Harris Nesbiti Focus on Healthcare Conference Presentation
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Transcript of Harris Nesbiti Focus on Healthcare Conference Presentation
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ConfidentialConfidential
Harris NesbittFocus on Healthcare
Harris NesbittFocus on Healthcare
December 8, 2005December 8, 2005
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This presentation contains “forward-looking statements” as defined under the federal securities laws. Actual results could vary materially. Factors that could cause actual results to vary materially are described in our filings with the Securities and Exchange Commission.
You should pay particular attention to the “risk factors” contained in documents we file from time to time with the Securities and Exchange Commission. The risks identified therein, as well as others not identified by the Company, could cause the Company’s actual results to differ materially from those expressed in any forward-looking statements.
Cautionary Statement Concerning Forward-Looking StatementsCautionary Statement Concerning Forward-Looking Statements
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Investment ConsiderationsInvestment Considerations
A Leader in Regenerative Medicine – the Next Frontier in Medicine
Product Focused – Driving Human ES Cell Therapies to the Clinic
Intellectual Property – Proprietary Human ES Cell Technology
Human Capital – Talented Team of Scientists and Management
Financial Resources – Strong Cash Position and Public Currency
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Realizing the Potential of Human Embryonic Stem Cells
Realizing the Potential of Human Embryonic Stem Cells
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Stem Cells are a Proven TherapyStem Cells are a Proven Therapy
First successful bone marrow transplant (BMT) in 1968
Tens of thousands of patients have been cured with BMT
Human embryonic stem cells first isolated in 1998
hESC’s have significant potential to treat diseases
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The Potential of Human ES Cells - PluripotencyThe Potential of Human ES Cells - Pluripotency
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ES Cells Form Complex TissuesES Cells Form Complex Tissues
Science 2002 295: 819
PNAS 2003, 100 Suppl 1:11911
Intestine Muscle Retina
Hair / Skin Cartilage Bone
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The Potential of Human ES CellsThe Potential of Human ES Cells
Beating heart cellsBeating heart cells
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Regenerative Medicine “The New Frontier”
Regenerative Medicine “The New Frontier”
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Regenerative MedicineCuring Devastating DiseaseRegenerative MedicineCuring Devastating Disease
800,000 Parkinson's patients 750,000
liver disease patients
20,000,000 heart disease patients
20,000,000 diabetes patients
5,000,000 epilepsy patients
4,000,000 Alzheimer's patients
2,000,000 stroke patients
300,000 kidney disease patients
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Growing Legislative SupportGrowing Legislative Support
California & Proposition 71Voters approve $3.0 billion in funding over next ten yearsFormation of CA Institute of Regenerative Medicine (CIRM)Recent awards of initial training grants
Other State InitiativesMA, CT, NJ, NY, IL, FL
Federal LegislationBi-partisan House of Representatives Bill H.R. 810Federal Funding for Alternative Methods of Deriving Human ES Cells
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The Next Frontier in MedicineThe Next Frontier in Medicine
"If the potential of stem cell research is realized, it would mean an end to the suffering of millions of people. If stem cell research succeeds, there isn’t a person in the country who won’t benefit, or know somebody who will."Michael J. Fox
“[Stem cell research] is the most promising research in healthcare perhaps in this history of the world and we should not be left behind in this research.”Senator Orin Hatch, (R-Utah)
“Science has presented us with a hope called stem-cell research, which may provide our scientists with answers that have so long been beyond our grasp.”Nancy Reagan
“This is not a matter of using a human embryo that has the potential to produce life. Rather, these otherwise discarded embryos have the potential to save lives.”Senator Arlen Specter (R-PA)
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ACT Business StrategyACT Business Strategy
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Focused Business StrategyFocused Business Strategy
Driving Human ES Cell Therapies to the Clinic
Solving Immune Rejection and the Ethical Debate
Leveraging Proprietary Technology Platform
Expanding Collaborations and Corporate Partnerships
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Driving Human ES Cell Therapies to the ClinicDriving Human ES Cell Therapies to the Clinic
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Driving Human ES Cell Therapies to the ClinicDriving Human ES Cell Therapies to the Clinic
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Driving Human ES Cell Therapies to the ClinicDriving Human ES Cell Therapies to the Clinic
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Our Product Development PathwayOur Product Development Pathway
Cell Discovery and ValidationFinding Cell Types with Therapeutic PotentialInitial FDA Discussion for Target Indication
“GMP” Cell ProductionDerive Human ES Cells under GMP Differentiate Target Cell Type under GMP
Preclinical and Clinical Testing Functional and Safety Preclinical TestingDevelop Plan with FDA for Human Clinical Trials
target cell typestarget cell types
target cell linestarget cell lines
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Cell Therapy – RPE cellsCell Therapy – RPE cells
Age-related diseases of the eye
Over 10 million cases MDG in U.S.
Early functional tests show therapeutic potential
GMP cell production – next step
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Cell Therapy – Hemangioblast CellsCell Therapy – Hemangioblast Cells
Potential treatment for multiple cardiac and blood disorders
Published data shows therapeutic potential in mouse model
Large market potential
In cell discovery now
Circulation Research 2004, 94: 820
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Cell Therapy – Dermal CellsCell Therapy – Dermal Cells
Unique capacity of early skin cells
Large applications in burns, wound repair and surgery
In cell discovery now
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Solving Immune Rejection and the Ethical DebateSolving Immune Rejection and the Ethical Debate
Two Significant Challenges to Regenerative Medicine Today
Solving Rejection of Cell Therapies by a Patient’s Immune System
Addressing the Ethical Debate Surrounding the Derivation of Human ES Cell
ACT Uses Proprietary Cellular Reprogramming to Address Both Challenges
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Chronic Diseases or Indications Requiring Custom TherapyToday - Somatic Cell Nuclear Transfer (“SCNT”)
Tomorrow – Transdifferentiation
Result - a custom-tailored, patient-specific cell therapy for patient
Acute Injuries or Indications Requiring Immediate TherapyTomorrow – Our Reduced Complexity Library (“RCL”)
Result – cell therapies for the immediate treatment of acute injuries which will provide a close match for most patients
Solving Immune Rejection – Cellular Reprogramming for “Chronic versus Acute”Solving Immune Rejection – Cellular Reprogramming for “Chronic versus Acute”
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Somatic Cell Nuclear Transfer – “SCNT”Somatic Cell Nuclear Transfer – “SCNT”
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Reduced Complexity LibraryReduced Complexity Library
ACT Reduced Complexity Library
HLA matched cell line for patient
Act 1Act 1
Act 2Act 2
Act 5Act 5
Act 6Act 6
Act 7Act 7Act 3Act 3
Act 8Act 8Act 4Act 4
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Strong IP in Alternative TechnologiesStrong IP in Alternative Technologies
10.17.05
Scientists Find New Ways to Derive Embryonic Stem Cells
- Forbes
Scientists Devise New Stem Cell Methods to Ease Concerns
- The New York Times
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No Damage to the EmbryoNo Damage to the Embryo
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Leveraging Proprietary Technology Platform Leveraging Proprietary Technology Platform
es cellses cells
patientpatient -- specific
specific
hemangioblast
hemangioblast
dermal
dermal
ALTERNATIVES / PGD
TRADITIONAL ES CELLS CELL DIFFERENTIATION HISTOCOMPATIBILITY / SCNT
TRANSDIFFERENTIATION
TECHNOLOGIESTECHNOLOGIES
INTELLECTUAL PROPERTYINTELLECTUAL PROPERTY
SCIENTIFIC TEAMSCIENTIFIC TEAM
RC
LR
CL
e s cellse s cells
RPE
RPE
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Expanding Academic Collaborationsand Corporate PartnershipsExpanding Academic Collaborationsand Corporate Partnerships
Collaboration potential:
•Existing scientific and academic relationships
•CA Proposition 71
•Large BIO / PharmaDIFFERENTIATION/COW OOCYTE
HISTOCOMPATIBILITY/SCNT
patientpatient -- specific
specificALTERNATIVE/PGD
TRADITIONAL ES CELLS CELL DIFFERENTIATION
rperpe
dermal
dermal
hemangioblast
hemangioblast
rclrcl
es cellses cells
PatientPatient -- specific
specificTRANSDIFFFERENTIATION
HISTOCOMPATIBILITY/SCNT
TECHNOLOGIESTECHNOLOGIES
INTELLECTUAL PROPERTYINTELLECTUAL PROPERTY
SCIENTIFIC TEAMSCIENTIFIC TEAM
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Key Financial InformationKey Financial Information
Strong Cash Position of $16 million
Funding StatusFunded into 2007
Potential additional $8.875 million in Convertible Notes – Funding into 2008
Conversion of notes at $4.60 per share stock price
Public Market StatusOTC-BB:ACTC
Apply for listing on Amex or NASDAQ Capital Market
Recent share price of $2.10 - 2.75
Approximate fully-diluted market cap of $125 - 150 million
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Senior Management TeamSenior Management Team
Mr. William Caldwell, IV, Chief Executive Officer30 Year Career in Management and Finance
Dr. Michael West, Chairman, Chief Scientific Officer and PresidentFounder of Geron and ACT
Dr. Robert Lanza, VP of Medical & Scientific Development25 Year Career in Biomedical and Scientific Research
Mr. James Stewart, SVP, Chief Financial Officer25 Year Career in Accounting, Finance
Mr. Jon Atzen, SVP, General Counsel15 Year Legal Career in Corporate and Securities Law
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2005 Corporate Milestones - Achieved2005 Corporate Milestones - Achieved
Expanded Senior Management and Scientific Team
Raised over $25 million in capitalSeries A Financing of $8.0 million in January
Convertible Note Financing of $17.75 million in September
Formed California Collaborations
Defined Product Areas of FocusRetinal, Dermal and Hemangioblasts
Published on Alternatives for Derivation of ES Cells – Nature 2005
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2006 Corporate Milestones - Objectives2006 Corporate Milestones - Objectives
“GMP” Cell ProductionDerive Human ES Cells under “GMP”
Differentiate and Scale Production of “GMP” cells
Launch Preclinical and Clinical PlanRecruit Senior Clinical Executive
Conduct Preclinical Testing of “GMP” cells
Work with FDA to expedite human clinical trials
Expand Technology Platform with Scientific Breakthroughs
Achieve Listing on AMEX or NASDAQ Capital Market
Announce Corporate Partnership
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SummarySummary
A Leader in Regenerative Medicine – the Next Frontier in Medicine
Product Focused – Driving Human ES Cell Therapies to the Clinic
Intellectual Property - Proprietary Human ES Cell Technology
Human Capital – Talented Team of Scientists and Management
Financial Resources – Strong Cash Position and Public Currency
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ConfidentialConfidential