GWT-LESI GANAS KULIT KULKEL.ppt
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Transcript of GWT-LESI GANAS KULIT KULKEL.ppt
LESI GANAS KULIT
FAKULTAS KEDOKTERANUNIVERSITAS METHODIST INDONESIA
MELANOMA RADIAL GROWTH PHASE MELANOMA
(SUPERFISIAL SPREADING) the very beginning of malignant melanoma.
VERTICAL GROWTH PHASE MELANOMA
RADIAL GROWTH PHASE MELANOMA (SUPERFISIAL SPREADING)
PATHOGENESIS
Arise from neoplastic transformation of normally epidermis melanocytes proliferation superficial spreading invasive metast to lymphatic/hematogen
CLINICAL FEATURE
Change in a mole developed Itching Increase size Lesion darkening
MACROSCOPICALLY Early melanoma radial growth phase Slightly elevated & palpable border Variably colored some parts unusually
black / dark brown Lighter brown shade mingled with pink &
light blue tints Entire lesion purely dark brown occasionaly
MICROSCOPICALLY Large epitheloid melanocytes dispersed in
nests / as individual cells entire thickness of epidermis
Brisk lymphocytis response May be only in epidermis (in situ) Focal extension papillary dermis is rule Grow in all directions Dermal mitoses (-)
VERTICAL GROWTH PHASE MELANOMA
1-2 years of radial growth character of growth change focally
Focal mitotic activity (+) Grow as spheroidal nodules Expand rapidly in surrounding papillary
dermis Net direction growth perpendicular
CHARACTERISTIC VERTICAL GROWTH PHASE
Cells differ in appearance little / no pigment ; radial : melanotic
Cellular aggregate characteristic vertical Larger cluster cells extend into lower half
reticular dermis Host cellular immune response (-)
TYPES :
1. Metastatic Melanoma
2. Nodular Melanoma
- Rarest form
- Radial growth phase (-)
- Malignant character expressed in initial
lesion
3. Lentigo Malignant Melanoma
- Usually in fair, elderly & whites
= Hutchinson’s freckle
4. Acral Lentiginous Melanoma
- Most common form dark-skinned
- Limited to palm, sole & subungual region
PROGNOSIS
1. Type of melanoma Lentigo better
2. Depth of invasion Breslow’s thickness
3. Level of invasion Clark
4. Number of inflammatory cells
5. Clinical Stage
6. Sex : female better
7. Regression (+) poorer prognosis
Lentigo maligna melanoma
Lentigo maligna
Lentigo maligna melanoma
Superficial spreading melanoma
Superficial spreading melanoma
Superficial spreading melanoma
Acral lentigo melanoma
Acral lentigo melanoma
Acral lentigo melanoma
Acral lentigo melanoma
Nodular melanoma
Nodular melanoma
Nodular melanoma
SKIN CARCINOMA
1. BASAL CELL CARCINOMA
2. SQUAMOUS CELL CARCINOMA
BASAL CELL CARCINOMA
Most common pale skin Locally aggressive Rare metastases
PATHOGENESIS Develop on sun damaged skin fair skin &
freckles Fingers & dorsum of hand Derived from pluripoten cells of basal layer Differentiated along skin appendage lines
CLINICAL FEATURE Pearly papule prototypic lesion Rodent ulcer small crater in center of pearl Superficial BCC scaly, red, sharply
demarcated plaque Morphea-like BCC ill defined, pale, firm, scar-
like tumor Pigmented BCC grossly resembles malignant
melanoma
PATHOLOGY Multiple nests of deeply basophilic epithelial cells
attached to epidermis protude into papillary dermis
Central part compose of closely packed keratinocytes
Nuclei deeply basophilic surround by small rim cytoplasm
Periphery nests composed of an organized layer of polarized, columnar keratinocytes
SQUAMOUS CELL CARCINOMA
Cancer of epidermis whose cells resemble differentiated keratinocytes
Incidence : second only to BCC Caused by UV, radiation, chemical
carcinogens, HPV Often originates in actinic keratoses
PATHOGENESIS
Related to UV light Chronic scarring process > metastase
than solar-related SCC
CLINICAL FEATURE
Arise on hand, face, lip / ear Small lesion, scaly / ulcerated
PATHOLOGY Composed of tumor cells mimic
epidermal stratum spinosum extend into subjacent dermis
Variably thickened & parakeratotic Atypia basal keratinocyte (+)
Squamous cell carcinoma in situ, medium power. The normal maturation pattern of keratinocytic apithelium is disturbed, imparting a “windblown” look to the neoplastic epithelium. There is a parakeratotic scale
Squamous cell carcinoma in situ, high power. The lesional cells exhibit nuclear attributes of malignancy-enlargement, hyperchromatism, pleomorphism, and dyskeratosis