GSK3 Signaling - Abcam
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Discover more at abcam.com/GSK3 GSK3 Signaling 029_12_AKR Reelin Role of GSK3 in Neurodegenerative and Neurological Diseases p110 Ptdins(3,4,5)P3 APOER2 VLDLR NPxY motif Reelin inactive PI3-K pGSK3 p85 DAB1 pAKT Src Family P p110 Ptdins(3,4,5)P3 Insulin receptor Insulin inactive active active PI3-Kinase pGSK3 p85 IRS elF2B pAKT PDK1 Glycogen synthase Protein synthesis Glycogen synthesis Hedgehog Wnt Phosphorylation and cleavage of Ci No ligand Ptc Smo CK1 CK1 Fu Sufu Cos2 Ci GSK3 PKA PKA Nucleus Transcription No cleavage, full length Ci translocates to nucleus Presence of ligand Ptc Smo Fu Sufu GSK3 Nucleus Transcription Ci P P Hh Cos2 Ci P Frizzled Frizzled co-receptors Wnt Destruction complex GSK3 Dishevelled β-catenin β-catenin β-catenin β-catenin pathway β-catenin Ub Ub Ub U Ub Ub U Ub Ub FRAT CK1 APC Axin Proteasome Nucleus Knypek ROR2 LRP5/6 i Diversin TCF/LEF β-catenin Transcription P P Paired helical filaments Tau-P Dopamine GSK3 GSK3 GSK3 D2 Receptor β-arrestin-2 γ-secretase PP2A AKT N β-secretase α-secretase β A APP C Aβ Increased cleavage of APP into Aβ in Alzheimer's disease Tau hyperphoshorylation in Alzheimer's disease and other tauopathies e Regulation of dopamine receptor D2 signaling effects - implications for schizophrenia GSK3 activity Neurofibrillary tangles Tau Tau Cargo Cargo Featured products Tau (phospho S396) antibody [E178] (ab32057) Clonality Applications Host Species reactivity M IHC-P, WB, ICC, IP Rabbit Mouse, Rat, Human Immunohistochemistical detection of Tau (phospho S396) antibody [E178] (ab32057) on formaldehyde-fixed paraffin-embedded human salivary gland sections. This antibody has been cited in 2 publications and has received 3 star reviews: Excellent Wnt1 antibody (ab15251) Clonality Applications Host Species reactivity P IHC-P, IHC-Fr, WB Rabbit Mouse, Human ICC/IF image of ab15251 stained mouse 3T3 cells. The secondary antibody (green) was Alexa Fluor ® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. DAPI was used to stain the cell nuclei (blue). Alexa Fluor ® 594 WGA was used to label plasma membranes (red). This antibody has been cited in 7 publications and has received 6 star reviews: Excellent Insulin Produced in collaboration with Dr Claudie Hooper Copyright © 2012 Abcam, All Rights Reserved. The Abcam logo is a registered trademark.
Transcript of GSK3 Signaling - Abcam
Discover more at abcam.com/GSK3
GSK3 Signaling
029_12_A
KR
Reelin Role of GSK3 in Neurodegenerative and Neurological Diseases
p110
Ptdins(3,4,5)P3
APOER2VLDLR
NPxY motif
Reelin
inactive
PI3-K pGSK3p85
DAB1 pAKTSrc
Family
P
p110
Ptdins(3,4,5)P3
Insulin receptor
Insulin
inactiveactive
active
PI3-Kinase
pGSK3
p85
IRS
elF2B
pAKT
PDK1
Glycogensynthase
Proteinsynthesis
Glycogensynthesis
Hedgehog
Wnt
Phosphorylationand cleavage of Ci
No ligand
Ptc
SmoCK1
CK1Fu
Sufu Cos2Ci GSK3
PKA
PKA
Nucleus
Transcription
No cleavage, full lengthCi translocates to nucleus
Presence of ligand
Ptc
SmoFu
Sufu
GSK3
Nucleus
Transcription
Ci
PPHh
Cos2
Ci
P
Frizzled
Frizzledco-receptors Wnt
DestructioncomplexGSK3
Dishevelled
β-cateninβ-catenin
β-cateninβ-cateninpathway
β-catenin
UbUbUbU
UbUbU
Ub
Ub
FRAT
CK1
APC
Axin
Proteasome
Nucleus
Kny
pe
k
RO
R2
LR
P5/
6
i
Diversin
TCF/LEF
β-catenin Transcription
PP
Paired helicalfilaments
Tau-P
Dopamine
GSK3
GSK3
GSK3
D2
Re
cep
tor
β-arrestin-2
γ-secretase
PP2A
AKT
Nβ-secretase
α-secretase
β
A
AP
P
C
Aβ
Increased cleavageof APP into Aβ in
Alzheimer's disease
Tau hyperphoshorylation inAlzheimer's disease and
other tauopathies
e
Regulation of dopamine receptor D2signaling effects - implications
for schizophrenia
GSK3activity
Neurofibrillarytangles
TauTau
Cargo Cargo
Featured productsTau (phospho S396) antibody [E178] (ab32057)
Clonality Applications Host Species reactivity
M IHC-P, WB, ICC, IP Rabbit Mouse, Rat, Human
Immunohistochemistical detection of Tau (phospho S396) antibody [E178] (ab32057)
on formaldehyde-fixed paraffin-embedded human salivary gland sections.
This antibody has been cited in 2 publications and has received 3 star
reviews: Excellent
Wnt1 antibody (ab15251)
Clonality Applications Host Species reactivity
P IHC-P, IHC-Fr, WB Rabbit Mouse, Human
ICC/IF image of ab15251 stained mouse 3T3 cells. The secondary antibody (green) was Alexa
Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. DAPI was used to stain
the cell nuclei (blue). Alexa Fluor® 594 WGA was used to label plasma membranes (red).
This antibody has been cited in 7 publications and has received 6 star
reviews: Excellent
Insulin
Produced in collaboration with Dr Claudie Hooper Copyright © 2012 Abcam, All Rights Reserved. The Abcam logo is a registered trademark.
