Gut hormones - Appetite, Mood and Health
-
Upload
quantified-self-dublin -
Category
Healthcare
-
view
19 -
download
1
Transcript of Gut hormones - Appetite, Mood and Health
![Page 1: Gut hormones - Appetite, Mood and Health](https://reader036.fdocuments.us/reader036/viewer/2022062522/58cf0cf91a28ab5f2b8b5ddf/html5/thumbnails/1.jpg)
Gut Hormones - Appetite, mood and health
Natasha Kapoor PhD Fellow, Diabetes Complication Research Centre, University College Dublin
![Page 2: Gut hormones - Appetite, Mood and Health](https://reader036.fdocuments.us/reader036/viewer/2022062522/58cf0cf91a28ab5f2b8b5ddf/html5/thumbnails/2.jpg)
Our body needs food as a source of fuel to power all of its processes.
Digestion – Gastrointestinal system Gastrointestinal hormones – help digest and absorb
food
![Page 3: Gut hormones - Appetite, Mood and Health](https://reader036.fdocuments.us/reader036/viewer/2022062522/58cf0cf91a28ab5f2b8b5ddf/html5/thumbnails/3.jpg)
Journey of a Pizza Slice
![Page 4: Gut hormones - Appetite, Mood and Health](https://reader036.fdocuments.us/reader036/viewer/2022062522/58cf0cf91a28ab5f2b8b5ddf/html5/thumbnails/4.jpg)
Stomach
Ghrelin
![Page 5: Gut hormones - Appetite, Mood and Health](https://reader036.fdocuments.us/reader036/viewer/2022062522/58cf0cf91a28ab5f2b8b5ddf/html5/thumbnails/5.jpg)
Ghrelin
hunger
Wren, A. M., et al. (2001). "Ghrelin enhances appetite and increases food intake in humans." J Clin Endocrinol Metab 86(12): 5992.
![Page 6: Gut hormones - Appetite, Mood and Health](https://reader036.fdocuments.us/reader036/viewer/2022062522/58cf0cf91a28ab5f2b8b5ddf/html5/thumbnails/6.jpg)
How to achieve lower Ghrelin Levels ?
Ghrelin seems to be a hormone that can’t be directly controlled with drugs, diets or supplements.
Avoid weight extremes Eat more proteinRegular eating No skipping meals Maintain a stable weight
![Page 7: Gut hormones - Appetite, Mood and Health](https://reader036.fdocuments.us/reader036/viewer/2022062522/58cf0cf91a28ab5f2b8b5ddf/html5/thumbnails/7.jpg)
![Page 8: Gut hormones - Appetite, Mood and Health](https://reader036.fdocuments.us/reader036/viewer/2022062522/58cf0cf91a28ab5f2b8b5ddf/html5/thumbnails/8.jpg)
Small Intestine
![Page 9: Gut hormones - Appetite, Mood and Health](https://reader036.fdocuments.us/reader036/viewer/2022062522/58cf0cf91a28ab5f2b8b5ddf/html5/thumbnails/9.jpg)
Hormone Cocktail
CholecystokininPeptide tyrosine tyrosineGlucagon like peptide- 1Oxyntomodulin
![Page 10: Gut hormones - Appetite, Mood and Health](https://reader036.fdocuments.us/reader036/viewer/2022062522/58cf0cf91a28ab5f2b8b5ddf/html5/thumbnails/10.jpg)
CCK
Gallbladder to release a substance called bile Bile- essential for the digestion and absorption of fat decreases food intake
Little, T. J., et al. (2005). "Role of cholecystokinin in appetite control and body weight regulation." Obes Rev 6(4): 297-306.
![Page 11: Gut hormones - Appetite, Mood and Health](https://reader036.fdocuments.us/reader036/viewer/2022062522/58cf0cf91a28ab5f2b8b5ddf/html5/thumbnails/11.jpg)
PYY
Released after a meal Reduces food intake Makes you feel full
Batterham, R. L., et al. (2002). "Gut hormone PYY3-36 physiologically inhibits food intake." Nature 418(6898): 650-654.
![Page 12: Gut hormones - Appetite, Mood and Health](https://reader036.fdocuments.us/reader036/viewer/2022062522/58cf0cf91a28ab5f2b8b5ddf/html5/thumbnails/12.jpg)
GLP-1
Released after a meal Reduces food intake Makes you feel full
Naslund, E., et al. (1999). "Energy intake and appetite are suppressed by glucagon-like peptide-1 (GLP-1) in obese men." Int J Obes Relat Metab Disord 23(3): 304-311.
![Page 13: Gut hormones - Appetite, Mood and Health](https://reader036.fdocuments.us/reader036/viewer/2022062522/58cf0cf91a28ab5f2b8b5ddf/html5/thumbnails/13.jpg)
OXM
Released after a meal Reduces food intake Makes you feel full
Cohen, M. A., et al. (2003). "Oxyntomodulin suppresses appetite and reduces food intake in humans." J Clin Endocrinol Metab 88(10): 4696-4701.
![Page 14: Gut hormones - Appetite, Mood and Health](https://reader036.fdocuments.us/reader036/viewer/2022062522/58cf0cf91a28ab5f2b8b5ddf/html5/thumbnails/14.jpg)
Two major roles for gut hormones in appetite regulation
The release of gut hormones can modulate normal hunger and satiety.
Obesity - 37% of Irish adults overweight, 24% obese
Very high levels of gut hormones may be released to generate food dislike and nausea.
![Page 15: Gut hormones - Appetite, Mood and Health](https://reader036.fdocuments.us/reader036/viewer/2022062522/58cf0cf91a28ab5f2b8b5ddf/html5/thumbnails/15.jpg)
Hot topics in the field of research
Gut hormone infusion study
GLP-1 analogue
GLP-1 responders/non- repsonders
Gut Hormone Study
![Page 16: Gut hormones - Appetite, Mood and Health](https://reader036.fdocuments.us/reader036/viewer/2022062522/58cf0cf91a28ab5f2b8b5ddf/html5/thumbnails/16.jpg)
How to achieve higher satiety gut hormone levels ?
Protein
Healthy Fats
Fiber
Complex carbohydrates
![Page 17: Gut hormones - Appetite, Mood and Health](https://reader036.fdocuments.us/reader036/viewer/2022062522/58cf0cf91a28ab5f2b8b5ddf/html5/thumbnails/17.jpg)
![Page 18: Gut hormones - Appetite, Mood and Health](https://reader036.fdocuments.us/reader036/viewer/2022062522/58cf0cf91a28ab5f2b8b5ddf/html5/thumbnails/18.jpg)