Fournier’s Gangrene: Descriptive Analysis and Outcome of ...
Healing and Gangrene
description
Transcript of Healing and Gangrene
Healing and Gangrene
Gangrene: It’s a necrosis with putrefaction,. It has 3 types: 1- Dry or senile gangrene. Gradual arterial occlusion
usually affect the extremities 2- Moist gangrene. Sudden arterial and venous occlusion,
Bacterial invasion , skin is black, moist and of foul odour 3- Gas gangrene. Due to infection with gas
producing organism
1- Dry gangrene “Gross”:
Dry gangrene: Gradual arterial occlusion, usually affect the extremities. The skin is dark brown or black and dry. There is a line of demarcation between the gangrenous area and the healthy tissues. e.g. senile gangrene of the lower limb
Healing: Replacement of damaged tissue by new,
healthy, living tissue. Either by:1- Regeneration mechanism : Replacement
of damaged cells by new cells of the same kind
2- Scaring “fibrosis”: is the replacement of tissue by Granulation tissue which matures to fibrous tissue.
2- Granulation tissue:
The damage area is invaded by granulation tissue that consist of: new capillaries form, spindle shaped fibroblasts,Homogenous pale pink ground substance showing few pink collagen fibers and and inflammatory cells .
3- Granulation tissue:
4- Primary union of wounds:
Blood clot formation at the site of wound.Phagocytic cells remove debris.Granulation tissues fibrous tissues scar.Epithelium regenerate and move toward the center
5- Secondary union of wounds :
Large tissue defectMore inflammationMore granulation tissue
6- Myocardial scaring:
Scar tissue appearing between cardiac muscles, it is appears homogenous, pink in color and new capillaries and fibroblast formed
7- Repair after myocardial infarction:
-the infarct area shows loss of details of the muscle fibers, the necrotic muscle fibers appear granular and pink with blue nuclear fragments.