to identifying and developing new treatment options for patients with heart failure. Learn more about our cardiovascular research: https://www.bms.com/researchers-and-partners/areas-of-focus.html
What is Heart Failure? Heart failure is a progressive, debilitating disease characterized by a deterioration of heart function and supply of blood to critical organs.1
Acute decompensated heart failure is a sudden worsening of heart failure symptoms.2
1 "Heart Failure." American Heart Association. Accessed June 27, 2017. http://watchlearnlive.heart.org/CVML_Player.php?moduleSelect=hrtflr. 2 Joseph, Susan M., MD, Ari M. Cedars, MD, Gregory A. Ewald, MD, and Douglas L. Mann, MD. "Acute Decompensated Heart Failure." Texas Heart Institute Journal 36, no. 6 (2009): 510-20. Accessed June 27, 2017. 3 "Warning Signs of Heart Failure." American Heart Association. May 8, 2017. Accessed June 14, 2017. http://www.heart.org/HEARTORG/Conditions/HeartFailure/WarningSignsforHeartFailure/Warning-Signs-of-Heart-Failure_UCM_002045_Article.jsp#.WUFqKVXyuos. 4 "Heart Failure Symptoms." Mayo Clinic. March 7, 2017. Accessed June 29, 2017. http://www.mayoclinic.org/diseases-conditions/heart-failure/basics/symptoms/con-20029801 5 Ponikowski et al. ESC Heart Fail. 2014;1:4–25. 6 "Who Is at Risk for Heart Failure?" National Heart Lung and Blood Institute. June 22, 2015. Accessed June 27, 2017. https://www.nhlbi.nih.gov/health/health-topics/topics/hf/atrisk 7 Heart Failure Complications." Mayo Clinic. March 07, 2017. Accessed June 19, 2017. http://www.mayoclinic.org/diseases-conditions/heart-failure/basics/complications/con-20029801. 8 Zaya, Melody. "Predictors of re-hospitalization in patients with chronic heart failure." World Journal of Cardiology 4, no. 2 (February 26, 2012): 23-30. Accessed February 13, 2018. doi:10.4330/wjc.v4.i2.23." 9 "Living with Heart Failure and Managing Advanced HF." American Heart Association. Accessed June 19, 2017. http://www.heart.org/HEARTORG/Conditions/HeartFailure/LivingWithHeartFailureAndAdvancedHF/Living-with-Heart-Failure-and-Managing-Advanced-HF_UCM_477835_Article.jsp#.WUfXrVXyuos. 10 Katz JN, Waters SB, Hollis IB, Chang PP. Advanced Therapies For End-Stage Heart Failure. Current Cardiology Reviews. 2015; 11(1):63-72. doi:10.2174/1573403X09666131117163825. 11 "Common Tests for Heart Failure." American Heart Association. Accessed June 19, 2017. http://www.heart.org/HEARTORG/Conditions/HeartFailure/DiagnosingHeartFailure/Common-Tests-for-Heart-Failure_UCM_306334_Article.jsp#.WUfcU1UrKos.
Heart Failure
Diagnosis There is no one test that can diagnose heart failure, so physicians consider family history, signs and symptoms, a physical exam, and tests to diagnose.
Tests include:11
• Chest X-ray
• Electrocardiogram (EKG)
• Echocardiography
• Exercise stress test
• Blood test
Treatment Half of patients have no approved evidence-based therapy. Current treatment options for heart failure are limited and there is a need for medications that help patients live longer, feel and function better and have fewer safety risks.
Normal Heart Failure
IschemiaHypertensionArrhythmia
ChronicInsult
Heart muscle pumps blood normally
Abnormal left ventricle pumps blood ineffectively
Prevalence
Approximately 26 MILLION people worldwide have
been diagnosed with heart failure. 5
Heart failure is most common in
people who are 65 OR OLDER.6
ImpactHeart failure is a serious condition that can have a significant impact on lives:
Heart failure is a leading contributor to hospitalizations, re-admissions and healthcare costs worldwide. In the U.S. alone, hospitalizations related to heart
failure cost >$30B and are projected to increase to $70B in 2030.
In the U.S., approximately 50% of patients with diagnosed heart failure are re-hospitalized within 6 MONTHS8
About HALF of all heart failure patients will die within 5 YEARS of diagnosis
If not treated properly, heart failure can result in SERIOUS COMPLICATIONS, including kidney damage or failure, heart valve problems, arrhythmias, and liver damage7
Around 10% of heart failure patients in the U.S. are at risk for advanced heart failure and require advanced therapies (e.g., transplants, defibrillators, continuous IV medications, or assist devices)9,10
Signs and symptoms of heart failure can include:3,4
Heart failure can be ongoing (chronic) or occur suddenly (acute). Acute decompensated heart failure is a sudden worsening of heart failure symptoms.4
Nausea or lack ofappetite
Confusion or impaired thinking
Increased or irregular
heart rate Fatigue
Persistent coughing or wheezing
Swelling/excess fluid
Shortness of breath
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