Health Council of the Netherlands More than 100 years of scientific advice on public health issues.
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Transcript of Health Council of the Netherlands More than 100 years of scientific advice on public health issues.
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Health Council of the Netherlands
More than 100 years of scientific advice on public health issues
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Growth of NVP in the Netherlands
2003Hepatitis B – children at risk
2006Pneumococcal disease
2002Meningococcal C infections
1993Haemophilus influenzae type b
1989Hepatitis B – mother HBsAg+
1974Rubella
1987Mumps
1976Measles
1957Polio
1957Tetanus
1957Pertussis
1957Diphtheria
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National Vaccination Programme(10-2006,*mother HBsAg+, &population at risk)
MMRdTP9
Influenza (yearly)>65
aPdTP4 years
MMRMenC14
PnDaPTPHib (HepB*&)11
PnDaPTPHib (HepB*&)4
PnDaPTPHib (HepB*&)3
PnDaPTPHib (HepB*&)2
HepB*0 months
Injection 2Injection 1Age
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Organization of NVP in the Netherlands
Linkage to population register Embedded in neonatal care and infant welfare Voluntariness Recalls, outreaching activities High quality information and health education Continuous education of infant welfare workers
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Organization of NVP in the Netherlands
National Institute of Public Health (RIVM)– Runs the programme, information, evaluation of
effectiveness, adverse effects
Netherlands Vaccine Institute (NVI)– Produces or buys the vaccines
Health Council (Gezondheidsraad, GR)– Independent, scientific advice
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Vaccination coverage, Netherlands(Source: RIVM)
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Committees of the Health Council
Independent Based on scientific state-of-the-art Multidisciplinary, including ethical and legal
aspects Personal membership, not representing
organizations Disclosure Deliberations confidential, reports publicized Advisors from RIVM, Inspectorate, Ministry Hearings for social organizations, industry
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Request for advice from the Minister of Health in response to report of National Institute of Public Health (RIVM, 2000) Need for new vaccinations in the NVP? Choice of specific (combinations of) vaccines with
respect to side effects? Starting points and assumptions used for cost-utility
analysis? Number of injections that can be administered at one
visit (acceptability in the population)? Total number of vaccinations that can be safely
given, risk of overburdening the immune system? Possibility or desirability to stop certain vaccinations
now in the NVP?
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NVP Review Committee
Composition of NVP– Criteria for inclusion– Prioritization
Risk perception and risk communication, health education
Vaccination and maturation of the immune system (Th1/Th2; innate immune system)
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Recent reports on NVP
Universal vaccination against hepatitis B (2001)
Programmatic vaccination of adults (2001) Universal vaccination against meningococcal
serogroup C and pneumococcal disease (2001) Vaccination of children against
hepatitis B (HBsAg+ mothers) (2003) Immunisation against tetanus (2003) Yearly reports on adverse events Pertussis (1997, 2000 and 2004) Pneumococcal vaccination (2005)
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Purpose of NVP
To protect the population and societal life against serious infectious diseases through vaccination
Subtargets:
1. To eradicate or eliminate a certain disease
2. To reach and maintain herd immunity
3. To protect as many individuals as possible
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Emphasis on children in current NVP
1. Children’s diseases are the diseases against which good immunity, also through vaccination, is possible
2. A NVP targeted at children offers the best chances of establishing a high vaccination coverage. A high coverage is important for establishing herd immunity
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NVP is becoming a programme for infectious disease control at all ages
1. Children’s diseases become diseases of adolescents and adults (pertussis)
1. Long-term protection? (diphtheria, tetanus)
1. Vaccination in the elderly (influenza, zoster)
1. Vaccination against STD (HPV)
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Criteria for inclusion of a vaccination in a public vaccination programme
Disease burden
1. The infectious disease is serious for individuals and affects a sizeable group
Effectiveness
1. Vaccination is effective in preventing disease or reducing symptoms
2. Adverse effects do not detract from the favourable health effects in considerable measure
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Criteria for inclusion of a vaccination in a public vaccination programme
Acceptability
1. The inconveniences of vaccination bear a proper proportion to the health effects to be gained
2. The inconveniences of the vaccination programme as a whole bear a proper proportion to the health effects to be gained
Efficiency
1. The cost-effectiveness ratio is favourable to other means of prevention
Urgency
1. Vaccination serves a (potentially) urgent public health problem
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Example: vaccination against chickenpox in the Netherlands?
Mostly seen as innocent, but 200 hospital admissions and 2.3 deaths/yr
Vaccination aimed at all children Goal is to prevent complications Vaccines available: separate (one dose), MMRV
(two doses) Linkage of epidemiology of chickenpox and
shingles
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Assessment of vaccination against chickenpox, Netherlands (ongoing)
1. Is c. serious for individuals and does it affect a sizeable group?
1. C. affects almost whole year classes, but is only rarely serious. Peaks at a relatively young age and incidence of complications relatively low compared to neighbouring countries. Incidence of complications could be underestimated in hospital discharge data.
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Assessment of vaccination against chickenpox, Netherlands (ongoing)
1. Is vaccination effective in preventing disease or reducing symptoms?
2. Do adverse effects detract from the favourable health effects in considerable measure?
1. Yes, VE about 90% in studies abroad
1. Possibly: effects on shingles unclear, incidence might rise
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Assessment of vaccination against chickenpox, Netherlands (ongoing)
1. Do inconveniences of vaccination bear a proper proportion to the health effects to be gained?
1. Do inconveniences of the vaccination programme as a whole bear a proper proportion to the health effects to be gained?
1. Not certain: inconveniences of one or two dose vaccination are limited, but health effects to gained probably as well
1. Not certain: inconveniences of extra jab are limited, but health effects to gained probably as well
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Assessment of vaccination against chickenpox, Netherlands (ongoing)
1. Is the cost-effectiveness ratio favourable to other means of prevention (or no prevention)?
1. Does vaccination serve a (potentially) urgent public health problem?
1. Not certain: most of the benefits are less loss of productivity of the parents
1. C. is a mostly innocent disease; it is uncertain how vaccination will encroach upon the dynamic equilibrium with shingles; most parents don’t see a need for vaccination
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Assessment of vaccination against chickenpox, Netherlands (ongoing)
Assess underreporting of complications of chickenpox
Possible influence on incidence of shingles will not become clear in short term
Rather vaccinate against shingles?
Reconsider vaccination against chickenpox for inclusion in NVP when new data on incidence of complications become available
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The NVP put to the test
All 15 current vaccinations meet the 7 criteria
Of 23 candidate vaccinations:
– No unqualified recommendationfor extension of NVP right now
– Reconsider within 2-3 yrs: shingles, chickenpox, rota, meningB, hepatitis B (all children), influenza (children, 50-65 yrs), HPV, RSV, CMV (hepatitis A?)
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Topics of future advisory reports
Future of the National Vaccination Programme
BCG vaccination
Influenza: children <2 yrs, 50-65 yrs, risk groups
Hepatitis B vaccination (adolescents)Protection of young infants against pertussis
Longer term NVP prospects
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Statutory task
"… to advise the government and the parliament on the current level of knowledge
with respect to public health issues ..."
Health Act 1956, 1997
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Present day fields
Health care
MTA
Preven-tive
medi-cineEnvi-
ron-mental health
Eco-toxi-
cology
Occu-pational health
Food & Nutri-tion
Advisory Council on
Health Research
(RGO)MTA
Preven-tive
medi-cineEnvi-
ron-mental health
Eco-toxi-
cology
Occu-pational health
Food & Nutri-tion
Health care
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Structure
PresidentVice-presidents (2)
Members~ 200
Standing committees (9):
ReviewWork programme
Standing committees (9):
ReviewWork programme
Standing committees (8):
ReviewWork programme
Autonomous ad hoc committees
(~40):Advisory reports
Autonomous ad hoc committees
(~40):Advisory reports
Autonomous ad hoc committees
(~40):Advisory reports
Secretariat:Exec. Director
~35 scientific staff~35 adm. staff