Hands - on

The process of discovery and development of drugs is ever longer and costly.

It happens in an environment of research teams from different organizations

(coming from the pharmaceutical industry, academia, SMEs, etc.) often

placed in distant locations where there the need for constant discussions and

interactions. Those communications seldom take place based on graphical

elements (3D, 2D, images…) that might require strict confidentiality due to

their high industrial value. Consequently, the majority of interactions is

performed in presence meetings, which is costly and time consuming.

The idea is to develop a software that enables research teams from the drug

discovery and development sector (pharmaceutical, biotechnological, etc) to

collaborate from a distance and discuss in real time over graphical elements

(3D molecules, result tables, images, etc.) without the need of face-to-face

meetings so often, accelerating the entire process.

Project idea

Hands - on

• Small-medium collaborative project

• Funding: around 3.000.000 €

• Length: maximum of 3 years

• Related fields: IST – eHealth, IST – eWork, GROWTH, Quality of

Life, etc. Possible topics:• IST II.2.2: New methods of work and electronic commerce - Smart organisations

To explore and validate novel technologies, applications, architectures and practices aimed at supporting the transformation of profit and non-profit entities into "smart" organisations: knowledge driven, internetworked, dynamically adaptive to new organisational forms and practices, learning as well as agile in their ability to create and exploit the opportunities offered by the digital economy.”• IST II.1.5: Promoting broad adoption of eCommerce & eWork in regional and sectoral settings. • GROWTH 1.4.1: New methods of organisation, work and human capital improvementThe aim is to develop new organisational and work practices together with developments in industrial products, processes and services, and the appropriate human capital, competence and skills. RTD should address methodologies and tools for efficient organisation, knowledge and technology management, and support close integration and networking of people, organisations and technologies, recognising the importance for innovation / competitiveness of better procurement methods and decision making tools.

Basic Characteristics

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Potential PartnersName Type Country Expertise Profile

Fundació Biomèdica (FBM)

Non-profit research centre

Spain Modelling 3D, software, drug discovery research

-

Lab. Vida S.A. (LV) Private company Spain Pharmaceutical company Usual collaborator

IBMF Technologies (IBMF)

Private company UK Software / hardware development generic

Known

Università de Milano (UMI)

Academia Italy Drug discovery research Unknown – Guru

Universidade Santiago de Compostela (USC)

Academia Spain Drug discovery research Usual collaborator

AstraSeneca (AS) Private company Sweden Top pharmaceutical company Unknown

Drug Discovery Software Srl (DDS)

Private company – SME

Italy Molecular software development Known

Joint Research Center (JRC)

European Commission

Europe Generic software research Unknown

Digital Security UK (DIGI)

Private company UK Security, encryptation Unknown

Universitat de Catalunya (UCAT)

Academia Spain Software development Known – Guru

Instituto de Tecnología de Murcia (ITM)

Non-profit research centre

Spain Security, encryptation Usual collaborator

University of Bremen (UBR)

Academia Germany Molecular software development, drug discovery research

Unknown – Guru

Microsoluciones SL (MICRO)

Private company – SME

Spain Software development (generic) Usual collaborator

Transgen SL (TGEN) Private company France Biotech Unknown

University of Düsseldorf (UD)

Academia Germany Drug discovery research Usual collaborator

Hands - on

1) List the objectives of the project

2) Select an acronym

3) Choose the partners for the consortium

Exercise 1

Hands - on

WRAP-UP 1

Project objectives

LINK3D aims to develop, test and prepare the commercial exploitation of a real-time, interactive distant collaboration environment for professionals working in an strategically crucial field: Molecular Discovery (MD). The specific objectives of the project are:

 1) To gather detailed requirements of MD professionals in terms of tele collaboration.

2) To develop a set of software applications, configuring a real-time tele-collaboration environment for Drug Discovery professionals.

3) To test the system in real-life environments, both for inter-organisational and intra-organisational collaborative settings and considering the different types of actors involved (industry, academia).

4) To analyse the potential market, the business possibilities of the LINK3D system, and prepare its commercial exploitation, considering extension to other sectors.

Hands - on

WRAP-UP 1

Partners LINK3D:

Name Type Country Expertise Profile

Fundació Biomèdica (FBM)

Non-profit research centre

Spain Modelling 3D, software, drug discovery research

-

Lab. Vida S.A. (LV) Private company Spain Pharmaceutical company

Usual collaborator

AstraSeneca (AS) Private company Sweden Pharmaceutical company

Unknown

Drug Discovery Software Srl (DDS)

Private company – SME

Italy Molecular software development

Known

Digital Security UK (DIGI)

Private company UK Security, encryptation Unknown

Universitat de Catalunya (UCAT)

Academia Spain Software development Known – Guru

University of Düsseldorf (UD)

Academia Germany Drug discovery research

Usual collaborator

Hands - on

1) List the Work Packages

2) Define Deliverables and Milestones

3) Assign Work Packages Leaders

Exercise 2

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WRAP-UP 2

List of Work Packages:

WP1 Project management and co-ordination (FBM)

WP2 User requirements gathering (FBM)

WP3 System specifications (DDS)

WP4 System development (UCAT)

WP5 In-process testing (DDS)

WP6 Real-world testing (FBM)

WP7 Exploitation (DDS)

WP8 Dissemination (FBM)

WP9 Assessment and evaluation (FBM)

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WRAP-UP 2

Tasks:

WP1 Project management and co-ordination (FBM)

T1.1. Day to day operational management

T1.2. Project co-ordination

WP2 User requirements gathering (FBM)

T2.1 Planning

T2.2 Execution

T2.3 Analysis of results

WP3 System specifications (DDS)

T3.1 File formats

T3.2 Communication protocols

T3.3 Security issues

T3.4 Definition of standard hardware configuration requirements

T3.5 Global definition of the system specifications

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WRAP-UP 2

Lista de Tasks:

WP4 System development (UCAT)

T4.1 Development of the communication protocols

T4.2 Development of the whiteboard metaphors and graphical engines

T4.3 Development of the security

T4.4 System adjustments

T4.5 User manuals

WP5 In-process testing (DDS)

T5.1 Planning

T5.2 Execution

T5.3 Analysis of results

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WRAP-UP 2

Tasks:

WP6 Real-world testing (FBM)

T6.1 Testing planning (inter-organisational setting)

T6.2 Testing execution (inter-organisational setting)

T6.3 Analysis of results (inter-organisational setting)

T6.4 Testing planning (intra-organisational setting)

T6.5 Testing execution (intra-organisational setting)

T6.6 Analysis of results (intra-organisational setting)

T6.7 Integration of testing results

WP7 Exploitation (DDS)

T7.1 Market analysis

T7.2 IPR issues

T7.3 Business plan

T7.4 Extension to other industrial sectors

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WRAP-UP 2

Tasks:

WP8 Dissemination (FBM)

T8.1 Web site

T8.2 Brochure

T8.3 Other activities

WP9 Assessment and evaluation (FBM)

T9.1. Quality assurance

T9.2. Risk management

T9.3. Project evaluation

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WRAP-UP 2

Deliverables list:Del. no. Deliverable name WP

no.Del. type* Delivery

(proj.month)

D1Report on the set-up of the organisation and infrastructure of the LINK3D project

1 Report 3

D2 Project presentation 8 Document 3

D3Report on user requirements (investigation methods and results)

2 Report 4

D4 Dissemination and use plan 8 Report 6

D5 Report on the specifications of the LINK3D system 3 Specification 7

D6First version of the LINK3D system including user manuals

4 Prototype 19

D7Report on the in-process testing (methods and results)

5 Report 19

D8First report on real-world testing of the LINK3D system (methods and results)

6 Report 22

D9Report on the specifications of the improved LINK3D system

3 Specification 23

D10 Report on market analysis 7 Report 24

D11Improved version of the LINK3D system including user manuals

4 Prototype 26

D12Final report on real-world testing of the LINK3D system (methods and results)

6 Report 29

D13 Final report on dissemination activities 8 Report 30

D14 Report on the business plan 7 Report 30

D15 Assessment and evaluation report 9 Report 30

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WRAP-UP 2

Milestones list:

M1 Definition of user requirements

M2 Completion of the system specifications (first version)

M3 Completion of the first version of the LINK3D system

M4 Completion of the first stage of the real-world testing

M5 Completion of the market analysis

M6 Completion of the improved system specifications

M7 Completion of an improved version of the LINK3D system

M8 Completion of the second stage of the real-world testing

M9 Completion of the business plan

M10 LINK3D project completion

Hands - on

1) GANTT chart

2) PERT diagram

Exercise 3

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WRAP-UP 3

Hands - on

• Responsibility Assignment Matrix, defined by

project roles

R: Responsible

W: Major contribution

I: Minor contribution

Exercise 4

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WRAP-UP 4: RAM LINK3D

  FMB LV AS DDS DIGI UCAT UD

WP1 - Project Management and Coordination

R     W W

WP2 - User requirements gathering R W W     W

WP3 - System specifications I     R W W  

WP4 - System development W       W R  

WP5 - In-process testing R I I W W W I

WP6 - Real-world testing R W W       W

WP7 - Exploitation W     R W I  

WP8 - Dissemination R I I I I I I

WP9 - Assessment and evaluation R   I I I I  

Hands - on

• RAM of efforts

• 3 steps:• Relative weight of each WP• Estimate the total effort amount• Estimate the breakdown of efforts per task

Hint: the total amount can be estimated dividing

the total funding by 5000-10000 Euro

(depending on the consortium profile).

Hint: Estimate the relation between R, W, I: • W= 2 I• R= 3 I

Exercise 5

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WRAP-UP 5: RAM LINK3D

  FMB LV AS DDS DIGI UCAT UDpm

totalpm

targetWeight

WP

WP1 - Project Management and Coordination

15     10 10 35 35 7

WP2 - User requirements gathering

17 11 11       11 50 50 10

WP3 - System specifications 4     13 9 9   35 35 7

WP4 - System development 36       36 54   125 125 25

WP5 - In-process testing 13 4 4 8 8 8 4 50 50 10

WP6 - Real-world testing 35 23 23       23 105 105 21

WP7 - Exploitation 13     19 13 6   50 50 10

WP8 - Dissemination 8 3 3 3 3 3 3 25 25 5

WP9 - Assessment and evaluation

11   4 4 4 4   25 25 5

total pm 151 41 45 57 72 93 41 500 500 100

Full-time Equivalents (FTE) 4,2 1,1 1,2 1,6 2,0 2,6 1,1 13,9

Hands - on

• Construct the budget

• Take into account the type of expenditure:

personnel, equipment, consumables, travel,

subcontracting, indirect costs.

• Take into account that funding agencies do

not always cover 100% of the direct costs of

the project (difference between “budget” and

“funding”).

Exercise 6

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WRAP-UP 6: Budget LINK3D  FMB LV AS DDS DIGI UCAT UD

total pm 151 41 45 57 72 93 41

Full-time Equivalents (FTE) 4,2 1,1 1,2 1,6 2,0 2,6 1,1

Average personnel rate 4000 4500 6000 5500 7000 3500 3900

Overhead rate 0,6 0,45 0,3 0,6 0,6 0,6 0,6

Other costs (travel, consumables, etc.)

45000 30000 30000 45000 30000 45000 30000

RTD

total pm 104 39 39 21 53 71 39

Personnel costs 417024 173750 231667 118021 369583 247292 150583

Subcontracting

Other direct costs 31110 27987 25763 17073 22107 34095 27987

Overheads max. 268880 78188 77229 81056 235014 168832 107142

Total costs 717014 279924 334659 216151 626705 450218 285712

EC contribution 537761 139962 167330 162113 313353 337664 214284

Management

total pm 15 0 0 10 0 10 0

Personnel costs 60000 0 0 55000 0 35000 0

Subcontracting 2000 0 0 1000 1000 1000 0

Other direct costs 4476 0 0 7956 0 4826 0

Overheads max. 38686 0 0 37774 0 23895 0

Total costs 105162 0 0 101730 1000 64721 0

EC contribution 105162 0 0 101730 1000 64721 0

Hands - on

  FMB LV AS DDS DIGI UCAT UDOther

total pm 32 3 6 25 19 13 3

Personnel costs 126190 12500 38095 138046 131944 44097 10833

Subcontracting

Other direct costs 9414 2013 4237 19970 7893 6080 2013

Overheads max. 81363 5625 12700 94809 83902 30106 7708

Total costs 216967 20138 55031 252825 223739 80283 20555

EC contribution 216967 20138 55031 252825 223739 80283 20555

total pm 151 41 45 57 72 93 41 500,0

Personnel costs 603214 186250 269762 311066 501528 326389 161417 2359626

Subcontracting 2000 0 0 1000 1000 1000 0 5000

Other direct costs 45000 30000 30000 45000 30000 45000 30000 255000

Overheads max. 388929 83813 89929 213640 318917 222833 114850 1432910

Total costs 1039143 300063 389690 570706 851444 595222 306267 4052536TOTAL COSTS

EC contribution 859889 160100 222361 516669 538092 482668 234839 3014618TOTAL

FUNDING

No. of certificates needed 2,3 0,4 0,6 1,4 1,4 1,3 0,6

TOTAL

WRAP-UP 6: Budget LINK3D