Healing and Gangrene

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Healing and Gangrene

description

Healing and Gangrene. Gangrene:. It’s a necrosis with putrefaction,. It has 3 types: 1- Dry or senile gangrene . Gradual arterial occlusion usually affect the extremities 2- Moist gangrene . Sudden arterial and venous occlusion, Bacterial invasion , skin is black, moist and of foul odour - PowerPoint PPT Presentation

Transcript of Healing and Gangrene

Page 1: Healing and Gangrene

Healing and Gangrene

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Gangrene: It’s a necrosis with putrefaction,. It has 3 types: 1- Dry or senile gangrene. Gradual arterial occlusion

usually affect the extremities 2- Moist gangrene. Sudden arterial and venous occlusion,

Bacterial invasion , skin is black, moist and of foul odour 3- Gas gangrene. Due to infection with gas

producing organism

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1- Dry gangrene “Gross”:

Dry gangrene: Gradual arterial occlusion, usually affect the extremities. The skin is dark brown or black and dry. There is a line of demarcation between the gangrenous area and the healthy tissues. e.g. senile gangrene of the lower limb

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Healing: Replacement of damaged tissue by new,

healthy, living tissue. Either by:1- Regeneration mechanism : Replacement

of damaged cells by new cells of the same kind

2- Scaring “fibrosis”: is the replacement of tissue by Granulation tissue which matures to fibrous tissue.

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2- Granulation tissue:

The damage area is invaded by granulation tissue that consist of: new capillaries form, spindle shaped fibroblasts,Homogenous pale pink ground substance showing few pink collagen fibers and and inflammatory cells .

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3- Granulation tissue:

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4- Primary union of wounds:

Blood clot formation at the site of wound.Phagocytic cells remove debris.Granulation tissues fibrous tissues scar.Epithelium regenerate and move toward the center

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5- Secondary union of wounds :

Large tissue defectMore inflammationMore granulation tissue

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6- Myocardial scaring:

Scar tissue appearing between cardiac muscles, it is appears homogenous, pink in color and new capillaries and fibroblast formed

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7- Repair after myocardial infarction:

-the infarct area shows loss of details of the muscle fibers, the necrotic muscle fibers appear granular and pink with blue nuclear fragments.