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![Page 1: Guidelines for the diagnosis and management of patients with thoracic aortic disease Circulation 2010;121.](https://reader036.fdocuments.us/reader036/viewer/2022062404/5519c9e5550346047c8b4972/html5/thumbnails/1.jpg)
Guidelines for the diagnosis and management of patients with thoracic aortic disease
Circulation 2010;121
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Introduction
• Usually asymptomatic until complication-imaging required for detection and monitoring
• Risk of radiation and contrast related toxicity• Results of treatment better in asymptomatic
stage• Identification of genetic alterations– Potential for early detection– Targeted therapy
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• Aneurysm:permanent localized dilatation of an artery with at least 50% increase in diameter compared with the expected normal diameter.Covered by all 3 layers
• Pseudoaneurysm:disruption of arterial wall&extravasation of blood contained by periarterial connective tissue
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• Aortic dissection:disruption of media layer of aorta with bleeding within and along the wall of aorta
• Intramural hematoma:clinical picture of dissection with hematoma in arterial wall,without an intimal disruption.no flow in false lumen
• Penetrating atherosclerotic ulcer:atherosclerotic lesion with ulceration that penetrates the internal elastic lamina.
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Normal thoracic aortic diameter
• Depends on– Age– Sex– Body size– Location of measurement – Method of measurement
• Diameter increases by 0.12-o.29mm/yr at each level
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Aortic diameter at various levels by CT
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Aortic root dimensions by echo
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Imaging modalities(classI)
• Measurements should be taken at reproducible anatomic landmarks,perpendicular to axis of flow
• CT&MRI-ext.diameter taken• Echo-internal diameter• For aortic root-the widest diameter at mid sinus level• Abnormalities of aortic morphology reported
separately• Minimise cumulative radiation exposure• classIIa-aortic diameter should be related to patient's
age and body size
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• Selection of most appropriate imaging study– Patient factors-hemodynamic status,renal
fn,contrast allergy– Availability
• IRAD-initial imaging modality was CT(61%),TEE(33%),MRI(1%)
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CT
• Advantages – Availability– Entire aorta imaged– Short time– Branch vessel invt.
• Ecg gating,MDCT
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MRI
• Advantage– No radiation– Identification of anatomic variants of AoD– branch vessel invt
• Disadvantage– Prolonged duration– Pt.inaccessible to care providers– Gadolinium contrast not used in renal impairment
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Echocardiography
• Proximal AoD-– TEE sensitivity 88-98%,specificity 90-95%– TTE 77-80% and 93-96%
• Distal AoD-TEE better• TEE blind spot-distal ascending
aorta&prox.arch-interposition of trachea <.main bronchus
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Acute aortic syndromes
• Consists of 3 conditions-aortic dissection,IMH,PAU
• 15% of AoD have an IMH without an intimal tear
• Incidence 2-3.5/1,00,000 person years• Mean age of presentation 63yrs• Male predominance-65%
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• Acute dissection-within 2 weeks of onset of pain
• Subacute-b/w 2-6wks• Chronic->6 wks
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• DeBakey classification:– Type I: Dissection originates in Asc.aorta and propagates to
include at least the aortic arch– Type II: Dissection originates in and confined to the
Asc.aorta– Type III: Dissection originates in the desc.aorta and
propagates most often distally• Stanford classification system– Type A:dissections involving the asc.aorta regardless of the
site of origin– Type B:dissections that do not involve the asc.aorta
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Classes of intimal tears
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• 1.classic dissection• 2.IMH• 3.intimal tear without IMH• 4.PAU• 5.iatrogenic/traumatic
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Evaluation
• High risk conditions-(class I)– Genetic syndromes like Marfan syn.,Ehlers-Danlos– Connective tissue diseases– F/h of aortic dissection– Known aortic valve disease– Recent aortic manipulation– Known aortic aneurysm
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• High risk pain features(classI)– Chest,back or abdominal pain– Abrupt in onset – Severe intensity– Ripping,tearing,stabbing or sharp
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• High risk exam features(classI)– Pulse deficit– Syst.BP limb diff.>20mmHg– Focal neurological deficit– Murmur of AR(new)– shock
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Recommendations for screening tests(classI)
• STEMI in ECG should be treated as primary cardiac event without delay for aortic imaging unless pt. is high risk
• Low and intermediate risk patients should be screened by CXR-– Findings s/o aortic d/s-definitive aortic imaging– Alternate diagnosis-manage accordingly
• High risk patients should directly undergo TEE,CT or MRI• Class III- negative CXR should not delay definitive aortic
imaging in high risk pt
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Diagnostic imaging studies(classI)
• Selection of imaging modality based on pt variables and institutional capabilities
• If high clinical suspicion exists in spite of negative initial imaging a second study should be performed
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Recommendations for management
• BP mesured in both arms-treatment strategy based on highest reading
• Patient not in shock-i.v drugs for rate and B.P control
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Class I rec.for medical management
• i.v beta blockade titrated to HR<60/min• CCB alternative if beta blocker contra.• After HR controlled,i.v vasodilators to reduce
B.P to a level that maintains organ perfusion• Beta blocker used cautiously in setting of a/c
AR• Vasodilator should not be given prior to rate
control(classIII)
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Recommendation for definitive management(classI)
• Ascending aorta involved-emergent surgical repair
• Desc. Aorta involved-managed medically unless lifethreatening complications– Malperfusion syndrome– Progression of dissection– Enlarging aneurysm– Inability to control BP or symptoms
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Recommendations for surgical management(classI)
• Ascending ao.dissection-aneurysmal aorta and proximal extent of dissection should be resected
• Prtially dissected root-repaired with valve resuspension
• Extensive dissection of aortic root-aortic root replacement with a composite graft or with a valve sparing root replacement
• DeBakey type II-entire dissected aorta should be replaced
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Class IIa
• IMH-treated similar to aortic dissection in the corresponding segment
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• Endovascular interventions-not approved for dissection involving asc.aorta or arch
• Intimal defect without IMH-– Asc.aorta-emergency surgery– Desc.aorta-endograft
• Intimal defect with IMH– Stable pt-delay def.Rx until IMH resorbs– Desc.aorta-endovascular Rx
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Thoracic aortic aneurysms
• Rec.for medical Rx:classI– Antihypertensives to a goal<140/90(goal<130/80 for
DM&CKD)– Beta blocker in Marfans syn.&aortic aneurysm– Smoking cessation
• classIIa-– Reduce B.P to the lowest point pt can tolerate with
beta blocker and ACEI or ARB– ARB (losartan) for pt with Marfans syn.– Treatment with statin to target LDL-C<70mg%
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• Use of beta blockers slowed aortic root dilatation(Shores J et al;nejm 1994,Ladouceur M et al;Am J Cardiol 2007)
• Beta blockers reduced aortic dilatation in c/c type B dissection(Genoni M et al;2001)
• ACEI perindopril-reduced aortic root dilatation in marfans(Ahimastos AA et al;JAMA2007)
• ARB-reduced aortic root dilatation in Marfans syn(Brooks BS et al;nejm2008)
• Statin use a/w decreased long term mortality in abd aortic aneurysm(Diehm N et al;2008)
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Surgical management-asymptomatic pt.(classI)
• Ascending aortic aneurysm degenerative etiology-surgical repair if diameter>5.5cm
• Genetic syn.-elective surgery at diameter 4.0 to 5.0 cm
• Growth rate>0.5cm/yr• Patients undergoing AVR at a diameter>4.5cm
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Rec.for surgery-classII a
• Genetic syn.-ratio of aortic root area(cm²)devided by height (m)>10-surgery indicated
• Loeys Diets syn,TGFBR1&2 mutation-diameter >4.2 by TEE,or >4.4 by CT or MRI
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• Patients with symptoms s/o expansion of aneurysm-prompt surgical intervention(classI)
• Endovascular stent grafts have not been approved by the US FDA for treatment of aneurysms or other conditions of asc. aorta.
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Rec.for open surgery(asc.aortic aneurysm)-class I
• Separate valve and asc.aortic replacement in patients without significant root dilatation
• Patients with significant root dilatation-excision of sinuses&modified David reimplantation or root replacement with valved graft conduit
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Rec. for arch aneurysms-classII
• Partial arch replacement-asc.aortic aneurysm involves proximal arch
• Replacement of entire aortic arch-– A/c or c/c dissection in an aneurysmal arch– Aneurysm of entire arch– Distal arch aneurysm that involves prox.desc.aorta– Asymptomatic pts. With diameter>5.5cm
• Annual reimaging-aneurysms<4cm• Endovascular stent graft not approved
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Recommendations for desc.thoracic aorta(classI)
• Endovascular stent grafting-– Degenerative or traumatic aneurysm>5.5cm– Saccular aneurysm– Post op.pseudoaneurysm
• Open repair– c/c dissection– a/w connective tissue d/s– Desc.thoracic aorta>5.5 cm
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• Thoraco abdominal aneurysm-surgery when diameter >6cm
• End organ ischemia-additional revascularisation procedure recommended
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Recommendations for genetic syn.
• classI-– Marfan syn.-echo to assess aortic root and asc.aorta at diagnosis
&6 months after to determine rate of growth• Annual imaging if stable and <4.5cm• More frequent imaging otherwise
– Loeys-Dietz syn,other gen. mutations –complete aortic imaging at diagnosis,6months
– Loeys-Dietz syn-annual MRI from cerebrovasc.circulation to pelvis– Turner syn-imaging at diagnosis for BAV,CoA,dilatation of
asc.aorta.• If any abnormalities-annual imaging• Otherwise-repeat 5 to 10yr
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• Class IIa– Marfan syn planning pregnancy-replacement of
aortic root and asc.aorta if >4.5cm
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Recommendations for familial thoracic aortic aneurysms
• ClassI– Aortic imaging for first degree relatives of pts with
thoracic aortic aneurysm or dissection– If a mutant gene a/w aneurysm identified-first
degree relatives should undergo genetic screening-those with genetic mutation undergo imaging
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• classIIa– If one or more first degree relatives of a patient
affected-imaging of second degree relatives– Sequencing of ACTA2 gene in patients with f/h of
thoracic aortic aneurysm or dissection
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Recommendations for BAV(class I)
• First degree relatives of pts with BAV,premature onset of thoracic aortic d/s,familial form of aortic aneurysm and dissection-should be evaluated for presence of BAV&aortic d/s
• All pts with BAV should be evaluated for aortic dilatation
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Recommendations for takayasu arteritis &GCA(classI)
• Initial evaluation should include CT or MRI of thoracic aorta and branches
• Initial therapy-corticosteroids at high dose• Periodic evaluation-physical examination&ESR
or CRP• Elective revasc.after a/c inflammatory state is
quiescent• Class II a –use of anti inflammatory agents
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Recommendations in pregnancy
• classI– Marfans syn and aortic d/s-counselled about risk
of dissection,heritable nature– Strict BP control for pts with predisposition to
dissection– Aortic root or asc.aortic dilatation-monthly echo– Arch,descending or abd.aortic dilatation-MRI
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• ClassIIa– CS for pts with significant aortic dilatation
• Class IIb– If progressive aortic dilatation-prophylactic
surgery recommended
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Aortic dissection in pregnancy
• Type A-– 1st or 2nd TM-urgent surgical repair and fetal
monitoring– 3rd TM-urgent CS f/b aortic repair
• Type B-medical therapy preferred
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Aortic arch atheroma
• classIIa-Rx with a statin• Class IIb-oral anticoagulation with warfarin or
antiplatelets in stroke pts with atheroma≥ 4 mm
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Pre op evaluation for CAD
• Class I-– thoracic aortic d/s undergoing intervention-evaluated for
CAD– unstable cor syn-undergo revascularisation prior to at time
of aortic surgery or intervention• classIIa-– Asc.aortic or arch d/s undergoing surgery-concomitant
CABG for stable significant CAD• Class IIb-– Descending thoracic aortic d/s-stable significant CAD-
benefits not certain
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Organ protection
• Class II a-– deep hypothermic circulatory arrest for brain
protection– Optimisation of spinal cord perfusion pressure and
moerate systemic hypothermia• Class II b-preop.hydration and intra
op.mannitol for preservation of renal fn during open repairs of desc.aorta
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Mortality risk
• Composite valve graft,AVR with asc.aortic repair-1-5%
• Valve sparing aortic root reconstruction-less than1.5%
• BAV &asc.aorta repair-1.5%• a/c AoD-3.5-10%• Total arch replacement-2-6%mortality,2-7%
risk of stroke
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Post op surveillance