H e a r t S T A T

blood flow and disease monitoring intervention

H e a r t S T A T

blood flow and disease monitoring intervention

Cover

H e a r t S T A T

H e a r t S T A T

Cover

a proprietary noninvasive system and disposable sensor

for practical and continuous monitoring of blood flow, perfusion, BP, and heart work.

a proprietary noninvasive system and disposable sensor

for practical and continuous monitoring of blood flow, perfusion, BP, and heart work.

our our CNBPCNBP

UniquelyUniquely comfortablecomfortable, , simplesimple

& & price-competitiveprice-competitive

11..22..

OldOld SystemSystem ( before new cost re-engr system)( before new cost re-engr system)

New I. P.New I. P. ( Multivariate Monitoring … Locked-up ) ( Multivariate Monitoring … Locked-up )

FDA cleared; $6 mil R&D invested; $5 mil Rev proof of acceptabilityFDA cleared; $6 mil R&D invested; $5 mil Rev proof of acceptability

ourour AdvanceAdvance

First practical measurement of:First practical measurement of:

• Blood FlowBlood Flow;;

• PerfusionPerfusion; ; andand

• Cardiovascular DynamicsCardiovascular Dynamics..

… … using a simple BP cuff in a new way.using a simple BP cuff in a new way.

forfor Vital Problems Vital Problems

• Septic Shock Septic Shock && Infections Infections Invasive Lines & BP cuffsInvasive Lines & BP cuffs

• Cardiogenic ShockCardiogenic Shock

• Brain Dysfunction Brain Dysfunction (caused in surgery)(caused in surgery)

• Drug interactionsDrug interactions

Over Over $40 Billion$40 Billion of hospital costs*of hospital costs* and and 300,000 300,000 unexpected deathsunexpected deaths occur annually owing to occur annually owing to::

Preventive blood flow monitoring is the Preventive blood flow monitoring is the means to control these problems.means to control these problems.

** Excludes legal malpractice costs.Excludes legal malpractice costs.

overcoming overcoming Critical Limitations Critical Limitations

hide septic shockhide septic shock & & blood loss blood loss … … until it is too lateuntil it is too late

discernable discernable brain damagebrain damage occurs with occurs with 50%50% of surgery patients with cardiovascular disease of surgery patients with cardiovascular disease

impede anesthesiology safety impede anesthesiology safety becausebecause blood flow is reduced by cardiovascular disease blood flow is reduced by cardiovascular disease

1.1.

2.2.

Of Of Preventive MonitoringPreventive Monitoring [[ BP & Pulse Ox BP & Pulse Ox

devicesdevices ]]

System

calibrates calibrates sensorsensor / / patientpatientandand measures measures 33 waveforms waveforms

for …for …

SystemSystem

first use first use of a of a provenproven

science-based blood flow technology science-based blood flow technology ……

Cor's

ComfortComfort unlimited useunlimited use

CalibratedCalibrated sensing precisionsensing precision

ControlledControlled single patient usesingle patient use

SterileSterilecross-contamination safetycross-contamination safety

BIC Sensor

arm

Disposable SensorDisposable Sensor

"BICS" "BICS" Biophysic Interval Cuff SensorBiophysic Interval Cuff Sensor

Monitor UnitMonitor Unit && Disposable SensorDisposable Sensor

Unprecedented AccuracyUnprecedented Accuracy

.97.97 correlation correlation clinical study of our system technology, using powerful anesthetic "vasoactive" drugs.

superior superior to present to present

cardiac outputcardiac output.. D.A. McDonald. Blood Flow in Arteries. Arnold. 1974 D.A. McDonald. Blood Flow in Arteries. Arnold. 1974

" The first practical science-based hemodynamic technology "" The first practical science-based hemodynamic technology "

In-depth assessment by preeminent flow dynamics authority, Dr. A. Noordergraaf, U. Penn

Uniquely PracticalUniquely Practical

•Risk-freeRisk-free (avoids infections)(avoids infections)

•Non-constrictiveNon-constrictive (avoids cuff trauma)(avoids cuff trauma)

•Low-cost Low-cost (for universal use)(for universal use)

•SimplicitySimplicity (a cuff and a button(a cuff and a button - no operator training) - no operator training)

With:With:

Enabling:Enabling: unlimitedunlimited unrestrictedunrestricted continuouscontinuous use ... use ...

Needed for:Needed for: Preventive MonitoringPreventive Monitoring. .

Hospital Recognition of NeedHospital Recognition of Need

Most cMost critical care providers … indicate:ritical care providers … indicate:

""Non-invasive hemodynamic Non-invasive hemodynamic

monitoring is #1 unmet needmonitoring is #1 unmet need"" * *

** GE Medical survey of 700 critical care providersGE Medical survey of 700 critical care providers

Present Cardiac OutputPresent Cardiac Output

Risks/CostsRisks/Costs.. Impractical forImpractical for preventive monitoringpreventive monitoring ( ( for 95% of patients.)for 95% of patients.)

Doesn't measureDoesn't measure::

• Brain Safety FlowBrain Safety Flow

• Heart load dynamicsHeart load dynamics

• BiophysicsBiophysics

LIMITED to 5% of patients -LIMITED to 5% of patients - heart cath & other impracticalities. heart cath & other impracticalities.LIMITED to 5% of patients -LIMITED to 5% of patients - heart cath & other impracticalities. heart cath & other impracticalities.

1.1.

2.2.

ourour GoalGoal

“ “ to to establish a standard of careestablish a standard of care

for for critical care safetycritical care safety””

with practical blood flow monitoring to

overcome flaws of BP and pulse oximeter monitoring

• LargeLarge market market

• Solution to Solution to majormajor unmet needs unmet needs controllable costscontrollable costs:: $6 million yrly *$6 million yrly * risks risks && malpractice exposure malpractice exposure: : 60 deaths yrly *60 deaths yrly *

• StrongStrong competitive barriers competitive barriers

• FDAFDA-easy-easy

• Experienced Experienced MGTMGT

SummarySummary

* For: Avg-sized 200-bed hospitals